Validación de la determinación cualitativa y cuantitativa de metanol en bebidas alcohólicas: un enfoque docente

Este trabajo se presenta como propuesta de proyecto de validación en un curso experimental universitario la “Determinación de metanol en bebidas alcohólicas”, abordada desde dos enfoques el cualitativo y el cuantitativo. Los resultados obtenidos mostraron que las metodologías presentadas son viables para poder emplearla en la enseñanza de validación de métodos analíticos, de una forma que sea accesible, eficiente, económica, donde se muestra la información necesaria para la generación de documentos y registros científicos, así como documentar estrictamente los registros experimentales y de cálculos e integrar y aplicar sus conocimientos en un laboratorio donde se valida un método analítico acuerdo con la normatividad o necesidades que cubran ampliamente las necesidades de un laboratorio que cuente con certificación (ISO 9001) o acreditación (IS0 17025).This work is presented as a project proposal for validation in an experimental university course, the "Determination of methanol in alcoholic beverages", addressed from two approaches to qualitative and quantitative. The results showed that the methodologies presented are feasible to be able to use it in the teaching of validation of analytical methods, in a way that is accessible, efficient, economical, where the information necessary for the generation of scientific documents and records, as well as strictly documenting experimental and calculation records and integrating and applying their knowledge in a laboratory where an analytical method is validated according to the regulations or needs that broadly meet the needs of a laboratory that is certified (ISO 9001) or accredited (IS0 17025)

Chiral symmetry restoration and the critical end point in QCD

Abstract: In a system of quark matter we study the chiralphasetransition,thebehaviorofthechiralandquark number susceptibility and the CEP at finite temperature andchemicalpotential.Thisisdonewithintheframework oftwo-flavorNambuandJona-Lasiniomodel.Wehavecalculatedthechiralquarkcondensateandthequarknumber densityand,withthis,wehavefoundthephasetransition type.Withthesequantitieswehavedeterminedthephase diagramforQCDandtheCEP. Keywords:chiralphasetransition,criticalendpoint,dynamicalmass,criticalbehavior,dynamicalchiralsymmetrybreakin

Wage inequality, segregation by skill and the price of capital in an assignment model

Some pieces of empirical evidence suggest that in the U.S., over the last few decades, (i) wage inequality between-plants has risen much more than wage inequality within-plants and (ii) there has been an increase in the segregation of workers by skill into separate plants. This paper presents a frictionless assignment model in which these two features can be explained simultaneously as the result of the decline in the relative price of capital. Additional implications of the model regarding the skill premium and the dispersion in labor productivity across plants are also consistent with the empirical evidence. [resumen de autor

The words of prevention, part I: changing the model

peer reviewedABSTRACT Objective: This part I article explores the different meanings of relevant keywords for General Practice/Family Medicine (GP/FM) in the prevention domain. The aim is to contribute to information process in GP/FM by keeping in line with the main terms used in health care organization. Methods: Important keywords for GP/FM in the prevention domain were selected. Then, a search was carried out on the main sources in GP/FM databases, as well as in Medical Subject Heading and major terminological databases available online. Results and Discussion: There is discrepancy between the conceptual contents of major prevention models amongst the usual bibliographic sources of knowledge in GP/FM in particular and medicine in general. Conclusion: For GP/FM, distribution of preventive activities is now firmly established on a new constructivist model, privileging the doctor-patient relationships and introducing a cybernetic thinking on the health care activities with a special commitment to ethics and the positive duty of beneficence

The words of prevention, part II: ten terms in the realm of quaternary prevention

peer reviewedABSTRACT Objective: This part II article about the ‘words of prevention’ presents in a terminological way the content of ten current concepts used in the prevention domain which are closely linked to quaternary prevention: (1) overinformation, (2) overdiagnosis, (3) medically unexplained symptoms, (4) overmedicalisation, (5) incidentaloma, (6) overscreening, (7) overtreatment, (8) shared decision making, (9) deprescribing, and (10) disease mongering. Methods: with the support of the laboratory team of the University of Rouen, France, which is dedicated to medical terminology and semantic relationships, it was possible to utilize a graphic user interface (called DBGUI) allowing the construction of links for each of chosen terms, and making automatic links to MeSH, if any. Those concepts are analyzed in their environment in current literature, as well as in their MeSH counterparts, if any, and related semantic online terminologies. Results and Discussion: The rules in terminological development aspire to cover the whole field of a concept and in the meantime, it helps to avoid the noise due to proxy and not exactly related issues. This refers to exhaustivity and specificity in information retrieval. Our finds show that referring to MeSH only in information retrieval in General Practice/Family medicine can induce much noise and poor adequacy to the subject investigated. Conclusion: Gathering concepts in specially prepared terminologies for further development of ontologies is a necessity to enter in the semantic web area and the era of distributed data

Chiral symmetry restoration and the critical end point in QCD

In a system of quark matter we study the chiral phase transition, the behavior of the chiral and quark number susceptibility and the CEP at finite temperature and chemical potential. This is done within the framework of two-flavor Nambu and Jona-Lasinio model. We have calculated the chiral quark condensate and the quark number density and, with this, we have found the phase transition type. With these quantities we have determined the phase diagram for QCD and the CEP

Efficacy of an aloe vera, chamomile, and thyme cosmetic cream for the prophylaxis and treatment of mild dermatitis induced by radiation therapy in breast cancer patients: a controlled clinical trial (Alantel Trials)

Abstract Background Dermatitis is a skin condition caused by multiple causes, including radiotherapy treatment. Pharmacological treatments can become chronic and are not exempt from side effects. The latest recommendations of the American Academy of Dermatology establish the use of natural, nourishing, and moisturizing cosmetic products as prevention and the first therapeutic step for dermatitis. Alantel® is a cream developed to reduce redness and irritation, promote the local immune system, combat immunosenescence, and promote the healing of epidermal lesions. The objective was to evaluate the effect of a cream (Alantel) based on natural products at high concentrations for the preventive and curative treatment (at early stages) of radiation-induced dermatitis in patients with breast cancer. Methods Our protocol is an experimental, prospective, triple-blind, multicenter, controlled clinical trial with two parallel arms. The experimental group will be treated with Alantel, while the control group will receive another moisturizing cream. Radiotherapy oncology professionals will recruit a total of 88 patients (44 per comparison group) with breast cancer who will receive radiotherapy oncology treatment for 15 days, and they will be randomly allocated to the experimental or control group. Selected patients will be followed up for four visits by primary care physicians for up to 1 week after completion of radiotherapy. The main study variable will be the incidence rate of mild post-radiation dermatitis. An intention-to-treat analysis will be performed, applying a comparison test for independent means and proportions. A bivariate and multivariate analysis will also be developed to check the treatment effect, adjusting for predictive sociodemographic and clinical variables. Discussion By carrying out this clinical trial, it is expected to verify that Alantel cream, based on natural products at high concentrations, has advantages over a moisturizing cream for the preventive and curative treatment of RD in patients with breast cancer. The COVID-19 pandemic has been influenced by delaying the start of the study. One of the main limitations of this study will be the time required to recruit the patients from the planned sample, given that the selection criteria are restrictive and, although the study is multicenter, recruitment will be coordinated through a single service on radiotherapy oncology. Trial registration ClinicalTrials.gov NCT04116151 . Registered on 4 October 2019

Implementación y desarrollo de competencias de investigación en la Educación Superior. El caso de los alumnos del Grado de Maestro en Educación

En la formación inicial del profesorado se ha puesto mayor énfasis en la enseñanza-aprendizaje de la didáctica, dejando desvinculadas de esta práctica los procesos de investigación. El objetivo de este proyecto fue diseñar e implementar un programa de competencias de investigación y de pensamiento abierto activo en los futuros maestros. En la experiencia participaron 75 alumnos del Grado de Maestro en Educación Primaria. Se utilizó un cuestionario mixto diseñado en base a la Escala de Pensamiento Activo Abierto para Adolescentes y a la Flexible Thinking Scale. Se concluye que hay una tendencia de los estudiantes a valorar los argumentos propios como mejores que los contraargumentos; asimismo, la mayoría del alumnado ha desarrollado habilidades de investigación como saber identificar información relevante, extraer conclusiones o seleccionar fuentes fiables. Sin embargo, cuando leen un texto que no entienden, gran parte de ellos reconocen que dejan de leerlo y no buscan más información. Si la investigación y el pensamiento abierto activo juegan un papel fundamental en la forma de razonar de las personas, es prioritario que en el contexto educativo universitario se desarrollen dichas competencias