Special Issue on Development and Application of Particle Detectors

Particle detection has been increasingly applied over a wide range of disciplines, including high-energy physics, astroparticles, space science and astronomy, biological sciences, medical imaging, remote sensing, environmental monitoring, cultural heritage, and homeland security [...

A flexible scintillation light apparatus for rare event searches

Compelling experimental evidences of neutrino oscillations and their implication that neutrinos are massive particles have given neutrinoless double beta decay a central role in astroparticle physics. In fact, the discovery of this elusive decay would be a major breakthrough, unveiling that neutrino and antineutrino are the same particle and that the lepton number is not conserved. It would also impact our efforts to establish the absolute neutrino mass scale and, ultimately, understand elementary particle interaction unification. All current experimental programs to search for neutrinoless double beta decay are facing with the technical and financial challenge of increasing the experimental mass while maintaining incredibly low levels of spurious background. The new concept described in this paper could be the answer which combines all the features of an ideal experiment: energy resolution, low cost mass scalability, isotope choice flexibility and many powerful handles to make the background negligible. The proposed technology is based on the use of arrays of silicon detectors cooled to 120 K to optimize the collection of the scintillation light emitted by ultra-pure crystals. It is shown that with a 54 kg array of natural CaMoO4 scintillation detectors of this type it is possible to yield a competitive sensitivity on the half-life of the neutrinoless double beta decay of 100Mo as high as ~10E24 years in only one year of data taking. The same array made of 40CaMoO4 scintillation detectors (to get rid of the continuous background coming from the two neutrino double beta decay of 48Ca) will instead be capable of achieving the remarkable sensitivity of ~10E25 years on the half-life of 100Mo neutrinoless double beta decay in only one year of measurement.Comment: 12 pages, 4 figures. Prepared for submission to EPJ

A computational model of cell viability and proliferation of extrusion-based 3D-bioprinted constructs during tissue maturation process

3D bioprinting is a novel promising solution for living tissue fabrication, with several potential advantages in many different applicative sectors. However, the implementation of complex vascular networks remains as one of the limiting factors for the production of complex tissues and for bioprinting scale-up. In this work, a physics-based computational model is presented to describe nutrients diffusion and consumption phenomena in bioprinted constructs. The model - a system of partial differential equations that is approximated by means of the finite element method - allows for the description of cell viability and proliferation, and it can be easily adapted to different cell types, densities, biomaterials, and 3D-printed geometries, thus allowing a preassessment of cell viability within the bioprinted construct. The experimental validation is performed on bioprinted specimens to assess the ability of the model to predict changes in cell viability. The proposed model constitutes a proof of concept of digital twinning of biofabricated constructs that can be suitably included in the basic toolkit for tissue bioprinting

Performance of scintillation materials at cryogenic temperatures

An increasing number of applications of scintillators at low temperatures, particularly in cryogenic experiments searching for rare events, has motivated the investigation of scintillation properties of materials over a wide temperature range. This paper provides an overview of the latest results on the study of luminescence, absorption and scintillation properties of materials selected for rare event searches so far. These include CaWO4, ZnWO4, CdWO4, MgWO4, CaMoO4, CdMoO4, Bi4Ge3O12, CaF2, MgF2, ZnSe and AL2O3-Ti. We discuss the progress achieved in research and development of these scintillators, both in material preparation and in the understanding of scintillation mechanisms, as well as the underlying physics. To understand the origin of the performance limitation of self-activated scintillators we employed a semi-empirical model of conversion of high energy radiation into light and made appropriate provision for effects of temperature and energy transfer. We conclude that the low-temperature value of the light yield of some modern scintillators, namely CaWO4, CdWO4 and Bi4Ge3O12, is close to the theoretical limit. Finally, we discuss the advantages and limitations of different materials with emphasis on their application as cryogenic phonon-scintillation detectors (CPSD) in rare event search experiments

Search for Dark Matter with CRESST

The search for direct interactions of dark matter particles remains one of the most pressing challenges of contemporary experimental physics. A variety of different approaches is required to probe the available parameter space and to meet the technological challenges. Here, we review the experimental efforts towards the detection of direct dark matter interactions using scintillating crystals at cryogenic temperatures. We outline the ideas behind these detectors and describe the principles of their operation. Recent developments are summarized and various results from the search for rare processes are presented. In the search for direct dark matter interactions, the CRESST-II experiment delivers competitive limits, with a sensitivity below 5x10^(-7) pb on the coherent WIMP-nucleon cross section.Comment: Accepted for publication in New Journal of Physics. 25 pages, 18 figure

The commissioning of the CUORE experiment: the mini-tower run

CUORE is a ton-scale experiment approaching the data taking phase in Gran Sasso National Laboratory. Its primary goal is to search for the neutrinoless double-beta decay in 130Te using 988 crystals of tellurim dioxide. The crystals are operated as bolometers at about 10 mK taking advantage of one of the largest dilution cryostat ever built. Concluded in March 2016, the cryostat commissioning consisted in a sequence of cool down runs each one integrating new parts of the apparatus. The last run was performed with the fully configured cryostat and the thermal load at 4 K reached the impressive mass of about 14 tons. During that run the base temperature of 6.3 mK was reached and maintained for more than 70 days. An array of 8 crystals, called mini-tower, was used to check bolometers operation, readout electronics and DAQ. Results will be presented in terms of cooling power, electronic noise, energy resolution and preliminary background measurements

Results from the Cuore Experiment

The Cryogenic Underground Observatory for Rare Events (CUORE) is the first bolometric experiment searching for neutrinoless double beta decay that has been able to reach the 1-ton scale. The detector consists of an array of 988 TeO2 crystals arranged in a cylindrical compact structure of 19 towers, each of them made of 52 crystals. The construction of the experiment was completed in August 2016 and the data taking started in spring 2017 after a period of commissioning and tests. In this work we present the neutrinoless double beta decay results of CUORE from examining a total TeO2 exposure of 86.3kg yr, characterized by an effective energy resolution of 7.7 keV FWHM and a background in the region of interest of 0.014 counts/ (keV kg yr). In this physics run, CUORE placed a lower limit on the decay half- life of neutrinoless double beta decay of 130Te > 1.3.1025 yr (90% C. L.). Moreover, an analysis of the background of the experiment is presented as well as the measurement of the 130Te 2vo3p decay with a resulting half- life of T2 2. [7.9 :- 0.1 (stat.) :- 0.2 (syst.)] x 10(20) yr which is the most precise measurement of the half- life and compatible with previous results

Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients

Clinical features and natural history of coronavirus disease 2019 (COVID-19) differ widely among different countries and during different phases of the pandemia. Here, we aimed to evaluate the case fatality rate (CFR) and to identify predictors of mortality in a cohort of COVID-19 patients admitted to three hospitals of Northern Italy between March 1 and April 28, 2020. All these patients had a confirmed diagnosis of SARS-CoV-2 infection by molecular methods. During the study period 504/1697 patients died; thus, overall CFR was 29.7%. We looked for predictors of mortality in a subgroup of 486 patients (239 males, 59%; median age 71 years) for whom sufficient clinical data were available at data cut-off. Among the demographic and clinical variables considered, age, a diagnosis of cancer, obesity and current smoking independently predicted mortality. When laboratory data were added to the model in a further subgroup of patients, age, the diagnosis of cancer, and the baseline PaO2/FiO2 ratio were identified as independent predictors of mortality. In conclusion, the CFR of hospitalized patients in Northern Italy during the ascending phase of the COVID-19 pandemic approached 30%. The identification of mortality predictors might contribute to better stratification of individual patient risk

Virtual proximity in the factory processes: designing interfaces between industrial equipment and human operators

The paradigm of Industry 4.0 is increasingly permeating the way people work, live and interact with others. In the context of smart factories, industrial machines are increasingly intelligent and automated, but human oversight in the industrial processes remains crucial and requires highly skilled personnel executing quick and precise interventions on the production line. Nevertheless, communication with factory machines still relies hardly comprehensible codes on interfaces that follow the traditional Window-Icon-Menu-Pointer model. Through research based on surveys and field observations, this study aims to analyse the state of the art of human-machine interfaces, user behaviour and communication processes in a smart factory. Presenting a case study, this contribution offers a report on an experimental research project carried out through a design thinking approach applied in an Industry 4.0 environment. This paper contributes to the ongoing discussion about the possible future of human-centric interfaces in the industrial workplace, as well as the role of user-centred design in building experiences that go beyond conventional screen-based interactions