La importancia de las redes sociales como instrumento de promoción turística. El caso de la ciudad de Segovia

El rápido desarrollo de las nuevas tecnologías de la información y comunicación (TIC) ha revolucionado la tradicional manera de hacer negocios. Empresas del sector turístico utilizan páginas web o redes sociales para mejorar la comunicación online con su público, adaptando sus productos y servicios a las necesidades que demandan sus usuarios. A través de una revisión documental y un análisis aplicado a la ciudad de Segovia, el presente trabajo pone de manifiesto la importancia de incorporar redes sociales como Instagram dentro de la estrategia de marketing de los destinos y su poder como herramienta de promoción y difusión turística.Grado en Turism

Las marcas ante la emergencia climática: el caso de National Geographic

La proliferación del plástico en nuestra sociedad es una amenaza real para los ecosistemas marinos del mundo. Ante ello, las marcas comerciales se enfrentan a este tipo de emergencias climáticas a través de su publicidad, con el fin de concienciar y movilizar al público a reducir el consumo de plásticos de un solo uso. El presente estudio busca conocer qué actuaciones desarrollan este tipo de entidades y de qué manera influyen en la mentalidad del público, en comparación con las acciones comunicacionales realizadas por organismos sin ánimo de lucro dedicados a la causa. Para ello, el principal objeto de estudio será “¿Planeta o Plástico?”, la última campaña lanzada por la corporación mediática National Geographic, considerada una de las mejores iniciativas globales contra el plástico dirigida por una empresa.Grado en Publicidad y Relaciones Pública

Valorisation of Camellia sinensis branches as a raw product with green technology extraction methods

This work deals with the study of tea stalks from pruning debris using environmental friendly extraction technology to offer new healthy properties. In the manufacturing tea industry, tea trees require to be pruned every year and most of their remains are discarded as a waste with no economic value. Microwave aqueous extraction and pressurized hot water extraction process (autohydrolysis) were used to recover bioactive compounds from the tea branches. Operating at a fixed solid: liquid ratio (1:15), the effect of the maximum heating temperatures from 140 to 220 °C was studied. Liquid extracts were analysed for total phenolic, oligosaccharides, protein, mineral and heavy metals content, as well as for antioxidant capacity. The antitumoral possibilities were also determined for selected samples. The obtained results indicated that both processes could be used as an alternative to recover bioactive compounds from tea wastes, although microwave-assisted extraction allowed saving time when compared with autohydrolysis processing. The temperature exhibited a relevant effect on the total phenolic content and antioxidant capacity, decreasing with the microwave treatment and increasing with the autohydrolysis temperature. The obtained extracts could be adequate for incorporation in food and non-food fields.Ministerio de Economía y Competitividad | Ref. IJCI-2016-27535Ministerio de Ciencia, Innovación y Universidades | Ref. RYC2018- 024454-

Differences in Body Composition between Playing Positions in Men’s Professional Soccer: A Systematic Review with Meta-Analysis

The performance of male soccer players (MSPs) depends on multiple factors, such as body composition. It is understandable to think that, due to the physical demands and specific functions during play, body composition may vary depending on the playing position. The aim of this systematic review and meta-analysis was to describe the anthropometric, BC, and somatotype characteristics of professional MSPs and to compare the reported values according to playing position. We systematically searched Embase, PubMed, SPORTDiscus, and Web of Science following the PRISMA statement. Random-effects meta-analysis, a pooled summary of means, and 95% CI (method or equation) were calculated. Random models were used with the Restricted Maximum Likelihood (REML) method. Twenty-six articles were included in the systematic review and the meta-analysis. After comparing the groups according to the playing position (goalkeeper, defender, midfielder, and forward), significant differences were found in age, height, weight, the sum of skinfolds, kilograms of muscle mass, and kilograms of fat-free mass (p = 0.001; p < 0.0001). No significant differences were observed in fat mass, percentage of fat-free mass, percentage of muscle mass, bone mass, and somatotype. Despite the limitations, this study provides useful information to help medical–technical staff to properly assess the BC of professional MSPs, providing reference values for the different positions

Resilience, Stress, and Cortisol Predict Cognitive Performance in Older Adults

Objective: to determine the relationship between stress, resilience, and cognitive perfor- mance in older people without dementia. Method: multiple linear regressions were performed using measures of cognitive performance as dependent variables, and measures of stress and resilience as predictors in a sample of 63 Spanish elderly people. Results: participants reported low levels of stress during their lifetime. In addition to socio-demographic variables, greater stress was related to better delayed recall and worse letter–number sequencing and block design. Higher capillary cortisol was associated with lower flexibility on the Stroop task. Regarding protective factors, we found that greater psychological resilience was related to higher scores on the Addenbrooke’s Cognitive Examination-III, letter–number sequencing, and verbal fluency. Conclusion: in older people with low stress, apart from age, gender, and education, psychological resilience is a significant predictor of global cognitive status, working memory, and fluency. Likewise, stress is related to verbal memory functioning, working memory, and visuoconstructive abilities. Capillary cortisol level predicts cogni- tive flexibility. These findings may help to identify risk and protective factors for cognitive decline in older people. Training-based programs to reduce stress and increase psychological resilience may play an important role in preventing cognitive decline

Hair cortisol concentrations in a Spanish sample of healthy adults

Hair cortisol concentration (HCC), as a novel promising method to retrospectively measure hypothalamic-pituitary-adrenal (HPA) axis activation, is being increasingly studied. We tested the relationships between HCC and a range of possible confounding variables in a Spanish sample of healthy adults and pregnant women. In this sample of healthy Spaniards, results suggested an association between HCC and physical exercise and educational level. In pregnant women, the prevalence of HCC was higher than in non-pregnant woman, and was related to educational level. This study emphasises the need to determine the relationship between HCC and confounders such as sociodemographic and lifestyle variables in the general population and specific groups formed by individuals such as pregnant women.This research is part of a doctoral thesis. It has been economically supported by the "PSI2015-63494-P" I+D Project of the Spanish Ministry of Economy and Competitiveness (MINECO) and FEDE

FOXP2 expression and gray matter density in the male brains of patients with schizophrenia

Common genetic variants of FOXP2 may contribute to schizophrenia vulnerability, but controversial results have been reported for this proposal. Here we evaluated the potential impact of the common FOXP2 rs2396753 polymorphism in schizophrenia. It was previously reported to be part of a risk haplotype for this disease and to have significant effects on gray matter concentration in the patients. We undertook the first examination into whether rs2396753 affects the brain expression of FOXP2 and a replication study of earlier neuroimaging findings of the influence of this genetic variant on brain structure. FOXP2 expression levels were measured in postmortem prefrontal cortex samples of 84 male subjects (48 patients and 36 controls) from the CIBERSAM Brain and the Stanley Foundation Array Collections. High-resolution anatomical magnetic resonance imaging was performed on 79 male subjects (61 patients, 18 controls) using optimized voxel-based morphometry. We found differences in FOXP2 expression and brain morphometry depending on the rs2396753, relating low FOXP2 mRNA levels with reduction of gray matter density. We detected an interaction between rs2396753 and the clinical groups, showing that heterozygous patients for this polymorphism have gray matter density decrease and low FOXP2 expression comparing with the heterozygous controls.This study shows the importance of independent replication of neuroimaging genetic studies of FOXP2 as a candidate gene in schizophrenia. Furthermore, our results suggest that the FOXP2 rs2396753 affects mRNA levels, thus providing new knowledge about its significance as a potential susceptibility polymorphism in schizophrenia

Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity

Fundació la Marató de TV3 (GrantNumber(s): 20133431; Grant recipient(s): Ana Cuenda) Wellcome Trust (GrantNumber(s): 97377, 102705; Grant recipient(s): GORDON D. BROWN) Ministerio de Economía y Competitividad (GrantNumber(s): SAF2016-79792-R, SAF2014- 52009-R, SAF2013-45331-R; Grant recipient(s): Ana Cuenda, SUSANA ALEMANY) Medical Research Council (GrantNumber(s): MR/N006364/1; Grant recipient(s): GORDON D. BROWN) ERC Consolidator Grant (GrantNumber(s): 310372; Grant recipient(s): Mihai Netea)Peer reviewedPublisher PD

Mediación y sustracción internacional de menores: buenas prácticas

Grado en Derecho. Derecho Internacional Privado Grupo II, 2020-201[ES]La sustracción internacional de menores tiene su origen en el seno de los conflictos familiares que como siempre plantean numerosas complejidades para ser solucionados, y con más intensidad cuando esos conflictos ocurren entre parejas que en el momento de la ruptura tienen descendientes menores de edad. La globalización ha contribuido al incremento de parejas mixtas, en el que cada sujeto en ocasiones tiene un origen diferente, algo que complica la situación de sus hijos cuando se producen separaciones o divorcios matrimoniales. Principalmente por ese elemento sentimental, que no se aprecia en otros sectores del Derecho, es importante una especial fijación y sensibilidad por el legislador para que se vele siempre por el interés y el bienestar del menor que en algunas ocasiones es el que sale más perjudicado de las situaciones descritas

RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness

Rank signaling enhances stemness in mouse and human mammary epithelial cells (MECs) and mediates mammary tumor initiation. Mammary tumors initiated by oncogenes or carcinogen exposure display high levels of Rank and Rank pathway inhibitors have emerged as a new strategy for breast cancer prevention and treatment. Here, we show that ectopic Rank expression in the mammary epithelia unexpectedly delays tumor onset and reduces tumor incidence in the oncogene-driven Neu and PyMT models. Mechanistically, we have found that ectopic expression of Rank or exposure to Rankl induces senescence, even in the absence of other oncogenic mutations. Rank leads to DNA damage and senescence through p16/p19. Moreover, RANK-induced senescence is essential for Rank-driven stemness, and although initially translates into delayed tumor growth, eventually promotes tumor progression and metastasis. We uncover a dual role for Rank in the mammary epithelia: Rank induces senescence and stemness, delaying tumor initiation but increasing tumor aggressiveness