Concise total syntheses of (–)-jorunnamycin A and (–)-jorumycin enabled by asymmetric catalysis

The bis-tetrahydroisoquinoline (bis-THIQ) natural products have been studied intensively over the past four decades for their exceptionally potent anticancer activity, in addition to strong gram-positive and -negative antibiotic character. Synthetic strategies toward these complex polycyclic compounds have relied heavily on electrophilic aromatic chemistry, such as the Pictet-Spengler reaction, that mimics their biosynthetic pathways. Herein we report an approach to two bis-THIQ natural products, jorunnamycin A and jorumycin, that instead harnesses the power of modern transition-metal catalysis for the three major bond-forming events and proceeds with high efficiency (15 and 16 steps, respectively). By breaking from biomimicry, this strategy allows for the preparation of a more diverse set of non-natural analogs

Primjena iskustava biološke fizike u savremenom ribarstvu

The EPSRC doctoral training grant supported RP (DTG grant: 1518070)). The EPSRC (EP/M003868/1) is also acknowledged for funding (JAF&PD).The scope of carbon monoxide-free Asymmetric Transfer HydroFormylation (ATHF) procedures using a highly active single catalyst system derived from 1,2-bis-((2,5)-diphenylphospholano)ethane as chiral ligand has been studied. This reveals some highly successful reactions, but also significant limitations. The development of a new protocol in which a catalyst for formaldehyde decomposition to CO and H2 is combined with the catalyst of choice for the subsequent asymmetric hydroformylation is described. This enables ATHF reactions that were problematic to be significantly improved. The new method has been used in the synthesis of several key precursors to biologically active molecules.PostprintPeer reviewe

High iso aldehyde selectivity in the hydroformylation of short-chain alkenes

The authors thank the Eastman Chemical Company for funding (LI, and later JAF) and permission to publish. The EPSRC (EP/M003868/1) is also acknowledged for funding (JAF).The hydroformylation of propene to give predominantly iso‐butanal has been achieved; class‐leading selectivity is possible even at higher temperatures that deliver fast conversion. Racemic rhodium complexes of bidentate phospholane phosphites derived from tropos‐biphenols and unusual solvent systems are the key to the selectivity observed.PostprintPeer reviewe

Concise total syntheses of (–)-jorunnamycin A and (–)-jorumycin enabled by asymmetric catalysis

The bis-tetrahydroisoquinoline (bis-THIQ) natural products have been studied intensively over the past four decades for their exceptionally potent anticancer activity, in addition to strong gram-positive and -negative antibiotic character. Synthetic strategies toward these complex polycyclic compounds have relied heavily on electrophilic aromatic chemistry, such as the Pictet-Spengler reaction, that mimics their biosynthetic pathways. Herein we report an approach to two bis-THIQ natural products, jorunnamycin A and jorumycin, that instead harnesses the power of modern transition-metal catalysis for the three major bond-forming events and proceeds with high efficiency (15 and 16 steps, respectively). By breaking from biomimicry, this strategy allows for the preparation of a more diverse set of non-natural analogs

Musizieren in der Sozialpädagogik : musikalische und kulturelle Förderung durch das Musikprojekt "Superar"

Diese Arbeit soll veranschaulichen, wie Musik mit ihren zahlreichen Funktionen in der sozialpädagogischen Arbeit eingesetzt werden kann. Musik hat verschiedene kulturelle, soziale oder auch psychologische Wirkungsweisen auf Menschen. Einen speziellen Fokus legt diese Arbeit auf das Musizieren und dessen Wirkung auf Menschen. Musik kann als Kommunikationsmittel dienen sowie auch zur Integration beitragen. Veranschaulicht werden diese Überlegungen im empirischen Teil der Arbeit, welcher sich mit dem sozial-integrativen Musikprojekt „Superar“ beschäftigt. Die Zielgruppe dieses Projektes sind Kinder und Jugendliche aus verschiedenen sozialen Schichten und unterschiedlichsten Herkunftsländern, die durch „Superar“ professionellen Musikunterricht erhalten.The aim of this paper is to show how music, with its numerous functions can be used in socio-pedagogical work. Music has various effects on humans, from a culturally, socially, as well as a psychologically point of view. This paper focuses particularly on making music and its effects on people. Music can contribute to communication as well as to integration. These considerations are illustrated in the empirical part of this paper, which deals with the socially inclusive music project “Superar”. The target group of this project are children and adolescents with various social and cultural backgrounds, who receive professional music lessons through “Superar”.vorgelegt von Julia Grünanger, BAZusammenfassungen in Deutsch und EnglischAbweichender Titel laut Übersetzung des Verfassers/der VerfasserinKarl-Franzens-Universität Graz, Masterarbeit, 2017(VLID)238416

Formation of 1H-Aziridines from Chalcones and Hydroxylamine

Highly substituted chalcones 1 do not react with two molecules of hydroxylamine affording dioximes 2 or hydroxyamino-oximes 3 as expected according to von Auwers' procedure1): only one molecule of hydroxylamine is consumed leading to trans-configurated 2-benzoyl-3-phenyl-1H-aziridines 4. Aus den hochsubstituierten Chalkonen 1 entstehen nicht die nach von Auwers1) zu erwartenden Dioxime 2 oder Hydroxyamino-oxime 3 unter Verbrauch von zwei Mol Hydroxylamin. Stattdessen wird nur ein Mol Hydroxylamin verbraucht, und es entstehen trans-konfigurierte 2-Benzoyl- 3-phenyl-1H-aziridine 4