The Emerging Role of the Sales Technologist

David J. Good, Ph.D., is professor of marketing, Grand Valley State University, Grand Rapids; MI 49504. Roberta J. Schultz, Ph.D., is associate professor of marketing, Western Michigan University, Grand Rapids, MI 49503

The Sales Entrepreneur: A New Generation of Challenges and Opportunities

Roberta J. Schultz, Ph.D., is associate professor of marketing, Western Michigan University, Grand Rapids, MI 49503. David J. Good, Ph.D., is professor of marketing, Grand Valley State University, Grand Rapids, MI 49504-6495

A Model Of Information Technology Impacts: An Invariance Analysis By Executive Position

The invariance, by executive position in the organization, of an information technology impacts model is examined.  The theoretical model links computer training, end-user previous computer experience, information (provided by the system) quality, ease of system use, customer knowledge in the firm’s industry, and the tasks performed using the system to individual and firm performance impacts through system use and satisfaction.  The empirical examination uses data from a national mail survey.  The respondents are business executives at four different organizational levels (i.e., owners, senior executives, marketing executives, and middle/operational executives).  The quantitative technique used is invariance analysis based on structural equation modeling.  The results indicate that the interrelationships among the theoretical constructs in the model are generally invariant across these different organizational positions.  The one difference identified is the path from information quality to system use.  Examining each executive group individually shows that this path is significant for marketing executives, but no other executive group.  Thus, the identified difference appears to be produced by the importance of information quality on marketing executives’ use of computer systems.  Managerial implications, conclusions, and suggestions for future research are discussed based upon these results

Automatic generation of alignments for 3D QSAR analyses

Many 3D QSAR methods require the alignment of the molecules in a dataset, which can require a fair amount of manual effort in deciding upon a rational basis for the superposition. This paper describes the use of FBSS, a pro-ram for field-based similarity searching in chemical databases, for generating such alignments automatically. The CoMFA and CoMSIA experiments with several literature datasets show that the QSAR models resulting from the FBSS alignments are broadly comparable in predictive performance with the models resulting from manual alignments

A Note on Monotonically Metacompact Spaces

We show that any metacompact Moore space is monotonically metacompact and use that result to characterize monotone metacompactness in certain generalized ordered (GO)spaces. We show, for example, that a generalized ordered space with a sigma-closed-discrete dense subset is metrizable if and only if it is monotonically (countably) metacompact, that a monotonically (countably) metacompact GO-space is hereditarily paracompact, and that a locally countably compact GO-space is metrizable if and only if it is monotonically (countably) metacompact. We give an example of a non-metrizable LOTS that is monotonically metacompact, thereby answering a question posed by S. G. Popvassilev. We also give consistent examples showing that if there is a Souslin line, then there is one Souslin line that is monotonically countable metacompact, and another Souslin line that is not monotonically countably metacompact

Loss of murine Paneth cell function alters the immature intestinal microbiome and mimics changes seen in neonatal necrotizing enterocolitis

Necrotizing enterocolitis (NEC) remains the leading cause of gastrointestinal morbidity and mortality in premature infants. Human and animal studies suggest a role for Paneth cells in NEC pathogenesis. Paneth cells play critical roles in host-microbial interactions and epithelial homeostasis. The ramifications of eliminating Paneth cell function on the immature host-microbial axis remains incomplete. Paneth cell function was depleted in the immature murine intestine using chemical and genetic models, which resulted in intestinal injury consistent with NEC. Paneth cell depletion was confirmed using histology, electron microscopy, flow cytometry, and real time RT-PCR. Cecal samples were analyzed at various time points to determine the effects of Paneth cell depletion with and without Klebsiella gavage on the microbiome. Deficient Paneth cell function induced significant compositional changes in the cecal microbiome with a significant increase in Enterobacteriacae species. Further, the bloom of Enterobacteriaceae species that occurs is phenotypically similar to what is seen in human NEC. This further strengthens our understanding of the importance of Paneth cells to intestinal homeostasis in the immature intestine

Hadron-nucleon Total Cross Section Fluctuations from Hadron-nucleus Total Cross Sections

The extent to which information about fluctuations in hadron-nucleon total cross sections in the frozen approximation can be extracted from very high energy hadron-nucleus total cross section measurements for a range of heavy nuclei is discussed. The corrections to the predictions of Glauber theory due to these fluctuations are calculated for several models for the distribution functions, and differences of the order of 50 mb are found for heavy nuclei. The generating function for the moments of the hadron-nucleon cross section distributions can be approximately determined from the derivatives of the hadron-nucleus total cross sections with respect to the nuclear geometric cross section. The argument of the generating function, however, it limited to the maximum value of a dimensionless thickness function obtained at zero impact parameter for the heaviest nuclear targets: about 1.8 for pions and 3.0 for nucleons.Comment: 14 pages, revtex 3.0, 4 figures available upon reques

Ursinus College Bulletin Vol. 10, No. 1, October 1893

A digitized copy of the October 1893 Ursinus College Bulletin.https://digitalcommons.ursinus.edu/ucbulletin/1088/thumbnail.jp