Evaluation of prognostic markers for canine mast cell tumors treated with vinblastine and prednisone

<p>Abstract</p> <p>Background</p> <p>Canine cutaneous mast cell tumor (MCT) is a common neoplastic disease associated with a variable biologic behavior. Surgery remains the primary treatment for canine MCT; however, radiation therapy (RT) and chemotherapy are commonly used to treat aggressive MCT. The goals of this study were to evaluate the prognostic utility of histologic grade, <it>c-KIT </it>mutations, KIT staining patterns, and the proliferation markers Ki67 and AgNORs in dogs postoperatively treated with vinblastine and prednisone +/- RT, and to compare the outcome of dogs treated with post-operative chemotherapy +/- RT to that of a prognostically matched group treated with surgery alone. Associations between prognostic markers and survival were evaluated. Disease-free intervals (DFI) and overall survival times (OS) of dogs with similar pretreatment prognostic indices postoperatively treated with chemotherapy were compared to dogs treated with surgery alone.</p> <p>Results</p> <p>Histologic grade 3 MCTs, MCTs with c-<it>KIT </it>mutations, MCTs with increased cytoplasmic KIT, and MCTs with increased Ki67 and AgNOR values were associated with decreased DFI and OS. Dogs with histologic grade 3 MCT had significantly increased DFI and OS when treated with chemotherapy vs. surgery alone. Although not statistically significant due to small sample sizes, MCTs with <it>c-KIT </it>mutations had increased DFI and OS when treated with chemotherapy vs. surgery alone.</p> <p>Conclusion and clinical importance</p> <p>This study confirms the prognostic value of histologic grade, c-<it>KIT </it>mutations, KIT staining patterns, and proliferation analyses for canine MCT. Additionally, the results of this study further define the benefit of postoperative vinblastine and prednisone for histologic grade 3 MCTs.</p

Abelian Chern-Simons Vortices and Holomorphic Burgers' Hierarchy

The Abelian Chern-Simons Gauge Field Theory in 2+1 dimensions and its relation with holomorphic Burgers' Hierarchy is considered. It is shown that the relation between complex potential and the complex gauge field as in incompressible and irrotational hydrodynamics, has meaning of the analytic Cole-Hopf transformation, linearizing the Burgers Hierarchy in terms of the holomorphic Schr\"odinger Hierarchy. Then the motion of planar vortices in Chern-Simons theory, appearing as pole singularities of the gauge field, corresponds to motion of zeroes of the hierarchy. Using boost transformations of the complex Galilean group of the hierarchy, a rich set of exact solutions, describing integrable dynamics of planar vortices and vortex lattices in terms of the generalized Kampe de Feriet and Hermite polynomials is constructed. The results are applied to the holomorphic reduction of the Ishimori model and the corresponding hierarchy, describing dynamics of magnetic vortices and corresponding lattices in terms of complexified Calogero-Moser models. Corrections on two vortex dynamics from the Moyal space-time non-commutativity in terms of Airy functions are found.Comment: 15 pages, talk presented in Workshop `Nonlinear Physics IV: Theory and Experiment`, 22-30 June 2006, Gallipoli, Ital

The entanglement in one-dimensional random XY spin chain with Dzyaloshinskii-Moriya interaction

The impurities of exchange couplings, external magnetic fields and Dzyaloshinskii--Moriya (DM) interaction considered as Gaussian distribution, the entanglement in one-dimensional random $XY$ spin systems is investigated by the method of solving the different spin-spin correlation functions and the average magnetization per spin. The entanglement dynamics at central locations of ferromagnetic and antiferromagnetic chains have been studied by varying the three impurities and the strength of DM interaction. (i) For ferromagnetic spin chain, the weak DM interaction can improve the amount of entanglement to a large value, and the impurities have the opposite effect on the entanglement below and above critical DM interaction. (ii) For antiferromagnetic spin chain, DM interaction can enhance the entanglement to a steady value. Our results imply that DM interaction strength, the impurity and exchange couplings (or magnetic field) play competing roles in enhancing quantum entanglement.Comment: 12 pages, 3 figure

Characterization and life cycle assessment of geopolymer mortars with masonry units and recycled concrete aggregates assorted from construction and demolition waste

YesDeveloping a fast, cost-effective, eco-friendly solution to recycle large amounts of construction and demolition waste (CDW) generated from construction industry-related activities and natural disasters is crucial. The present investigation aims to offer a solution for repurposing CDW into building materials suitable for accelerated construction and housing in developing countries and disaster-prone areas. Feasibility of recycled concrete aggregate (RCA) inclusion in geopolymer mortars constituted entirely from CDW (masonry elements) was investigated via an environmental impact-oriented approach by addressing the composition related key parameters. Mechanical performance was evaluated through compressive strength tests, and scanning electron microscope (SEM) imaging with line mapping analyses were carried out to monitor the interfacial transition zone (ITZ) properties. To investigate the environmental impacts of the geopolymer mortars and highlight the advantages over Portland cement-based mortars, a cradle-to-gate life cycle assessment (LCA) was performed. Findings revealed that roof tile (RT)-based geopolymer mortars mainly exhibited better strength performance due to their finer particle size. Mixtures activated with 15 M NaOH solution and cured at 105 °C achieved an average compressive strength above 55 MPa. RCA size was the most influential parameter on compressive strength, and a smaller maximum RCA size significantly increased the compressive strength. Microstructural analyses showed that the ITZ around smaller RCAs was relatively thinner, resulting in better compressive strength results. LCA proved that CDW-based geopolymer mortars provide the same compressive strength with around 60% less CO2 emissions and similar energy consumption compared to Portland cement-based mortars.This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 894100. The authors also wish to acknowledge the support of the Scientific and Technical Research Council of Turkey (TUBITAK) provided under project: 117M44

Remnant radio-loud AGN in the Herschel-ATLAS field

Only a small fraction of observed active galactic nuclei (AGN) display large-scale radio emission associated with jets, yet these radio-loud AGN have become increasingly important in models of galaxy evolution. In determining the dynamics and energetics of the radio sources over cosmic time, a key question concerns what happens when their jets switch off. The resulting ‘remnant' radio-loud AGN have been surprisingly evasive in past radio surveys, and therefore statistical information on the population of radio-loud AGN in their dying phase is limited. In this paper, with the recent developments of Low-Frequency Array (LOFAR) and the Very Large Array, we are able to provide a systematically selected sample of remnant radio-loud AGN in the Herschel-ATLAS field. Using a simple core-detection method, we constrain the upper limit on the fraction of remnants in our radio-loud AGN sample to 9 per cent, implying that the extended lobe emission fades rapidly once the core/jets turn off. We also find that our remnant sample has a wide range of spectral indices (−1.5 ⩽ α1400150 ⩽ −0.5), confirming that the lobes of some remnants may possess flat spectra at low frequencies just as active sources do. We suggest that, even with the unprecedented sensitivity of LOFAR, our sample may still only contain the youngest of the remnant population

The Ubiquitous Dermokine Delta Activates Rab5 Function in the Early Endocytic Pathway

The expression of the recently identified dermokine (Dmkn) gene leads to four families of proteins with as yet unknown functions. The secreted α, β and γ isoforms share an epidermis-restricted expression pattern, whereas the δ isoform is intracellular and ubiquitous. To get an insight into Dmknδ function, we performed yeast two-hybrid screening and identified the small GTPases Rab5 as partners for Dmknδ. The Rab5 proteins are known to regulate membrane docking and fusion in the early endocytic pathway. GST pull-down assays confirmed the direct interaction between Rab5 and Dmknδ. Transient expression of Dmknδ in HeLa cells led to the formation of punctate structures colocalized with endogenous Rab5 and clathrin, indicating Dmknδ involvement in the early steps of endocytosis. Dmknδ indeed colocalized with transferrin at early stages of endocytosis, but did not modulate its endocytosis or recycling kinetics. We also showed that Dmknδ was able to bind both inactive (GDP-bound) and active (GTP-bound) forms of Rab5 in vitro but preferentially targeted GDP-bound form in HeLa cells. Interestingly, Dmknδ expression rescued the Rab5S34N-mediated inhibition of endosome fusion. Moreover, Dmknδ caused the enlargement of vesicles positive for Rab5 by promoting GTP loading onto the small GTPase. Together our data reveal that Dmknδ activates Rab5 function and thus is involved in the early endosomal trafficking

A LOFAR-IRAS cross-match study : the far-infrared radio correlation and the 150-MHz luminosity as a star-formation rate

13 pages, 13 figures, accepted for publication in A&A, © ESO 2019Aims. We aim to study the far-infrared radio correlation (FIRC) at 150 MHz in the local Universe (at a median redshift z~0:05) and improve the use of the rest-frame 150-MHz luminosity, L150, as a star-formation rate (SFR) tracer, which is unaffected by dust extinction. Methods. We cross-match the 60-um selected Revised IRAS Faint Source Survey Redshift (RIFSCz) catalogue and the 150-MHz selected LOFAR value-added source catalogue in the Hobby-Eberly Telescope Dark Energy Experiment (HETDEX) Spring Field. We estimate L150 for the cross-matched sources and compare it with the total infrared (IR) luminosity, LIR, and various SFR tracers. Results. We find a tight linear correlation between log L150 and log LIR for star-forming galaxies, with a slope of 1.37. The median qIR value (defined as the logarithm of the LIR to L150 ratio) and its rms scatter of our main sample are 2.14 and 0.34, respectively. We also find that log L150 correlates tightly with the logarithm of SFR derived from three different tracers, i.e., SFR_Halpha based on the Halpha line luminosity, SFR_60 based on the rest-frame 60-um luminosity and SFR_IR based on LIR, with a scatter of 0.3 dex. Our best-fit relations between L150 and these SFR tracers are, log L150 (Lsun) = 1.35(0.06) x log SFR_Halpha (Msun/yr) + 3.20(0.06), log L150 (Lsun) = 1.31(0.05) x log SFR_60 (Msun/yr) + 3.14(0.06), and log L150 (Lsun) = 1.37(0.05) x log SFR_IR (Msun/yr) + 3.09(0.05), which show excellent agreement with each other.Peer reviewedFinal Accepted Versio

Factor XII and Upar Upregulate Neutrophil Functions to Influence Wound Healing

Coagulation factor XII (FXII) deficiency is associated with decreased neutrophil migration, but the mechanisms remain uncharacterized. Here, we examine how FXII contributes to the inflammatory response. In 2 models of sterile inflammation, FXII-deficient mice (F12–/–) had fewer neutrophils recruited than WT mice. We discovered that neutrophils produced a pool of FXII that is functionally distinct from hepatic-derived FXII and contributes to neutrophil trafficking at sites of inflammation. FXII signals in neutrophils through urokinase plasminogen activator receptor–mediated (uPAR-mediated) Akt2 phosphorylation at S474 (pAktS474). Downstream of pAkt2S474, FXII stimulation of neutrophils upregulated surface expression of αMβ2 integrin, increased intracellular calcium, and promoted extracellular DNA release. The sum of these activities contributed to neutrophil cell adhesion, migration, and release of neutrophil extracellular traps in a process called NETosis. Decreased neutrophil signaling in F12–/– mice resulted in less inflammation and faster wound healing. Targeting hepatic F12 with siRNA did not affect neutrophil migration, whereas WT BM transplanted into F12–/– hosts was sufficient to correct the neutrophil migration defect in F12–/– mice and restore wound inflammation. Importantly, these activities were a zymogen FXII function and independent of FXIIa and contact activation, highlighting that FXII has a sophisticated role in vivo that has not been previously appreciated

Compliance and Functional Testing of IEEE 1451.1 for NCAP-to-NCAP Communications in a Sensor Network

Distributed control in a networked environment is an irreplaceable feature in systems with remote sensors and actuators. Although distributed control was not originally designed to be networked, usage of off-the-shelf networking technologies has become so prevalent that control systems are desired to have access mechanisms similar to computer networks. However, proprietary transducer interfaces for network communications and distributed control overwhelmingly dominate this industry. Unless the lack of compatibility and interoperability among transducers is resolved, the mature level of access (that computer networking can deliver) will not be achieved in such networked distributed control systems. Standardization of networked transducer interfaces will enable devices from different manufacturers to talk to each other and ensure their plug-and-play capability. One such standard is the suite of IEEE 1451 for sensor network communication and transducer interfaces. The suite not only provides a standard interface for smart transducers, but also outlines the connection of an NCAP (network capable application processor) and transducers (through a transducer interface module TIM). This paper presents the design of the compliance testing of IEEE 1451.1 (referred to as Dot1) compatible NCAP-to-NCAP communications on a link-layer independent medium. The paper also represents the first demonstration of NCAP-to-NCAP communications with Dot1 compatibility: a tester NCAP and an NCAP under test (NUT)

The bright end of the infrared luminosity functions and the abundance of hyperluminous infrared galaxies

16 pages, 11 figures, accepted for publication in A&A as part of the LOFAR Deep Fields Paper Splash. © 2020 The European Southern Observatory (ESO)We provide the most accurate estimate yet of the bright end of the infrared (IR) luminosity functions (LFs) and the abundance of hyperluminous IR galaxies (HLIRGs) with IR luminosities > 10^13 L_solar, thanks to the combination of the high sensitivity, angular resolution, and large area of the LOFAR Deep Fields, which probes an unprecedented dynamic range of luminosity and volume. We cross-match Herschel sources and LOFAR sources in Bootes (8.63 deg^2), Lockman Hole (10.28 deg^2), and ELAIS-N1 (6.74 deg^2) with rms sensitivities of around 32, 22, and 20 mJy per beam, respectively. We divide the matched samples into unique and multiple categories. For the multiple matches, we de-blend the Herschel fluxes using the LOFAR positions and the 150-MHz flux densities as priors. We perform spectral energy distribution (SED) fitting, combined with multi-wavelength counterpart identifications and photometric redshift estimates, to derive IR luminosities. The depth of the LOFAR data allows us to identify highly complete (around 92% completeness) samples of bright Herschel sources with a simple selection based on the 250 micron flux density (45, 40, and 35 mJy in Bootes, Lockman Hole, and ELAIS-N1, respectively). Most of the bright Herschel sources fall into the unique category (i.e. a single LOFAR counterpart). For the multiple matches, there is excellent correspondence between the radio emission and the far-IR emission. We find a good agreement in the IR LFs with a previous study out to z around 6 which used de-blended Herschel data. Our sample gives the strongest and cleanest indication to date that the population of HLIRGs has surface densities of around 5 to 18 / deg^2 (with variations due to a combination of the applied flux limit and cosmic variance) and an uncertainty of a factor of 2. In comparison, the GALFORM semi-analytic model significantly under-predicts the abundance of HLIRGs.Peer reviewe