Moderators of the Relationship between Exercise and Mood Changes: Gender, Exertion Level, and Workout Duration

ABSTRACT Although the role of exercise in improving mood is well established, less is known about moderators of this effect, particularly outside of the laboratory. The current study examined the effect of gender, type of exercise, level of exertion, and duration of workout on the exercisemood relationship in a naturalistic setting. One hundred and thirty five participants (64 females) either engaged in weight training (n=52) or cardiovascular (n=83) exercise. Pre-and postexercise assessments of mood were collected and changes in two types of mood, negative mood and exhaustion, were examined. Overall, participants reported improved mood after exercise in both domains. Workout duration and level of exertion significantly moderated the relationship of exercise to mood improvement (i.e., an increase in either corresponded to greater improved mood, ps < 0.05). Overall, women showed more improved mood than men in the domain of exhaustion (p=0.001)

Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1

Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a significant heritability. We carried out a genome-wide association discovery study of 1866 patients with AAA and 5435 controls and replication of promising signals (lead SNP with a p value < 1 × 10-5) in 2871 additional cases and 32,687 controls and performed further follow-up in 1491 AAA and 11,060 controls. In the discovery study, nine loci demonstrated association with AAA (p < 1 × 10-5). In the replication sample, the lead SNP at one of these loci, rs1466535, located within intron 1 of low-density-lipoprotein receptor-related protein 1 (LRP1) demonstrated significant association (p = 0.0042). We confirmed the association of rs1466535 and AAA in our follow-up study (p = 0.035). In a combined analysis (6228 AAA and 49182 controls), rs1466535 had a consistent effect size and direction in all sample sets (combined p = 4.52 × 10-10, odds ratio 1.15 [1.10-1.21]). No associations were seen for either rs1466535 or the 12q13.3 locus in independent association studies of coronary artery disease, blood pressure, diabetes, or hyperlipidaemia, suggesting that this locus is specific to AAA. Gene-expression studies demonstrated a trend toward increased LRP1 expression for the rs1466535 CC genotype in arterial tissues; there was a significant (p = 0.029) 1.19-fold (1.04-1.36) increase in LRP1 expression in CC homozygotes compared to TT homozygotes in aortic adventitia. Functional studies demonstrated that rs1466535 might alter a SREBP-1 binding site and influence enhancer activity at the locus. In conclusion, this study has identified a biologically plausible genetic variant associated specifically with AAA, and we suggest that this variant has a possible functional role in LRP1 expression

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis

Pathways to Work: Social Structural Differences in the Relationships Between College Expectations, Planfulness, and Intense Adolescent Work

This research examines variation in the relationships between college expectations, planfulness, and intense adolescent work by socioeconomic factors using data from Add Health (n = 8,836). Results show that higher college expectations are related to higher odds of intense school-year work among lower social class youth, but lower odds of intense work among youth from higher social class backgrounds. Moreover, planful adolescents are more likely to work intensely during the school year among youth from disadvantaged neighborhoods, but less likely to work intensely among those from advantaged neighborhoods. Results also show less variability in these relationships when considering summer work

Pathways to Work: Social Structural Differences in the Relationships between College Expectations, Planfulness, and Intense Adolescent Work

Article published in Work and Occupations, 42(1), 2014. Version of Record found at https://doi.org/10.1177%2F0730888414554237.This research examines variation in the relationships between college expectations, planfulness, and intense adolescent work by socioeconomic factors using data from Add Health (n = 8,836). Results show that higher college expectations are related to higher odds of intense school-year work among lower social class youth, but lower odds of intense work among youth from higher social class backgrounds. Moreover, planful adolescents are more likely to work intensely during the school year among youth from disadvantaged neighborhoods, but less likely to work intensely among those from advantaged neighborhoods. Results also show less variability in these relationships when considering summer work

Adolescent Work and Alcohol Use: Moderation by Neighborhood Context and the Role of Peers

Article published in Deviant Behavior, 38 (11), 2016. Version of Record found at https://doi.org/10.1080/01639625.2016.1248712.Using data from the National Longitudinal Study of Adolescent to Adult Health (Add Health), this study looks at the adolescent work and binge drinking relationship among a sample of 4,826 adolescents. The paper assesses variability in the work-binge drinking relationship by social class and neighborhood disadvantage and seeks to explain variability by considering social control and social learning processes. Results reveal that the detrimental relationships between work intensity and binge drinking are stronger for those from more advantaged neighborhoods. Results also show that perceived peer substance use explains neighborhood disadvantage differences in the relationship between intense work and binge drinking

Guilt by Association: The Relationship between Deviant Peers and Deviant Labels

This study broadens labeling theory by examining the role deviant peers play in earlier stages of the labeling process. We propose that deviant peers serve as a source of information used in the decision to apply a deviant label by parents and school authorities. Using data from the National Longitudinal Study of Adolescent Health with cross-sectional (n = 12,011) and longitudinal (n = 9,267) samples, results show that higher levels of peer deviance are related to receiving both informal and formal labels. We also find that associating with deviant peers amplifies the effect of individual deviance on receiving an informal label