39 research outputs found
Insights into the Genetic Architecture of Early Stage Age-Related Macular Degeneration: A Genome-Wide Association Study Meta-Analysis
- Author
- A Abdelsalam
- A Hofman
- A Muto
- A Ruiz i Altaba
- A Thakkinstian
- AC Bird
- Albert V. Smith
- Alex W. Hewitt
- Ananth Viswanathan
- André G. Uitterlinden
- AW Foong
- B Bhatia
- Barbara E. K. Klein
- Barbara McKnight
- Belinda K. Cornes
- BM Neale
- Bruce M. Psaty
- Caroline C. W. Klaver
- CC Clogg
- CC Klaver
- Ching Yu Cheng
- CJ Hammond
- Cornelia M. van Duijn
- D Harold
- David Siscovick
- DN Hu
- DT Bishop
- E. Shyong Tai
- EL Heinzen
- Elena Rochtchina
- Elizabeth G. Holliday
- Eric Boerwinkle
- FB Sallo
- Fridbert Jonasson
- Gabriëlle H. S. Buitendijk
- Gerald Liew
- Gudny Eiriksdottir
- H Nan
- IM Heiba
- Investigators The ARIC
- J Evans
- J Thornton
- Jerome I. Rotter
- JH Barrett
- Jie Jin Wang
- JJ Weiter
- JM Seddon
- JM Seddon
- JM Seddon
- Johannes R. Vingerling
- John Attia
- K Estrada
- Kent Taylor
- KH Wu
- L Ma
- Lenore Launer
- LJ Kopplin
- LP Fried
- LS Lim
- Mary Frances Cotch
- Michael Inouye
- NA Riobo
- P Mitchell
- P Sulem
- PA Raymond
- Patrick McElduff
- Paul Mitchell
- Paul N. Baird
- PI de Bakker
- PJ Francis
- PJ Francis
- PN Baird
- R Klein
- Richard A. Jensen
- RJ Klein
- RJ Pruim
- Rodney J. Scott
- Ronald Klein
- RP Middelberg
- RP Stokowski
- S Arakawa
- S Kim
- S Memoli
- S Schmidt
- S Seshadri
- S Zareparsi
- Sophia Xie
- SP Sundelin
- Tamara Harris
- TB Harris
- Thomas Lumley
- Thor Aspelund
- Tien Y. Wong
- Tin Aung
- U Chakravarthy
- U Friedrich
- U Schraermeyer
- Vilmundur Gudnason
- W Chen
- Wanting Tay
- Xiao-Ping Miao
- Xiaohui Li
- Xueling Sim
- Y Jin
- Y Li
- Y Yu
- Y Yu
- Y Zheng
- Yik Ying Teo
- YS Aulchenko
- YS Aulchenko
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2013
- Field of study
10.1371/journal.pone.0053830PLoS ONE81
BHPR research: qualitative1. Complex reasoning determines patients' perception of outcome following foot surgery in rheumatoid arhtritis
- Author
- Abernethy Veronica
- Abignano Giuseppina
- Abraham David
- Abraham David
- Abraham David J.
- Abraham Sonya
- Adams Jo
- Adams Jo
- Adshead Rebecca
- Ahmad Yasmeen A.
- Ahmed Tazeen J.
- Ainley Louise
- Al-Allaf Wahab
- Alber Catherine Fouad
- Alhusain Awal Z.
- Ali Fizzah
- Allen Roger
- Alston Claire
- Alton Peter
- Anderson Marina
- Appleton Louise H.
- Ariyo Mercy
- Aronson Diane
- Arthanari S.
- Atteno Mariangela
- Backhouse Michael R.
- Backhouse Michael R.
- Bacon Paul A.
- Bacon Pauline
- Baker Sarah
- Baker Sharon
- Baker Sharon
- Balarajah Sharmili
- Ball Elisabeth
- Baqai Charlotte
- Bari Farhan
- Barton Anne
- Benson Claire
- Berry Jacqueline
- Bertolino Arthur
- Betteridge Zoe
- Beutler Anna
- Beutler Anna
- Beynon Huw
- Bhaduri Mahua
- Birt Linda
- Black Carol M.
- Bombardieri Michele
- Boton-Maggs Ben
- Bourke Brian E.
- Bouças Sofia Barbosa
- Braun Jürgen
- Breslin Anne
- Briggs N.
- Brophy Richard
- Brophy Sinead
- Brown Diane
- Browne Hannah K.
- Bruce Ian
- Bruce Ian
- Brunner Hermine
- Buch Maya H.
- Buckley Christopher
- Bunn Chris
- Bunn Diane
- Burns James
- Cadman Susan
- Campbell Sophie
- Carroll Douglas
- Carroll Douglas
- Castiglione Fabiana
- Cavet Guy
- Chaitow Jeffrey
- Chamberlain Victoria A.
- Chan Marian
- Chard Michael
- Charles Peter
- Charleton Rebecca C.
- Charlton-Menys Valentine
- Chattopadhyay Chandrabhusan
- Chattopadhyay Chandrabhusan
- Chevance Aurelie
- Chighizola Cecilia
- Chowdhary Bhavani
- Choy Ernest
- Choy Ernest H.
- Ciurtin Coziana
- Ciurtin Coziana
- Clayton Ann M.
- Clemence Mark
- Clewes Adrian
- Coghlan Gerry
- Coghlan Gerry
- Cohen Carla J.
- Collins David
- Conaghan Philip
- Conaghan Philip
- Conaghan Philip
- Connor John
- Cook Haley
- Cooksey Roxanne
- Cooney Jennifer K.
- Coop Hazel
- Cope Andrew
- Cornell Patricia
- Cornell Tricia
- Costa Luisa
- Crooks Daniel
- Cuomo Giovanna
- Dabu Bogdan
- Dabu Mihaela
- Dahmen Georg
- Dale Rebecca M.
- Dario Di Minno M. N.
- Davies Helen
- Davies Rebecca
- Davies Ursula
- Dawson Julie
- De Benedetti Fabrizio
- De Lord Denise
- Del Galdo Francesco
- Dennis Michael S.
- Dennis Sean
- Denton Chris
- Denton Christopher P.
- Denton Christopher P.
- Denton Christopher P.
- Denton Christopher P.
- Denton Christopher P.
- Denton Christopher P.
- Derrett-Smith Emma
- Devlin Clare
- Dey Dzifa
- Di Cicco Maria
- Dimofte Ionela
- Dixon William
- Dobarro David
- Dobarro David
- Done John
- Donnelly Simon P.
- Dougados Maxime
- Douiri Abdel
- Drew Sarah
- Duddy Martin
- Dunkley Lisa
- Dunphy Juliet
- Dures Emma
- Durrington Paul
- Dyke Claire
- Dziedzic Krysia
- Edwards Elizabeth A.
- Ehrenstein Michael
- Ellegard Karen
- Emery Paul
- Emery Paul
- Emery Paul
- Emery Paul
- Emery Paul
- Ennis Holly
- Epis Oscar
- Espada Graciela
- Evans Rob
- Eyes Brian
- Farewell Daniel
- Farrar Claire
- Ferguson Anna M.
- Filer Andrew
- Fisher Ben
- Flato Berit
- Fleischmann Roy
- Flurey Caroline A.
- Foglia Francesca
- Fonseca Carmen
- Foo Joanne
- France Brisa
- France Brisa
- Freeman Tanya
- Freeston Jane
- Freeston Jane
- Furlong Anita
- Furlong Anita
- Galloway James
- Gathany Tim
- Gaywood Ian C.
- Genovese Mark C.
- George Malal Joby J.
- Giancola Giorgio
- Giles Ian
- Gill Rachel
- Gladman Dafna
- Gladman Dafna
- Gooberman-Hill Rachael
- Goodacre Lynne
- Goodfellow Rhian
- Gordhan Chandrika
- Gorodkin Rachel
- Grainger Andrew
- Greenhalgh Ann
- Greenwood James
- Greenwood Mandy
- Griffith Sian
- Griffiths Ann E.
- Griffiths Bridget
- Grover Bob
- Gsteiger Sandro
- Gullick Nicola J.
- Gullick Nicola J.
- Hadjinicolaou Andreas V.
- Hadjinicolaou Andreas V.
- Hale Elizabeth
- Hale Elizabeth D.
- Hall Frances C.
- Hall Frances C.
- Hall John
- Halls Serena
- Hamilton Jennifer
- Hamilton Jennifer
- Hammond Alison
- Han Chenglong
- Han Chenglong
- Han Chenglong
- Handler Clive
- Handler Clive
- Hands Rebecca
- Haney Doug
- Hanson Mark
- Haq Inam
- Haq Inam
- Hayes Janita
- Haywood Kirstie L.
- Heckaman Michele
- Heckaman Michele
- Helliwell Philip
- Helliwell Philip
- Hensor Elizabeth
- Hensor Elizabeth
- Herrick Ariane L.
- Herrick Ariane L.
- Hewlett Sarah
- Hewlett Sarah
- Heycock Carol
- Hill Ingrid
- Hill Ingrid
- Hislop Kelly
- Ho Pauline
- Hodgson Richard
- Holmes A.
- Horneff Gerd
- Howell Kevin
- Hoyles Rachel
- Hsia Elizabeth
- Hueber Wolfgang
- Hughes Gwenan
- Hughes Lyndsay
- Hughes Rod
- Humby Fran
- Hurley Mike
- Hyrich Kimme
- Hyrich Kimme
- Ibrahim Fowzia
- Iervolino Salvatore
- Ioannou John
- Irvine Elizabeth
- Isaacs Anthony
- Isaacs David
- Isaacs John
- Ishorari Jasmine
- Jack James
- Jenkins Jessica
- Jenkins Suzanne
- Jinks Clare
- Jinks Clare
- Jobanputra Paresh
- John Holly
- Jones Jeremy
- Jones Jeremy G.
- Jones Tadeusz
- Jordan Kelsey
- Jordan Kelvin P.
- Juneja Parmjit
- Kamath Sanjeet
- Karaderi Tugce
- Karaderi Tugce
- Kavanaugh Arthur
- Kavanaugh Arthur
- Keenan Anne-Maree
- Keenan Anne-Maree
- Keidel Sarah
- Keller Majella
- Kelly Clive
- Kelly Clive
- Kelly Stephen
- Kenwright Andrew
- Keystone Edward
- Khan Korsa
- Khan Korsa
- Khan Korsa
- Kiely Patrick D.
- Kiely Patrick D.
- Kingsley Gabrielle H.
- Kingsley Gabrielle H.
- Kirkham Bruce
- Kirkham Bruce W.
- Kirwan John
- Kitas George
- Kitas George D.
- Kitas George D.
- Kitas George D.
- Kraus Alexandra
- Krueger Gerald
- Landewé Robert
- Law Rebecca-Jane
- Law Rebecca-Jane
- Lawson Tom
- Lazarus Mark
- Leandro Maria
- Leask Andrew
- Lemmey Andrew
- Lempp Heidi
- Leone Francesca
- Leung Alexander
- Lille Kate
- Liu Shangxi
- Lloyd Mark
- Lloyd Mark
- Lofrano Mariana
- Lottay Neena
- Lovell Daniel
- Low Audrey
- Lunt Mark
- Lunt Mark
- Lynch Michael
- Ma Margaret H.
- Mack Michael
- Mackay Kirsten
- Maddison Peter
- Maddison Peter
- Maddison Peter J.
- Makadsi Raad
- Malaviya Anshuman P.
- Malaviya Anshuman P.
- Malik Saadia
- Malik Saadia
- Manning Joanne
- Markland David
- Martin James C.
- Martin Keith
- Martini Alberto
- McArthur Margaret
- McHugh Neil
- McHugh Neil
- McInnes Iain
- McInnes Iain
- McInnes Iain
- McKeeman Helen
- McKenna Frank
- McLaughlin Maeve
- McLoughlin YokeMei
- McNeilly Natasha E.
- Mease Philip
- Mease Philip
- Mease Philip
- Mercer Louise
- Mewar Devesh
- Mirjafari Hoda
- Moffat Claire
- Moinzadeh Pia
- Moinzadeh Pia
- Moore Jonathan P.
- Moore Owen
- Moore Tonia
- Morris Marianne
- Morris Vanessa
- Mudivarthy Surekha
- Muir Lindsay
- Munns Catherine
- Nandagudi Anupama
- Neville Cai
- Neville Cai
- Ng Nora
- Ngcozana Tanaka
- Nguyen Dianne
- Nightingale Peter
- Nihtyanova Svetlana
- Nisar M.
- Nisar Muhammad K.
- Nisar Muhammad K.
- Nordenskiold Ulla
- O'Connor Philip J.
- Ong Bie Nio
- Ong Voon
- Ong Voon
- Ong Voon
- Owen Pat
- Packham Jon
- Pande Ira
- Panthakalam Sathianathan
- Pardeo Manuela
- Parker Louise
- Parker S.
- Partlett Rosamund
- Patel Dipti
- Patterson Chris
- Pauling John
- Pauling John D.
- Pavey Chee
- Pease Colin T.
- Pease Emily E.
- Pellegrini Vincent
- Peluso Rosario
- Penn Henry
- Petford Sharon
- Pitzalis Costantino
- Pointon Jennifer J.
- Pointon Jennifer J.
- Pollard Louise C.
- Pollock Jon
- Pradère Marie-Josèphe
- Price Elizabeth
- Price Shyra
- Puntis Daniel
- Quest Enid
- Quinlan Tim M.
- Rahmeh Fouz
- Rajak Rizwan
- Rajak Rizwan
- Ramanujan Saroja
- Rankin Elizabeth
- Raut-Roy Dominique
- Redmond Anthony
- Redmond Anthony
- Reynolds John A.
- Rhodes Carol
- Rhys-Dillon Ceril
- Rhys-Dillon Ceril
- Richards Pam
- Richards Selwyn
- Richardson Ann
- Robinson Sandra M.
- Rodziewicz Mia
- Rose Katy
- Rosenberg William M.
- Rubbert-Roth Andrea
- Ruddlesden Michael
- Ruddlesden Michael
- Ruperto Nicola
- Russell Bridget
- Ryan Sarah
- Ryan Sarah
- Ryan Sarah
- Rynne Martin
- Sandhu Amrita
- Sandhu Virinderjit
- Sandoo Aamer
- Sandoo Aamer
- Sanyal Kaushik
- Saravanan Vadivelu
- Scali Juan
- Scarpa Raffaele
- Schneider Rayfel
- Schreiber Benjamin E.
- Schreiber Benjamin E.
- Schulze-Koops Hendrik
- Scott David
- Scott David L.
- Scott David L.
- Scott David L.
- Scott David L.
- Sebba Anthony
- Sen Debajit
- Sengupta Raj
- Sengupta Raj
- Shah Preeti
- Shattles Warren
- Shipley Mike
- Shiwen Xu
- Shiwen Xu
- Siebert Stefan
- Sieper Joachim
- Silman Alan
- Singh Animesh
- Smith Angela
- Smith H.
- Smith Jacqueline
- Smith Jacqueline
- Smith Jacqueline P.
- Soh Vicky
- Soscia Ernesto
- Spencer Simon
- Stratton Richard
- Stratton Richard
- Strickland Gemma
- Sykes Rebecca
- Symmons Deborah
- Symmons Deborah
- Taggart Allister
- Tahir Hasan
- Tak Paul P.
- Tandon Neeta
- Tanner Lorraine
- Tarzi Mike
- Taylor Peter
- Taylor Peter
- Tennant Alan
- Terslev Lene
- Thalayasingam Nishanthi
- Thom Jeanette
- Thom Jeanette M.
- Thom Jeanette M.
- Thomas Amanda
- Thomas Amanda
- Thomas Eleri
- Thomas Tasmin
- Thompson Katherine
- Thompson Liz
- Thompson Nicola
- Thwaites Catharine
- Tibble Jeremy
- Toberty Elizabeth
- Toms Tracey
- Toms Tracey E.
- Trehane Anne
- Treharne Gareth J.
- Turner Michael
- Turner-Cobb Julie
- Tyson Sarah
- Vail Andy
- Valentini Gabriele
- van der Heijde Desiree
- van der Heijde Désirée
- Van Vollenhoven Ronald
- van Zanten Jet J. Veldhuijzen
- Verstappen Suzanne M.
- Vinall Karen A.
- Wajed Julekha
- Wakefield Richard J.
- Walker David
- Wallis Dinny
- Wardle Phil
- Warrell Clare
- Warrell Clare E.
- Waterfield Jackie
- Watson Kath
- Watson Liam
- Westlake Sarah L.
- Westlake Sarah L.
- White Catherine
- White Derrick
- Wig Surabhi
- Wilby M. J.
- Wilkinson Kate
- Williams Ann
- Williamson Lyn
- Wilson Jo
- Wilson Oonagh
- Wincup Chris
- Winfield Rachel A.
- Wing Charlotte
- Winter Richard
- Wollenhaupt Jürgen
- Wong Henna
- Woo Patricia
- Wordsworth Bryan P.
- Wordsworth Bryan P.
- Wren Damian
- Wright Gary
- Xu Weichun
- Yau Wing Hoi
- Youll Matthew J.
- Young Adam
- Young Adam
- Zayat Ahmed S.
- Zilberstein Moshe
- Zouita Louisa
- Publication venue
- Publication date
- 02/08/2017
- Field of study
Background: Foot surgery is common in patients with RA but research into surgical outcomes is limited and conceptually flawed as current outcome measures lack face validity: to date no one has asked patients what is important to them. This study aimed to determine which factors are important to patients when evaluating the success of foot surgery in RA Methods: Semi structured interviews of RA patients who had undergone foot surgery were conducted and transcribed verbatim. Thematic analysis of interviews was conducted to explore issues that were important to patients. Results: 11 RA patients (9 ♂, mean age 59, dis dur = 22yrs, mean of 3 yrs post op) with mixed experiences of foot surgery were interviewed. Patients interpreted outcome in respect to a multitude of factors, frequently positive change in one aspect contrasted with negative opinions about another. Overall, four major themes emerged. Function: Functional ability & participation in valued activities were very important to patients. Walking ability was a key concern but patients interpreted levels of activity in light of other aspects of their disease, reflecting on change in functional ability more than overall level. Positive feelings of improved mobility were often moderated by negative self perception ("I mean, I still walk like a waddling duck”). Appearance: Appearance was important to almost all patients but perhaps the most complex theme of all. Physical appearance, foot shape, and footwear were closely interlinked, yet patients saw these as distinct separate concepts. Patients need to legitimize these feelings was clear and they frequently entered into a defensive repertoire ("it's not cosmetic surgery; it's something that's more important than that, you know?”). Clinician opinion: Surgeons' post operative evaluation of the procedure was very influential. The impact of this appraisal continued to affect patients' lasting impression irrespective of how the outcome compared to their initial goals ("when he'd done it ... he said that hasn't worked as good as he'd wanted to ... but the pain has gone”). Pain: Whilst pain was important to almost all patients, it appeared to be less important than the other themes. Pain was predominately raised when it influenced other themes, such as function; many still felt the need to legitimize their foot pain in order for health professionals to take it seriously ("in the end I went to my GP because it had happened a few times and I went to an orthopaedic surgeon who was quite dismissive of it, it was like what are you complaining about”). Conclusions: Patients interpret the outcome of foot surgery using a multitude of interrelated factors, particularly functional ability, appearance and surgeons' appraisal of the procedure. While pain was often noted, this appeared less important than other factors in the overall outcome of the surgery. Future research into foot surgery should incorporate the complexity of how patients determine their outcome Disclosure statement: All authors have declared no conflicts of interes
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
- Baptiste Pertrice
- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
- Barlow Karen
- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
- Beasley Helen
- Beasley Oliver
- Beaucham Leslie
- Beaudet Arthur
- Beck Alfred
- Beck Stephen
- Becker Michael
- Bell Emma
- Bell George I.
- Bellard Terell M.
- Bellerby Damian
- Bellerby Tristram
- Belter Edward A., Jr.
- Bemrose Richard
- Benard Michael Anthony
- BenKahla Alia
- Benke J
- Benner William
- Bennett James
- Bensasson Douda
- Bentley Andrew
- Bentley Dan
- Bentley David
- Berardinis Véronique de
- Bercovitz John
- Berghoff Amy
- Bergmann Anne
- Berkowicz Nicolas
- Berks Mary
- Berks Michael
- Bethel Graeme
- Beugelsdijk Tony J.
- Bhakta Rita
- Bhuchar Venita
- Bi Shihua
- Bian Xuemeng
- Bieri Tamberlyn
- Bimage Kesha E.
- Bird Christine
- Birditt Brian
- Birney Ewan
- Birney Ewan
- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
- Black Stacey
- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
- Blanks Tia
- Blasiar Darin
- Blazej Robert
- Blitshsteyn Berta
- Blomstrom David B.
- Bloom Scott
- Bloom Toby
- Blumer Heather
- Blye Jason
- Blyth Peter R.
- Blöcker Helmut
- Boatright Elizabeth
- Boehm John
- Boen Juanan
- Boguslavskiy Leonid
- Bolton Christel
- Bolund Lars
- Bondoc Marnel
- Bonfield James
- Bonnett Ralph
- Bonnin David
- Border Richard
- Borowsky Mark
- Borzym Katja
- Boukhgalter Boris
- Bowen Eric
- Bradley Amanda
- Bradshaw-Cordum Holly
- Brady Nicola
- Brandriff Brigitte F.
- Brannon Wade
- Branscomb Elbert
- Bray Jason
- Bray-Allen Sarah
- Brettin Thomas
- Bridgeman Anne
- Bridgers Michael
- Brimhall Angela K.
- Brokstein Peter
- Brook Jonathan
- Brooking Shane
- Brottier Philippe
- Brown Andrew
- Brown Clive
- Brown Jacqui
- Brown Margaret
- Brown Mary
- Brown Mary J.
- Brown Michael
- Brown Nancy C.
- Bruce David D.
- Bruce Robert
- Bruno William J.
- Bruskiewich Richard
- Bryant Jackie
- Bryant Jennifer E.
- Bryant Nathaniel P.
- Brüls Thomas
- Buatsi Delali
- Buck David
- Buckingham Judith M.
- Buckle Veronica
- Buczek Donald
- Budd Claire
- Buhay Christian J.
- Bulbul Kerem
- Buller Sarah
- Bunker Nathan
- Burberry Jill
- Burch Paula Ellen
- Burford Deborah
- Burgess Joanne
- Burgin Matt
- Burkett Carrie E.
- Burkhart-Schultz Karolyn
- Burrell Kevin L.
- Burrill Wayne
- Burrows Christine
- Burton Christine
- Burton John
- Butcher Phil
- Butler Adam
- Butler Jon
- Butler Paul
- Caenepeel Sean
- Cahill Patrick
- Cai Tianjing
- Cai Zhen
- Cairns Murray
- Calderon Eliana
- Callen David F.
- Camarata Jody
- Camire David
- Camm Nick
- Campbell Christopher
- Campbell Connie S.
- Campbell Evelyn W.
- Campbell Mary I.
- Campbell Mary L.
- Campo Kevin
- Canning Bruno
- Cao Ting
- Cao Yuzhu
- Caoile Chenier
- Cardenas Faviola
- Cardenas Lolo
- Cardenas Veronica
- Carder Carol
- Carder Paul
- Carpenter Kelly
- Carrano Anthony V.
- Carriere Jason
- Carter Jason
- Carter Kelvin
- Carter Nigel
- Caruso Lauren
- Casias Kristal
- Cattolico Laurence
- Cavanna Tamara
- Cavazos Iracema
- Cavazos Sandra R.
- Ceasar Heather
- Cedroni Maria
- Cepeda Mario
- Chacko Joseph
- Chain Patrick
- Chalk Shani
- Challacombe Jean F.
- Chan Ka
- Chan Sheryl N.
- Chan Yee Man
- Chang Jean L.
- Chapman Jarrod
- Chapman Joanna
- Chapple Jeffrey
- Charles Rachel
- Chasteen Leslie A.
- Chavarria Simeon
- Chazaro Bruno
- Chen Baoxian
- Chen Bin
- Chen Chira
- Chen Chong
- Chen Chong
- Chen Chun-Nan
- Chen Cong
- Chen Ellson
- Chen Hsiu-Chuan
- Chen Jianlong
- Chen Jie
- Chen Jin
- Chen Junbao
- Chen Lihong
- Chen Lixia
- Chen Ray
- Chen Shu
- Chen Tong
- Chen Xiaoyun
- Chen Xinyi
- Chen Yanjiong
- Chen Yiyu
- Chen Zhu
- Chen Zhu
- Chen Zhu
- Cheng Jan-Fang
- Cheng Zhihua
- Chertkov Olga
- Cheshatsang Yama
- Chi Cheng
- Chi Han C.
- Chillingworth Neil
- Chin Sylvia
- Chinn Corey
- Chinwalla Asif
- Chissoe Stephanie
- Chiu Sally
- Chothia Tom
- Christensen Mari
- Christopoulos Constantine
- Chu Joseph
- Chui Connie
- Chung A
- Cinkowsky Michael J.
- Citroen Mieke
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- Cox Caroline D.
- Cox Tony
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- Coyle Marcus D.
- Craig Matthew
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- Curran Adam
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- Cutts Jeffrey
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- D\u27Souza Lisa Marie
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- Daum Christopher
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- Dawson Elisabeth
- De Anda Claudia
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- DeArellano Kurt
- Deaven Larry I.
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- Griffiths Coline
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- Hitchens Matthew Edward
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- Mercado Iracema C.
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- Motoyama Ayuko
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- Wyatt Julia
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- Xi Yan
- Xi Yingying
- Xie Fei
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- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
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- Xu Wei
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- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
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- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
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- Yang Huanming
- Yang Huanming
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- Yao Zhijian
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- Ye Chen
- Yeager Shane
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- Yokobata Kathy
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- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
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- Wei Spencer
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- Weiner David
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- Weinstein Gregory
- Weiss Christian
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- Wennerberg Erik
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- Wittig Burghardt
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolfreys Alison
- Won Haejung
- Wong Chihunt
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- Wong Gabriel
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- Woodside Darren G
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- Yadav Mahesh
- Yagiz Kader
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- Ylösmäki Erkko
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- Young Steve W
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- Zafar Sadia
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zappasodi Roberta
- Zappasodi Roberta
- Zauderer Maurice
- Zeh Herbert
- Zelenetz Andrew D
- Zeng Weiping
- Zeng Xue
- Zha Yuanyuan
- Zhang Danhui
- Zhang Jing
- Zhang Ping
- Zhang Qifang
- Zhang Shannon S
- Zhang Theresa
- Zhang Winter
- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
- Alomar Osama
- Alonso Jesús Aarón Martínez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alonso Veronica
- Alqallaf Abdullah
- Alqaseer Asma
- Alrayes Bourhan
- Alsefri Maryam
- Alser Osaid
- Alsharif Mohammed
- Alsori Mohamed
- Altaf Abdulmalik
- Altinel Yuksel
- Altiner Saygin
- Altouny Ahmad
- Altun Demet
- Alvarez Natalia
- Alvarez-Lozada Luis Adrian
- Alvi Abdul
- Alwael Athari
- Alwash Mohammed
- Alyami Ziyad
- Alyousef Mohammed
- Alzahrani Saud
- Alzerwi Nasser
- Amin Shivang
- Amir Mohammed
- Ammar Ahmed Siddique
- Ammendola Michele
- Amores Remedios Revilla
- Amrayev Sultan
- Anastasiadou Sofia
- Ancans Guntis
- Anderson Caroline
- Andreani Lorenzo
- Andreotti Dario
- Andreuccetti Jacopo
- Andrianakis Alexandros
- Andro Christophe
- Anesi Alexandre
- Angamuthu Stephen
- Angeles Martina Aida
- Angelico Roberta
- Angelis Fragkiskos
- Angelou Dimitrios
- Angelou Kyveli
- Angulo Victor Pinto
- Anjum Arfa
- Anjum Muhammad Ayyub
- Annicchiarico Alfredo
- Anoldo Pietro
- Ansaloni Luca
- Anthoulakis Christos
- Antonelli Amedeo
- Anwar Mohamed
- Anwar Sumadi Lukman
- Anwer Mariyah
- Anyanwu Lofty-John
- Apostolou Christos
- Apostolou Konstantinos
- Appiah-Kubi Adu
- Aprea Giovanni
- Arbab Hana
- Archer James
- Ardura Francisco
- Aremu Muyiwa
- Arif Tahera
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- Armatura Giulia
- Armijos Daniel
- Arnaout Ali
- Arnaoutoglou Eleni
- Arnaud Alexis P.
- Arneja Jugpal
- Arrangoiz Rodrigo
- Arshad Muhammad
- Arthur Joshua
- Ashcroft James
- Ashford Bruce
- Ashraf Fariha
- Asiimwe Daniel
- Asirifi Samuel Amoako
- Asla Amir
- Aslam Ramisha
- Aspide Raffaele
- Ataya Karim
- Ateca Ibabe Villalabeitia
- Atici Semra Demirli
- Atis Gokhan
- Atkins William
- Atkinson Kate
- Attwood Joseph
- Auerkari Aino
- Augestad Knut Magne
- Augustin Goran
- Aujayeb Avinash
- Avella Pasquale
- Awad Ahmed K.
- Awad Hadeel
- Awad Rabih
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- Aydin Yener
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- Azab Ahmed
- Azami Rizwan
- Azize Diallo Abdoul
- Azzam Ahmed Y.
- Azzis Olivier
- Baba Yabasin Iddrisu
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- Baduell Albert
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- Bahrami-Hessari Michael
- Baia Marco
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- Baiocchi Glauco
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- Bajaj Ankur
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- Balagobi Balasingam
- Balasubramanian Ishwarya
- Balduzzi Alberto
- Baldwin Alexander
- Balla Andrea
- Balogh Zsolt J.
- Balogun James A.
- Balogun Simon
- Baloyiannis Ioannis
- Ban Vin Shen
- Bandyopadhyay Samik Kumar
- Bandyopadhyay Soham
- Banerjee Sumit
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- Banky Balazs
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- Barberis Andrea
- Barbosa-Breda Joao
- Bareka Metaxia
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- Barlas Aziz Mutlu
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- Kauppila Joonas H
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- Kealey Joshua
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- Tuyishime Eugene
- Tzelves Lazaros
- Tzima Ioanna
- Tzimas George
- Ubiali Paolo
- Ubom Akaninyene Eseme
- Ugwu Aloy Okechukwu
- Ugwu Ebere
- Ugwu Ifeanyichukwu
- Ul Huda Maria Noor
- Ulas Ali Bilal
- Uldry Emilie
- Ulgur Hanife Seyda
- Ulkucu Attila
- Ulman Elif Akbas
- Ulman Hilmican
- Ulutaş Mehmet Eşref
- Underwood Kirk
- Unsworth Richard
- Uprak Tevfik Kivilcim
- Urriza Pablo Vallés
- Usman Muhammad
- Usman Mustapha Ibrahim
- Vaassen Lauretta
- Vaccara Vincenzo La
- Vagena Xanthoula
- Vagge Aldo
- Vailas Michail
- Valadez Andrea Estefania Cueto
- Valadez Tania Abigail Cueto
- Valanci Sofia
- Valdespino Cristina Puentes
- Valeanu Liana
- Valioulis Ioannis
- Valladares Sergio Chávez
- Vallve-Bernal Marc
- Van Acker Jill
- Van Den Eynde Jef
- Van Goor Harry
- Van Vliet Helen
- Van Wyk Naomi Natasha
- Vanni Camilla
- Vas Aurelia
- Vasarhelyi Edward
- Vaschetti Roberto
- Vassiliu Panteleimon
- Vatansever Dogan
- Vatish Jamie
- Vaughan-Shaw Peter G.
- Vaysburg Dennis
- Veglia Antonella
- Velten Markus
- Velázquez Maria Jose Martinez
- Venkatappa Sunil Kumar
- Venketeswaran Meenakshi
- Venskutonis Donatas
- Verbic Milena Senica
- Verdi Daunia
- Vergara-Fernandez Omar
- Verhoeff Kevin
- Veroux Massimiliano
- Verras Georgios-Ioannis
- Verre Luigi
- Vida Lucian
- Vidya Raghavan
- Viglietta Edoardo
- Vijay Vardhini
- Vijgen Guy
- Vilaró Blanca Capdevila
- Villanueva Julio
- Vilz Tim O.
- Vincent Elizabeth
- Vinci Danilo
- Viola Simona
- Violante Tommaso
- Vishnoi Jeewan Ram
- Vissapragada Ravi
- Vivancos Laura Guillamon
- Vives Josep Maria Muñoz
- Vizzielli Giuseppe
- Vohra Lubna
- Vokshi Ismail
- Vosinakis Christos
- Vásquez Javier Alberto Gutiérrez
- Vázquez Gil
- Vázquez Irene Ortega
- Vǎcǎraşu Andrei Bogdan
- Wade Ryckie
- Wafi Omar
- Wagner Gabriela
- Wallis Christopher
- Wanjara Samuel
- Waqar Shahzad Hussain
- Warden Claire
- Warner Christian
- Wasim D.
- Wason Shaun
- Wasserman Isaac
- Watcyn-Jones Tom
- Waterson Ben
- Watson David
- Watson Matthew
- Weber Clemens
- Wheatstone P.
- Wheeler James
- Wheldon Luke
- White Michelle
- White Stuart
- White William
- Wickramasinghe Dakshitha
- Widmer Lukas Werner
- Wiedemann Dominik
- Wiesinger Clemens Georg
- Wijekoon Naveen
- Wijenayake Wasantha
- Wijeyaratne Manuk
- Wijeysundera Duminda
- Wiles Matthew
- Wilkin Richard
- Wilkins Alex
- Wilkins James
- William Tinka George
- Williams Omolara Modupe
- Williams Shekinah
- Windsor John
- Winnand Philipp
- Wittmann Maria
- Wolde Amanuel
- Wolfenden John W. D.
- Wong Benjamin Ngie Xiong
- Wong Enoch
- Wong Evan G.
- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
- Wu Fiona
- Wurm Markus
- Xenaki Sofia
- Yadev Ip
- Yahaya Ahmad Shuib
- Yakubu Mustapha
- Yang Wah
- Yanik Özge
- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Organic metals : studies related to the synthesis of acceptors derived from TCNQ
- Author
- Publication venue
- University of British Columbia Press
- Publication date
- 01/01/1979
- Field of study
Since a report that the complex of TTF.TCNQ showed novel solid state properties including high room temperature conductivity, there has been considerable interest in the study of these so called "organic metals." This thesis describes the synthesis of new acceptors derived from TCNQ. First the synthesis of 2-methoxycarbonyl-7,7,8,8-tetracyanoquino-dimethane (56) is presented. Bromination of methyl 2,5-dimethylbenzoate followed by treatment with sodium cyanide yielded the dicyano compound 60 which was converted to the dihydro-TCNQ 62 via the corresponding phenylenetetracyanodiacetate intermediate. Oxidation of 62 afforded 2-methoxycarbonyl-7,7,8,8-tetracyanoquinodimethane (56), which was found to be unstable. The synthesis of 2,3-dimethoxycarbonyl-7,7,8,8-tetra-cyanoquinodimethane was attempted in the following manner: the Diels-Alder cyclization of trans,trans-2,4-hexadiene and dimethyl acetylenedi-carboxylate followed by dehydrogenation of the adduct gave dimethyl 3,6-dimethylphthalate. Benzylic bromination of this material followed by displacement of the bromines by cyanide yielded the dicyano compound 73. However, several attempts to convert 73 to the corresponding tetraester 78 were unsuccessful.
The synthesis of 2,3-dimethyl-7,7,8,8-tetracyanoquinodimethane is presented. The intermediate 2,3-dimethylcyclohexane-l,4-dione (87) was prepared from 2,3-dimethylphenol by standard means. It was then condensed with malononitrile, and the product was treated with bromine/pyridine to give the dihydro-DMTCNQ 89. When this compound was treated with a mixture of palladium and sulfur at 180°C the desired 2,3-dimethyl-TCNQ 83 was obtained in low yield.
The second part of this thesis describes the preparation of 11,11, 12 ,12-tetracyano-4,5,9,10-tetrahydropyreno-2,7-quinodimethane (TCNTP) from mesitylene. This compound was bisbrominated to give 3,5-bis-(bromomethyl)toluene, which was then coupled with 3,5-bis(mercaptomethyl)-toluene to produce the dithia[3.3jmetacyclophane 98. This was converted to the dimethyl[2.2]metacyclophane 96 via Wittig rearrangement followed by reduction with lithium in liquid ammonia. This cyclophane was then brominated and the resulting dibromo compound was converted to the corresponding dicyano-94. The latter compound was treated with bromine in the presence of iron powder to produce 2,7-bis(cyanomethyl)-4,5,9,10-tetrahydropyrene. Introduction of the remaining two nitrile groups was accomplished via use of the tetracyanodiacetate intermediate 92. Hydrolysis and decarboxylation of 92 followed by oxidation with NBS/triethylamine at -78°C furnished the desired TCNTP (90).Science, Faculty ofChemistry, Department ofGraduat
Monsanto, PCBs, and the creation of a “world-wide ecological problem”
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Ventilatory Constraints During Exercise in Patients With Chronic Heart Failure
- Author
- Ainsworth
- Borg
- Bruce D. Johnson
- Cabanes
- Chiba
- Clark
- Collins
- Crapo
- Duguet
- Faggiano
- Fink
- Gerald T. Gau
- Hammond
- Harms
- Hosenpud
- Ingram
- Johnson
- Johnson
- Johnson
- Johnson
- Johnson
- Kathy A. O'Malley
- Kenneth C. Beck
- Killian
- Knudson
- Lyle J. Olson
- Mancini
- Mancini
- Mancini
- McParland
- Milani
- Miller
- Musch
- O'Donnell
- Paintal
- Petermann
- Ray W. Squires
- Remetz
- Saxton
- Sullivan
- Thomas G. Allison
- Triebwasser
- Tzelepis
- Vinegar
- Weber
- Younes
- Younes
- Publication venue
- 'American College of Chest Physicians'
- Publication date
- Field of study
Larvicidal, Antimycobacterial and Antifungal Compounds from the Bark of the Peruvian Plant Swartzia polyphylla DC
- Author
- Ahmad I. Beg A. Z.
- Betty Bustamante
- Caviedes L. Delgado J., Gilman R.
- Chalchat J. C. Garry R. P., Michet
- de Hoog G. S. Guarro J., Gen&e
- Gerald Bruce Hammond
- Hufford C. D. Funderburk J. M., Mo
- Irma Fernádez
- Lewis W. H.
- Lewis W. H.
- Luz Caviedes
- Neto C. C. Owens C. W., Langfield
- Olga Lock
- OSAWA K
- Palmira Ventosilla
- Robert Henry Gilman
- Rojas R. Bustamante B., Bauer J.,
- Rosario Rojas
- Publication venue
- 'Pharmaceutical Society of Japan'
- Publication date
- 01/01/2006
- Field of study
Correction: Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation In Vivo
- Author
- Albert Hofman
- Albert Vernon Smith
- Alex W. Hewitt
- Andre G. Uitterlinden
- Annie K. McAuley
- Barbara E. K. Klein
- Barbara McKnight
- Bruce M. Psaty
- Ching-Yu Cheng
- Christopher J. Hammond
- Cornelia M. van Duijn
- David A. Mackey
- David S. Siscovick
- E. Shyong Tai
- Elizabeth G. Holliday
- Eric Boerwinkle
- F. M. Amirul Islam
- Fernando Rivadeneira
- Fridbert Jonasson
- Gerald Liew
- Global BPgen Consortium
- Gudny Eiriksdottir
- Jerome I. Rotter
- Jie Jin Wang
- Johannes R. Vingerling
- John Attia
- Josh C. Bis
- Kent D. Taylor
- Kerri L. Wiggins
- Lenore J. Launer
- Linda Kao
- M. Arfan Ikram
- M. Kamran Ikram
- Mary Frances Cotch
- Monique M. B. Breteler
- Nicholas G. Martin
- Nicole L. Glazer
- Ning Cheung
- Paul Mitchell
- Paulus T. V. M. de Jong
- Quansheng Xi
- Richard A. Jensen
- Rodney J. Scott
- Ronald Klein
- Samantha Fahy
- Stuart MacGregor
- Sudha K. Iyengar
- Susan R. Heckbert
- Tamara B. Harris
- Terri L. Young
- Theru A. Sivakumaran
- Thomas Lumley
- Thor Aspelund
- Tien Y. Wong
- Toby Andrew
- Vilmundur Gudnason
- Xiaohui Li
- Xueling Sim
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/11/2010
- Field of study