Transient receptor potential canonical type 3 channels control the vascular contractility of mouse mesenteric arteries

Transient receptor potential canonical type 3 (TRPC3) channels are non-selective cation channels and regulate intracellular Ca2+ concentration. We examined the role of TRPC3 channels in agonist-, membrane depolarization (high K+)-, and mechanical (pressure)-induced vasoconstriction and vasorelaxation in mouse mesenteric arteries. Vasoconstriction and vasorelaxation of endothelial cells intact mesenteric arteries were measured in TRPC3 wild-type (WT) and knockout (KO) mice. Calcium concentration ([Ca2+]) was measured in isolated arteries from TRPC3 WT and KO mice as well as in the mouse endothelial cell line bEnd.3. Nitric oxide (NO) production and nitrate/nitrite concentrations were also measured in TRPC3 WT and KO mice. Phenylephrine-induced vasoconstriction was reduced in TRPC3 KO mice when compared to that of WT mice, but neither high K+- nor pressure-induced vasoconstriction was altered in TRPC3 KO mice. Acetylcholine-induced vasorelaxation was inhibited in TRPC3 KO mice and by the selective TRPC3 blocker pyrazole-3. Acetylcholine blocked the phenylephrine-induced increase in Ca2+ ratio and then relaxation in TRPC3 WT mice but had little effect on those outcomes in KO mice. Acetylcholine evoked a Ca2+ increase in endothelial cells, which was inhibited by pyrazole-3. Acetylcholine induced increased NO release in TRPC3 WT mice, but not in KO mice. Acetylcholine also increased the nitrate/nitrite concentration in TRPC3 WT mice, but not in KO mice. The present study directly demonstrated that the TRPC3 channel is involved in agonist-induced vasoconstriction and plays important role in NO-mediated vasorelaxation of intact mesenteric arteries.Fil: Yeon, Soo-In. Yonsei University College of Medicine; Corea del SurFil: Kim, Joo Young. Yonsei University College Of Medicine; . Yonsei University College of Medicine; Corea del SurFil: Yeon, Dong-Soo. Kwandong University College of Medicine; Corea del SurFil: Abramowitz, Joel. National Institute of Environmental Health Sciences; Estados UnidosFil: Birnbaumer, Lutz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. National Institute of Environmental Health Sciences; Estados UnidosFil: Muallem, Shmuel. National Institutes of Health; Estados UnidosFil: Lee, Young-Ho. Yonsei University College of Medicine; Corea del Su

High-ionization mid-infrared lines as black hole mass and bolometric luminosity indicators in active galactic nuclei

We present relations of the black hole mass and the optical luminosity with the velocity dispersion and the luminosity of the [Ne V] and the [O IV] high-ionization lines in the mid-infrared (MIR) for 28 reverberation-mapped active galactic nuclei. We used high-resolution Spitzer Infrared Spectrograph and Infrared Space Observatory Short Wavelength Spectrometer data to fit the profiles of these MIR emission lines that originate from the narrow-line region of the nucleus. We find that the lines are often resolved and that the velocity dispersion of [Ne V] and [O IV] follows a relation similar to that between the black hole mass and the bulge stellar velocity dispersion found for local galaxies. The luminosity of the [Ne V] and the [O IV] lines in these sources is correlated with that of the optical 5100A continuum and with the black hole mass. Our results provide a means to derive black hole properties in various types of active galactic nuclei, including highly obscured systems.Comment: accepted for publication in ApJ

Cosmic Train Wreck by Massive Black Holes: Discovery of a kpc-Scale Triple Active Galactic Nucleus

Hierarchical galaxy mergers will lead to the formation of binary and, in the case of a subsequent merger before a binary coalesce, triple supermassive black holes (SMBHs), given that most massive galaxies harbor SMBHs. A triple of SMBHs becomes visible as a triple active galactic nucleus (AGN) when the BHs accrete large amounts of gas at the same time. Here we report the discovery of a kpc-scale triple AGN, SDSSJ1027+1749 at z = 0.066, from our systematic search for hierarchical mergers of AGNs. The galaxy contains three emission-line nuclei, two of which are offset by ~ 450 and 110 km/s in velocity and by 2.4 and 3.0 kpc in projected separation from the central nucleus. All three nuclei are classified as obscured AGNs based on optical diagnostic emission line ratios, with black hole mass estimates M_BH ~> 10^8 M_sun from stellar velocity dispersions measured in the associated stellar components. Based on dynamical friction timescale estimates, the three stellar components in SDSSJ1027+1749 will merge in ~ 40 Myr, and their associated SMBHs may evolve into a gravitationally interacting triple system in ~< 200 Myr. Our result sets a lower limit of ~ 5 x 10^(-5) for the fraction of kpc-scale triples in optically selected AGNs at z ~ 0.1.Comment: minor revisions; to appear in ApJ

Hubble Space Telescope H-Band Imaging Survey of Massive Gas-Rich Mergers

We report the results from a deep HST NICMOS H-band imaging survey of a carefully selected sample of 33 luminous, late-stage galactic mergers at z < 0.3. Signs of a recent galactic interaction are seen in all of the objects in the HST sample, including all 7 IR-excess Palomar-Green (PG) QSOs in the sample. Unsuspected double nuclei are detected in 5 ULIRGs. A detailed two-dimensional analysis of the surface brightness distributions in these objects indicates that the great majority (81%) of the single-nucleus systems show a prominent early-type morphology. However, low-surface-brightness exponential disks are detected on large scale in at least 4 of these sources. The hosts of 'warm' AGN-like systems are of early type and have less pronounced merger-induced morphological anomalies than the hosts of cool systems with LINER or HII region-like nuclear optical spectral types. The host sizes and luminosities of the 7 PG~QSOs in our sample are statistically indistinguishable from those of the ULIRG hosts. In comparison, highly luminous quasars, such as those studied by Dunlop et al. (2003), have hosts which are larger and more luminous. The hosts of ULIRGs and PG QSOs lie close to the locations of intermediate-size (about 1 -- 2 L*) spheroids in the photometric projection of the fundamental plane of ellipticals, although there is a tendency in our sample for the ULIRGs with small hosts to be brighter than normal spheroids. Excess emission from a young stellar population in the ULIRG/QSO hosts may be at the origin of this difference. Our results provide support for a possible merger-driven evolutionary connection between cool ULIRGs, warm ULIRGs, and PG~QSOs although this sequence may break down at low luminosity. (abridged)Comment: Paper to be published in the Astrophysical Journal; revised based on comments from referee. A PDF file combining both text and figures is available at http://www.astro.umd.edu/~veilleux/pubs/nicmos.pd

Accretion and star formation rates in low redshift type-II active galactic nuclei

Accretion and star formation (SF) rates in low redshift SDSS type-II active galactic nuclei (AGN) are critically evaluated. Comparison with photoionization models indicates that bolometric luminosity (Lbol) estimates based on L(oiii 5007A) severely underestimate Lbol in low ionization sources such as LINERs. An alternative method based on L(hb) is less sensitive to ionization level and a novel method, based on a combination of L(oiii 5007A) and L(oi 6300A), is erhaps the best. Using this method I show that low ionization AGN are accreting faster than assumed until now. Significant related other findings are: 1. Any type-II AGN property related to the black hole (BH) mass is more reliably obtained by removing blue galaxies from the sample. 2. Seyfert 2s and LINER 2s form a continuous sequence of L/Ledd with no indication for a change in accretion mechanism, or mode of mass supply. There are very few, if any, LINERs in all type-I samples which results in a much arrower L/Ledd distribution compared with type-II samples. 3. There is a strong correlation between SF luminosity, Lsf, and Lbol over more than five orders of magnitude in luminosity. This leads to a simple relationship between bulge and BH growth rates, g(bulge)/g(BH) propto Lbol^(-0.2), where g(bulge)/g(BH) = 115 for Lbol=10^42 erg/sec. Seyfert 2s and LINER 2s follow the same Lsf-Lbol correlation for all sources with a stellar age indicator, D4000, smaller than 1.8. This suggests that a similar fraction of SF gas finds its way to the center in all AGN. 4. Lbol, Lsf, L/Ledd and the specific SF rate follow D4000 in a similar way.Comment: 16 pages, 16 figures, accepted for publication in MNRA

Discovery of Nuclear X-ray Sources in SINGS Galaxies

We present the results of a search for nuclear X-ray activity in nearby galaxies using Chandra archival data in a sample of 62 galaxies from the Spitzer Infrared Nearby Galaxy Survey (SINGS). We detect 37 nuclear X-ray sources; seven of these are new detections. Most of the nuclear X-ray sources are likely to be AGNs. The fraction of galaxies hosting AGNs is thus about 60%, much higher than that found with optical searches, and demonstrates the efficacy of X-ray observations to find hidden AGNs in optically normal galaxies. We find that the nuclear X-ray sources are preferentially present in earlier type galaxies. Unlike what is observed at high redshift, we do not find a strong correlation between the AGN luminosity and the 24 micron luminosity of the host galaxy; we find a strong correlation with the 3.6 micron luminosity instead. This suggests that at the present epoch the accretion rate depends on the total mass of the galaxy, as perhaps does the black hole mass.Comment: 35 pages, 10 figures; Accepted for publication in Ap

The Connection between 3.3 {\mu}m PAH Emission and AGN Activity

We investigate the connection between starburst and AGN activity by comparing the 3.3 {\mu}m PAH eimission with AGN properties. Utilizing the slit-less spectroscopic capability of the AKARI space telescope, we observe moderate-luminosity Type I AGN at z~0.4 to measure global starburst activity. The 3.3 {\mu}m PAH emissions are detected for 7 out of 26 target galaxies. We find no strong correlation between the 3.3 {\mu}m PAH emission and AGN luminosity in the limted range of the observed AGN luminosity, suggesting that global star formation may not be tightly related with AGN activity. Combining our measurements with the previous 3.3 {\mu}m measurements of the low redshift Type I AGN in the literature, we investigate the connection between nuclear starburst and AGN activity. In contrast to global star formation, the 3.3 {\mu}m PAH luminosity measured from the central part of galaxies correlates with AGN luminosity, implying that starburst and AGN activity are directly connected at the nuclear region.Comment: 8 pages, 6 figures, accepted for publication in AJ, minor typos and references correcte

Dust covering factor, silicate emission and star formation in luminous QSOs

We present Spitzer IRS low resolution, mid-IR spectra of a sample of 25 high luminosity QSOs at 2<z<3.5. When combined with archival IRS observations of local, low luminosity type-I AGNs, the sample spans five orders of magnitude in luminosity. We find that the continuum dust thermal emission at lambda(rest)=6.7um is correlated with the optical luminosity, following the non-linear relation L(6.7um) propto L(5100A)^0.82. We also find an anti correlation between the ratio L(6.7um)/L(5100A) and the [OIII]5007A line luminosity. These effects are interpreted as a decreasing covering factor of the circumnuclear dust as a function of luminosity. Such a result is in agreement with the decreasing fraction of absorbed AGNs as a function of luminosity recently found in various surveys. We clearly detect the silicate emission feature in the average spectrum, but also in four individual objects. These are the Silicate emission in the most luminous objects obtained so far. When combined with the silicate emission observed in local, low luminosity type-I AGNs, we find that the silicate emission strength is correlated with luminosity. The silicate strength of all type-I AGNs also follows a positive correlation with the black hole mass and with the accretion rate. The Polycyclic Aromatic Hydrocarbon (PAH) emission features, expected from starburst activity, are not detected in the average spectrum of luminous, high-z QSOs. The upper limit inferred from the average spectrum points to a ratio between PAH luminosity and QSO optical luminosity significantly lower than observed in lower luminosity AGNs, implying that the correlation between star formation rate and AGN power saturates at high luminosities.Comment: accepted for publication in A&A, 17 pages, 9 figure

The Mid-Infrared High-Ionization Lines from Active Galactic Nuclei and Star-Forming Galaxies

We used Spitzer/IRS spectroscopic data on 426 galaxies including quasars, Seyferts, LINER and HII galaxies to investigate the relationship among the mid-IR emission lines. There is a tight linear correlation between the [Ne V]14.3 um and 24.3 um (97.1 eV) and the [O IV]25.9 um (54.9 eV) high-ionization emission lines. The correlation also holds for these high-ionization emission lines and the [Ne III]15.56 um (41 eV) emission line, although only for active galaxies. We used these correlations to calculate the [Ne III] excess due to star formation in Seyfert galaxies. We also estimated the [O IV] luminosity due to star formation in active galaxies and determined that it dominates the [O IV] emission only if the contribution of the active nucleus to the total luminosity is below 5%. We find that the AGN dominates the [O IV] emission in most Seyfert galaxies, whereas star-formation adequately explains the observed [O IV] emission in optically classified HII galaxies. Finally we computed photoionization models to determine the physical conditions of the narrow line region where these high-ionization lines originate. The estimated ionization parameter range is -2.8 < log U < -2.5 and the total hydrogen column density range is 20 < log nH (cm-2) < 21.Comment: Accepted for Publication in ApJ, 19 pages, 13 figure