Centuries of Heat Waves over India during 20th and 21st Century

An assessment of temperature extremes is made for the Indian subcontinent to identify the changes since 1951 to 2015, and for the future climate periods till 2100 for all the 21 CMIP5 (Coupled Model intercomparision Project phase 5) models and the representative concentration pathways RCP4.5 and RCP8.5 were examined for the period from 1 March to 31 May to characterize the heat waves in future climates and mean maximum and mean minimum bias were evaluated for the Indian subcontinent. Later two highest recorded temperature regions were chosen Northwest & Central India (NW&CIN) and only central India (CIN) box and the features of heat waves such as intensity and frequency were evaluated up to 2100. Corresponding temperature predictions from historical runs for the period 1951–2005 of 21 global CMIP model outputs and statistics were performed with the India Meteorological Department (IMD) gridded maximum temperature data for validation. Statistical metrics of BIAS, RMSE and MAE have indicated low BIAS, high correlation and high IOA (Index of Agreement) validating CMIP climate simulations. By analyzing the statistics of all the 21 models with respect to the observational gridded data from IMD came to conclusion that among all the 21 models 5 models were performing well for Indian region and having good index of agreement with IMD. The frequencies of the days having thresholds of 40 ºC, 42 ºC and 45 ºC for the maximum temperature over India during the pre-monsoon are evaluated up to 21st century. All models are showing that the intensity and frequency of heat waves were increasing significantly for both RCP4.5 and RCP8.5. Specifically, the characteristics of heat waves in terms of intensity, duration and area extent are calculated and compared to heat waves of the current climate.

The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima.

Myriapods (e.g., centipedes and millipedes) display a simple homonomous body plan relative to other arthropods. All members of the class are terrestrial, but they attained terrestriality independently of insects. Myriapoda is the only arthropod class not represented by a sequenced genome. We present an analysis of the genome of the centipede Strigamia maritima. It retains a compact genome that has undergone less gene loss and shuffling than previously sequenced arthropods, and many orthologues of genes conserved from the bilaterian ancestor that have been lost in insects. Our analysis locates many genes in conserved macro-synteny contexts, and many small-scale examples of gene clustering. We describe several examples where S. maritima shows different solutions from insects to similar problems. The insect olfactory receptor gene family is absent from S. maritima, and olfaction in air is likely effected by expansion of other receptor gene families. For some genes S. maritima has evolved paralogues to generate coding sequence diversity, where insects use alternate splicing. This is most striking for the Dscam gene, which in Drosophila generates more than 100,000 alternate splice forms, but in S. maritima is encoded by over 100 paralogues. We see an intriguing linkage between the absence of any known photosensory proteins in a blind organism and the additional absence of canonical circadian clock genes. The phylogenetic position of myriapods allows us to identify where in arthropod phylogeny several particular molecular mechanisms and traits emerged. For example, we conclude that juvenile hormone signalling evolved with the emergence of the exoskeleton in the arthropods and that RR-1 containing cuticle proteins evolved in the lineage leading to Mandibulata. We also identify when various gene expansions and losses occurred. The genome of S. maritima offers us a unique glimpse into the ancestral arthropod genome, while also displaying many adaptations to its specific life history.This work was supported by the following grants: NHGRIU54HG003273 to R.A.G; EU Marie Curie ITN #215781 “Evonet” to M.A.; a Wellcome Trust Value in People (VIP) award to C.B. and Wellcome Trust graduate studentship WT089615MA to J.E.G; Marine rhythms of Life” of the University of Vienna, an FWF (http://www.fwf.ac.at/) START award (#AY0041321) and HFSP (http://www.hfsp.org/) research grant (#RGY0082/2010) to KT-­‐R; MFPL Vienna International PostDoctoral Program for Molecular Life Sciences (funded by Austrian Ministry of Science and Research and City of Vienna, Cultural Department -­‐Science and Research to T.K; Direct Grant (4053034) of the Chinese University of Hong Kong to J.H.L.H.; NHGRI HG004164 to G.M.; Danish Research Agency (FNU), Carlsberg Foundation, and Lundbeck Foundation to C.J.P.G.; U.S. National Institutes of Health R01AI55624 to J.H.W.; Royal Society University Research fellowship to F.M.J.; P.D.E. was supported by the BBSRC via the Babraham Institute;This is the final version of the article. It first appeared from PLOS via http://dx.doi.org/10.1371/journal.pbio.100200

Interval Laparoscopic En-Bloc Resection of the Pelvis (L-EnBRP) in patients with stage IIIC-IV ovarian cancer: Description of the technique and surgical outcomes

Objective To describe the technique and evaluate the feasibility, efficacy and morbidity of the Laparoscopic En-Bloc Resection of the Pelvis (L-EnBRP) during Visceral-Peritoneal Debulking (VPD) at time of interval surgery. Methods This report is part of a prospective non randomized study (service evaluation protocol) on the feasibility and safety of laparoscopy in patients with stage IIIC-IV ovarian cancer and gross residual disease following neoadjuvant chemotherapy. Primary endpoints of this part of the study were the feasibility (rate of patients in whom the surgery could be completed by laparoscopy), efficacy (rate of patients ended with a complete resection) and morbidity (number of patients that suffered complications specifically associated to the procedure) of L-EnBRP. The results were compared between patients in group 1 (L-EnBRP + L-VPD), group 2 (L-EnBRP + VPD) and group 3 (VPD). Results Eighteen patients were in group 1, 8 in group 2 and 32 in group 3. Feasibility of L-EnBRP was 45% (26 patients out of 58), efficacy was 100% of the pelvic disease (94.4% overall disease) and morbidity was 5.5%. Main cause for conversion to laparotomy was high tumor load on diaphragm and/or mesentery. All but one patient had a complete resection (CR) of the disease. Group 1 patients had significantly earlier hospital discharge, lower blood loss and reduced overall morbidity than group 2 and 3. Conclusion L-EnBRP was feasible in almost half of the patients. In these patients a CR was achieved with a low morbidity rate. The latter was significantly decreased when compared to the patients who had a laparotomy

Endoscopy in gynecologic oncology

Endoscopic surgery offers the advantages of quicker recovery, shorter hospital stay and a lower risk of complications such as infections, blood loss, wound infection, ileus and incisional hernias. The feasibility of endoscopy in gynecological cancer has been shown in numerous papers demonstrating equivalence in terms of radicality. Evidence for oncological outcome in terms of survival has been slower to arrive, but there is significant evidence being reported now in all three of the major gynecological cancers

Latest developments and techniques in gynaecological oncology surgery

Purpose of review: To highlight the advances and the data published in the field of gynaecological oncology surgery in the last few years. The review includes not only newly introduced surgical techniques but also data that consolidate recent developments. Recent findings: Ultimate data on the use of laparoscopy in the treatment of gynaecologic malignancies have proven similar survival outcomes to the traditional surgical route and confirmed the benefits in terms of faster recovery and lower morbidity. Thanks to a faster learning curve, the use of robotic surgery has contributed to the increase in the number of surgeons who moved away from open surgery. A few pioneers are expanding the indications of laparoscopy to exenterative surgery and treatment of ovarian cancer. Summary: Laparoscopic surgery has become the gold standard treatment for patients with primary endometrial or cervical cancer. The advent of robotic surgery has reinforced the domain of endoscopic surgery

Routine Intraoperative Frozen Section Examination to Minimize Bimodal Treatment in Early-Stage Cervical Cancer

In early-stage cervical cancer, single modality therapy is the main objective, to minimize patient morbidity while offering equivalent cure rates. Intraoperative frozen section examination (FSE) of lymph nodes (LNs) can facilitate this aim, ensuring that radical surgery is avoided in patients requiring adjuvant therapy for metastatic LN involvement. We aimed to evaluate the accuracy of routine intraoperative FSE of pelvic LNs during the surgical staging of early-stage cervical cancers and identify a group at low risk for nodal metastases.A retrospective cohort study of 94 women aged 23 to 80 years who underwent primary surgery and planned intraoperative FSE of the pelvic LNs at the gynecological cancer center in Oxford was performed. The diagnostic value of FSE and the prediction of metastatic nodal disease were assessed by use of preoperative and intraoperative variables.A total of 1825 LNs were submitted for FSE. Of 94 women (13.8%), 13 had positive LNs at FSE. Two false-negative cases were reported with micrometastases but no false-positive cases. Frozen section examination as a diagnostic test reached a sensitivity of 86.7% and a specificity of 100%. A regression model including grade I to II and tumor size of less than 20 mm identified a low-risk group for LN involvement.In light of diverse practice patterns, FSE should be routinely offered to women with early-stage cervical cancer in a 1-step protocol. We equally devised a model to predict those patients at least risk of nodal disease, who may be spared of FSE

Synthesis of low-melting metal oxide and sulfide nanowires and nanobelts

The bulk nucleation and basal growth of semiconducting nanowires from molten Ga pools has been demonstrated earlier using oxygen/hydrogen plasma over molten Ga pools. Herein, we extend the above concept for bulk synthesis of oxide and sulfide nanowires of low-melting metal melts such as Sn and In. Specifically, nanowires of β-Ga_2O_3, β-In_2O_3, SnO_2, α-Ga_2S_3, and β-In_2S_3 were synthesized using direct reactions between respective molten metal pools and the gases such as oxygen/hydrogen mixture for oxides and H_2S for sulfides. In the case of β-Ga_2O_3 and SnO_2, a change in the morphology from nanowires to nanobelts was observed with an increase in the synthesis temperature. No such behavior was observed in the case of β-In_2O_3. Furthermore, we present evidence for α-Ga_2S_3 nanowires, which to our knowledge is being reported for the first time in the literature. Our studies with the sulfide nanowires suggest that H_2S reacts directly at the molten metal surface to form gallium sulfide. Finally, we discuss the role of chamber pressure and hydrogen on the size distribution of nanostructured β-Ga_2O_3 and SnO_2