Forecasting of Warranty Returns Based on the Reliability of Delivery Assessment

The paper presents a method to evaluate the reliability of deliveries with the application of Reliasoft Weibull++ software. The first stage in the proposed method was to collect data on outbound deliveries on a monthly basis and convert them into reliability data (life data). Next, by combining selected statistical tests and the maximum likelihood estimation method, the most accurate model of reliability of deliveries was obtained. Using the model which was generated, selected reliability indices were determined, such as: reliability of deliveries, unreliability of deliveries, failure rate of deliveries. Consequently, the number of future failed deliveries was forecast, taking into account the confidence bounds. The approach presented may be easily applied in companies in the logistics sector. The authors underlined that the reliability of deliveries is one of the key factors determining business competitiveness

Regionalization of low flow for chosen catchments of the upper Vistula river basin using non-hierarchical cluster analysis

The aim of this work was the regionalization of low flow for chosen catchments located in the upper Vistula river basin using non-hierarchical cluster analysis. Next, with such creative clusters, the regional relationships were determined between the specific low flow discharge q95 and the meteorological and physiographic parameters of the catchment. The study evaluated regional regression models for low flow (specific q95 discharge) in selected, 30 catchments located in the upper Vistula river basin. The data for calculations were a series of observations of daily discharge from the multiannual period of 1963–2016 and were obtained from the Institute of Meteorology and Water Management – National Research Institute in Warsaw. The study showed, that the k-means method can be used for regional regression determination. The parameters which influenced the catchments grouping in clusters were the specific low flow discharge q95, precipitation, median catchment altitude, mean catchment slope, soil, and land use. The study indicated that k-means method may be an effective tool for evaluating low flow in rivers of the southern parts of Poland

Vascular cognitive impairment linked to brain endothelium inflammation in early stages of heart failure in mice

Background Although advanced heart failure ( HF ) is a clinically documented risk factor for vascular cognitive impairment, the occurrence and pathomechanisms of vascular cognitive impairment in early stages of HF are equivocal. Here, we characterize vascular cognitive impairment in the early stages of HF development and assess whether cerebral hypoperfusion or prothrombotic conditions are involved. Methods and Results Tgαq*44 mice with slowly developing isolated HF triggered by cardiomyocyte‐specific overexpression of G‐αq*44 protein were studied before the end‐stage HF , at the ages of 3, 6, and 10 months: before left ventricle dysfunction; at the stage of early left ventricle diastolic dysfunction (with preserved ejection fraction); and left ventricle diastolic/systolic dysfunction, respectively. In 6‐ to 10‐month‐old but not in 3‐month‐old Tgαq*44 mice, behavioral and cognitive impairment was identified with compromised blood‐brain barrier permeability, most significantly in brain cortex, that was associated with myelin sheet loss and changes in astrocytes and microglia. Brain endothelial cells displayed increased E‐selectin immunoreactivity, which was accompanied by increased amyloid‐β 1‐42 accumulation in piriform cortex and increased cortical oxidative stress (8‐ OH dG immunoreactivity). Resting cerebral blood flow measured by magnetic resonance imaging in vivo was preserved, but ex vivo NO ‐dependent cortical arteriole flow regulation was impaired. Platelet hyperreactivity was present in 3‐ to 10‐month‐old Tgαq*44 mice, but it was not associated with increased platelet‐dependent thrombogenicity. Conclusions We report for the first time that vascular cognitive impairment is already present in the early stage of HF development, even before left ventricle systolic dysfunction. The underlying pathomechanism, independent of brain hypoperfusion, involves preceding platelet hyperreactivity and brain endothelium inflammatory activation. </jats:sec

Subsequent Event Risk in Individuals with Established Coronary Heart Disease:Design and Rationale of the GENIUS-CHD Consortium

BACKGROUND: The "GENetIcs of sUbSequent Coronary Heart Disease" (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185,614 participants with either acute coronary syndrome, stable CHD or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events. RESULTS: Enrollment into the individual studies took place between 1985 to present day with duration of follow up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (HR 1.15 95% CI 1.14-1.16) per 5-year increase, male sex (HR 1.17, 95% CI 1.13-1.21) and smoking (HR 1.43, 95% CI 1.35-1.51) with risk of subsequent CHD death or myocardial infarction, and differing associations with other individual and composite cardiovascular endpoints. CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and non-genetic determinants of subsequent event risk in individuals with established CHD, in order to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators

A Study on the Effect of Adhesive Cavities on the Scuffing Initiation in a Sliding Contact

Scuffing is a particularly problematic wear phenomenon in sliding contact that has not yet been fully elucidated. The complicated mechanism of the development of this phenomenon results from the simultaneous influence of many factors. There is a continuous need for new research to gain a deeper understanding of the complex frictional processes that scuffing is. Components such as cams, tappets, piston rings and gears are extremely susceptible to scuffing. The idea of the research on the scuffing wear development is the study of the formation of adhesive cavities as the effects of the destruction of adhesive bonds at various operating parameters. The goal of the presented work is the analysis of the influence of the oscillation frequency on the formation of adhesive cavities leading to scuffing. The tests carried out with the use of S235 steel showed that the adhesive cavities on the surfaces of the tested components appear regardless of the adopted values of the oscillation frequency. The surfaces of the specimen and counter-specimen were analyzed before and after wear tests on the block-on-ring test stand at the different values of the oscillation frequency. The conducted research revealed that the greatest change in the values of the friction coefficient occurs with an increase in frequency from 2 to 5 Hz, and the largest change in the number of scuffing initiating cycles occurs with an increase in the oscillation frequency from 1 to 2 Hz