The Levantine Basin - crustal structure and origin

The origin of the Levantine Basin in the Southeastern Mediterranean Sea is related to the opening of the Neo-Tethys. The nature of its crust has been debated for decades. Therefore, we conducted a geophysical experiment in the Levantine Basin. We recorded two refraction seismic lines with 19 and 20 ocean bottom hydrophones, respectively, and developed velocity models. Additional seismic reflection data yield structural information about the upper layers in the first few kilometers. The crystalline basement in the Levantine Basin consists of two layers with a P-wave velocity of 6.06.4 km/s in the upper and 6.56.9 km/s in the lower crust. Towards the center of the basin, the Moho depth decreases from 27 to 22 km. Local variations of the velocity gradient can be attributed to previously postulated shear zones like the Pelusium Line, the DamiettaLatakia Line and the BaltimHecateus Line. Both layers of the crystalline crust are continuous and no indication for a transition from continental to oceanic crust is observed. These results are confirmed by gravity data. Comparison with other seismic refraction studies in prolongation of our profiles under Israel and Jordan and in the Mediterranean Sea near Greece and Sardinia reveal similarities between the crust in the Levantine Basin and thinned continental crust, which is found in that region. The presence of thinned continental crust under the Levantine Basin is therefore suggested. A β-factor of 2.33 is estimated. Based on these findings, we conclude that sea-floor spreading in the Eastern Mediterranean Sea only occurred north of the Eratosthenes Seamount, and the oceanic crust was later subducted at the Cyprus Arc

Black holes and black strings of N=2, d=5 supergravity in the H-FGK formalism

We study general classes and properties of extremal and non-extremal static black-hole solutions of N=2, d=5 supergravity coupled to vector multiplets using the recently proposed H-FGK formalism, which we also extend to static black strings. We explain how to determine the integration constants and physical parameters of the black-hole and black-string solutions. We derive some model-independent statements, including the transformation of non-extremal flow equations to the form of those for the extremal flow. We apply our methods to the construction of example solutions (among others a new extremal string solution of heterotic string theory on K_3 \times S^1). In the cases where we have calculated it explicitly, the product of areas of the inner and outer horizon of a non-extremal solution coincides with the square of the moduli-independent area of the horizon of the extremal solution with the same charges.Comment: 33 pages. Revised version: references added. No other change

The Hidden Giant: How a rift pulse triggered a cascade of sector collapses and voluminous secondary mass‐transport events in the early evolution of Santorini

Volcanic island sector collapses have the potential to trigger devastating tsunamis and volcanic eruptions that threaten coastal communities and infrastructure. Considered one of the most hazardous volcano-tectonic regions in the world, the Christiana-Santorini-Kolumbo Volcanic Field (CSKVF) lies in the South Aegean Sea in an active rift zone. Previous studies identified an enigmatic voluminous mass-transport deposit west and east of Santorini emplaced during the early evolution of the edifice. However, the distribution and volume as well as the nature and emplacement dynamics of this deposit remained unknown up to now. In this study, we use an extensive dataset of high-resolution seismic profiles to unravel the distribution and internal architecture of this deposit. We show that it is located in all basins surrounding Santorini and has a bulk volume of up to 125 km3, thus representing the largest known volcanic island mass-transport deposit in the entire Mediterranean Sea. We propose that the deposit is the result of a complex geohazard cascade that was initiated by an intensive rift pulse. This rifting event triggered a series of smaller precursory mass-transport events before large-scale sector collapses occurred on the northeastern flank of the extinct Christiana Volcano and on the southeastern flank of the nascent Santorini. This was followed by the emplacement of large-scale secondary sediment failures on the slopes of Santorini, which transitioned into debris and turbidity flows that traveled far into the neighboring rift basins. Following this cascade, a distinct change in the volcanic behavior of the CSKVF occurred, suggesting a close relationship between crustal extension, mass transport, and volcanism. Cascading geohazards seem to be more common in the evolution of marine volcanic systems than previously appreciated. Wider awareness and a better understanding of cascading effects are crucial for more holistic hazard assessments

The Tensor Hierarchies of Pure N=2,d=4,5,6 Supergravities

We study the supersymmetric tensor hierarchy of pure (gauged) N=2,d=4,5,6 supergravity and compare them with those of the pure, ungauged, theories (worked out by Gomis and Roest for d=5) and the predictions of the Kac-Moody approach made by Kleinschmidt and Roest. We find complete agreement in the ungauged case but we also find that, after gauging, new Stueckelberg symmetries reduce the number of independent "physical" top-forms. The analysis has to be performed to all orders in fermion fields. We discuss the construction of the worldvolume effective actions for the p-branes which are charged with respect to the (p+1)-form potentials and the relations between the tensor hierarchies and p-branes upon dimensional reduction.Comment: LaTeX2e file, 20 pages, 1 figure Results refined by extension of the analysis to all orders in fermion

Close binary stars in the solar-age Galactic open cluster M67

We present multi-colour time-series CCD photometry of the solar-age galactic open cluster M67 (NGC 2682). About 3600 frames spread over 28 nights were obtained with the 1.5 m Russian-Turkish and 1.2 m Mercator telescopes. High-precision observations of the close binary stars AH Cnc, EV Cnc, ES Cnc, the $\delta$ Scuti type systems EX Cnc and EW Cnc, and some long-period variables belonging to M67 are presented. Three full multi-colour light curves of the overcontact binary AH Cnc were obtained during three observing seasons. Likewise we gathered three light curves of EV Cnc, an EB-type binary, and two light curves of ES Cnc, a blue straggler binary. Parts of the light change of long-term variables S1024, S1040, S1045, S1063, S1242, and S1264 are obtained. Period variation analysis of AH Cnc, EV Cnc, and ES Cnc were done using all times of mid-eclipse available in the literature and those obtained in this study. In addition, we analyzed multi-colour light curves of the close binaries and also determined new frequencies for the $\delta$ Scuti systems. The physical parameters of the close binary stars were determined with simultaneous solutions of multi-colour light and radial velocity curves. Finally we determined the distance of M67 as 857(33) pc via binary star parameters, which is consistent with an independent method from earlier studies.Comment: 12 pages, 9 Figures, 13 Table

Binarity and multiperiodicity in high-amplitude delta Scuti stars

We have carried out a photometric and spectroscopic survey of bright high-amplitude delta Scuti (HADS) stars. The aim was to detect binarity and multiperiodicity (or both) in order to explore the possibility of combining binary star astrophysics with stellar oscillations. Here we present the first results for ten, predominantly southern, HADS variables. We detected the orbital motion of RS Gru with a semi-amplitude of ~6.5 km/s and 11.5 days period. The companion is inferred to be a low-mass dwarf star in a close orbit around RS Gru. We found multiperiodicity in RY Lep both from photometric and radial velocity data and detected orbital motion in the radial velocities with hints of a possible period of 500--700 days. The data also revealed that the amplitude of the secondary frequency is variable on the time-scale of a few years, whereas the dominant mode is stable. Radial velocities of AD CMi revealed cycle-to-cycle variations which might be due to non-radial pulsations. We confirmed the multiperiodic nature of BQ Ind, while we obtained the first radial velocity curves of ZZ Mic and BE Lyn. The radial velocity curve and the O-C diagram of CY Aqr are consistent with the long-period binary hypothesis. We took new time series photometry on XX Cyg, DY Her and DY Peg, with which we updated their O-C diagrams.Comment: 15 pages, 16 pages, accepted for publication in MNRA

Development of Clinical Criteria for Functional Assessment to Predict Primary Nonfunction of High-Risk Livers Using Normothermic Machine Perfusion

Increased use of high-risk allografts is critical to meet the demand for liver transplantation. We aimed to identify criteria predicting viability of organs, currently declined for clinical transplantation, using functional assessment during normothermic machine perfusion (NMP). Twelve discarded human livers were subjected to NMP following static cold storage. Livers were perfused with a packed red cell-based fluid at 37°C for 6 hours. Multilevel statistical models for repeated measures were employed to investigate the trend of perfusate blood gas profiles and vascular flow characteristics over time and the effect of lactate-clearing (LC) and non-lactate-clearing (non-LC) ability of the livers. The relationship of lactate clearance capability with bile production and histological and molecular findings were also examined. After 2 hours of perfusion, median lactate concentrations were 3.0 and 14.6 mmol/L in the LC and non-LC groups, respectively. LC livers produced more bile and maintained a stable perfusate pH and vascular flow &gt;150 and 500 mL/minute through the hepatic artery and portal vein, respectively. Histology revealed discrepancies between subjectively discarded livers compared with objective findings. There were minimal morphological changes in the LC group, whereas non-LC livers often showed hepatocellular injury and reduced glycogen deposition. Adenosine triphosphate levels in the LC group increased compared with the non-LC livers. We propose composite viability criteria consisting of lactate clearance, pH maintenance, bile production, vascular flow patterns, and liver macroscopic appearance. These have been tested successfully in clinical transplantation. In conclusion, NMP allows an objective assessment of liver function that may reduce the risk and permit use of currently unused high-risk livers.</p

Hazardous explosive eruptions of a recharging multi-cyclic island arc caldera

Caldera-forming eruptions of silicic volcanic systems are among the most devastating events on Earth. By contrast, post-collapse volcanic activity initiating new caldera cycles is generally considered less hazardous. Formed after Santorini’s latest caldera-forming eruption of ~1600 bce, the Kameni Volcano in the southern Aegean Sea enables the eruptive evolution of a recharging multi-cyclic caldera to be reconstructed. Santorini’s eruptive record has been documented by onshore products and historical descriptions of mainly effusive eruptions dating back to 197 bce. Here we combine high-resolution seismic reflection data with cored lithologies from International Ocean Discovery Program Expedition 398 at four sites to determine the submarine architecture and volcanic history of intra-caldera deposits from Kameni. Our shore-crossing analysis reveals the deposits of a submarine explosive eruption that produced up to 3.1 km3 of pumice and ash, which we relate to a historical eruption in 726 ce. The estimated volcanic explosivity index of magnitude 5 exceeds previously considered worst-case eruptive scenarios for Santorini. Our finding that the Santorini caldera is capable of producing large explosive eruptions at an early stage in the caldera cycle implies an elevated hazard potential for the eastern Mediterranean region, and potentially for other recharging silicic calderas

Targeted Gene Panel Sequencing for Early-onset Inflammatory Bowel Disease and Chronic Diarrhea

Background: In contrast to adult-onset inflammatory bowel disease (IBD), where many genetic loci have been shown to be involved in complex disease etiology, early-onset IBD (eoIBD) and associated syndromes can sometimes present as monogenic conditions. As a result, the clinical phenotype and ideal disease management in these patients often differ from those in adult-onset IBD. However, due to high costs and the complexity of data analysis, high-throughput screening for genetic causes has not yet become a standard part of the diagnostic work-up of eoIBD patients. Methods: We selected 28 genes of interest associated with monogenic IBD and performed targeted panel sequencing in 71 patients diagnosed with eoIBD or early-onset chronic diarrhea to detect causative variants. We compared these results to whole-exome sequencing (WES) data available for 25 of these patients. Results: Target coverage was significantly higher in the targeted gene panel approach compared with WES, whereas the cost of the panel was considerably lower (approximately 25% of WES). Disease-causing variants affecting protein function were identified in 5 patients (7%), located in genes of the IL10 signaling pathway (3), WAS (1), and DKC1 (1). The functional effects of 8 candidate variants in 5 additional patients (7%) are under further investigation. WES did not identify additional causative mutations in 25 patients. Conclusions: Targeted gene panel sequencing is a fast and effective screening method for monogenic causes of eoIBD that should be routinely established in national referral centers.info:eu-repo/semantics/publishedVersio