Materials for Pharmaceutical Dosage Forms: Molecular Pharmaceutics and Controlled Release Drug Delivery Aspects

Controlled release delivery is available for many routes of administration and offers many advantages (as microparticles and nanoparticles) over immediate release delivery. These advantages include reduced dosing frequency, better therapeutic control, fewer side effects, and, consequently, these dosage forms are well accepted by patients. Advances in polymer material science, particle engineering design, manufacture, and nanotechnology have led the way to the introduction of several marketed controlled release products and several more are in pre-clinical and clinical development

Unexplained blasting vulnerabilities in a historic town

Paper presented at the 6th International Conference on Structural Analysis of Historic Constructions (SAHC08), 2-4 July, 2008, Bath, U.K.Historic residential and commercial structures in an early twentieth century town in the southeastern United States have regularly and repeatedly been damaged by an adjacent quarry, despite the diligent keeping of blasting levels below peak particle acceleration levels previously thought to be safe. This paper explores the possibility of the damage mechanism being blasting-induced partial, repetitive liquefaction. The detonation of high explosives has been used in research to induce liquefaction at designated field sites and in laboratories, but the possibility of this occurring as an unintentional side-effect of commercial blasting has not been explored. This paper evaluates data from an actual community to assess the likelihood that the recorded damage is being caused by the quarrying in the southeastern United States. Although the results are not definitive they are strongly indicative that induced liquefaction is endangering this historic town.Not applicableConference website no longer accesible. Current website - http://www.sahc2010.org/. Link to publisher version of book - http://www.routledge.com/books/details/9780415468725/. DG au, ke, de - TS 26/07/1

Toward business 2030

Contemporary business organizations operate in a complex, interconnected world. They\u2019re expected to generate shareholder value by dealing successfully with a series of significant challenges ranging from political to economic uncertainties, from digitalization to reverse globalization, and from excessive short-termism to the need to restore greater levels of trust between the business and its key stakeholders. This means business organizations and their leaders are increasingly asked to be a force for good in society by aligning their corporate purpose to sustainable strategy and business models

Unexplained blasting vulnerabilities in a historic town

Paper presented at the 6th International Conference on Structural Analysis of Historic Constructions (SAHC08), 2-4 July, 2008, Bath, U.K.Historic residential and commercial structures in an early twentieth century town in the southeastern United States have regularly and repeatedly been damaged by an adjacent quarry, despite the diligent keeping of blasting levels below peak particle acceleration levels previously thought to be safe. This paper explores the possibility of the damage mechanism being blasting-induced partial, repetitive liquefaction. The detonation of high explosives has been used in research to induce liquefaction at designated field sites and in laboratories, but the possibility of this occurring as an unintentional side-effect of commercial blasting has not been explored. This paper evaluates data from an actual community to assess the likelihood that the recorded damage is being caused by the quarrying in the southeastern United States. Although the results are not definitive they are strongly indicative that induced liquefaction is endangering this historic town.Not applicableConference website no longer accesible. Current website - http://www.sahc2010.org/. Link to publisher version of book - http://www.routledge.com/books/details/9780415468725/. DG au, ke, de - TS 26/07/1