12,087 research outputs found
Noninvasive detection of high-risk adenomas using stool-derived eukaryotic RNA sequences as biomarkers
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A revised chronostratigraphic framework for International Ocean Discovery Program Expedition 355 sites in Laxmi Basin, eastern Arabian Sea
AbstractInternational Ocean Discovery Program Expedition 355 drilled Sites U1456 and U1457 in Laxmi Basin (eastern Arabian Sea) to document the impact of the South Asian monsoon on weathering and erosion of the Himalaya. We revised the chronostratigraphic framework for these sites using a combination of biostratigraphy, magnetostratigraphy and strontium isotope stratigraphy. The sedimentary section at the two sites is similar and we divided it into six units bounded by unconformities or emplaced as a mass-transport deposit (MTD). Unit 1 underlies the MTD, and is of early–middle Miocene age at Site U1456 and early Paleocene age at Site U1457. An unconformity (U1) created by emplacement of the MTD (unit 2) during the late Miocene Epoch (at c. 9.83–9.69 Ma) separates units 1 and 2 and is identified by a marked change in lithology. Unit 3 consists of hemipelagic sediment with thin interbeds of graded sandstone of late Miocene age, separated from unit 4 by a second unconformity (U2) of 0.5–0.9 Myr duration. Unit 4 consists of upper Miocene interbedded mudstone and sandstone and hemipelagic chalk deposited between c. 8 and 6 Ma. A c. 1.4–1.6 Myr hiatus (U3) encompasses the Miocene–Pliocene boundary and separates unit 4 from unit 5. Unit 5 includes upper Pliocene – lower Pleistocene siliciclastic sediment that is separated from unit 6 by a c. 0.45 Myr hiatus (U4) in the lower Pleistocene sediments. Unit 6 includes a thick package of rapidly deposited Pleistocene sand and mud overlain by predominantly hemipelagic sediment deposited since c. 1.2 Ma
Absence of halfmetallicity in defect-free Cr, Mn-delta-doped Digital Magnetic Heterostructures
We present results of a combined density functional and many-body
calculations for the electronic and magnetic properties of the defect-free
digital ferromagnetic heterostructures obtained by doping GaAs with Cr and Mn.
While local density approximation/(+U) predicts half-metallicity in these
defect-free delta-doped heterostructures, we demonstrate that local many-body
correlations captured by Dynamical Mean Field Theory induce within the minority
spin channel non-quasiparticle states just above . As a consequence of the
existence of these many-body states the half-metallic gap is closed and the
carriers spin polarization is significantly reduced. Below the Fermi level the
minority spin highest valence states are found to localize more on the GaAs
layers being independent of the type of electronic correlations considered.
Thus, our results confirm the confinement of carriers in these delta-doped
heterostructures, having a spin-polarization that follow a different
temperature dependence than magnetization. We suggest that polarized
hot-electron photoluminescence experiments might bring evidence for the
existence of many-body states within the minority spin channel and their finite
temperature behavior.Comment: 10 pages 8 figures, submitted to PR
An Investigation of Somali Women’s Beliefs, Practices, and Attitudes about Health, Health Promoting Behaviours and Cancer Prevention
This pilot study examined Somali women's perception of health/access to care, examined their knowledge and attitudes about cancer prevention, and discussed strategies to improve service provision and education. Using a multidisciplinary approach, twelve face-to-face interviews were conducted with Somali women ages 18 and older, residing in a mid-western city. Open coding was used to categorize and reflect the interview statements and to identify reoccurring themes. Somali women are concerned about a variety of health issues and cited the role of culture and religion in developing prevention strategies. Participants emphasized the use of religious leaders, health care advocates, oral traditions, and translators in providing culturally appropriate health care services. Religion and culture play a prominent role in the Somali community and impact beliefs about health and wellness. Health practitioners need to work closely with individuals and community leaders to tailor services that are culturally appropriate and accessible.
From meadows to milk to mucosa – adaptation of Streptococcus and Lactococcus species to their nutritional environments
Lactic acid bacteria (LAB) are indigenous to food-related habitats as well as associated with the mucosal surfaces of animals. The LAB family Streptococcaceae consists of the genera Lactococcus and Streptococcus. Members of the family include the industrially important species Lactococcus lactis, which has a long history safe use in the fermentative food industry, and the disease-causing streptococci Streptococcus pneumoniae and Streptococcus pyogenes. The central metabolic pathways of the Streptococcaceae family have been extensively studied because of their relevance in the industrial use of some species, as well as their influence on virulence of others. Recent developments in high-throughput proteomic and DNA-microarray techniques, in in vivo NMR studies, and importantly in whole-genome sequencing have resulted in new insights into the metabolism of the Streptococcaceae family. The development of cost-effective high-throughput sequencing has resulted in the publication of numerous whole-genome sequences of lactococcal and streptococcal species. Comparative genomic analysis of these closely related but environmentally diverse species provides insight into the evolution of this family of LAB and shows that the relatively small genomes of members of the Streptococcaceae family have been largely shaped by the nutritionally rich environments they inhabit.
One-dimensional orbital fluctuations and the exotic magnetic properties of YVO
Starting from the Mott insulator picture for cubic vanadates, we derive and
investigate the model of superexchange interactions between V ions, with
nearly degenerate orbitals occupied by two electrons each. The
superexchange interactions are strongly frustrated and demonstrate a strong
interrelation between possible types of magnetic and orbital order. We
elucidate the prominent role played by fluctuations of and orbitals
which generate ferromagnetic superexchange interactions even in the absence of
Hund's exchange. In this limit we find orbital valence bond state which is
replaced either by -type antiferromagnetic order with weak -type orbital
order at increasing Hund's exchange, or instead by -type antiferromagnetic
order when the lattice distortions stabilize -type orbital order. Both
phases are observed in YVO and we argue that a dimerized -type
antiferromagnetic phase with stronger and weaker FM bonds alternating along the
c axis may be stabilized by large spin-orbital entropy at finite temperature.
This suggests a scenario which explains the origin of the exotic -AF order
observed in YVO in the regime of intermediate temperatures and allows one
to specify the necessary ingredients of a more complete future theory.Comment: 23 pages, 15 figure
Oral cavity squamous cell carcinoma xenografts retain complex genotypes and intertumor molecular heterogeneity
Orbital liquid in ferromagnetic manganites: The orbital Hubbard model for electrons
We have analyzed the symmetry properties and the ground state of an orbital
Hubbard model with two orbital flavors, describing a partly filled
spin-polarized band on a cubic lattice, as in ferromagnetic manganites.
We demonstrate that the off-diagonal hopping responsible for transitions
between and orbitals, and the absence of SU(2) invariance
in orbital space, have important implications. One finds that superexchange
contributes in all orbital ordered states, the Nagaoka theorem does not apply,
and the kinetic energy is much enhanced as compared with the spin case.
Therefore, orbital ordered states are harder to stabilize in the Hartree-Fock
approximation (HFA), and the onset of a uniform ferro-orbital polarization and
antiferro-orbital instability are similar to each other, unlike in spin case.
Next we formulate a cubic (gauge) invariant slave boson approach using the
orbitals with complex coefficients. In the mean-field approximation it leads to
the renormalization of the kinetic energy, and provides a reliable estimate for
the ground state energy of the disordered state. Using this approach one finds
that the HFA fails qualitatively in the regime of large Coulomb repulsion
-- the orbital order is unstable, and instead a strongly
correlated orbital liquid with disordered orbitals is realized at any electron
filling.Comment: 25 pages, 9 figure
Environmental factors influence both abundance and genetic diversity in a widespread bird species.
Genetic diversity is one of the key evolutionary variables that correlate with population size, being of critical importance for population viability and the persistence of species. Genetic diversity can also have important ecological consequences within populations, and in turn, ecological factors may drive patterns of genetic diversity. However, the relationship between the genetic diversity of a population and how this interacts with ecological processes has so far only been investigated in a few studies. Here, we investigate the link between ecological factors, local population size, and allelic diversity, using a field study of a common bird species, the house sparrow (Passer domesticus). We studied sparrows outside the breeding season in a confined small valley dominated by dispersed farms and small-scale agriculture in southern France. Population surveys at 36 locations revealed that sparrows were more abundant in locations with high food availability. We then captured and genotyped 891 house sparrows at 10 microsatellite loci from a subset of these locations (N = 12). Population genetic analyses revealed weak genetic structure, where each locality represented a distinct substructure within the study area. We found that food availability was the main factor among others tested to influence the genetic structure between locations. These results suggest that ecological factors can have strong impacts on both population size per se and intrapopulation genetic variation even at a small scale. On a more general level, our data indicate that a patchy environment and low dispersal rate can result in fine-scale patterns of genetic diversity. Given the importance of genetic diversity for population viability, combining ecological and genetic data can help to identify factors limiting population size and determine the conservation potential of populations
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