Teaching climate change in the context of the climate system. A mixed method study on the development of systems thinking skills in German 7th grade students regarding the climate

Research has shown a fragmented understanding of climate change among students that hardly accounts for the dynamic interrelations in the climate system and may pose a barrier in understanding adaptation and mitigation strategies (Shepardson et al., 2017, 2011, Calmbach 2016). While much is known the impact of short-term interventions on the general system understanding of students, what is lacking to date is 1) a specific intervention on climate system understanding and 2) insights into the process of developing system understanding in students. Helpful insights in this context come from Conceptual Development theories for they allow the development of systemic thinking to be viewed in terms of conceptual expansion or conceptual change. Starting from these desiderates, a teaching-learning sequence was developed based on the SYSDENE model of system competence (Frischknecht et al. 2008). In the sequence young learners systematically link experiences from formal science education with the experiences at three non-formal learning environments. A mixed-methods approach was used to explore the impact of this 3-month sequence on 19 7th grade students. A written pre-/post-test suggested a significant improvement in Climate System Reconstruction for the group (pre-test Median = 6.75 vs. post-test Median = 12.5, Wilcoxon Test: p = .003, r = .82). However, a qualitative analysis of classroom conversations, interviews and concept maps indicated that cognitive development toward a higher level of system thinking was neither continuous nor did every student reach it. Moreover, the SYSDENE model’s Competence Area “Describe System Model” proves critical. Being able to describe the main climate system factors is not sufficient, one also needs to be able to distinct weather from climate and grasp several scientific concepts related to the climate (e.g. greenhouse effect, water cycle, evaporation, reflection) in order to understand climate as a system. (DIPF/Orig.)Der Beitrag ist Teil einer größeren Studie zur Entwicklung von Systemdenken in Bezug auf das Klima bei Gesamtschüler:innen der Jahrgangsstufe 7. Wie die Forschung zeigt, weisen Schüler:innen ein fragmentiertes Verständnis des Klimawandels auf, das dynamische Zusammenhänge im Klimasystem kaum berücksichtigt und insofern ein Hindernis für das Verständnis von Anpassungs- und Minderungsstrategien darstellt (Shepardson et al., 2017, 2011, Calmbach 2016). Davon ausgehend wurde eine auf dem SYSDENE-Modell der Systemkompetenz basierende Lehr-Lern-Sequenz zum Klimasystem entwickelt (Frischknecht et al. 2008). In der Sequenz verknüpfen junge Lernende systematisch Erfahrungen aus dem formalen naturwissenschaftlichen Unterricht mit den Erfahrungen in drei non-formalen Lernumgebungen. Mit einem Mixed-Method-Ansatz wurden die Auswirkungen dieser dreimonatigen Sequenz auf 19 Schülerinnen und Schüler der siebten Klasse untersucht. Ein schriftlicher Prä-/Posttest deutete auf eine signifikante Verbesserung in der Rekonstruktion von Klima als komplexes System hin (Median Prä = 6,75, Median Post = 12,5, Wilcoxon-Test: p = .003, r = .82). Eine qualitative Analyse der Klassengespräche, Interviews und Concept Maps zeigte jedoch, dass die kognitive Entwicklung hin zu einer höheren Ebene des Systemischen Denkens weder kontinuierlich verlief, noch von allen Schülern realisiert werden konnte. Darüber hinaus erweist sich der grundlegende Kompetenzbereich "Modell Beschreiben" des SYSDENE-Modells als kritisch. Es genügt hierbei nicht, die wichtigsten Faktoren des Klimasystems beschreiben zu können, Lernende müssen auch in der Lage sein, Wetter und Klima voneinander zu unterscheiden und verschiedene wissenschaftliche Konzepte im Zusammenhang mit dem Klima (z. B. Treibhauseffekt, Wasserkreislauf, Verdunstung, Reflexion) zu verstehen und anzuwenden. (Autorin

Motivationen für das Böse. Warum sich Hunderttausende von Deutschen an der Durchführung des Holocaust beteiligt haben

Kühl S. Motivationen für das Böse. Warum sich Hunderttausende von Deutschen an der Durchführung des Holocaust beteiligt haben. In: Gorr C, Bauer MC, eds. Was treibt uns an? Motivation und Frustration aus Sicht der Hirnforschung. Berlin: Springer; 2018: 195-206

Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice

Myoglobin (MB) is expressed in different cancer types and may act as a tumor suppressor in breast cancer. The mechanisms by which basal MB expression level impacts murine mammary tumorigenesis are unclear. We investigated how MB expression in breast cancer influences proliferation, metastasis, tumor hypoxia, and chemotherapy treatment in vivo. We crossed PyMT and WapCreTrp53$^{flox}$ mammary cancer mouse models that differed in tumor grade/type and onset of mammary carcinoma with MB knockout mice. The loss of MB in WapCre;Trp53$^{flox}$ mice did not affect tumor development and progression. On the other hand, loss of MB decreased tumor growth and increased tissue hypoxia as well as the number of lung metastases in PyMT mice. Furthermore, Doxorubicin therapy prevented the stronger metastatic propensity of MB-deficient tumors in PyMT mice. This suggests that, although MB expression predicts improved prognosis in breast cancer patients, MB-deficient tumors may still respond well to first-line therapies. We propose that determining the expression level of MB in malignant breast cancer biopsies will improve tumor stratification, outcome prediction, and personalized therapy in cancer patients

Death at no cost? Persons with no health insurance claims in the last year of life in Switzerland.

BACKGROUND Lack of health insurance claims (HIC) in the last year of life might indicate suboptimal end-of-life care, but reasons for no HIC are not fully understood because information on causes of death is often missing. We investigated association of no HIC with characteristics of individuals and their place of residence. METHODS We analysed HIC of persons who died between 2008 and 2010, which were obtained from six providers of mandatory Swiss health insurance. We probabilistically linked these persons to death certificates to get cause of death information and analysed data using sex-stratified, multivariable logistic regression. Supplementary analyses looked at selected subgroups of persons according to the primary cause of death. RESULTS The study population included 113,277 persons (46% males). Among these persons, 1199 (proportion 0.022, 95% CI: 0.021-0.024) males and 803 (0.013, 95% CI: 0.012-0.014) females had no HIC during the last year of life. We found sociodemographic and health differentials in the lack of HIC at the last year of life among these 2002 persons. The likelihood of having no HIC decreased steeply with older age. Those who died of cancer were more likely to have HIC (adjusted odds ratio for males 0.17, 95% CI: 0.13-0.22; females 0.19, 95% CI: 0.12-0.28) whereas those dying of mental and behavioural disorders (AOR males 1.83, 95% CI:1.42-2.37; females 1.65, 95% CI: 1.27-2.14), and males dying of suicide (AOR 2.15, 95% CI: 1.72-2.69) and accidents (AOR 2.41, 95% CI: 1.96-2.97) were more likely to have none. Single, widowed, and divorced persons also were more likely to have no HIC (AORs in range of 1.29-1.80). There was little or no association between the lack of HIC and characteristics of region of residence. Patterns of no HIC differed across main causes of death. Associations with age and civil status differed in particular for persons who died of cancer, suicide, accidents and assaults, and mental and behavioural disorders. CONCLUSIONS Particular groups might be more likely to not seek care or not report health insurance costs to insurers. Researchers should be aware of this aspect of health insurance data and account for persons who lack HIC

FUERA DEL CANON

El artículo comienza con una definición del canon y con una consideración sobre cómo se establece. Luego, habla de algunos escritores canónicos de Centro América, como Sergio Ramírez o Gioconda Belli. Después, se refieren a escritores “fuera del canon”: la poesía feminista, la generación “x”, el grupo de Marco Antonio Flores, la literatura escrita por mujeres, la escrita por indígenas, la literatura póstuma. Al final, trata de establecer características generales, estilo, temas y motivos

Lancet

BACKGROUND: In 2015, the second cycle of the CONCORD programme established global surveillance of cancer survival as a metric of the effectiveness of health systems and to inform global policy on cancer control. CONCORD-3 updates the worldwide surveillance of cancer survival to 2014. METHODS: CONCORD-3 includes individual records for 37.5 million patients diagnosed with cancer during the 15-year period 2000-14. Data were provided by 322 population-based cancer registries in 71 countries and territories, 47 of which provided data with 100% population coverage. The study includes 18 cancers or groups of cancers: oesophagus, stomach, colon, rectum, liver, pancreas, lung, breast (women), cervix, ovary, prostate, and melanoma of the skin in adults, and brain tumours, leukaemias, and lymphomas in both adults and children. Standardised quality control procedures were applied; errors were rectified by the registry concerned. We estimated 5-year net survival. Estimates were age-standardised with the International Cancer Survival Standard weights. FINDINGS: For most cancers, 5-year net survival remains among the highest in the world in the USA and Canada, in Australia and New Zealand, and in Finland, Iceland, Norway, and Sweden. For many cancers, Denmark is closing the survival gap with the other Nordic countries. Survival trends are generally increasing, even for some of the more lethal cancers: in some countries, survival has increased by up to 5% for cancers of the liver, pancreas, and lung. For women diagnosed during 2010-14, 5-year survival for breast cancer is now 89.5% in Australia and 90.2% in the USA, but international differences remain very wide, with levels as low as 66.1% in India. For gastrointestinal cancers, the highest levels of 5-year survival are seen in southeast Asia: in South Korea for cancers of the stomach (68.9%), colon (71.8%), and rectum (71.1%); in Japan for oesophageal cancer (36.0%); and in Taiwan for liver cancer (27.9%). By contrast, in the same world region, survival is generally lower than elsewhere for melanoma of the skin (59.9% in South Korea, 52.1% in Taiwan, and 49.6% in China), and for both lymphoid malignancies (52.5%, 50.5%, and 38.3%) and myeloid malignancies (45.9%, 33.4%, and 24.8%). For children diagnosed during 2010-14, 5-year survival for acute lymphoblastic leukaemia ranged from 49.8% in Ecuador to 95.2% in Finland. 5-year survival from brain tumours in children is higher than for adults but the global range is very wide (from 28.9% in Brazil to nearly 80% in Sweden and Denmark). INTERPRETATION: The CONCORD programme enables timely comparisons of the overall effectiveness of health systems in providing care for 18 cancers that collectively represent 75% of all cancers diagnosed worldwide every year. It contributes to the evidence base for global policy on cancer control. Since 2017, the Organisation for Economic Co-operation and Development has used findings from the CONCORD programme as the official benchmark of cancer survival, among their indicators of the quality of health care in 48 countries worldwide. Governments must recognise population-based cancer registries as key policy tools that can be used to evaluate both the impact of cancer prevention strategies and the effectiveness of health systems for all patients diagnosed with cancer. FUNDING: American Cancer Society; Centers for Disease Control and Prevention; Swiss Re; Swiss Cancer Research foundation; Swiss Cancer League; Institut National du Cancer; La Ligue Contre le Cancer; Rossy Family Foundation; US National Cancer Institute; and the Susan G Komen Foundation

Interaction of HIF and USF signaling pathways at human genes flanked by hypoxia-response elements and E-box palindromes

Rampant activity of the hypoxia-inducible factor (HIF)-1 in cancer is frequently associated with the malignant progression into a harder-to-treat, increasingly aggressive phenotype. Clearly, anti-HIF strategies in cancer cells are of considerable clinical interest. One way to fine-tune, or inhibit, HIF's transcriptional outflow independently of hydroxylase activities could be through competing transcription factors. A CACGTG-binding activity in human hepatoma cells was previously found to restrict HIF's access to hypoxia response cis-elements (HRE) in a Daphnia globin gene promoter construct (phb2). The CACGTG factor, and its impact on hypoxia-responsive human genes, was analyzed in this study by genome-wide computational scans as well as gene-specific quantitative PCR, reporter and DNA-binding assays in hepatoma (Hep3B), cervical carcinoma (HeLa), and breast carcinoma (MCF7) cells. Among six basic helix-loop-helix transcription factors known to target CACGTG palindromes, we identified upstream stimulatory factor (USF)-1/2 as predominant phb2 CACGTG constituents in Hep3B, HeLa, and MCF7 cells. Human genes with adjacent or overlapping HRE and CACGTG motifs included with lactate dehydrogenase A (LDHA) and Bcl-2/E1B 19 kDa interacting protein 3 (BNIP3) hypoxia-induced HIF-1 targets. Parallel recruitment of HIF-1α and USF1/2a to the respective promoter chromatin was verified for all cell lines investigated. Mutual complementing (LDHA) or moderating (BNIP3) cross-talk was seen upon overexpression or silencing of HIF-1α and USF1/2a. Distinct (LDHA) or overlapping (BNIP3) promoter-binding sites for HIF-1 and USFs were subsequently characterized. We propose that, depending on abundance or activity of its protein constituents, O(2)-independent USF signaling can function to fine-tune or interfere with HIF-mediated transcription in cancer cells. Mol Cancer Res; 1-17. ©2011 AACR

Reaction mixtures formed by nitrite and selected sulfa-drugs showed mutagenicity in acidic medium

Nitrite, which is present in preserved meat and can be produced in the oral cavity by reduction of nitrate taken from vegetables, could react in stomach with nitrosatable drugs, giving genotoxic-carcinogenic N-nitroso compounds (NOC). The mutagenicity of reaction mixtures formed by sodium nitrite and selected sulfa-drugs (sulfathiazole, HST; phtalylsulfathiazole, PhST; complex Co(II)-sulfathiazole, Co(II)-ST) in acidic medium was evaluated using the Salmonella typhimurium reverse mutation assay (Ames test), with TA98 and TA 100 strains. The reactions were carried out at room temperature, with a mole ratio [nitrite]/[sulfa-drug] > 1. The three reaction mixtures showed mutagenic effects in the considered range