2,879 research outputs found
A four-season prospective study of muscle strain reoccurrences in a professional football club
The aim of this investigation was to characterise muscle strain reinjuries and examine their impact on playing resources in a professional football club. Muscle strains and reoccurrences were prospectively diagnosed over four seasons in first-team players (n = 46). Altogether, 188 muscle strains were diagnosed with 44 (23.4%) of these classed as reinjuries, leading to an incidence of 1.32 strain reoccurrences per 1,000 hours exposure (95% Confidence Interval [CI], 0.93â1.71). The incidence of recurrent strains was higher in match-play compared with training (4.51, 95% CI, 2.30â6.72 vs 0.94, 95% CI, 0.59â1.29). Altogether, 50.0% of players sustained at least 1 reoccurrence of a muscle strain, leading to approximately 3 days lost and 0.4 matches missed per player per season. The incidence of recurrent strains was highest in centre-forwards (2.15, 95% CI, 1.06â3.24), peaked in May (3.78, 95% CI, 0.47â7.09), and mostly affected the hamstrings (38.6% of all reoccurrences). Mean layoff for nonreoccurrences and recurrences was similar: âŒ7.5 days. These results provide greater insight into the extent of the problem of recurrent muscle strains in professional football
Dark halo baryons not in ancient halo white dwarfs
Having ruled out the possibility that stellar objects are the main
contributor of the dark matter embedding galaxies, microlensing experiments
cannot exclude the hypothesis that a significant fraction of the Milky Way dark
halo might be made of MACHOs with masses in the range 0.5-0.8 \msun. Ancient
white dwarfs are generally considered the most plausible candidates for such
MACHOs. We report the results of a search for such white dwarfs in a proper
motion survey covering a 0.16 sqd field at three epochs at high galactic
latitude, and 0.938 sqd at two epochs at intermediate galactic latitude (VIRMOS
survey), using the CFH telescope. Both surveys are complete to I = 23, with
detection efficiency fading to 0 at I = 24.2. Proper motion data are suitable
to separate unambiguously halo white dwarfs identified by belonging to a non
rotating system. No candidates were found within the colour-magnitude-proper
motion volume where such objects can be safely discriminated from any standard
population as well as from possible artefacts. In the same volume, we estimate
the maximum white dwarf halo fraction compatible with this observation at
different significance levels if the halo is at least 14 gigayears old and
under different ad hoc initial mass functions. Our data alone rules out a halo
fraction greater than 14% at 95% confidence level. Combined with two previous
investigations exploring comparable volumes pushes the limit below 4 % (95%
confidence level) or below 1.3% (64% confidence), this implies that if baryonic
dark matter is present in galaxy halos, it is not, or it is only marginally in
the form of faint hydrogen white dwarfs.Comment: accepted in Astronomy and Astrophysics (19-05-2004
Observations of whistler mode waves with nonlinear parallel electric fields near the dayside magnetic reconnection separatrix by the Magnetospheric Multiscale mission
We show observations from the Magnetospheric Multiscale (MMS) mission of whistler mode waves in the Earth's low-latitude boundary layer (LLBL) during a magnetic reconnection event. The waves propagated obliquely to the magnetic field toward the X line and were confined to the edge of a southward jet in the LLBL. Bipolar parallel electric fields interpreted as electrostatic solitary waves (ESW) are observed intermittently and appear to be in phase with the parallel component of the whistler oscillations. The polarity of the ESWs suggests that if they propagate with the waves, they are electron enhancements as opposed to electron holes. The reduced electron distribution shows a shoulder in the distribution for parallel velocities between 17,000 and 22,000âkm/s, which persisted during the interval when ESWs were observed, and is near the phase velocity of the whistlers. This shoulder can drive Langmuir waves, which were observed in the high-frequency parallel electric field data
Socioeconomic status and treatment outcomes for individuals with HIV on antiretroviral treatment in the UK: cross-sectional and longitudinal analyses
Background: Few studies have assessed the effect of socioeconomic status on HIV treatment outcomes in settings with universal access to health care. Here we aimed to investigate the association of socioeconomic factors with antiretroviral therapy (ART) non-adherence, virological non-suppression, and virological rebound, in HIV-positive people on ART in the UK.
Methods: We used data from the Antiretrovirals, Sexual Transmission Risk and Attitudes (ASTRA) questionnaire study, which recruited participants aged 18 years or older with HIV from eight HIV outpatient clinics in the UK between Feb 1, 2011, and Dec 31, 2012. Participants self-completed a confidential questionnaire on sociodemographic, health, and lifestyle issues. In participants on ART, we assessed associations of financial hardship, employment, housing, and education with: self-reported ART non-adherence at the time of the questionnaire; virological non-suppression (viral load >50 copies per mL) at the time of questionnaire in those who started ART at least 6 months ago (cross-sectional analysis); and subsequent virological rebound (viral load >200 copies per mL) in those with initial viral load of 50 copies per mL or lower (longitudinal analysis).
Findings: Of the 3258 people who completed the questionnaire, 2771 (85%) reported being on ART at the time of the questionnaire, and 2704 with complete data were included. 873 (32%) of 2704 participants reported non-adherence to ART and 219 (9%) of 2405 had virological non-suppression in cross-sectional analysis. Each of the four measures of lower socioeconomic status was strongly associated with non-adherence to ART, and with virological non-suppression (prevalence ratios [PR] adjusted for gender/sexual orientation, age, and ethnic origin: greatest financial hardship vs none 2·4, 95% CI 1·6â3·4; non-employment 2·0, 1·5â2·6; unstable housing vs homeowner 3·0, 1·9â4·6; non-university education 1·6, 1·2â2·2). 139 (8%) of 1740 individuals had subsequent virological rebound (rate=3·6/100 person-years). Low socioeconomic status was predictive of longitudinal rebound risk (adjusted hazard ratio [HR] for greatest financial hardship vs none 2·3, 95% CI 1·4â3·9; non-employment 3·0, 2·1â4·2; unstable housing vs homeowner 3·3, 1·8â6·1; non-university education 1·6, 1·1â2·3).
Interpretation: Socioeconomic disadvantage was strongly associated with poorer HIV treatment outcomes in this setting with universal health care. Adherence interventions and increased social support for those most at risk should be considered
Electron fractionalization induced dephasing in Luttinger liquids
Using the appropriate fractionalization mechanism, we correctly derive the
temperature (T) and interaction dependence of the electron lifetime in
Luttinger liquids. For strong enough interactions, we report that
, with being the standard Luttinger exponent; This
reinforces that electrons are {\it not} good quasiparticles. We immediately
emphasize that this is of importance for the detection of electronic
interferences in ballistic 1D rings and carbon nanotubes, inducing
``dephasing'' (strong reduction of Aharonov-Bohm oscillations).Comment: 5 pages, 1 figure (Final version for PRB Brief Report
Connection between charge-density-wave order and charge transport in the cuprate superconductors
Charge-density-wave (CDW) correlations within the quintessential CuO
planes have been argued to either cause [1] or compete with [2] the
superconductivity in the cuprates, and they might furthermore drive the
Fermi-surface reconstruction in high magnetic fields implied by quantum
oscillation (QO) experiments for YBaCuO (YBCO) [3] and
HgBaCuO (Hg1201) [4]. Consequently, the observation of bulk
CDW order in YBCO was a significant development [5,6,7]. Hg1201 features
particularly high structural symmetry and recently has been demonstrated to
exhibit Fermi-liquid charge transport in the relevant temperature-doping range
of the phase diagram, whereas for YBCO and other cuprates this underlying
property of the CuO planes is partially or fully masked [8-10]. It
therefore is imperative to establish if the pristine transport behavior of
Hg1201 is compatible with CDW order. Here we investigate Hg1201 ( = 72 K)
via bulk Cu L-edge resonant X-ray scattering. We indeed observe CDW
correlations in the absence of a magnetic field, although the correlations and
competition with superconductivity are weaker than in YBCO. Interestingly, at
the measured hole-doping level, both the short-range CDW and Fermi-liquid
transport appear below the same temperature of about 200 K. Our result points
to a unifying picture in which the CDW formation is preceded at the higher
pseudogap temperature by = 0 magnetic order [11,12] and the build-up of
significant dynamic antiferromagnetic correlations [13]. Furthermore, the
smaller CDW modulation wave vector observed for Hg1201 is consistent with the
larger electron pocket implied by both QO [4] and Hall-effect [14]
measurements, which suggests that CDW correlations are indeed responsible for
the low-temperature QO phenomenon
Base damage, local sequence context andTP53mutation hotspots: a molecular dynamics study of benzo[a]pyrene induced DNA distortion and mutability
The mutational pattern for the TP53 tumour suppressor gene in lung tumours differs to other cancer types by having a higher frequency of G:C>T:A transversions. The aetiology of this differing mutation pattern is still unknown. Benzo[a]pyrene,diol epoxide (BPDE) is a potent cigarette smoke carcinogen that forms guanine adducts at TP53 CpG mutation hotspot sites including codons 157, 158, 245, 248 and 273. We performed molecular modelling of BPDE-adducted TP53 duplex sequences to determine the degree of local distortion caused by adducts which could influence the ability of nucleotide excision repair. We show that BPDE adducted codon 157 has greater structural distortion than other TP53 G:C>T:A hotspot sites and that sequence context more distal to adjacent bases must influence local distortion. Using TP53 trinucleotide mutation signatures for lung cancer in smokers and non-smokers we further show that codons 157 and 273 have the highest mutation probability in smokers. Combining this information with adduct structural data we predict that G:C>T:A mutations at codon 157 in lung tumours of smokers are predominantly caused by BPDE. Our results provide insight into how different DNA sequence contexts show variability in DNA distortion at mutagen adduct sites that could compromise DNA repair at well characterized cancer related mutation hotspots
Relativistic and Radiative Energy Shifts for Rydberg States
We investigate relativistic and quantum electrodynamic effects for
highly-excited bound states in hydrogenlike systems (Rydberg states). In
particular, hydrogenic one-loop Bethe logarithms are calculated for all
circular states (l = n-1) in the range 20 <= n <= 60 and successfully compared
to an existing asymptotic expansion for large principal quantum number n. We
provide accurate expansions of the Bethe logarithm for large values of n, for
S, P and circular Rydberg states. These three expansions are expected to give
any Bethe logarithms for principal quantum number n > 20 to an accuracy of five
to seven decimal digits, within the specified manifolds of atomic states.
Within the numerical accuracy, the results constitute unified, general formulas
for quantum electrodynamic corrections whose validity is not restricted to a
single atomic state. The results are relevant for accurate predictions of
radiative shifts of Rydberg states and for the description of the recently
investigated laser-dressed Lamb shift, which is observable in a strong
coherent-wave light field.Comment: 8 pages; RevTeX
Distally based sural fasciomusculocutaneous flap for treatment of wounds of the distal third of the leg and ankle with exposed internal hardware
Soft tissue reconstruction of the distal third of the lower limb with exposure of the internal hardware is a challenging problem with several potential complications, such as exposure of the fracture line, fracture instability and bacterial contamination. The treatment of these lesions usually consists of substitution of the internal hardware with external fixation devices and further flap coverage. We propose a different reconstructive approach, characterized by harvesting a sural fasciomusculocutaneous flap on the exposed internal hardware once a sterile ground has been obtained. Four patients were retrospectively analyzed. Soft tissue reconstruction was achieved in all cases. In one case hardware removal was necessary for complete healing. The sural fasciomusculocutaneous flap is a safe alternative to other pedicled and free flaps. Moreover, it allows direct coverage of internal fixators, thus completing the reconstruction in less time. This flap fits best to the morphology of the wound and internal hardware, leaving the main vascular trunk of the leg intact and at the same time providing a reliable vascular supply
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