Social capital in distributed system development: A case of grid development in particle physics

No organisation, no matter how large, can remain totally reliant on the stocks of new knowledge it generates itself. In order to keep abreast of the latest scientific and technological developments, R&D organisations must continuously import knowledge from beyond the organisations boundaries. How does this external knowledge which is critical to success then become absorbed and integrated into the firm? Our paper addresses this question through the lens of the influential technological gatekeeper theory. Drawing on social network analysis (SNA) and interview evidence from a medical devices R&D group, we find that the gatekeeper role is still vital, but no longer needs to be performed by a single individual. Instead, the modern R&D group can keep abreast of the latest technological advances through a combination of Web-enabled internal and external communication specialists. A unique contribution this paper makes to the IT-enable social network literature is the development of an updated conceptual framework of how the gatekeeper role is performed in the modern R&D group

Who’s in Charge, Anyway – A Proposal for Community-Based Legal Services (with Raymond H. Brescia and Robin Golden)

For over one hundred years, some of our country\u27s most dedicatedlawyers have struggled to provide legal services to poor people.The road has not been an easy one. Richard Nixon vetoed alegal services bill over the issue of presidential appointments, thensigned the Legal Services Corporation Act just before resigning.Nixon\u27s Vice-President, Spiro Agnew, was a vocal opponent of federally-funded legal services. Ronald Reagan submitted eight consecutivebudgets seeking to eliminate all federal funding for theLegal Services Corporation ( LSC ). Simultaneously, he appointeda hostile LSC board of directors. Bill Clinton\u27s election,however, brought new hope to advocates. Hillary Clinton is a formerpresident of the LSC Board. The early Clinton budgets includedan increase in LSC funding, but they were countereddramatically by the severe cuts and restrictions imposed by the1994 Republican-controlled Congress

Multi-Regge kinematics and the moduli space of Riemann spheres with marked points

We show that scattering amplitudes in planar N = 4 Super Yang-Mills in multi-Regge kinematics can naturally be expressed in terms of single-valued iterated integrals on the moduli space of Riemann spheres with marked points. As a consequence, scattering amplitudes in this limit can be expressed as convolutions that can easily be computed using Stokes' theorem. We apply this framework to MHV amplitudes to leading-logarithmic accuracy (LLA), and we prove that at L loops all MHV amplitudes are determined by amplitudes with up to L + 4 external legs. We also investigate non-MHV amplitudes, and we show that they can be obtained by convoluting the MHV results with a certain helicity flip kernel. We classify all leading singularities that appear at LLA in the Regge limit for arbitrary helicity configurations and any number of external legs. Finally, we use our new framework to obtain explicit analytic results at LLA for all MHV amplitudes up to five loops and all non-MHV amplitudes with up to eight external legs and four loops.Comment: 104 pages, six awesome figures and ancillary files containing the results in Mathematica forma

A practical, bioinformatic workflow system for large data sets generated by next-generation sequencing

Transcriptomics (at the level of single cells, tissues and/or whole organisms) underpins many fields of biomedical science, from understanding the basic cellular function in model organisms, to the elucidation of the biological events that govern the development and progression of human diseases, and the exploration of the mechanisms of survival, drug-resistance and virulence of pathogens. Next-generation sequencing (NGS) technologies are contributing to a massive expansion of transcriptomics in all fields and are reducing the cost, time and performance barriers presented by conventional approaches. However, bioinformatic tools for the analysis of the sequence data sets produced by these technologies can be daunting to researchers with limited or no expertise in bioinformatics. Here, we constructed a semi-automated, bioinformatic workflow system, and critically evaluated it for the analysis and annotation of large-scale sequence data sets generated by NGS. We demonstrated its utility for the exploration of differences in the transcriptomes among various stages and both sexes of an economically important parasitic worm (Oesophagostomum dentatum) as well as the prediction and prioritization of essential molecules (including GTPases, protein kinases and phosphatases) as novel drug target candidates. This workflow system provides a practical tool for the assembly, annotation and analysis of NGS data sets, also to researchers with a limited bioinformatic expertise. The custom-written Perl, Python and Unix shell computer scripts used can be readily modified or adapted to suit many different applications. This system is now utilized routinely for the analysis of data sets from pathogens of major socio-economic importance and can, in principle, be applied to transcriptomics data sets from any organism

A practical, bioinformatic workflow system for large data sets generated by next-generation sequencing

Transcriptomics (at the level of single cells, tissues and/or whole organisms) underpins many fields of biomedical science, from understanding the basic cellular function in model organisms, to the elucidation of the biological events that govern the development and progression of human diseases, and the exploration of the mechanisms of survival, drug-resistance and virulence of pathogens. Next-generation sequencing (NGS) technologies are contributing to a massive expansion of transcriptomics in all fields and are reducing the cost, time and performance barriers presented by conventional approaches. However, bioinformatic tools for the analysis of the sequence data sets produced by these technologies can be daunting to researchers with limited or no expertise in bioinformatics. Here, we constructed a semi-automated, bioinformatic workflow system, and critically evaluated it for the analysis and annotation of large-scale sequence data sets generated by NGS. We demonstrated its utility for the exploration of differences in the transcriptomes among various stages and both sexes of an economically important parasitic worm (Oesophagostomum dentatum) as well as the prediction and prioritization of essential molecules (including GTPases, protein kinases and phosphatases) as novel drug target candidates. This workflow system provides a practical tool for the assembly, annotation and analysis of NGS data sets, also to researchers with a limited bioinformatic expertise. The custom-written Perl, Python and Unix shell computer scripts used can be readily modified or adapted to suit many different applications. This system is now utilized routinely for the analysis of data sets from pathogens of major socio-economic importance and can, in principle, be applied to transcriptomics data sets from any organism

Can nature deliver on the sustainable development goals?

The increasing availability of data and improved analytical techniques now enable better understanding of where environmental conditions and human health are tightly linked, and where investing in nature can deliver net benefits for people—especially with respect to the most vulnerable populations in developing countries. These advances bring more opportunities for interventions that can advance multiple SDGs at once. We have harmonised a suite of global datasets to explore the essential nexus of forests, poverty, and human health, an overlap of SDG numbers 1, 2, 3, 6, and 15. Our study combined demographic and health surveys for 297 112 children in 35 developing countries with data describing the local environmental conditions for each child (appendix).4 This allowed us to estimate the effect forests might have in supporting human health, while controlling for the influence of important socio-economic differences.4 We extended this work to look at how forests affect three childhood health concerns of global significance for the world's poorest people: stunting, anaemia, and diarrhoeal disease

Prospectus, October 10, 1984

SO YOU AND THE BULLY ON THE BLOCK ARE GOING TO DESTROY THE WORLD?\u27; PC Digest; Use your vote to make needed changes; First semester headaches; Auntie Miranda-Yes? or No?; Dear Reader; PC Happenings; Lifelong Learners to meet; Parkalnd schedules special registration; Workshop focuses on time management; Animal Health Technicians conference set; Health issues series continues; Emotional problems reason for help, not condemnation; Consumer Health Care Hotline; Notes of interest Prospectus read far and wide; Pictures worth more than a thousand words and dollars; Parkland instructor to teach GM class; Staff profile-Jim Scott-Entertainment writer; Advice from the duodenum-by Auntie Miranda; Wallace and Gray assets to both Parkland and \u27Taken in Marriage\u27; Music Poll; Explore the workings of the brain; Who\u27s top in pop?; Chick\u27s newest more than child\u27s play; Don\u27t miss a night of hilarity; Creative Corner...Especially for you!!; \u27The Foreigner\u27; The alarm clock-Monday morning blues; Natural selection; Bittersweet Memory; Pathways; Beautiful Stranger; Too Late; Love in the winter woods; \u27Doom Story\u27 the nightmare begins; Eternity; Green Eyes; Our day; Rejoice the Poet; Life Choices; Our place; Classifieds; Trust and acceptance provide supportive atmosphere; Change brings creation of destiny; Did You Know...; Kirby leads Cobra harriers to 7th; Lady Cobras win three, improve record to 18-5; A Tale of Three Freshmen; IM Volleyball; IM Football; Kirby says \u27Running is good for heart\u27; Schriefer takes pride in Parkland X-Country; Stewart places 3rd to lead Lady Cobras; Mullen twins guests on Cobra Raphttps://spark.parkland.edu/prospectus_1984/1009/thumbnail.jp

Male Breadwinning Revisited: How Specialisation, Gender Role Attitudes and Work Characteristics Affect Overwork and Underwork in Europe

We examine how male breadwinning and fatherhood relate to men’s overwork and underwork in western Europe. Male breadwinners should be less likely to experience overwork than other men, particularly when they have children, if specialising in paid work suits them. However, multinomial logistic regression analysis of the European Social Survey data from 2010 (n = 4662) challenges this position: male breadwinners, with and without children, want to work fewer than their actual hours, making visible one of the downsides of specialisation. Male breadwinners wanting to work fewer hours is specifically related to the job interfering with family life, as revealed by a comparison of the average marginal effects of variables across models. Work–life interference has an effect over and beyond the separate effects of work characteristics and family structure, showing the salience of the way work and life articulate

The function of fear in institutional maintenance: Feeling frightened as an essential ingredient in haute cuisine

Fear is a common and powerful emotion that can regulate behaviour. Yet institutional scholars have paid limited attention to the function of fear in processes of institutional reproduction and stability. Drawing on an empirical study of elite chefs within the institution of haute cuisine, this article finds that the multifaceted emotion of fear characterised their experiences and served to sustain their institution. Chefs’ individual feelings of fear prompted conformity and a cognitive constriction, which narrowed their focus on to the precise reproduction of traditional practices whilst also limiting challenges to the norms underpinning the institution. Through fear work, chefs used threats and violence to connect individual experiences of fear to the violation of institutionalized rules, sustaining the conditions in which fear-driven maintenance work thrived. The study also suggests that fear is a normative element of haute cuisine in its own right, where the very experience and eliciting of fear preserved an essential institutional ingredient. In this way, emotions such as fear do not just accompany processes of institutionalization but can be intimately involved in the maintenance of institutions