Evaluación de diversas características responsables de la calidad de los chorizos elaborados en México

227 p.El primer objetivo de este estudio fue determinar diversas propiedades físicas, químicas y microbiológicas de los diferentes tipos o calidades de chorizos mexicanos comercializados en el Estado de Hidalgo (chorizos de carnicerías, de mercados rurales, chorizos de marca de ámbito nacional obtenidos en centros comerciales y chorizos económicos obtenidos en centrales de abastos). Con la determinación de esas propiedades se pretende conocer las características responsables de la calidad del chorizo consumido en la región y establecer diferencias entre tipos de chorizos. El segundo objetivo planteado fue conocer la evolución de la composición química, microbiológica y de diversas características responsables de la calidad sensorial de los chorizos mexicanos frescos almacenados a refrigeración, envasados bien en atmósfera normal o en atmósfera modificada (20% de CO2 y 80% de N2) a diferentes grados de secado (diferentes valores de aw entre valores de 0,92 y 0,96

Blood culture-negative infective endocarditis: a worse outcome? Results from a large multicentre retrospective Spanish cohort study

[Background] To assess the impact of blood cultures negative infective endocarditis (BCNIE) on in-hospital mortality.[Methods] Prospective multicentre study with retrospective analysis of a Spanish cohort including adult patients with definite IE. Cardiac implantable devices infection were excluded. Comparisons between blood cultures positive and BCNIE groups were performed to analyse in-hospital mortality.[Results] 1001 cases were included of which 83 (8.3%) had BCNIE. Alternative microbiological diagnosis was achieved for 39 (47%) out 83 cases. The most frequent identifications were: Coxiella burnetii (11; 28.2%), Tropheryma whipplei (4; 10.3%), Streptococcus gallolyticus (4;10.3%) and Staphylococcus epidermidis (3; 7.7%). Surgery was performed more frequently in BCNIE group (57.8 vs. 36.9%, p < .001). All-cause in-hospital mortality rate was 26.7% without statistical difference between compared groups. BCNIE was not associated to worse mortality rate in Cox regression model (aHR = 1.37, 95% CI 0.90–2.07, p = .14). Absence of microbiological diagnosis was also not associated to worse in-hospital prognosis (aHR = 1.62, 95% CI 0.99–2.64, p = .06).[Conclusions] In our cohort, BCNIE was not associated to greater in-hospital mortality based in multivariate Cox regression models. The variables most frequently associated with mortality were indicated but not performed surgery (aHR = 2.48, 95% CI 1.73–3.56, p < .001), septic shock (aHR = 2.24, 95% CI 1.68–2.99, p < .001), age over 65 years (aHR = 1.88, 95% CI 1.40-2.52, p < .001) and complicated endocarditis (aHR = 1.79, 95% CI 1.36–2.37, p < .001).Peer reviewe

An Empirical Calibration of Star Formation Rate Estimators

(Abridged) The observational determination of the behaviour of the star formation rate (SFR) with look-back time or redshift has two main weaknesses: 1- the large uncertainty of the dust/extinction corrections, and 2- that systematic errors may be introduced by the fact that the SFR is estimated using different methods at different redshifts. To assess the possible systematic differences among the different SFR estimators and the role of dust, we have compared SFR estimates using H$\alpha$, SFR(H$\alpha$), [OII]$\lambda$3727\AA, SFR(OII), UV, SFR(UV) and FIR, SFR(FIR) luminosities of a sample comprising the 31 nearby star forming galaxies having high quality photometric data in the UV, optical and FIR. We review the different "standard" methods for the estimation of the SFR and find that while the standard method provides good agreement between SFR(H$\alpha$) and SFR(FIR), both SFR(OII) and SFR(UV) are systematically higher than SFR(FIR), irrespective of the extinction law. We show that the excess in the SFR(OII) and SFR(UV) is mainly due to an overestimate of the extinction resulting from the effect of underlying stellar Balmer absorptions in the measured emission line fluxes. Taking this effect into consideration in the determination of the extinction brings the SFR(OII) and SFR(UV) in line with the SFR(FIR) and simultaneously reduces the internal scatter of the SFR estimations. Based on these results we have derived "unbiased" SFR expressions for the SFR(UV), SFR(OII) and SFR(H$\alpha$). We have used these estimators to recompute the SFR history of the Universe using the results of published surveys.Comment: Accepted for publication in MNRA

Narrowband CCD Photometry of Giant HII Regions

We have obtained accurate CCD narrow band H_beta and H_alpha photometry of Giant HII Regions in M 33, NGC 6822 and M 101. Comparison with previous determinations of emission line fluxes show large discrepancies; their probable origins are discussed. Combining our new photometric data with global velocity dispersion (sigma) derived from emission line widths we have reviewed the L(H_beta)-sigma relation. A reanalysis of the properties of the GEHRs included in our sample shows that age spread and the superposition of components in multiple regions introduce a considerable spread in the regression. Combining the information available in the literature regarding ages of the associated clusters, evolutionary footprints on the interstellar medium, and kinematical properties of the knots that build up the multiple GEHRs, we have found that a subsample - which we refer to as young and single GEHRs - do follow a tight relation in the L-sigma plane.Comment: Accepted for publication in MNRAS, large figures available on a separate tarfil

Abundance determination of multiple star-forming regions in the HII galaxy SDSS J165712.75+321141.4

We analyze high signal-to-noise spectrophotometric observations acquired simultaneously with TWIN, a double-arm spectrograph, from 3400 to 10400 \AA of three star-forming regions in the HII galaxy SDSS J165712.75+321141.4. We have measured four line temperatures: Te([OIII]), Te([SIII]), Te([OII]), and Te([SII]), with high precision, rms errors of order 2%, 5%, 6% and 6%, respectively, for the brightest region, and slightly worse for the other two. The temperature measurements allowed the direct derivation of ionic abundances of oxygen, sulphur, nitrogen, neon and argon. We have computed CLOUDY tailor-made models which reproduce the O2+ measured thermal and ionic structures within the errors in the three knots, with deviations of only 0.1 dex in the case of O+ and S2+ ionic abundances. In the case of the electron temperature and the ionic abundances of S+/H+, we find major discrepancies which could be consequence of the presence of colder diffuse gas. The star formation history derived using STARLIGHT shows a similar age distribution of the ionizing population among the three star-forming regions. This fact suggests a similar evolutionary history which is probably related to a process of interaction with a companion galaxy that triggered the star formation in the different regions almost at the same time. The hardness of the radiation field mapped through the use of the softness parameter $\eta$ is the same within the observational errors for all three regions, implying that the equivalent effective temperature of the radiation fields are very similar for all the studied regions of the galaxy, in spite of some small differences in the ionization state of different elements.Comment: 18 pages, 10 figures, accepted by MNRA

The OpenMolcas Web: A Community-Driven Approach to Advancing Computational Chemistry

The developments of the open-source OpenMolcas chemistry software environment since spring 2020 are described, with a focus on novel functionalities accessible in the stable branch of the package or via interfaces with other packages. These developments span a wide range of topics in computational chemistry and are presented in thematic sections: electronic structure theory, electronic spectroscopy simulations, analytic gradients and molecular structure optimizations, ab initio molecular dynamics, and other new features. This report offers an overview of the chemical phenomena and processes OpenMolcas can address, while showing that OpenMolcas is an attractive platform for state-of-the-art atomistic computer simulations

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Gestión del conocimiento: perspectiva multidisciplinaria. Volumen 13

El libro “Gestión del Conocimiento. Perspectiva Multidisciplinaria”, Volumen 13 de la Colección Unión Global, es resultado de investigaciones. Los capítulos del libro, son resultados de investigaciones desarrolladas por sus autores. El libro es una publicación internacional, seriada, continua, arbitrada, de acceso abierto a todas las áreas del conocimiento, orientada a contribuir con procesos de gestión del conocimiento científico, tecnológico y humanístico. Con esta colección, se aspira contribuir con el cultivo, la comprensión, la recopilación y la apropiación social del conocimiento en cuanto a patrimonio intangible de la humanidad, con el propósito de hacer aportes con la transformación de las relaciones socioculturales que sustentan la construcción social de los saberes y su reconocimiento como bien público. El libro “Gestión del Conocimiento. Perspectiva Multidisciplinaria”, Volumen 13, de la Colección Unión Global, es resultado de investigaciones. Los capítulos del libro, son resultados de investigaciones desarrolladas por sus autores. El libro cuenta con el apoyo de los grupos de investigación: Universidad Sur del Lago “Jesús María Semprúm” (UNESUR) - Zulia – Venezuela; Universidad Politécnica Territorial de Falcón Alonso Gamero (UPTFAG) - Falcón – Venezuela; Universidad Politécnica Territorial de Mérida Kléber Ramírez (UPTM) - Mérida - Venezuela; Universidad Guanajuato (UG) - Campus Celaya - Salvatierra - Cuerpo Académico de Biodesarrollo y Bioeconomía en las Organizaciones y Políticas Públicas (CABBOPP) - Guanajuato – México; Centro de Altos Estudios de Venezuela (CEALEVE) - Zulia – Venezuela, Centro Integral de Formación Educativa Especializada del Sur (CIFE - SUR) - Zulia – Venezuela; Centro de Investigaciones Internacionales SAS (CEDINTER) - Antioquia – Colombia y diferentes grupos de investigación del ámbito nacional e internacional que hoy se unen para estrechar vínculos investigativos, para que sus aportes científicos formen parte de los libros que se publiquen en formatos digital e impreso