Ali Smith, Girl Meets Boy (2007)

Recommends Smith\u27s novel, which rewrites classical myth through the love story of a modern-day lesbian couple, as challenging conventional notions of identity on multiple levels, pointing to the transformative potential of queer identity to embrace a clever reconciliation of local community and cosmopolitan mindset, and offering a reading of Scottish identity that is culturally progressive and politically sound

Il Sistema Locale per lo Sviluppo Turistico-Creativo in Costiera Amalfitana

In recent years creativity has become a resource not only in relation to artistic and cultural activities but also in terms of economic growth and development of tourism enterprises and geographical regions. This has determined the diffusion of creative tourism based on principles of sustainability. However, debate on the issue – above all in Italy – is still ongoing as concerns definitions in line with scientific literature. Our research attempts to show that the foundations for the success of this kind of tourism lies in the consolidating of the local economy based on creativity in a systems logic. To this aim a case study on the Amalfi Coast area (Salerno) is presented providing a framework of the characteristics and creative potential in terms of tourism in order to highlight both the dynamics in act and the most significant elements for the construction of a creative ambience. Our study concludes however, that such a model cannot be considered merely a solution for all ills, but on the contrary, can be exploited only by territories that enjoy a creative humus. In other words, strategies put in place should exalt what is rooted in the geographical, social and cultural reality, i.e. as the potential base for the affirming of this new niche of cultural tourism. Otherwise, any initiatives undertaken risk becoming useless and a waste of resources.Negli ultimi anni la creatività è stata sempre più considerata una risorsa non solo in relazione alle attività artistiche e culturali, ma anche per lo sviluppo economico di imprese turistiche e di regioni geografiche, al punto da determinare la diffusione del turismo creativo, secondo i principi della sostenibilità, pure se il dibattito - soprattutto in Italia - ancora non è perfettamente definito. In sintonia con la letteratura scientifica, la presente ricerca si pone l’obiettivo di dimostrare che la condizione ineludibile per il decollo di tale forma di turismo è il consolidamento dell’economia locale basata sulla creatività, in chiave sistemica. A tal fine si presenta il caso della Costiera Amalfitana (Salerno), fornendo un quadro delle caratteristiche turistiche e delle potenzialità creative, mettendo in luce le dinamiche in atto e gli elementi più significativi per la costruzione di un’atmosfera creativa. Questo lavoro giunge a sostenere che il modello a cui si fa riferimento non può essere assunto come una “panacea”, bensì può essere implementato soltanto da quei territori che godono di humus creativi, in modo che le strategie vadano ad esaltare quanto è radicato nella realtà geografica, sociale e culturale, ossia la base potenziale per l’affermazione di questa nuova nicchia del turismo culturale. In caso contrario, qualunque iniziativa rischia di risultare un inutile dispendio di risorse

Papel do Enfermeiro de Reabilitação à Pessoa em situação Crítica com COVID-19: Estudo de caso

Introduction: COVID-19 disease severity can range from mild to severe illness with prolonged stay in intensive care units which can have respiratory, motor, and cognitive consequences, in this way it is important to understand the role of the rehabilitation nurse in the recovery of the critical patient. Methodology: this case study complies with CASE Report guidelines. This is a 67 year old male hospitalized in internal medicine ward, in a COVID-19 dedicated area, with the diagnoses of COVID-19 pneumonia. The focus of attention was selfcare, muscular strength, balance, walking, ventilation, and swallowing. An intervention plan was designed according to main problems and it was implemented according to the person´s evolution and subsequently the main outcomes were reassessed.   Results: After five days of intervention, according to different evaluated scales patient improved: Barthel from 5 to 65; from 8 to 3; FiO2 from 35% to 21%; Tinetti from 0/0 to 11/9; Medical Research Council Muscle Scale (MRC) from 2 to 4; and gugging swallowing screen (GUSS) from 5 to 8. Discussion: the case study highlights the need and importance to implement a plan suitable for each patient, based on safety criteria and progressing according to the patient´s tolerance. Conclusion: with rehabilitation nurse interventions it is possible to reduce the consequences resulting from intensive care unit hospitalization.Introducción: El COVID-19 puede causar una enfermedad moderada a grave con hospitalización prolongada en una unidad de cuidados intensivos, con repercusiones a nivel respiratorio, motor y cognitivo, pero lo que es importante comprender la contribución de las enfermeras de rehabilitación en la recuperación de los enfermos críticos. Metodología: Estudio de caso descriptivo según las pautas del Reporte de Caso. Se trata de un varón de 67 años, internado en medicina interna, área dedicada a COVID-19, con diagnóstico de neumonía por COVID-19. El foco de atención fue el autocuidado, la fuerza muscular, el equilibrio, la marcha, la ventilación y la deglución. Ante estos enfoques, se diseñó e implementó un plan de intervención acorde a la evolución de la persona y posteriormente se reevaluaron los principales outcomes. Resultados: Después de cinco días de intervención, la persona, según la escala de Barthel, mejoró de un puntaje de 5 a 65; puntuación de Borg de 8 a 3; FiO2 35% a 21%; Tinetti 0/0 al 9/11; puntuación del consejo de investigación médica (MRC) de fuerza muscular de 2 a 4 y puntuación de Gugging Swallowing Screen (GUSS) de 5 a 8. Discusión: El caso práctico destaca la necesidad de implementar un plan de cuidados adecuado para cada cliente, basado en criterios de seguridad y progresando según la tolerancia del cliente. Conclusión: Con las intervenciones del enfermero de rehabilitación es posible reducir las secuelas derivadas de la hospitalización en la unidad de cuidados intensivos.Introdução: A COVID-19 pode provocar doença moderada a severa com internamento prolongado em unidade de cuidados intensivos tendo repercussões a nível respiratório, motor e cognitivo. Como tal é importante perceber o contributo dos enfermeiros de reabilitação na recuperação da pessoa em situação crítica. Metodologia: Estudo de caso do tipo descritivo de acordo com as guidelines do Case Report. Trata-se de uma pessoa do sexo masculino, com 67 anos, internado na medicina interna, área dedicada a COVID-19, com o diagnóstico de pneumonia por COVID-19. Os focos de atenção foram o autocuidado, a força muscular, o equilíbrio, a marcha, a ventilação, e a deglutição.  Face a estes focos foi delineado e implementado um plano de intervenção de acordo com a evolução da pessoa e posteriormente reavaliados os principais outcomes. Resultados: Com cinco dias de intervenção a pessoa, segundo a escala de Barthel melhorou de um score 5 para 65; Borg score de 8 para 3; FiO2 35% para 21%; Tinetti 0/0 para 11/9; força muscular medical research council (MRC) score 2 para 4 e gugging swallowing screen (GUSS) score 5 para 8. Discussão: O estudo de caso evidencia a necessidade e importância da implementação de um plano de cuidados adequados a cada pessoa, tendo por base critérios de segurança e progredindo conforme a tolerância da pessoa. Conclusão: Com as intervenções do Enfermeiro Especialista em enfermagem de Reabilitação é possível reduzir as sequelas decorrentes do internamento em UCI

Prime stime mediante simulazioni numeriche delle velocita' di lancio di ejecta allo stromboli e valutazioni sul rischio vulcanico indotto

The typical strombolian activity of Stromboli volcano ranges from a nearly continuous venting of ash and gases (normal strombolian activity) to moderate, up to violent explosive pulses (violent strombolian activity). Moreover, both regimes are sometimes punctuated without warning by phases of scaled up, distinct and more energetic huge bursts separated by time intervals ranging from minutes to hours (paroxysmal activity). As this eruptive style causes the blasting from the summit vents of hot fragments of new lava and blocks with different velocities, densities and impact sites, the main volcanic risk at Stromboli is related to the hazard due to ballistic showers of these ejecta on the built-up areas of the island (Stromboli and Ginostra villages). For that reason i) a land use map of the island has been produced and ii) a number of numerical simulations of ballistic trajectories for to constrain the velocity ranges of the three different explosive regimes has been performed with the "Eject!" software (L.G. Mastin, 2001) by using the average density of dense blocks (2800 kg/m3) and juvenile bombs (1970 kg/m3) from a set of 44 ejecta that we collected on the flanks of the volcano. The reliable ranges of initial velocity at the takeoff point (summit vents) that we obtained are: 40 m/s ÷ 60 m/s for normal strombolian activity, 70 m/s ÷ 100 m/s for violent strombolian activity and 120 m/s ÷ 200 m/s for paroxysmal strombolian activity. Without wind, the cross-correlation of the land use - velocity data indicates that both for the villages of Stromboli and Ginostra an ejecta impact probability is realistic only in paroxysmal activity periods, while it’s definitively absent during normal and violent strombolian regimes. Following tail-winds = 25 m/s simulations (wind velocity sometimes observed at the Stromboli island), the resulting hazard increases with respect to the tail-winds = 0 m/s simulations for both Stromboli and Ginostra during the paroxysmal regime, and become appreciable for the Ginostra village even during violent strombolian activity

Gli studenti portano la scienza nello Spazio

Il progetto XenoGRISS ha vinto il bando dell’Agenzia Spaziale Italiana (ASI) YiSS - Youth ISS Science 2019 ed è stato condotto sulla Stazione Spaziale Internazionale (ISS) dall’astronauta Luca Parmitano nel dicembre 2019 durante la missione "Beyond". XenoGRISS, che ha scopi sia scientifici che educativi, è stato progettato e presentato congiuntamente da ricercatori delle Università degli Studi di Milano e Firenze, da un gruppo di 9 studenti dell’ITIS A. Meucci di Firenze e da tre insegnanti dello stesso Istituto. Gli studenti sono stati coinvolti nello studio della crescita e della rigenerazione dei girini di Xenopus laevis in assenza di gravità e hanno affrontato sia gli aspetti scientifico-biologici dell'esperimento sia quelli tecnologici relativi all’hardware necessario al mantenimento dei girini per 30 giorni nello Spazio e alle rilevazioni scientifiche

Managing chronic myeloid leukemia for treatment-free remission: a proposal from the GIMEMA CML WP

Several papers authored by international experts have proposed recommendations on the management of BCR-ABL1+ chronic myeloid leukemia (CML). Following these recommendations, survival of CML patients has become very close to normal. The next, ambitious, step is to bring as many patients as possible into a condition of treatment-free remission (TFR). The Gruppo Italiano Malattie EMatologiche dell'Adulto (GIMEMA; Italian Group for Hematologic Diseases of the Adult) CML Working Party (WP) has developed a project aimed at selecting the treatment policies that may increase the probability of TFR, taking into account 4 variables: the need for TFR, the tyrosine kinase inhibitors (TKIs), the characteristics of leukemia, and the patient. A Delphi-like method was used to reach a consensus among the representatives of 50 centers of the CML WP. A consensus was reached on the assessment of disease risk (EUTOS Long Term Survival [ELTS] score), on the definition of the most appropriate age boundaries for the choice of first-line treatment, on the choice of the TKI for first-line treatment, and on the definition of the responses that do not require a change of the TKI (BCR-ABL1 6410% at 3 months, 641% at 6 months, 640.1% at 12 months, 640.01% at 24 months), and of the responses that require a change of the TKI, when the goal is TFR (BCR-ABL1 >10% at 3 and 6 months, >1% at 12 months, and >0.1% at 24 months). These suggestions may help optimize the treatment strategy for TFR

Inter-society consensus for the use of inhaled corticosteroids in infants, children and adolescents with airway diseases

Background: In 2019, a multidisciplinary panel of experts from eight Italian scientific paediatric societies developed a consensus document for the use of inhaled corticosteroids in the management and prevention of the most common paediatric airways disorders. The aim is to provide healthcare providers with a multidisciplinary document including indications useful in the clinical practice. The consensus document was intended to be addressed to paediatricians who work in the Paediatric Divisions, the Primary Care Services and the Emergency Departments, as well as to Residents or PhD students, paediatric nurses and specialists or consultants in paediatric pulmonology, allergy, infectious diseases, and ear, nose, and throat medicine. Methods: Clinical questions identifying Population, Intervention(s), Comparison and Outcome(s) were addressed by methodologists and a general agreement on the topics and the strength of the recommendations (according to the GRADE system) was obtained following the Delphi method. The literature selection included secondary sources such as evidence-based guidelines and systematic reviews and was integrated with primary studies subsequently published. Results: The expert panel provided a number of recommendations on the use of inhaled corticosteroids in preschool wheezing, bronchial asthma, allergic and non-allergic rhinitis, acute and chronic rhinosinusitis, adenoid hypertrophy, laryngitis and laryngospasm. Conclusions: We provided a multidisciplinary update on the current recommendations for the management and prevention of the most common paediatric airways disorders requiring inhaled corticosteroids, in order to share useful indications, identify gaps in knowledge and drive future research

The future of road transport

A perfect storm of new technologies and new business models is transforming not only our vehicles, but everything about how we get around, and how we live our lives. The JRC report “The future of road transport - Implications of automated, connected, low-carbon and shared mobility” looks at some main enablers of the transformation of road transport, such as data governance, infrastructures, communication technologies and cybersecurity, and legislation. It discusses the potential impacts on the economy, employment and skills, energy use and emissions, the sustainability of raw materials, democracy, privacy and social fairness, as well as on the urban context. It shows how the massive changes on the horizon represent an opportunity to move towards a transport system that is more efficient, safer, less polluting and more accessible to larger parts of society than the current one centred on car ownership. However, new transport technologies, on their own, won't spontaneously make our lives better without upgrading our transport systems and policies to the 21st century. The improvement of governance and the development of innovative mobility solutions will be crucial to ensure that the future of transport is cleaner and more equitable than its car-centred present.JRC.C.4-Sustainable Transpor

Neutralizing antibodies to Omicron after the fourth SARS-CoV-2 mRNA vaccine dose in immunocompromised patients highlight the need of additional boosters

IntroductionImmunocompromised patients have been shown to have an impaired immune response to COVID-19 vaccines.MethodsHere we compared the B-cell, T-cell and neutralizing antibody response to WT and Omicron BA.2 SARS-CoV-2 virus after the fourth dose of mRNA COVID-19 vaccines in patients with hematological malignancies (HM, n=71), solid tumors (ST, n=39) and immune-rheumatological (IR, n=25) diseases. The humoral and T-cell responses to SARS-CoV-2 vaccination were analyzed by quantifying the anti-RBD antibodies, their neutralization activity and the IFN-γ released after spike specific stimulation.ResultsWe show that the T-cell response is similarly boosted by the fourth dose across the different subgroups, while the antibody response is improved only in patients not receiving B-cell targeted therapies, independent on the pathology. However, 9% of patients with anti-RBD antibodies did not have neutralizing antibodies to either virus variants, while an additional 5.7% did not have neutralizing antibodies to Omicron BA.2, making these patients particularly vulnerable to SARS-CoV-2 infection. The increment of neutralizing antibodies was very similar towards Omicron BA.2 and WT virus after the third or fourth dose of vaccine, suggesting that there is no preferential skewing towards either virus variant with the booster dose. The only limited step is the amount of antibodies that are elicited after vaccination, thus increasing the probability of developing neutralizing antibodies to both variants of virus.DiscussionThese data support the recommendation of additional booster doses in frail patients to enhance the development of a B-cell response directed against Omicron and/or to enhance the T-cell response in patients treated with anti-CD20