Analysis of Intermittent Distributed Connectivity in Urban Areas

Analysis of hypothetical connectivity of wirelessly interconnected networks and infrastructures deployed over a one-square kilometre of the Brussels Metropolitan area is presented. Upper and lower margins of wireless transceiver range are considered with a view to characterise representative interconnectivity profiles. Graph and percolation analyses of intermittent connectivity and its implications for resilience and vulnerability of the network are discussed. Based on these findings the report presents a proposal for the dimensioning of connectivity profiles for generic areas based on intrinsic algebraic network properties.JRC.E.4-Safety and Security of Building

Dietary Fibers and Cardiometabolic Diseases

The high prevalence of cardiovascular disease (CVD) is largely attributable to the contemporary lifestyle that is often sedentary and includes a diet high in saturated fats and sugars and low ingestion of polyunsaturated fatty acids (PUFAs), fruit, vegetables, and fiber. Experimental data from both animals and humans suggest an association between increased dietary fiber (DF) intakes and improved plasma lipid profiles, including reduced low density lipoprotein cholesterol (LDL-C) concentrations. These observations underline that the intake of DF may protect against heart disease and stroke

Argentine Network of Forest Science and Technology -REDFOR.ar: A means of articulating and strengthening scientific-technical capacities for sustainable forest development

La REDFOR.ar es una iniciativa conjunta de las instituciones vinculadas a las Ciencias Forestales, que está conformada por docentes, investigadores e instituciones relacionados con la educación, la ciencia y la tecnología forestal. Con un Consejo Directivo integrado por las universidades nacionales en las que se dictan carreras forestales de posgrado, grado y pregrado -UNSE, UNaM, UNaF, UNPSJB, UNCo, UNLP- además del CONICET, el INTA y el INTI, se halla incluida dentro del ámbito de las Redes Institucionales Orientadas a la Solución de Problemas (RIOSP) que constituye una iniciativa de la Gerencia de Desarrollo Científico y Tecnológico del CONICET. En este artículo se describen las etapas que dieron origen a la REDFOR.ar, se presentan los resultados de una encuesta nacional realizada por la Red que permitieron delinear los fines y se detallan las actividades que actualmente se están llevando a cabo.The REDFOR.ar is a joint initiative of institutions linked to the Forest Sciences, integrated by teachers, researchers and institutions related to forest education, science and technology. With a Board of Directors composed by the representatives of the national universities where graduate and undergraduate forestry programs are taught -UNSE, UNaM, UNaF, UNPSJB, UNCo, UNLP- together with the CONICET, INTA and INTI, it is part of the Solving Problems-Oriented Institutional Networks (RIOSP, in Spanish), an initiative of the Management of Scientific and Technological Development Office of the CONICET. In this article the stages that gave rise to the REDFOR.ar are described, the results of a national survey conducted by the Network that allowed to state its purposes introduced and the activities that are currently being carried out detailed.Fil: Carabelli, Francisco Andrés Carabelli. Universidad Nacional de la Patagonia "San Juan Bosco"; ArgentinaFil: Lupi, Ana María. Instituto Nacional de Tecnología Agropecuaria; ArgentinaFil: Graziano, Corina. Universidad Nacional de La Plata; ArgentinaFil: Villagra, Pablo Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias; Argentin

Standardized Duplex Ultrasound-Based Protocol for Early Diagnosis of Transplant Renal Artery Stenosis: Results of a Single-Institution Retrospective Cohort Study

Transplant renal artery stenosis (TRAS) is the most frequent vascular complication after kidney transplantation (KT) and has been associated with potentially reversible refractory hypertension, graft dysfunction, and reduced patient survival. The aim of the study is to describe the outcomes of a standardized Duplex Ultrasound- (DU-) based screening protocol for early diagnosis of TRAS and for selection of patients potentially requiring endovascular intervention. We retrospectively reviewed our prospectively collected database of KT from January 1998 to select patients diagnosed with TRAS. The follow-up protocol was based on a risk-adapted, dynamic subdivision of eligible KT patients in different risk categories (RC) with different protocol strategies (PS). Of 598 patients included in the study, 52 (9%) patients had hemodynamically significant TRAS and underwent percutaneous angioplasty (PTA) and stent placement. Technical and clinical success rates were 97% and 90%, respectively. 7 cases of restenosis were recorded at follow-up and treated with re-PTA plus stenting. Both DU imaging and clinical parameters improved after stent placement. Prospective high-quality studies are needed to test the efficacy and safety of our protocol in larger series. Accurate trial design and standardized reporting of patient outcomes will be key to address the current clinical needs

Characterization of seismic signals recorded in Tethys Bay, Victoria Land (Antarctica): data from atmosphere-cryosphere-hydrosphere interaction

In this paper, we analysed 3-component seismic signals recorded during 27 November 2016 - 10 January 2017 by two stations installed in Tethys Bay (Victoria Land, Antarctica), close to Mario Zucchelli Station. Due to the low noise levels , it was possible to identify three different kinds of signals: teleseismic earthquakes, microseisms, and icequakes . We focus on the latter two. A statistically significant relationship was found between microseism amplitude and both wind speed and sea swell. Thus, we suggest that the recorded microseism data are caused by waves at the shore close to the seismic stations rather than in the deep ocean during storms. In addition, w e detected three icequakes , with dominant low frequencies (below 2 Hz), located in the David Glacier area with local magnitude of 2.4-2.6. These events were likely to have been generated at the rock–ice interface under the glacier. This work shows how seismic signals recorded in Antarctica provide insights on the interactions between the atmosphere-cryosphere-hydrosphere. Since climate patterns drive these interactions, investigations on Antarctic seismic signals could serve as a proxy indicator for estimating climate changes

Fucoxantin: A Treasure from the Sea

The World Health Organization (WHO) estimates that 2.3 billion people will be overweight and 700 million obese in 2015. The reasons for this disastrous trend are attributed to the global tendency toward the reduced magnitude of exercise and physical activity and the increased dietary intake of fats, sugars and calories with reduced amount of vitamins and minerals. To prevent life-style-related diseases, like Metabolic Syndrome (MS), researchers’ attention is increasingly focusing on some of the so called “functional foods” which may be useful for their prevention and treatment. One of these functional ingredients is fucoxanthin (FX), a characteristic carotenoid present in edible brown seaweeds, such as Undaria pinnatifida (Wakame), Hijikia fusiformis (Hijiki), Laminaria japonica (Ma-Kombu) and Sargassum fulvellum. The increasing popularity of this molecule is certainly due to its anti-obesity effect, primarily detected by murine studies. These works revealed FX mediated induction of uncoupling protein-1 (UCP-1) in abdominal white adipose tissue (WAT) mitochondria, leading to the oxidation of fatty acids and heat production in WAT. Beyond this important role, in recent studies FX has shown a great antioxidant activity, anti-cancer, anti-diabetic and anti-photoaging properties. The aim of this review is to highlight the main effects of FX on human health

Red Listing plants under full national responsibility: Extinction risk and threats in the vascular flora endemic to Italy

Taxa endemic to a country are key elements for setting national conservation priorities and for driving conservation strategies, since their persistence is entirely dependent on national policy. We applied the IUCN Red List categories to all Italian endemic vascular plants (1340 taxa) to assess their current risk of extinction and to highlight their major threats. Our results revealed that six taxa are already extinct and that 22.4% (300 taxa) are threatened with extinction, while 18.4% (247; especially belonging to apomictic groups) have been categorized as Data Deficient. Italian endemic vascular plants are primarily threatened by natural habitat modification due to agriculture, residential and tourism development. Taxa occurring in coastal areas and lowlands, where anthropogenic impacts and habitat destruction are concentrated, display the greatest population decline and extinction. The national network of protected areas could be considered effective in protecting endemic-rich areas (ERAs) and endemic taxa, but ineffective in protecting narrow endemic-rich areas (NERAs), accordingly changes to the existing network may increase the effectiveness of protection. For the first time in the Mediterranean Basin biodiversity hotspot, we present a comprehensive extinction assessment for endemic plants under the full responsibility of a single country. This would provide an important step towards the prioritization and conservation of threatened endemic flora at Italian, European, and Mediterranean level. A successful conservation strategy of the Italian endemic vascular flora should implement the protected area system, solve some taxonomical criticism in poorly known genera, and should rely on monitoring threatened species, and on developing species-specific action plans

Cetuximab continuation after first progression in metastatic colorectal cancer (CAPRI-GOIM): A randomized phase II trial of FOLFOX plus cetuximab versus FOLFOX

Background: Cetuximab plus chemotherapy is a first-line treatment option in metastatic KRAS and NRAS wild-type colorectal cancer (CRC) patients. No data are currently available on continuing anti-epidermal growth factor receptor (EGFR) therapy beyond progression. Patients and methods: We did this open-label, 1:1 randomized phase II trial at 25 hospitals in Italy to evaluate the efficacy of cetuximab plus 5-fluorouracil, folinic acid and oxaliplatin (FOLFOX) as second-line treatment of KRAS exon 2 wild-type metastatic CRC patients treated in first line with 5-fluorouracil, folinic acid and irinotecan (FOLFIRI) plus cetuximab. Patients received FOLFOX plus cetuximab (arm A) or FOLFOX (arm B). Primary end point was progressionfree survival (PFS). Tumour tissues were assessed by next-generation sequencing (NGS). This report is the final analysis. Results: Between 1 February 2010 and 28 September 2014, 153 patients were randomized (74 in arm A and 79 in arm B). Median PFS was 6.4 [95% confidence interval (CI) 4.7-8.0] versus 4.5 months (95% CI 3.3-5.7); [hazard ratio (HR), 0.81; 95% CI 0.58-1.12; P = 0.19], respectively. NGS was performed in 117/153 (76.5%) cases; 66/117 patients (34 in arm A and 32 in arm B) had KRAS, NRAS, BRAF and PIK3CA wild-type tumours. For these patients, PFS was longer in the FOLFOX plus cetuximab arm [median 6.9 (95% CI 5.5-8.2) versus 5.3 months (95% CI 3.7-6.9); HR, 0.56 (95% CI 0.33-0.94); P = 0.025]. There was a trend in better overall survival: median 23.7 [(95% CI 19.4-28.0) versus 19.8 months (95% CI 14.9-24.7); HR, 0.57 (95% CI 0.32-1.02); P = 0.056]. Conclusions: Continuing cetuximab treatment in combination with chemotherapy is of potential therapeutic efficacy in molecularly selected patients and should be validated in randomized phase III trials