A Proposal To Support Wellbeing in People With Borderline Personality Disorder: Applying Reminiscent Theory in a Mobile App

In this paper the research draws upon reminiscence therapy, which is used in treating dementia, as an applied theory to promote well being in people who experience low moods. The application proposed here aims to promote wellbeing for people suffering from mood disorders and dementia but could potentially be used to enhance wellbeing for many types of users. Use of the application is anticipated to improve mood in a group of users where severe emotional problems are prevalent. The research aims to evaluate the effectiveness of a reminiscence based application in promoting well being in people specifically with Borderline Personality Disorder (BPD). The long term objective of this research is to establish the effectiveness of reminiscence theory on user groups aside from dementia, particularly other mental illnesses. The research advocates involving end users within the design process both to inform and evaluate the development of a mobile and tablet application.Comment: Conference pape

Transportation and National Development

Given the importance of transportation in the commercial life, industry and the overall economic development of a nation, this paper attempts to evaluate the impact of developments in transportation on Nigeria’s national development. It addresses five key areas in its discussion of transportation and national development. First, it tries to conceptualize transportation and national development. Second, it tries to provide a historical brief of the role of transportation in the evolution of the Nigerian nation. Third, it discusses the developments in the different modes of transportation from the colonial period to date. Fourth, it tries to examine the impact of transportation on Nigeria’s national development from three perspectives viz: economic, social and political. It observes that apart from lumping transportation and communication together in the budgetary allocation of resources, what is allocated to the sector is inadequate, given the crucial role of transportation in the modern economy. Finally, it suggests the separation of transportation from communication in the budgetary allocation of resources, increase in the allocation to the former, prompt release of the actual budgeted funds, and proper utilization of the approved and released funds to implement the designed transportation facilities if it is to contribute its quota to over attainment of national development

Wettability versus roughness of engineering surfaces

Wetting of real engineering surfaces occurs in many industrial applications (liquid coating, lubrication, printing, painting, ...). Forced and natural wetting can be beneficial in many cases, providing lubrication and therefore reducing friction and wear. However the wettability of surfaces can be strongly affected by surface roughness. This influence can be very significant for static and dynamic wetting [1]. In this paper authors experimentally investigate the roughness influence on contact angle measurements and propose a simple model combining Wenzel and Cassie-Baxter theories with simple 2D roughness profile analysis. The modelling approach is applied to real homogeneous anisotropic surfaces, manufactured on a wide range of engineering materials including aluminium alloy, iron alloy, copper, ceramic, plastic (poly-methylmethacrylate: PMMA) and titanium alloy

Bayesian hierarchical random effects models in forensic science

Statistical modeling of the evaluation of evidence with the use of the likelihood ratio has a long history. It dates from the Dreyfus case at the end of the nineteenth century through the work at Bletchley Park in the Second World War to the present day. The development received a significant boost in 1977 with a seminal work by Dennis Lindley which introduced a Bayesian hierarchical random effects model for the evaluation of evidence with an example of refractive index measurements on fragments of glass. Many models have been developed since then. The methods have now been sufficiently well-developed and have become so widespread that it is timely to try and provide a software package to assist in their implementation. With that in mind, a project (SAILR: Software for the Analysis and Implementation of Likelihood Ratios) was funded by the European Network of Forensic Science Institutes through their Monopoly programme to develop a software package for use by forensic scientists world-wide that would assist in the statistical analysis and implementation of the approach based on likelihood ratios. It is the purpose of this document to provide a short review of a small part of this history. The review also provides a background, or landscape, for the development of some of the models within the SAILR package and references to SAILR as made as appropriate

Minimal Stable Sets in Tournaments

We propose a systematic methodology for defining tournament solutions as extensions of maximality. The central concepts of this methodology are maximal qualified subsets and minimal stable sets. We thus obtain an infinite hierarchy of tournament solutions, which encompasses the top cycle, the uncovered set, the Banks set, the minimal covering set, the tournament equilibrium set, the Copeland set, and the bipartisan set. Moreover, the hierarchy includes a new tournament solution, the minimal extending set, which is conjectured to refine both the minimal covering set and the Banks set.Comment: 29 pages, 4 figures, changed conten

Revisiting the contribution of transpiration to global terrestrial evapotranspiration

Even though knowing the contributions of transpiration (T), soil and open water evaporation (E), and interception (I) to terrestrial evapotranspiration (ET=T+E+I) is crucial for understanding the hydrological cycle and its connection to ecological processes, the fraction of T is unattainable by traditional measurement techniques over large scales. Previously reported global mean T/(E+T+I) from multiple independent sources, including satellite-based estimations, reanalysis, land surface models, and isotopic measurements, varies substantially from 24% to 90%. Here we develop a new ET partitioning algorithm, which combines global evapotranspiration estimates and relationships between leaf area index (LAI) and T/(E+T) for different vegetation types, to upscale a wide range of published site-scale measurements. We show that transpiration accounts for about 57.2% (with standard deviation6.8%) of global terrestrial ET. Our approach bridges the scale gap between site measurements and global model simulations,and can be simply implemented into current global climate models to improve biological CO2 flux simulations

Relaxin gene family in teleosts: phylogeny, syntenic mapping, selective constraint, and expression analysis

<p>Abstract</p> <p>Background</p> <p>In recent years, the relaxin family of signaling molecules has been shown to play diverse roles in mammalian physiology, but little is known about its diversity or physiology in teleosts, an infraclass of the bony fishes comprising ~ 50% of all extant vertebrates. In this paper, 32 relaxin family sequences were obtained by searching genomic and cDNA databases from eight teleost species; phylogenetic, molecular evolutionary, and syntenic data analyses were conducted to understand the relationship and differential patterns of evolution of relaxin family genes in teleosts compared with mammals. Additionally, real-time quantitative PCR was used to confirm and assess the tissues of expression of five relaxin family genes in <it>Danio rerio </it>and <it>in situ </it>hybridization used to assess the site-specific expression of the insulin 3-like gene in <it>D. rerio </it>testis.</p> <p>Results</p> <p>Up to six relaxin family genes were identified in each teleost species. Comparative syntenic mapping revealed that fish possess two paralogous copies of human <it>RLN3</it>, which we call <it>rln3a </it>and <it>rln3b</it>, an orthologue of human <it>RLN2</it>, <it>rln</it>, two paralogous copies of human <it>INSL5</it>, <it>insl5a and insl5b</it>, and an orthologue of human <it>INSL3</it>, <it>insl3</it>. Molecular evolutionary analyses indicated that: <it>rln3a, rln3b </it>and <it>rln </it>are under strong evolutionary constraint, that <it>insl3 </it>has been subject to moderate rates of sequence evolution with two amino acids in <it>insl3/INSL3 </it>showing evidence of positively selection, and that <it>insl5b </it>exhibits a higher rate of sequence evolution than its paralogue <it>insl5a </it>suggesting that it may have been neo-functionalized after the teleost whole genome duplication. Quantitative PCR analyses in <it>D. rerio </it>indicated that <it>rln3a </it>and r<it>ln3b </it>are expressed in brain, <it>insl3 </it>is highly expressed in gonads, and that there was low expression of both <it>insl5 </it>genes in adult zebrafish. Finally, <it>in situ </it>hybridization of <it>insl3 </it>in <it>D. rerio </it>testes showed highly specific hybridization to interstitial Leydig cells.</p> <p>Conclusions</p> <p>Contrary to previous studies, we find convincing evidence that teleosts contain orthologues of four relaxin family peptides. Overall our analyses suggest that in teleosts: 1) <it>rln3 </it>exhibits a similar evolution and expression pattern to mammalian <it>RLN3</it>, 2) <it>insl3 </it>has been subject to positive selection like its mammalian counterpart and shows similar tissue-specific expression in Leydig cells, 3) <it>insl5 </it>genes are highly represented and have a relatively high rate of sequence evolution in teleost genomes, but they exhibited only low levels of expression in adult zebrafish, 4) <it>rln </it>is evolving under very different selective constraints from mammalian <it>RLN</it>. The results presented here should facilitate the development of hypothesis-driven experimental work on the specific roles of relaxin family genes in teleosts.</p

The British Fight against Cancer: Publicity and Education, 1900–1948

This article explores the early history of cancer education in Britain, focusing on the period between 1900, when discussions about a public ‘crusade’ against cancer began in Britain, and the foundation of the National Health Service (NHS) in 1948. Arising from debates around the development of invasive operations for cervical cancer, the campaign had a cautious start because of important uncertainties about the efficacy of available therapies, worries about the undesirable effects of partial knowledge, and anxieties about creating demands that could not be fulfilled. Against this background, anti-cancer activists attempted to produce a discourse which would not undermine people's faith in medical science, and which would encourage people to consult their doctors without putting excessive pressure on health services funded by public money. A ‘regime’ of hope came to the fore that served to draw patients, philanthropists, practitioners and researchers together into a joint market agenda