Autocorrelations of stellar light and mass at z~0 and ~1: From SDSS to DEEP2

We present measurements of projected autocorrelation functions w_p(r_p) for the stellar mass of galaxies and for their light in the U, B and V bands, using data from the third data release of the DEEP2 Galaxy Redshift Survey and the final data release of the Sloan Digital Sky Survey (SDSS). We investigate the clustering bias of stellar mass and light by comparing these to projected autocorrelations of dark matter estimated from the Millennium Simulations (MS) at z=1 and 0.07, the median redshifts of our galaxy samples. All of the autocorrelation and bias functions show systematic trends with spatial scale and waveband which are impressively similar at the two redshifts. This shows that the well-established environmental dependence of stellar populations in the local Universe is already in place at z=1. The recent MS-based galaxy formation simulation of Guo et al. (2011) reproduces the scale-dependent clustering of luminosity to an accuracy better than 30% in all bands and at both redshifts, but substantially overpredicts mass autocorrelations at separations below about 2 Mpc. Further comparison of the shapes of our stellar mass bias functions with those predicted by the model suggests that both the SDSS and DEEP2 data prefer a fluctuation amplitude of sigma_8 0.8 rather than the sigma_8=0.9 assumed by the MS.Comment: 10 pages, 4 figures, accepted for publication in Monthly Notices, minor revisions in tex

The inhibition of complement system in formal and emerging indications: results from parallel one-stage pairwise and network meta-analyses of clinical trials and real-life data studies

Producción CientíficaThis manuscript presents quantitative findings on the actual effectiveness of terminal complement component 5 (C5) inhibitors and complement component 1 (C1) esterase inhibitors through their formal and common “off-label” (compassionate) indications. The results emanated from pairwise and network meta-analyses to present evidence until September 2019. Clinical trials (CT) and real-life non-randomized studies of the effects of interventions (NRSI) are consistent on the benefits of C5 inhibitors and of the absence of effects of C1 esterase inhibitors (n = 7484): Mathematically, eculizumab (surface under the cumulative ranking area (SUCRA) >0.6) and ravulizumab (SUCRA ≥ 0.7) were similar in terms of their protective effect on hemolysis in paroxysmal nocturnal hemoglobinuria (PNH), thrombotic microangiopathy (TMA) in atypical hemolytic uremic syndrome (aHUS), and acute kidney injury (AKI) in aHUS, in comparison to pre-/off-treatment state and/or placebo (SUCRA < 0.01), and eculizumab was efficacious on thrombotic events in PNH (odds ratio (OR)/95% confidence interval (95% CI) in CT and real-life NRSI, 0.07/0.03 to 0.19, 0.24/0.17 to 0.33) and chronic kidney disease (CKD) occurrence/progression in PNH (0.31/0.10 to 0.97, 0.66/0.44 to 0.98). In addition, meta-analysis on clinical trials shows that eculizumab mitigates a refractory generalized myasthenia gravis (rgMG) crisis (0.29/0.13 to 0.61) and prevents new acute antibody-mediated rejection (AMR) episodes in kidney transplant recipients (0.25/0.13 to 0.49). The update of findings from this meta-analysis will be useful to promote a better use of complement inhibitors, and to achieve personalization of treatments with this class of drugs

The VIMOS Public Extragalactic Redshift Survey (VIPERS) : The decline of cosmic star formation: quenching, mass, and environment connections

RT acknowledges financial support from the European Research Council through grant n. 202686.We use the final data of the VIMOS Public Extragalactic Redshift Survey (VIPERS) to investigate the effect of the environment on the evolution of galaxies between z = 0.5 and z = 0.9. We characterise local environment in terms of the density contrast smoothed over a cylindrical kernel, the scale of which is defined by the distance to the fifth nearest neighbour. This is performed by using a volume-limited sub-sample of galaxies complete up to z = 0.9, but allows us to attach a value of local density to all galaxies in the full VIPERS magnitude-limited sample to i < 22.5. We use this information to estimate how the distribution of galaxy stellar masses depends on environment. More massive galaxies tend to reside in higher-density environments over the full redshift range explored. Defining star-forming and passive galaxies through their (NUV-r) vs. (r-K) colours, we then quantify the fraction of star-forming over passive galaxies, fap, as a function of environment at fixed stellar mass. fap is higher in low-density regions for galaxies with masses ranging from log (M/M⊙) = 10.38 (the lowest value explored) to at least log (M/M⊙) ~ 11.3, although with decreasing significance going from lower to higher masses. This is the first time that environmental effects on high-mass galaxies are clearly detected at redshifts as high as z ~ 0.9. We compared these results to VIPERS-like galaxy mock catalogues based on a widely used galaxy formation model. The model correctly reproduces fap in low-density environments, but underpredicts it at high densities. The discrepancy is particularly strong for the lowest-mass bins. We find that this discrepancy is driven by an excess of low-mass passive satellite galaxies in the model. In high-density regions, we obtain a better (although not perfect) agreement of the model fap with observations by studying the accretion history of these model galaxies (that is, the times when they become satellites), by assuming either that a non-negligible fraction of satellites is destroyed, or that their quenching timescale is longer than ~ 2 Gyr.PostprintPeer reviewe

The VIMOS Public Extragalactic Redshift Survey (VIPERS). Downsizing of the blue cloud and the influence of galaxy size on mass quenching over the last eight billion years

R.T. acknowledges financial support from the European Research Councilthrough grant No. 202686.We use the full VIPERS redshift survey in combination with SDSS-DR7 to explore the relationships between star-formation history (using d4000), stellar mass and galaxy structure, and how these relationships have evolved since z ~ 1. We trace the extents and evolutions of both the blue cloud and red sequence by fitting double Gaussians to the d4000 distribution of galaxies in narrow stellar mass bins, for four redshift intervals over 0 < z < 1. This reveals downsizing in star formation, since the high-mass limit of the blue cloud has retreated steadily from time from ℳ ~ 1011.2 M⊙ at z ~ 0.9 to ℳ ~ 1010.7 M⊙ to the present day. The number density of massive blue-cloud galaxies (ℳ ~ 1011 M⊙, d4000 < 1.55) drops sharply by a factor five between z ~ 0.8 and z ~ 0.5. These galaxies are becoming quiescent at a rate that largely matches  the increase in the numbers of massive passive galaxies seen over this period. We examine the size-mass relation of blue-cloud galaxies,  finding that its high-mass boundary runs along lines of constant ℳ /re or equivalently inferred velocity dispersion. Larger galaxies can continue to form stars to higher stellar masses than smaller galaxies. As  blue-cloud galaxies approach this high-mass limit, entering a narrow diagonal region within the size-mass plane termed the “quenching zone”, they start to be quenched, their d4000 values increasing to push them towards the green valley. In parallel, their structures change, showing higher Sérsic indices and central stellar mass densities. For these galaxies, bulge growth is required for them to reach the high-mass limit of the blue cloud and be quenched by internal mechanisms. The blue-cloud galaxies that are being quenched at z ~ 0.8 lie along the same size-mass relation as present day quiescent galaxies and seem the likely progenitors of today’s S0s.Publisher PDFPeer reviewe

Eculizumab as a New Treatment for Severe Acute Post-infectious Glomerulonephritis: Two Case Reports.

Acute post-infections glomerulonephritis (APIGN) is a frequent cause of glomerulonephritis and represents the most common cause of acute glomerulonephritis in children. It can evolve to severe acute renal failure and chronic kidney disease or even end-stage kidney disease. The precise pathophysiological mechanisms of APIGN are still incompletely understood. The implication of the alternative complement pathway and the potential benefits of C5 blockade have been recently highlighted, in particular in the presence of a C3 Nephritic Factor (C3Nef), anti-Factor B or H autoantibodies. We report two children with severe APIGN, successfully treated with eculizumab. The first patient presented a severe form of APIGN with advanced renal failure and anuria, associated with a decreased level of C3 and an increased level of soluble C5b-9, in the presence of a C3NeF autoantibody. The second case had a severe oliguric APIGN associated with low C3 level. Kidney biopsy confirmed the diagnosis of APIGN in both cases. Eculizumab allowed full renal function recovery and the avoidance of dialysis in both cases. In conclusion, the alternative and terminal complement pathways activation might be common in PIGN, and in severe cases, eculizumab might help

On the formulation of new explicit conditions for steepness from a former result of N.N. Nekhoroshev

The application of the Nekhoroshev theorem to many problems arising in different fields of Physics and Astronomy depends on a non-degeneracy property, called steepness, that a suitable Hamiltonian approximation must satisfy. Since steepness is implicitly defined , we have the problem of recognizing whether a given function is steep or not. For this purpose, we here consider some sufficient conditions for steepness provided by Nekhoroshev in 1979, based on the solvability of a collection of systems depending on the number n of degrees of freedom, the derivatives of the function up to a certain order r, and some auxiliary parameters. These conditions are really explicit only for r=2, corresponding to quasi-convexity , and for r=3. Instead, for r \geq 4, the conditions are implicit, since they require an elaborate computation of the closure of a certain set. In this paper, we first revisit Nekhoroshev's result and we show that the number of parameters in the collections of systems can be suitably reduced. Then, we show that for r=4 Nekhoroshev's result is interesting only for n=2,3 and 4, and in these cases we find explicit conditions for steepness which are formulated in a purely algebraic form

The Friday evening case of acute kidney injury: a crystal dilemma

We report a case of acute kidney injury (AKI) induced by amoxycillin crystalluria suggested by massive amounts of urinary crystals of unusual morphology. This hypothesis was further reinforced by a particular solubility pattern when the urine sample was exposed to various temperatures, alkali, acids and alcohol. We therefore suspended amoxycillin, which produced a rapid and complete recovery of kidney function. Infrared spectroscopy later confirmed the amoxycillin composition of the crystals. Since infrared spectroscopy is not easily available, we propose that these solubility tests of urinary crystals be used as a first-step investigation when amoxycillin crystalluria is suspected