Endemic mycosis

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Altered locus coeruleus–norepinephrine function following single prolonged stress

Data from preclinical and clinical studies have implicated the norepinephrine system in the development and maintenance of post‐traumatic stress disorder. The primary source of norepinephrine in the forebrain is the locus coeruleus ( LC ); however, LC activity cannot be directly measured in humans, and previous research has often relied upon peripheral measures of norepinephrine to infer changes in central LC –norepinephrine function. To directly assess LC –norepinephrine function, we measured single‐unit activity of LC neurons in a validated rat model of post‐traumatic stress disorder – single prolonged stress ( SPS ). We also examined tyrosine hydroxylase mRNA levels in the LC of SPS and control rats as an index of norepinephrine utilisation. For electrophysiological recordings, 92 LC neurons were identified from 19 rats ( SPS , 12; control, 7), and spontaneous and evoked responses to a noxious event (paw compression) were recorded. Baseline and restraint stress‐evoked tyrosine hydroxylase mRNA expression levels were measured in SPS and control rats ( n  = 16 per group) in a separate experiment. SPS rats showed lower spontaneous activity but higher evoked responses, leading to an enhanced signal‐to‐noise ratio of LC neurons, accompanied by impaired recovery from post‐stimulus inhibition. In concert, tyrosine hydroxylase mRNA expression in the LC of SPS rats tended to be lower at baseline, but was exaggerated following restraint stress. These data demonstrate persistent changes in LC function following stress/trauma in a rat model of post‐traumatic stress, as measured by differences in both the electrophysiological properties of LC neurons and tyrosine hydroxylase mRNA transcription. Single unit activity of LC neurons and TH mRNA levels were measured in the S ingle P rolonged S tress model of P ost‐traumatic stress disorder. SPS decreased rates of spontaneous discharge, exaggerated phasic responses of LC neurons and augmented stress‐enhanced TH mRNA expression. These data demonstrate sustained LC ‐ NE system abnormalities in SPS , providing an opportunity to study the interaction between LC ‐ NE system, and other PTSD ‐like physiological and behavioral changes seen in this model.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97273/1/ejn12095.pd

Measurements of Secondary Cosmic Microwave Background Anisotropies with the South Pole Telescope

We report cosmic microwave background (CMB) power spectrum measurements from the first 100 sq. deg. field observed by the South Pole Telescope (SPT) at 150 and 220 GHz. On angular scales where the primary CMB anisotropy is dominant, ell ~< 3000, the SPT power spectrum is consistent with the standard LambdaCDM cosmology. On smaller scales, we see strong evidence for a point source contribution, consistent with a population of dusty, star-forming galaxies. After we mask bright point sources, anisotropy power on angular scales of 3000 50 at both frequencies. We combine the 150 and 220 GHz data to remove the majority of the point source power, and use the point source subtracted spectrum to detect Sunyaev-Zel'dovich (SZ) power at 2.6 sigma. At ell=3000, the SZ power in the subtracted bandpowers is 4.2 +/- 1.5 uK^2, which is significantly lower than the power predicted by a fiducial model using WMAP5 cosmological parameters. This discrepancy may suggest that contemporary galaxy cluster models overestimate the thermal pressure of intracluster gas. Alternatively, this result can be interpreted as evidence for lower values of sigma8. When combined with an estimate of the kinetic SZ contribution, the measured SZ amplitude shifts sigma8 from the primary CMB anisotropy derived constraint of 0.794 +/- 0.028 down to 0.773 +/- 0.025. The uncertainty in the constraint on sigma8 from this analysis is dominated by uncertainties in the theoretical modeling required to predict the amplitude of the SZ power spectrum for a given set of cosmological parameters.Comment: 28 pages, 11 figures, submitted to Ap

Was Adam Smith an individualist?

Smith is generally regarded as an individualist without qualification. This article argues that his predominantly individualist policy prescription is rooted in a more complex philosophy. He sees nature, including human nature, as a vast machine supervised by God and designed to maximize human happiness. Human weaknesses, as well as strengths, display the wisdom of God and play their part in this scheme. While Smith pays lip-service to justice, it is really social order that preoccupies him, and, within that, the defence of property. Individuals are valued as bearers of property. As persons, individuals are deceived by nature into acting in a socially beneficial way. In different ways Smith systematically denies the autonomy of the individual with respect to the whole of which he or she is part. For Smith, individual liberty is not the end, but the means, of sustaining social order and property

Vegetation demographics in Earth System Models: A review of progress and priorities

Numerous current efforts seek to improve the representation of ecosystem ecology and vegetation demographic processes within Earth System Models (ESMs). These developments are widely viewed as an important step in developing greater realism in predictions of future ecosystem states and fluxes. Increased realism, however, leads to increased model complexity, with new features raising a suite of ecological questions that require empirical constraints. Here, we review the developments that permit the representation of plant demographics in ESMs, and identify issues raised by these developments that highlight important gaps in ecological understanding. These issues inevitably translate into uncertainty in model projections but also allow models to be applied to new processes and questions concerning the dynamics of real-world ecosystems. We argue that stronger and more innovative connections to data, across the range of scales considered, are required to address these gaps in understanding. The development of first-generation land surface models as a unifying framework for ecophysiological understanding stimulated much research into plant physiological traits and gas exchange. Constraining predictions at ecologically relevant spatial and temporal scales will require a similar investment of effort and intensified inter-disciplinary communication

Capturing health and eating status through a nutritional perception screening questionnaire (NPSQ9) in a randomised internet-based personalised nutrition intervention : the Food4Me study

BACKGROUND: National guidelines emphasize healthy eating to promote wellbeing and prevention of non-communicable diseases. The perceived healthiness of food is determined by many factors affecting food intake. A positive perception of healthy eating has been shown to be associated with greater diet quality. Internet-based methodologies allow contact with large populations. Our present study aims to design and evaluate a short nutritional perception questionnaire, to be used as a screening tool for assessing nutritional status, and to predict an optimal level of personalisation in nutritional advice delivered via the Internet. METHODS: Data from all participants who were screened and then enrolled into the Food4Me proof-of-principle study (n = 2369) were used to determine the optimal items for inclusion in a novel screening tool, the Nutritional Perception Screening Questionnaire-9 (NPSQ9). Exploratory and confirmatory factor analyses were performed on anthropometric and biochemical data and on dietary indices acquired from participants who had completed the Food4Me dietary intervention (n = 1153). Baseline and intervention data were analysed using linear regression and linear mixed regression, respectively. RESULTS: A final model with 9 NPSQ items was validated against the dietary intervention data. NPSQ9 scores were inversely associated with BMI (β = -0.181, p < 0.001) and waist circumference (Β = -0.155, p < 0.001), and positively associated with total carotenoids (β = 0.198, p < 0.001), omega-3 fatty acid index (β = 0.155, p < 0.001), Healthy Eating Index (HEI) (β = 0.299, p < 0.001) and Mediterranean Diet Score (MDS) (β = 0. 279, p < 0.001). Findings from the longitudinal intervention study showed a greater reduction in BMI and improved dietary indices among participants with lower NPSQ9 scores. CONCLUSIONS: Healthy eating perceptions and dietary habits captured by the NPSQ9 score, based on nine questionnaire items, were associated with reduced body weight and improved diet quality. Likewise, participants with a lower score achieved greater health improvements than those with higher scores, in response to personalised advice, suggesting that NPSQ9 may be used for early evaluation of nutritional status and to tailor nutritional advice. TRIAL REGISTRATION: NCT01530139 .Peer reviewedFinal Published versio

Angular Power Spectra of the Millimeter Wavelength Background Light from Dusty Star-forming Galaxies with the South Pole Telescope

We use data from the first 100 square-degree field observed by the South Pole Telescope (SPT) in 2008 to measure the angular power spectrum of temperature anisotropies contributed by the background of dusty star-forming galaxies (DSFGs) at millimeter wavelengths. From the auto and cross-correlation of 150 and 220 GHz SPT maps, we significantly detect both Poisson distributed and, for the first time at millimeter wavelengths, clustered components of power from a background of DSFGs. The spectral indices between 150 and 220 GHz of the Poisson and clustered components are found to be 3.86 +- 0.23 and 3.8 +- 1.3 respectively, implying a steep scaling of the dust emissivity index beta ~ 2. The Poisson and clustered power detected in SPT, BLAST (at 600, 860, and 1200 GHz), and Spitzer (1900 GHz) data can be understood in the context of a simple model in which all galaxies have the same graybody spectrum with dust emissivity index of beta = 2 and dust temperature T_d = 34 K. In this model, half of the 150 GHz background light comes from redshifts greater than 3.2. We also use the SPT data to place an upper limit on the amplitude of the kinetic Sunyaev-Zel'dovich power spectrum at l = 3000 of 13 uK^2 at 95% confidence.Comment: 18 pages, 9 figure

Extragalactic millimeter-wave sources in South Pole Telescope survey data: source counts, catalog, and statistics for an 87 square-degree field

We report the results of an 87 square-degree point-source survey centered at R.A. 5h30m, decl. -55 deg. taken with the South Pole Telescope (SPT) at 1.4 and 2.0 mm wavelengths with arc-minute resolution and milli-Jansky depth. Based on the ratio of flux in the two bands, we separate the detected sources into two populations, one consistent with synchrotron emission from active galactic nuclei (AGN) and one consistent with thermal emission from dust. We present source counts for each population from 11 to 640 mJy at 1.4 mm and from 4.4 to 800 mJy at 2.0 mm. The 2.0 mm counts are dominated by synchrotron-dominated sources across our reported flux range; the 1.4 mm counts are dominated by synchroton-dominated sources above ~15 mJy and by dust-dominated sources below that flux level. We detect 141 synchrotron-dominated sources and 47 dust-dominated sources at S/N > 4.5 in at least one band. All of the most significantly detected members of the synchrotron-dominated population are associated with sources in previously published radio catalogs. Some of the dust-dominated sources are associated with nearby (z << 1) galaxies whose dust emission is also detected by the Infrared Astronomy Satellite (IRAS). However, most of the bright, dust-dominated sources have no counterparts in any existing catalogs. We argue that these sources represent the rarest and brightest members of the population commonly referred to as sub-millimeter galaxies (SMGs). Because these sources are selected at longer wavelengths than in typical SMG surveys, they are expected to have a higher mean redshift distribution and may provide a new window on galaxy formation in the early universe.Comment: 35 emulateapj pages, 12 figures, 5 table

Sunyaev-Zel'dovich Cluster Profiles Measured with the South Pole Telescope

We present Sunyaev-Zel'dovich measurements of 15 massive X-ray selected galaxy clusters obtained with the South Pole Telescope. The Sunyaev-Zel'dovich (SZ) cluster signals are measured at 150 GHz, and concurrent 220 GHz data are used to reduce astrophysical contamination. Radial profiles are computed using a technique that takes into account the effects of the beams and filtering. In several clusters, significant SZ decrements are detected out to a substantial fraction of the virial radius. The profiles are fit to the beta model and to a generalized NFW pressure profile, and are scaled and stacked to probe their average behavior. We find model parameters that are consistent with previous studies: beta=0.86 and r_core/r_500 = 0.20 for the beta model, and (alpha, beta, gamma, c_500)=(1.0,5.5,0.5,1.0) for the generalized NFW model. Both models fit the SPT data comparably well, and both are consistent with the average SZ profile out to the virial radius. The integrated Compton-y parameter Y_SZ is computed for each cluster using both model-dependent and model-independent techniques, and the results are compared to X-ray estimates of cluster parameters. We find that Y_SZ scales with Y_X and gas mass with low scatter. Since these observables have been found to scale with total mass, our results point to a tight mass-observable relation for the SPT cluster survey.Comment: 21 pages, 24 figures, updated to published versio