Mapping research in the obesity, adipose tissue, and microRNA field: a bibliometric analysis

Recent studies have investigated the control of adipose tissue expansion and inflammatory process by microRNAs (miRNAs). These two processes are of great interest because both are associated with obesity and metabolic syndrome. However, despite the great relevance of the role of miRNAs in obesity and adipose tissue, no qualitative and quantitative analysis on the subject has been performed. Thus, we aimed to examine global research activity and current trends with respect to the interaction between obesity, adipose tissue and miRNAs through a bibliometric analysis. This research was performed on the Scopus database for publications containing miRNA, obesity, and adipose tissue keyword combinations. In total, 898 articles were analyzed and the most frequently occurring keywords were selected and clustered into three well-defined groups. As a result, first group of keywords pointed to the research area on miRNAs expressed in obesity-associated diseases. The second group demonstrated the regulation of the adipogenesis process by miRNAs, while the third group highlighted brown adipose tissue and thermogenesis as one of the latest global research trends related to the theme. The studies selected in this paper describe the expression and performance of different miRNAs in obesity and comorbidities. Most studies have focused on identifying miRNAs and signaling pathways associated with obesity, type 2 diabetes mellitus, and cardiovascular disease. Thus, the miRNA profile for these diseases may be used as biomarkers and therapeutic targets in the prevention and treatment of obesity-associated diseases812CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP132365/2018-9sem informação17/09602-4; 2017/19504-

A multi-element psychosocial intervention for early psychosis (GET UP PIANO TRIAL) conducted in a catchment area of 10 million inhabitants: study protocol for a pragmatic cluster randomized controlled trial

Multi-element interventions for first-episode psychosis (FEP) are promising, but have mostly been conducted in non-epidemiologically representative samples, thereby raising the risk of underestimating the complexities involved in treating FEP in 'real-world' services

Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2019-01-23T17:39:01Z No. of bitstreams: 1 CAMARA, E.J. Elevated IL-17 levels...2018.pdf: 630861 bytes, checksum: 45cf921daca33febb1c6615dbdee607e (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2019-01-23T17:54:22Z (GMT) No. of bitstreams: 1 CAMARA, E.J. Elevated IL-17 levels...2018.pdf: 630861 bytes, checksum: 45cf921daca33febb1c6615dbdee607e (MD5)Made available in DSpace on 2019-01-23T17:54:22Z (GMT). No. of bitstreams: 1 CAMARA, E.J. Elevated IL-17 levels...2018.pdf: 630861 bytes, checksum: 45cf921daca33febb1c6615dbdee607e (MD5) Previous issue date: 2018Conselho Nacional de Pesquisa e Tecnologia (CNPq), Brazil. VRRM and LCLS were supported by CNPq.Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Universidade Federal da Bahia. Complexo Hospitalar Professor Edgard Santos. Unidade Docente Assistencial de Cardiologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Faculdade de Tecnologia e Ciências. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Faculdade de Tecnologia e Ciências. Salvador, BA, Brasil.Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Unidade Docente Assistencial de Cardiologia. Salvador, BA, Brasil.Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Unidade Docente Assistencial de Cardiologia. Salvador, BA, Brasil.Climecar. Clinica de Cardiologia. Itaberaba, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Investigação em Imunologia. São Paulo, SP, Brasil.The immunological and clinical impact of trypanocidal treatment in chronic Chagas' disease (CCD) is unclear. Methodology and findings: Several cytokines were measured in plasma of 66 patients with CCD. Thirtythree patients had been previously treated with benznidazole and 33 had never been treated. The treated group exhibited higher levels of IL-17 (median 142.45 1.22 pg/ml, P = 0.025), which was the only one significantly associated with Bz treatment, especially after adjusting for time of disease and NYHA class (P = 0.024; OR 1.006, 95% CI 1.001-1.010). Compared to untreated patients, the treated group exhibited higher median values of mitral annular E’ lateral (13.0 10.0 cm/s, P = 0.038), S’ infero-lateral (8.9 7.6 cm/s, P = 0.013), S’ septal (8.5 7.4 cm/s, P = 0.034), mean S’ (9.0 7.9 cm/s, P = 0.013) and tricuspid annular S’ (13.3 11.1 cm/s, P = 0.001) and lower values of E/E’ septal (7.2 9.5 cm/s, P = 0.049). After adjustment for time of disease and NYHA class, S’ infero-lateral (P = 0.031), mean S’ (P = 0.049) and S’ tricuspid (P = 0.024) persisted as significantly associated with treatment. Conclusion: The present findings suggest that the group of CCD patients treated with Bz displayed increased plasma levels of IL-17 and preserved myocardial function, reinforcing the idea that Bz treatment may be beneficial