Comparison and Evaluation of the TES and ANEM Algorithms for Land Surface Temperature and Emissivity Separation over the Area of Valencia, Spain

Land Surface temperature (LST) is a key magnitude for numerous studies, especially for climatology and assessment of energy fluxes between surface and atmosphere. Retrieval of accurate LST requires a good characterization of surface emissivity. Both quantities are coupled in a single radiance measurement; for this reason, for N spectral bands available in a remote sensor, there will always be N + 1 unknowns. To solve the indeterminacy, temperature-emissivity separation methods have been proposed, among which the Temperature Emissivity Separation (TES) algorithm is one of the most widely used. The Adjusted Normalized Emissivity Method (ANEM) was proposed as a modification of the Normalized Emissivity Method (NEM) algorithm by adjusting the initial emissivity guess using an estimation provided by the Vegetation Cover Method (VCM). In this work, both methods were applied to a set of five ASTER scenes over the area of Valencia, Spain, which were recalibrated and atmospherically corrected using local radiosoundings and ground measurements. These scenes were compared to the ASTER temperature and emissivity standard products (AST08 and AST05, respectively). The comparison to reference measurements showed a better agreement of ANEM LST in low spectral contrast surfaces, with biases of +0.4 K, +0.8 K for TES and +1.4 K for the AST08 product in a rice crop site. For sea surface temperature, bias was −0.1 K for ANEM, +0.3 K for TES and +1.3 K for the AST08 product. The larger differences of the AST08 product could be ascribed mainly to the atmospheric correction based on NCEP profiles in contrast to the local correction used in TES and ANEM and to a lesser extent the Maximum-Minimum Difference (MMD) empirical relationship used by TES. In terms of emissivity, ANEM obtained biases up to ±0.007 (positive over vegetation and negative over water), while TES biases were up to −0.015. The AST05 product showed differences up to −0.050, although for high contrast areas, such as sand surfaces, it showed better accuracy than both TES and ANEM. A comparison between TES and ANEM on four different classes within the scene showed a systematic difference between both algorithms, which was more pronounced for low spectral contrast surfaces. Therefore, ANEM improves the accuracy at low spectral contrast surfaces, while obtaining similar results to TES at higher spectral contrast surfaces, such as urban areas. The combination of both methods could provide a procedure benefiting from the strengths shown by each of them

Compound Markov counting processes and their applications to modeling infinitesimally over-dispersed systems

We propose an infinitesimal dispersion index for Markov counting processes. We show that, under standard moment existence conditions, a process is infinitesimally (over-) equi-dispersed if, and only if, it is simple (compound), i.e. it increases in jumps of one (or more) unit(s), even though infinitesimally equi-dispersed processes might be under-, equi- or over-dispersed using previously studied indices. Compound processes arise, for example, when introducing continuous-time white noise to the rates of simple processes resulting in Levy-driven SDEs. We construct multivariate infinitesimally over-dispersed compartment models and queuing networks, suitable for applications where moment constraints inherent to simple processes do not hold.Comment: 26 page

EPA 9—Collaborate as a Member of an Interprofessional Team: a Short Communication from the AAMC Core EPAs for Entering Residency Pilot Schools

Members of the Association of American Medical Colleges Core Entrustable Professional Activities (EPAs) for Entering Residency Pilot worked to conceptualize how graduates might be entrusted for EPA 9: Collaborate as a member of an interprofessional team. Through an iterative group process informed by the literature and application to local curriculum and clinical experiences, we drafted a developmental framework and curriculum mapping tool. Ultimately, entrustment requires assessment in clinical settings. Nonetheless, teamwork and communication skills that are relevant to future entrustment can be taught and assessed in pre-clinical contexts such as small groups to ensure students are on an entrustment trajectory

Deletion of the Zinc Transporter Lipoprotein AdcAII Causes Hyperencapsulation of Streptococcus pneumoniae Associated with Distinct Alleles of the Type I Restriction-Modification System.

The capsule is the dominant Streptococcus pneumoniae virulence factor, yet how variation in capsule thickness is regulated is poorly understood. Here, we describe an unexpected relationship between mutation of adcAII, which encodes a zinc uptake lipoprotein, and capsule thickness. Partial deletion of adcAII in three of five capsular serotypes frequently resulted in a mucoid phenotype that biochemical analysis and electron microscopy of the D39 adcAII mutants confirmed was caused by markedly increased capsule thickness. Compared to D39, the hyperencapsulated ΔadcAII mutant strain was more resistant to complement-mediated neutrophil killing and was hypervirulent in mouse models of invasive infection. Transcriptome analysis of D39 and the ΔadcAII mutant identified major differences in transcription of the Sp_0505-0508 locus, which encodes an SpnD39III (ST5556II) type I restriction-modification system and allelic variation of which correlates with capsule thickness. A PCR assay demonstrated close linkage of the SpnD39IIIC and F alleles with the hyperencapsulated ΔadcAII strains. However, transformation of ΔadcAII with fixed SpnD39III alleles associated with normal capsule thickness did not revert the hyperencapsulated phenotype. Half of hyperencapsulated ΔadcAII strains contained the same single nucleotide polymorphism in the capsule locus gene cps2E, which is required for the initiation of capsule synthesis. These results provide further evidence for the importance of the SpnD39III (ST5556II) type I restriction-modification system for modulating capsule thickness and identified an unexpected linkage between capsule thickness and mutation of ΔadcAII Further investigation will be needed to characterize how mutation of adcAII affects SpnD39III (ST5556II) allele dominance and results in the hyperencapsulated phenotype.IMPORTANCE The Streptococcus pneumoniae capsule affects multiple interactions with the host including contributing to colonization and immune evasion. During infection, the capsule thickness varies, but the mechanisms regulating this are poorly understood. We have identified an unsuspected relationship between mutation of adcAII, a gene that encodes a zinc uptake lipoprotein, and capsule thickness. Mutation of adcAII resulted in a striking hyperencapsulated phenotype, increased resistance to complement-mediated neutrophil killing, and increased S. pneumoniae virulence in mouse models of infection. Transcriptome and PCR analysis linked the hyperencapsulated phenotype of the ΔadcAII strain to specific alleles of the SpnD39III (ST5556II) type I restriction-modification system, a system which has previously been shown to affect capsule thickness. Our data provide further evidence for the importance of the SpnD39III (ST5556II) type I restriction-modification system for modulating capsule thickness and identify an unexpected link between capsule thickness and ΔadcAII, further investigation of which could further characterize mechanisms of capsule regulation

Connecting fish, flows and habitats on lowland river floodplains

Connectivity between river and floodplain habitats is important to many lowland river fishes enabling them to complete their life cycle, maximise growth potential and minimise early life-history mortality. There is increasing recognition of this need and in regulated systems, increasing sophistication of management processes and infrastructure around environmental water allocations to facilitate this connectivity. Providing connecting flows with limited water resources often means prioritising watering one area over another; so comparative evaluation of fish movement, growth and productivity can be important to demonstrate success. In the Great Darling Anabranch, we used directional-netting, measures of whole stream productivity and fish otolith growth and body condition analysis to investigate benefits of connecting flows in 500km of restored ephemeral river channel alongside the same factors in an alternative flow-path, the Darling River. The Hattah Lakes, a complex of regulated, lowland-river floodplain lakes can be filled using large, purpose built environmental pumps; transferring water and fish recruits from the Murray River to productive floodplain habitats. We investigated the lateral movement of resident fish during filling and draw-down of the lakes, using acoustic tags in a native fish species, Golden perch (Macquaria ambigua) and an invasive fish, Carp (Cyprinus carpio). We generated regular movement-trajectories for tagged fish using interpolation, then tested observations against null models to evaluate individual and group movements against a one-dimensional behavioural hypothesis; “do fish move towards or away from the river in response to draw-down or filling?” Results are assisting natural resource managers develop designs for environmental watering hydrographs for connecting flows in large anabranch channels and floodplain lakes

New version of PLNoise: a package for exact numerical simulation of power-law noises

In a recent paper I have introduced a package for the exact simulation of power-law noises and other colored noises (E. Milotti, Comput. Phys. Commun. {\bf 175} (2006) 212): in particular the algorithm generates $1/f^\alpha$ noises with $0 < \alpha \leq 2$. Here I extend the algorithm to generate $1/f^\alpha$ noises with $2 < \alpha \leq 4$ (black noises). The method is exact in the sense that it produces a sampled process with a theoretically guaranteed range-limited power-law spectrum for any arbitrary sequence of sampling intervals, i.e., the sampling times may be unevenly spaced.Comment: 3 figures, submitted to Computer Physics Communication

Communities of practice in academia

Up to now, the relationships among the fundamental notions of communities of practice (CoPs), i.e. knowledge, participation, identity, and artefact development have been based mainly on results from qualitative studies; they are not yet sufficiently based on quantitative evidence. Starting from a literature review, we formulate a quantitative, causal model of CoPs that describes these variables in the context of academic communities, and aim to validate this model in two academic CoPs with a total of N = 208 participants. A cluster analysis classifies the participants into clusters that are in line with the core-periphery structure known from previous qualitative studies. A regression analysis provides evidence for the hypothesized model on the basis of quantitative data. Suggested directions for future research are to focus on factors that determine CoP participants’ contributions to artefact development and on approaches to automated monitoring of virtual CoPs

Identification of 2-Aminothiazole-4-Carboxylate Derivatives Active against Mycobacterium tuberculosis H37Rv and the β-Ketoacyl-ACP Synthase mtFabH

Background Tuberculosis (TB) is a disease which kills two million people every year and infects approximately over one-third of the world's population. The difficulty in managing tuberculosis is the prolonged treatment duration, the emergence of drug resistance and co-infection with HIV/AIDS. Tuberculosis control requires new drugs that act at novel drug targets to help combat resistant forms of Mycobacterium tuberculosis and reduce treatment duration. Methodology/Principal Findings Our approach was to modify the naturally occurring and synthetically challenging antibiotic thiolactomycin (TLM) to the more tractable 2-aminothiazole-4-carboxylate scaffold to generate compounds that mimic TLM's novel mode of action. We report here the identification of a series of compounds possessing excellent activity against M. tuberculosis H37Rv and, dissociatively, against the β-ketoacyl synthase enzyme mtFabH which is targeted by TLM. Specifically, methyl 2-amino-5-benzylthiazole-4-carboxylate was found to inhibit M. tuberculosis H37Rv with an MIC of 0.06 µg/ml (240 nM), but showed no activity against mtFabH, whereas methyl 2-(2-bromoacetamido)-5-(3-chlorophenyl)t​hiazole-4-carboxylateinhibited mtFabH with an IC50 of 0.95±0.05 µg/ml (2.43±0.13 µM) but was not active against the whole cell organism. Conclusions/Significance These findings clearly identify the 2-aminothiazole-4-carboxylate scaffold as a promising new template towards the discovery of a new class of anti-tubercular agents

Optics elements for modeling electrostatic lenses and accelerator components II. Acceleration columns

A set of optical models for a variety of electrostatic lenses and accelerator columns has been developed for the computer code TRACE 3-D. TRACE 3-D is an envelope (matrix) code including space charge that is often used to model bunched beams in magnetic transport systems and radiofrequency (RF) accelerators when the effects of beam current may be important. Several new matrix models have been developed that allow the code to be used for modeling beam lines and accelerators with electrostatic components. The new models include a number of options for: (1) einzel lenses, (2) accelerator columns, (3) electrostatic deflectors (prisms), and (4) an electrostatic quadrupole. A prescription for setting up the initial beam appropriate to modeling 2-D (continuous) beams has also been developed. The new models for (2) are described in this paper, selected comparisons with other calculations are presented, and a beamline application is summarized