A realistic approach to policy formulation: the adapted EMMIE framework

Policy formulation is a crucial stage of the policy cycle, where social problems and demands are addressed, and transformed into government policies. This stage is complex and is one of the least analytically developed stages of the policy making process. In this article, we propose an adaptation of the EMMIE framework (created to review and rate the quality of evidence on crime reduction initiatives) as a practical means of encouraging an evidence based, systematic way of formulating policies. We argue that the five components of EMMIE (i.e. Effect, Mechanisms, Moderators, Implementation and Economics) provide useful dimensions that policy makers can apply to understand, plan and formulate successful policies. We suggest the application of the adapted EMMIE framework can improve policy formulation and in turn increase the likelihood of effective policy implementation and evaluation

Transnational organised crime in Europe and North America: towards a framework of prevention

Previous volumes of the HEUNI regional reports have paid little or no attention to transnational organized crime. Although the literature on transnational organized crime (hereafter TOC) is expanding rapidly, there remain fewstandardized measures of the problem. There is even less of a formal framework for thinking about how to prevent TOC in its various forms. The present chapter begins to address these issues, with an emphasis upon practical aspects of the latter. In the following section, TOC is defined and set in a global context, a broad overview of factors relating to recent changes is given, and international legislative responses are described. This is followed by the presentation of a framework that is frequently used in discussions of more general crime prevention efforts. It is proposed that its utilization in this context will help inform the analysis of efforts to prevent TOC

Police perceptions of problem-oriented policing and evidence-based policing: evidence from England and Wales

The history of policing is littered with reform programmes, which aim to improve effectiveness, efficiency and legitimacy. Problem-oriented policing (POP) and evidence-based policing (EBP) are two popular and enduring reform efforts, both of which have generated significant researcher and practitioner attention. There are important similarities between POP and EBP: both approaches provide a framework intended to improve the outcomes of policing. There are also key differences, however, in terms of their main objectives, standards of evidence and units of analysis. Despite both approaches being widely advocated and implemented, presently little is known about police practitioner understanding of the relationship between POP and EBP, both in principle and in practice. To address this gap, this paper draws on survey (n = 4,141) and interview (n = 86) data collected from 19 police forces in England and Wales in 2019 to explore police practitioners’ views on the relationship between POP and EBP, and the extent to which these two approaches inform contemporary police practices. Our findings indicate that respondents generally viewed the two approaches as complementary and important frameworks for orienting police work. However, respondents also drew attention to how the two approaches are not always connected organisationally nor in the minds of police personnel. In addition, challenges were identified in the application of both approaches in practice. Our results suggest that more needs to be done to maximise the potential of POP and EBP, both separately and synergistically. The article concludes by suggesting some ways in which this might be achieved

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

Background and aims: Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set to become the second leading cause of cancer death in our society. The study aim was to investigate the association between DNA damage response (DDR), replication stress and novel therapeutic response in PC to develop a biomarker driven therapeutic strategy targeting DDR and replication stress in PC. Methods: We interrogated the transcriptome, genome, proteome and functional characteristics of 61 novel PC patient-derived cell lines to define novel therapeutic strategies targeting DDR and replication stress. Validation was done in patient derived xenografts and human PC organoids. Results: Patient-derived cell lines faithfully recapitulate the epithelial component of pancreatic tumors including previously described molecular subtypes. Biomarkers of DDR deficiency, including a novel signature of homologous recombination deficiency, co-segregates with response to platinum (P < 0.001) and PARP inhibitor therapy (P < 0.001) in vitro and in vivo. We generated a novel signature of replication stress with which predicts response to ATR (P < 0.018) and WEE1 inhibitor (P < 0.029) treatment in both cell lines and human PC organoids. Replication stress was enriched in the squamous subtype of PC (P < 0.001) but not associated with DDR deficiency. Conclusions: Replication stress and DDR deficiency are independent of each other, creating opportunities for therapy in DDR proficient PC, and post-platinum therapy

A Roadmap for HEP Software and Computing R&D for the 2020s

Particle physics has an ambitious and broad experimental programme for the coming decades. This programme requires large investments in detector hardware, either to build new facilities and experiments, or to upgrade existing ones. Similarly, it requires commensurate investment in the R&D of software to acquire, manage, process, and analyse the shear amounts of data to be recorded. In planning for the HL-LHC in particular, it is critical that all of the collaborating stakeholders agree on the software goals and priorities, and that the efforts complement each other. In this spirit, this white paper describes the R&D activities required to prepare for this software upgrade.Peer reviewe

Time to Switch to Second-line Antiretroviral Therapy in Children With Human Immunodeficiency Virus in Europe and Thailand.

Background: Data on durability of first-line antiretroviral therapy (ART) in children with human immunodeficiency virus (HIV) are limited. We assessed time to switch to second-line therapy in 16 European countries and Thailand. Methods: Children aged <18 years initiating combination ART (≥2 nucleoside reverse transcriptase inhibitors [NRTIs] plus nonnucleoside reverse transcriptase inhibitor [NNRTI] or boosted protease inhibitor [PI]) were included. Switch to second-line was defined as (i) change across drug class (PI to NNRTI or vice versa) or within PI class plus change of ≥1 NRTI; (ii) change from single to dual PI; or (iii) addition of a new drug class. Cumulative incidence of switch was calculated with death and loss to follow-up as competing risks. Results: Of 3668 children included, median age at ART initiation was 6.1 (interquartile range (IQR), 1.7-10.5) years. Initial regimens were 32% PI based, 34% nevirapine (NVP) based, and 33% efavirenz based. Median duration of follow-up was 5.4 (IQR, 2.9-8.3) years. Cumulative incidence of switch at 5 years was 21% (95% confidence interval, 20%-23%), with significant regional variations. Median time to switch was 30 (IQR, 16-58) months; two-thirds of switches were related to treatment failure. In multivariable analysis, older age, severe immunosuppression and higher viral load (VL) at ART start, and NVP-based initial regimens were associated with increased risk of switch. Conclusions: One in 5 children switched to a second-line regimen by 5 years of ART, with two-thirds failure related. Advanced HIV, older age, and NVP-based regimens were associated with increased risk of switch