Long-term physical activity: an exogenous risk factor for sporadic amyotrophic lateral sclerosis?

Objectives: To conduct a geographically defined, UK-based case-control study, to examine any association between physical activity (PA) and amyotrophic lateral sclerosis (ALS). Methods: A novel historical PA questionnaire was designed, validated, and subsequently administered in individual face-to-face interviews of 175 newly diagnosed sporadic ALS cases and 317 age- and sex-matched community controls. Historical PA energy expenditure and time spent in vigorous-intensity PA were derived from questionnaire data and compared between cases and controls. Results: Participation in an extra 10kJ/kg/day of PA (equivalent to approximately 45minutes brisk walking) was consistently associated with an increased risk of ALS, with the strongest association observed for adulthood exercise-related PA (OR 1.47, 95% CI 1.10-1.97). An extra 10mins/day of vigorous PA was also associated with the odds of ALS (OR 1.03, 95% CI 1·01-1·05). Results were slightly attenuated following adjustment for smoking and educational attainment. Conclusions: To our knowledge this is the first study to demonstrate a positive association between ALS and PA participation using a specifically designed and validated historical PA questionnaire. Despite the well-established health benefits of PA, a high activity lifestyle may also be associated with elevated risk of ALS. Large-scale prospective studies in the future may help to confirm this association.This study was funded by a Medical Research Council/Motor Neurone Disease Association Lady Edith Wolfson Fellowship.This is the final version of the article. It first appeared from Taylor and Francis via https://doi.org/10.3109/21678421.2016.115457

Long-term physical activity: an exogenous risk factor for sporadic amyotrophic lateral sclerosis?

OBJECTIVES: To conduct a geographically defined, UK-based case-control study, to examine any association between physical activity (PA) and amyotrophic lateral sclerosis (ALS). METHODS: A novel historical PA questionnaire was designed, validated, and subsequently administered in individual face-to-face interviews of 175 newly diagnosed sporadic ALS cases and 317 age- and sex-matched community controls. Historical PA energy expenditure and time spent in vigorous-intensity PA were derived from questionnaire data and compared between cases and controls. RESULTS: Participation in an extra 10kJ/kg/day of PA (equivalent to approximately 45minutes brisk walking) was consistently associated with an increased risk of ALS, with the strongest association observed for adulthood exercise-related PA (OR 1.47, 95% CI 1.10-1.97). An extra 10mins/day of vigorous PA was also associated with the odds of ALS (OR 1.03, 95% CI 1·01-1·05). Results were slightly attenuated following adjustment for smoking and educational attainment. CONCLUSIONS: To our knowledge this is the first study to demonstrate a positive association between ALS and PA participation using a specifically designed and validated historical PA questionnaire. Despite the well-established health benefits of PA, a high activity lifestyle may also be associated with elevated risk of ALS. Large-scale prospective studies in the future may help to confirm this association.This study was funded by a Medical Research Council/Motor Neurone Disease Association Lady Edith Wolfson Fellowship.This is the final version of the article. It first appeared from Taylor and Francis via https://doi.org/10.3109/21678421.2016.115457

Early fetal maturity assessed from patterns of ossification in the hand and foot

The assessment of fetal age at death is fraught with many complications and often the determination of the maturity of the fetus is a more realistic solution to the question of fetal viability. This study examines the pattern of appearance of primary centres of ossification in the fetal hand and foot, in an attempt to construct a maturity continuum. The results show that completion of ossification in the hand precedes that in the foot and generally occurs in a more regular pattern. The method proves useful at assessing fetal maturity between the third and tenth months of intra-uterine life. In addition, the relationship to other major centres of ossification is considered

2022 Swinburne Annual Reconciliation Lecture - Truth, Understanding and Transformation

Swinburne University of Technology and the National Centre for Reconciliation Practice is delighted to welcome Commissioner Sue-Anne Hunter, Deputy Chair Yoorrook Justice Commission, to deliver the 2022 Swinburne Annual Reconciliation Lecture on Thursday 28 July. Commissioner Hunter is a proud Wurundjeri and Ngurai Illum Wurrung woman currently holding the titles of Deputy Chair and Commissioner with the Yoorrook Justice Commission