Valor alimenticio comparativo del pasto kikuyo (Pennisetum clandestinum, var. Whittet) en dos estaciones de crecimiento con ryegrass (Lolium multiflorum ) Y sudán (Sorgum sudanense) ofrecido a novillos Holstein

P. 135-139Cuatro novillos Holstein (167kg) con cánulas en rumen y duodeno proximal fueron distribuidos en un diseño Cuadro Latino 4×4 para estimar el valor alimenticio comparativo del pasto kikuyo (Pennisetum clandestinum var. Whittet) cosechado en verano e invierno con el de henos de gramínea de verano (pasto sudán; Sorgum sudanense) e invierno (ryegrass anual; Lolium multiflorum var. Oregon). Las dietas experimentales (88,4% MO, 35,5% FDN y 11,8% PC) fueron formuladas con 70% forraje y 30% suplemento. No hubo efecto de tratamientos (P>0,05) en digestión ruminal de la FDN, N, eficiencia microbial ruminal (g de NM/kg de MO fermentada), ni en eficiencia ruminal del N (N no amoniacal que entra a tracto bajo/N consumido). No hubo efecto (P>0,10) de la estación (cosecha en verano vs invierno) en la digestión ruminal y total de la MO, FDN y N en dietas con kikuyo. La digestión ruminal y total de MO, FDN y N fueron similares (P>0,10) para dietas compuestas por kikuyo y sudán. Sin embargo, la digestión ruminal y total de MO y N fue menor (19, 12 y 9%, respectivamente) para dietas con kikuyo a la observada con ryegrass (P0,05) en la relación acetato-propionato. Se concluye que kikuyo tiene un valor alimenticio similar a sudán y representa una alternativa en la alimentación animal como cultivo perenne con aceptable valor nutricional durante el verano.S

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Influence of substituting steam-flaked corn for dry rolled corn on feedlot cattle growth performance when cattle are allowed either or restricted access to the finishing diet

Objective The influence of substituting steam-flaked corn (SFC) for dry rolled corn (DRC) on feedlot cattle growth performance and dietary net energy when cattle are allowed either ad libitum or 2-h restricted access to the finishing diet was evaluated. Methods Treatment effects were tested using 96 crossbred steers (251±2 kg) during the initial 56 d of the finishing phase. Cattle were blocked by weight and randomly assigned within blocks to 16 pens (4 pens/treatment). Bunk space was sufficient (41 cm/head) to allow all steers access to the feed bunk at the same time. Treatments consisted of two finishing diets containing (dry matter basis) 77.1% corn grain processed by dry rolling (density = 0.50 kg/L) or steam flaking (density = 0.36 kg/L). Cattle were fed twice daily at 06:00 and 14:00 h, allowing for approximately 5% residual. In the case of restricted feeding, steers were allowed access to feeders for 1 h following each feeding, after which residual feed was withdrawn. Results There were no treatment interactions on dry matter intake (DMI), average daily gain (ADG), gain efficiency (G:F), or dietary net energy (NE). Restricting feed access time reduced (p <0.01) feed intake, and hence, ADG. Substitution of SFC for DRC increased (p<0.01) ADG, feed efficiency (G:F), and estimated dietary NE, without affecting DMI. Based on tabular net energy of maintenance (NEm) value (2.18 Mcal/kg) for DRC, the estimated NEm value for SFC using the replacement technique, averaged 2.44 Mcal/kg; an improvement of 10.7%. The ratio of observed-to-expected dietary NE was not affected by feed access time. Conclusion Substitution of SFC for DRC in finishing diets for feedlot cattle enhanced ADG, gain efficiency, and the NE value of the diet. Although restriction of feed access time depressed DMI and ADG, it did not affect the comparative benefit of steam flaking toward enhancement of ADG, G:F, and dietary NE

Influence of substituting steam-flaked corn for dry rolled corn on feedlot cattle growth performance when cattle are allowed either ad libitum or restricted access to the finishing diet.

ObjectiveThe influence of substituting steam-flaked corn (SFC) for dry rolled corn (DRC) on feedlot cattle growth performance and dietary net energy when cattle are allowed either ad libitum or 2-h restricted access to the finishing diet was evaluated.MethodsTreatment effects were tested using 96 crossbred steers (251±2 kg) during the initial 56 d of the finishing phase. Cattle were blocked by weight and randomly assigned within blocks to 16 pens (4 pens/treatment). Bunk space was sufficient (41 cm/head) to allow all steers access to the feed bunk at the same time. Treatments consisted of two finishing diets containing (dry matter basis) 77.1% corn grain processed by dry rolling (density = 0.50 kg/L) or steam flaking (density = 0.36 kg/L). Cattle were fed twice daily at 06:00 and 14:00 h, allowing for approximately 5% residual. In the case of restricted feeding, steers were allowed access to feeders for 1 h following each feeding, after which residual feed was withdrawn.ResultsThere were no treatment interactions on dry matter intake (DMI), average daily gain (ADG), gain efficiency (G:F), or dietary net energy (NE). Restricting feed access time reduced (p &lt;0.01) feed intake, and hence, ADG. Substitution of SFC for DRC increased (p&lt;0.01) ADG, feed efficiency (G:F), and estimated dietary NE, without affecting DMI. Based on tabular net energy of maintenance (NEm) value (2.18 Mcal/kg) for DRC, the estimated NEm value for SFC using the replacement technique, averaged 2.44 Mcal/kg; an improvement of 10.7%. The ratio of observed-to-expected dietary NE was not affected by feed access time.ConclusionSubstitution of SFC for DRC in finishing diets for feedlot cattle enhanced ADG, gain efficiency, and the NE value of the diet. Although restriction of feed access time depressed DMI and ADG, it did not affect the comparative benefit of steam flaking toward enhancement of ADG, G:F, and dietary NE