Learnings from Local Collaborative Transformations: Setting a Basis for a Sustainability Framework

The complexity of the sustainability challenge demands for collaboration between different actors, be they governments, businesses, or grassroots movements, at all levels. Nevertheless, and according to previous research, many tensions and obstacles to partnership still exist and results are far from meaningful. By investigating potential synergies, our purpose is to define a sustainability framework to promote better collaboration between community-based initiatives and local governments, in the context of transformation. Specifically, the research aim presented in this paper is to harvest learnings from existing collaborative experiments at the municipal level. As a starting point and using exploratory literature review concerning areas like policy (e.g., public administration) or business and management research, we propose a ‘Compass for Collaborative Transformation’. This heuristic device can support the study of these sustainability experiments. We also introduce a method to map the governance imprint of these collaborations and to provide a ‘proxy’ of transformative efforts. We then present and discuss results from 71 surveyed cases happening in 16 countries in America and Europe, comparing distinctive frameworks involved. Finally, we consider the preconditions of a framework to improve these local collaborations—namely the capacity to support joint navigation through transformative efforts, facing high levels of uncertainty and complexity—and present ongoing efforts to codesign a new sustainability framework.info:eu-repo/semantics/publishedVersio

Methods for Compression of Feedback in Adaptive Multicarrier 4G Schemes

In this paper, several algorithms for compressing the feedback of channel quality information are presented and analyzed. These algorithms are developed for a proposed adaptive modulation scheme for future multi-carrier 4G mobile systems. These strategies compress the feedback data and, used together with opportunistic scheduling, drastically reduce the feedback data rate. Thus the adaptive modulation schemes become more suitable and efficient to be implemented in future mobile systems, increasing data throughput and overall system performance.This work has been partly funded by the Spanish government with projects MACAWI (TEC 2005-07477-c02-02), MAMBO2 (CCG06-UC3M-TIC-0698), and European COST Action 289 and is a result of work done within this European actio

¿Tiene sentido seguir distinguiendo entre aprendizaje de conceptos, resolución de problemas de lápiz y papel y realización de prácticas de laboratorio?

Nuestra pretensión en este trabajo es cuestionar la distinción clásica entre «teoría», «prácticas de laboratorio» y «problemas». Intentaremos mostrar qué investigaciones realizadas en los tres campos privan de sentido a esta separación que, conviene notar, no guarda paralelismo alguno con la actividad científica real.Our aim with this paper is to question the typical distinction between «theory», «lab» and «paper and pencil problemsolving» activities. We intend to show that research done on these domains does not support their separation in the teaching/learning process. In fact, this separation does not take place in any real scientific activity

Biochemical biomarkers for multiple sclerosis

Introduction: Multiple sclerosis (MS) is the most frequent demyelinating disease of the central nervous system. Although there is currently no definite cure for MS, new therapies have recently been developed based on a continuous search for new biomarkers. Development: MS diagnosis relies on the integration of clinical, imaging and laboratory findings as there is still no single pathognomonic clinical feature or diagnostic laboratory biomarker. The most commonly laboratory test used is the presence of immunoglobulin G oligoclonal bands (OCB) in cerebrospinal fluid of MS patients. This test is now included in the 2017 McDonald criteria as a biomarker of dissemination in time. Nevertheless, there are other biomarkers currently in use such as kappa free light chain, which has shown higher sensitivity and specificity for MS diagnosis than OCB. In addition, other potential laboratory tests involved in neuronal damage, demyelination and/or inflammation could be used for detecting MS. Conclusions: CSF and serum biomarkers have been reviewed for their use in MS diagnosis and prognosis to stablish an accurate and prompt MS diagnosis, crucial to implement an adequate treatment and to optimize clinical outcomes over time

Discovering a Project for the Development of Geotourism in Rural Areas: The Paleontological and Archaeological Interpretation Centre of Tamajón (CIPAT, Guadalajara, Spain)

The important paleontological and archaeological discoveries made in Tamajón in recent years have enriched the exceptional natural and cultural heritage of this town in the north of the Guadalajara province (central Spain). The extraordinary educational and outreach value of these findings led the PaleoIbérica Research Group to develop a project for the design and creation of the Paleontological and Archaeological Interpretation Centre of Tamajón (CIPAT, acronym in Spanish). In this new space, students and the general public have access to knowledge of the past of the region through three exhibition and didactic areas and the support of a rigorous and engaging infographic. The Paleontological Area allows visitors to explore, through fossils, replicas, models (real and virtual) and dioramas, the diversity of coastal and marine life that inhabited the region during the Late Cretaceous Age. Moreover, the area highlights crocodylomorphs, dinosaurs and fishes (identified through their fossilized tracks), and the remains of plants and invertebrates. The Archaeological Area shows the origin and uses of the building material known as Tamajón Stone by means of rough or carved samples, tools traditionally used in its extraction and carving, and historical photographs. Furthermore, in the Didactic Area, innovative specific educational activities are carried out, facilitating the knowledge and appreciation of the rich natural and cultural heritage of Tamajón. After its recent inauguration (August 2021), the CIPAT is a valuable tool to encourage the practice of positive attitudes toward geoconservation and to promote the sustainable and socioeconomic development of the region through geotourism.Research Projects and Contracts UI/BD/150971/2021 of the Foundation for Science and Technology (Portugal), and UCM.CT31/21 of the Complutense University of Madrid (Spain); and BOP-168 of the Provincial Council of Guadalajara, and 94/2018, 21/2019, 147/2021 of the University of Alcalá-Town Council of Tamajón (Spain). Aid for Rural Development 2021 of the Eurocaja Rural Foundation (Spain)

Bacterial Rhizoplane Colonization Patterns of Buchloe dactyloides Growing in Metalliferous Mine Tailings Reflect Plant Status and Biogeochemical Conditions

Plant establishment during phytostabilization of legacy mine tailings in semiarid regions is challenging due to low pH, low organic carbon, low nutrients, and high toxic metal(loid) concentrations. Plant-associated bacterial communities are particularly important under these harsh conditions because of their beneficial services to plants. We hypothesize that bacterial colonization profiles on rhizoplane surfaces reflect deterministic processes that are governed by plant health and the root environment. The aim of this study was to identify associations between bacterial colonization patterns on buffalo grass (Buchloe dactyloides) rhizoplanes and both plant status (leaf chlorophyll and plant cover) and substrate biogeochemistry (pH, electrical conductivity, total organic carbon, total nitrogen, and rhizosphere microbial community). Buffalo grass plants from mesocosm- and field-scale phytostabilization trials conducted with tailings from the Iron King Mine and Humboldt Smelter Superfund Site in Dewey-Humboldt, Arizona, were analyzed. These tailings are extremely acidic and have arsenic and lead concentrations of 2-4 g kg-1 substrate. Bacterial communities on rhizoplanes and in rhizosphere-associated substrate were characterized using fluorescence in situ hybridization and 16S rRNA gene amplicon sequencing, respectively. The results indicated that the metabolic status of rhizoplane bacterial colonizers is significantly related to plant health. Principal component analysis revealed that root-surface Alphaproteobacteria relative abundance was associated most strongly with substrate pH and Gammaproteobacteria relative abundance associated strongly with substrate pH and plant cover. These factors also affected the phylogenetic profiles of the associated rhizosphere communities. In summary, rhizoplane bacterial colonization patterns are plant specific and influenced by plant status and rhizosphere biogeochemical conditions.National Institute of Environmental and Health Sciences (NIEHS) Superfund Research Program (SRP) [P42 ES004940, R01 ES01709]; National Science Foundation Graduate Research Fellowhip Program (NSF GRFP) [DGE-1143953]12 month embargo; published online: 2 June 2017This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

¿Puede hablarse de consenso constructivista en la educación científica?

In this paper we analyse some of the criticisms that are being made to the «constructivist paradigm» and their implications on the development of the didactic of the sciences as a theoretical body knowledge

Technology as 'Applied Science': a Serious Misconception that Reinforces Distorted and Impoverished Views of Science

The current consideration of technology as 'applied science', this is to say, as something that comes 'after' science, justifies the lack of attention paid to technology in science education. In our paper we question this simplistic view of the science-technology relationship, historically rooted in the unequal appreciation of intellectual and manual work, and we try to show how the absence of the technological dimension in science education contributes to a na¿ ve and distorted view of science which deeply affects the necessary scientific and technological literacy of all citizens

EV-associated miRNAs from peritoneal lavage as potential diagnostic biomarkers in colorectal cancer

Background: Colorectal cancer (CRC) is the third leading cause of cancer-related mortality worldwide. Current systematic methods for diagnosing have inherent limitations so development of a minimally-invasive diagnosis, based on the identification of sensitive biomarkers in liquid biopsies could therefore facilitate screening among population at risk. Methods: In this study, we aim to develop a novel approach to identify highly sensitive and specific biomarkers by investigating the use of extracellular vesicles (EVs) isolated from the peritoneal lavage as a source of potential miRNA diagnostic biomarkers. We isolated EVs by ultracentrifugation from 25 ascitic fluids and 25 peritoneal lavages from non-cancer and CRC patients, respectively. Analysis of the expression of EV-associated miRNAs was performed using Taqman OpenArray technology through which we could detect 371 miRNAs. Results: 210 miRNAs were significantly dysregulated (adjusted p value < 0.05 and abs(logFC) ≥ 1). The top-10 miRNAs, which had the AUC value higher than 0.95, were miRNA-199b-5p, miRNA-150-5p, miRNA-29c-5p, miRNA-218-5p, miRNA-99a-3p, miRNA-383-5p, miRNA-199a-3p, miRNA-193a-5p, miRNA-10b-5p and miRNA-181c-5p. Conclusions: This finding opens the avenue to the use of EV-associated miRNA of peritoneal lavages as an untapped source of biomarkers for CRC.EC hold a postdoctoral fellowship from the Departament de Salut of the Generalitat de Catalunya (SLT002/16/00274). This work was supported by grants: Discovery, validation and implementation of biomarkers for Precision Oncology (ISCIII PIE15/00029), CIBERONC (CB16/12/00231 and CB16/12/00328). Grups consolidats de la Generalitat de Catalunya (2017SGR1368 and 2017SGR1661). Work supported by IRBLleida BIOBANK (B.0000682) and Plataforma biobancos PT17/0015/0027