38 research outputs found
Orthogonal polynomials, Julia sets, and invariant measures (mathematical sciences)
Issued as Preliminary report and Final report, Project no. G-37-63
The Influence of Knowledge Management on Business Value in IT Projects: A Theoretical Model
This paper develops a theoretical model to explain the relationships between knowledge management and business value in IT-enabled business projects. It draws upon a wide range of literatures including project management, management information systems, software engineering, organization and management theory, organizational behaviour and strategy. The overall model comprises two sub-models. The first shows how the alignment of three project-based knowledges directly influences business value. The second shows how four knowledge-based concepts, knowledge management, knowledge stock, enabling environment, and knowledge practices, combine to create the project-based knowledges. Together these two sub-models provide an overall model of the causal system through which knowledge management influences business value. This research makes contributions to the research into IT Projects by (1) integrating fragmented literatures which connect knowledge management and project success; and (2) proposing for discussion a predictive model in which knowledge management influences business value. It has the potential when further developed to clarify what project managers can do to manage knowledge in a systematic way
Brief Amici Curiae of Electronic Frontier Foundation, 1851 Center for Constitutional Law, and Profs. Jonathan Entin, David F. Forte, Andrew Geronimo, Raymond Ku, Stephen Lazarus, Kevin Francis OâNeill, Margaret Tarkington, Aaron H. Caplan, and Eugene Volokh in Support of Respondent-Appellant, Joni Bey and Rebecca Rasawehr v. Jeffrey Rasawehr, Supreme Court of Ohio (Case No. 2019-0295)
The brief argues that the Third District Court of Appeals, in violation of the First Amendment, erred in upholding an injunction that barred defendant from any online postings regarding plaintiff, whether or not those postings were to plaintiff or to third parties
A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection
One of the largest single sources of epilepsy in the world is produced as a neurological sequela in survivors of cerebral malaria. Nevertheless, the pathophysiological mechanisms of such epileptogenesis remain unknown and no adjunctive therapy during cerebral malaria has been shown to reduce the rate of subsequent epilepsy. There is no existing animal model of postmalarial epilepsy. In this technical report we demonstrate the first such animal models. These models were created from multiple mouse and parasite strain combinations, so that the epilepsy observed retained universality with respect to genetic background. We also discovered spontaneous sudden unexpected death in epilepsy (SUDEP) in two of our strain combinations. These models offer a platform to enable new preclinical research into mechanisms and prevention of epilepsy and SUDEP
A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection.
One of the largest single sources of epilepsy in the world is produced as a neurological sequela in survivors of cerebral malaria. Nevertheless, the pathophysiological mechanisms of such epileptogenesis remain unknown and no adjunctive therapy during cerebral malaria has been shown to reduce the rate of subsequent epilepsy. There is no existing animal model of postmalarial epilepsy. In this technical report we demonstrate the first such animal models. These models were created from multiple mouse and parasite strain combinations, so that the epilepsy observed retained universality with respect to genetic background. We also discovered spontaneous sudden unexpected death in epilepsy (SUDEP) in two of our strain combinations. These models offer a platform to enable new preclinical research into mechanisms and prevention of epilepsy and SUDEP
Performance of the X-Calibur Hard X-Ray Polarimetry Mission during its 2018/19 Long-Duration Balloon Flight
X-Calibur is a balloon-borne telescope that measures the polarization of
high-energy X-rays in the 15--50keV energy range. The instrument makes use of
the fact that X-rays scatter preferentially perpendicular to the polarization
direction. A beryllium scattering element surrounded by pixellated CZT
detectors is located at the focal point of the InFOC{\mu}S hard X-ray mirror.
The instrument was launched for a long-duration balloon (LDB) flight from
McMurdo (Antarctica) on December 29, 2018, and obtained the first constraints
of the hard X-ray polarization of an accretion-powered pulsar. Here, we
describe the characterization and calibration of the instrument on the ground
and its performance during the flight, as well as simulations of particle
backgrounds and a comparison to measured rates. The pointing system and
polarimeter achieved the excellent projected performance. The energy detection
threshold for the anticoincidence system was found to be higher than expected
and it exhibited unanticipated dead time. Both issues will be remedied for
future flights. Overall, the mission performance was nominal, and results will
inform the design of the follow-up mission XL-Calibur, which is scheduled to be
launched in summer 2022.Comment: 19 pages, 31 figures, submitted to Astropart. Phy
Impact of Clouds and Hazes on the Simulated JWST Transmission Spectra of Habitable Zone Planets in the TRAPPIST-1 System
The TRAPPIST-1 system, consisting of an ultra-cool host star having seven
known Earth-size planets will be a prime target for atmospheric
characterization with JWST. However, the detectability of atmospheric molecular
species may be severely impacted by the presence of clouds and/or hazes. In
this work, we perform 3-D General Circulation Model (GCM) simulations with the
LMD Generic model supplemented by 1-D photochemistry simulations at the
terminator with the Atmos model to simulate several possible atmospheres for
TRAPPIST-1e, 1f and 1g: 1) modern Earth, 2) Archean Earth, and 3) CO2-rich
atmospheres. JWST synthetic transit spectra were computed using the GSFC
Planetary Spectrum Generator (PSG). We find that TRAPPIST-1e, 1f and 1g
atmospheres, with clouds and/or hazes, could be detected using JWST's NIRSpec
prism from the CO2 absorption line at 4.3 um in less than 15 transits at 3
sigma or less than 35 transits at 5 sigma. However, our analysis suggests that
other gases would require hundreds (or thousands) of transits to be detectable.
We also find that H2O, mostly confined in the lower atmosphere, is very
challenging to detect for these planets or similar systems if the planets'
atmospheres are not in a moist greenhouse state. This result demonstrates that
the use of GCMs, self-consistently taking into account the effect of clouds and
sub-saturation, is crucial to evaluate the detectability of atmospheric
molecules of interest as well as for interpreting future detections in a more
global (and thus robust and relevant) approach.Comment: 36 pages, 19 figure
The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe
The preponderance of matter over antimatter in the early Universe, the
dynamics of the supernova bursts that produced the heavy elements necessary for
life and whether protons eventually decay --- these mysteries at the forefront
of particle physics and astrophysics are key to understanding the early
evolution of our Universe, its current state and its eventual fate. The
Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed
plan for a world-class experiment dedicated to addressing these questions. LBNE
is conceived around three central components: (1) a new, high-intensity
neutrino source generated from a megawatt-class proton accelerator at Fermi
National Accelerator Laboratory, (2) a near neutrino detector just downstream
of the source, and (3) a massive liquid argon time-projection chamber deployed
as a far detector deep underground at the Sanford Underground Research
Facility. This facility, located at the site of the former Homestake Mine in
Lead, South Dakota, is approximately 1,300 km from the neutrino source at
Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino
charge-parity symmetry violation and mass ordering effects. This ambitious yet
cost-effective design incorporates scalability and flexibility and can
accommodate a variety of upgrades and contributions. With its exceptional
combination of experimental configuration, technical capabilities, and
potential for transformative discoveries, LBNE promises to be a vital facility
for the field of particle physics worldwide, providing physicists from around
the globe with opportunities to collaborate in a twenty to thirty year program
of exciting science. In this document we provide a comprehensive overview of
LBNE's scientific objectives, its place in the landscape of neutrino physics
worldwide, the technologies it will incorporate and the capabilities it will
possess.Comment: Major update of previous version. This is the reference document for
LBNE science program and current status. Chapters 1, 3, and 9 provide a
comprehensive overview of LBNE's scientific objectives, its place in the
landscape of neutrino physics worldwide, the technologies it will incorporate
and the capabilities it will possess. 288 pages, 116 figure
The Comet Interceptor Mission
Here we describe the novel, multi-point Comet Interceptor mission. It is dedicated to the exploration of a little-processed long-period comet, possibly entering the inner Solar System for the first time, or to encounter an interstellar object originating at another star. The objectives of the mission are to address the following questions: What are the surface composition, shape, morphology, and structure of the target object? What is the composition of the gas and dust in the coma, its connection to the nucleus, and the nature of its interaction with the solar wind? The mission was proposed to the European Space Agency in 2018, and formally adopted by the agency in June 2022, for launch in 2029 together with the Ariel mission. Comet Interceptor will take advantage of the opportunity presented by ESAâs F-Class call for fast, flexible, low-cost missions to which it was proposed. The call required a launch to a halo orbit around the Sun-Earth L2 point. The mission can take advantage of this placement to wait for the discovery of a suitable comet reachable with its minimum ÎV capability of 600 msâ1. Comet Interceptor will be unique in encountering and studying, at a nominal closest approach distance of 1000 km, a comet that represents a near-pristine sample of material from the formation of the Solar System. It will also add a capability that no previous cometary mission has had, which is to deploy two sub-probes â B1, provided by the Japanese space agency, JAXA, and B2 â that will follow different trajectories through the coma. While the main probe passes at a nominal 1000 km distance, probes B1 and B2 will follow different chords through the coma at distances of 850 km and 400 km, respectively. The result will be unique, simultaneous, spatially resolved information of the 3-dimensional properties of the target comet and its interaction with the space environment. We present the missionâs science background leading to these objectives, as well as an overview of the scientific instruments, mission design, and schedule