173 research outputs found
Inventory Games
AMS classifications: 90D12, 90B05.inventory management;information;cooperative games;proportional division
Programa de gestión de mantenimiento para mejorar el control de los equipos e instalaciones de una institución educativa
Esta investigación tuvo como objetivo principal diseñar un Programa de
mantenimiento para mejorar el control de los equipos e instalaciones de una
institución educativa, por lo que se usó la metodología de tipo aplicado,
preexperimental que se desarrolló en una muestra de los equipos y mobiliarios de
la una institución educativa, se hizo una prueba previa denominada test de
observación para ver qué nivel tiene la institución con respecto al control de su
mantenimiento. Para conseguir este objetivo se implementó un aplicativo en Excel
denominado CIMA (Control Integral de Mantenimiento), ayudados con la
herramienta Visual Basic, que controla el ingreso de activos, las fechas de
mantenimiento, la generación e impresión de órdenes de trabajo y los ingresos y
devoluciones. Los datos que se ingresan se colocan automáticamente en hojas de
cálculo que hacen las veces de bases de datos. Estos datos brindan la posibilidad
de generar indicadores que pueden ayudar en la toma de decisiones de la
gestión
A systematic review and meta-analysis of the effects of flavanol-containing tea, cocoa and apple products on body composition and blood lipids: exploring the factors responsible for variability in their efficacy
Several randomized controlled trials (RCTs) and meta-analyses support the benefits of flavanols on cardiometabolic health, but the factors affecting variability in the responses to these compounds have not been properly assessed. The objectives of this meta-analysis were to systematically collect the RCTs-based-evidence of the effects of flavanol-containing tea, cocoa and apple products on selected biomarkers of cardiometabolic risk and to explore the influence of various factors on the variability in the responses to the consumption of these products. A total of 120 RCTs were selected. Despite a high heterogeneity, the intake of the flavanol-containing products was associated using a random model with changes (reported as standardized difference in means (SDM)) in body mass index (−0.15, p < 0.001), waist circumference (−0.29, p < 0.001), total-cholesterol (−0.21, p < 0.001), LDL-cholesterol (−0.23, p < 0.001), and triacylglycerides (−0.11, p = 0.027), and with an increase of HDL-cholesterol (0.15, p = 0.005). Through subgroup analyses, we showed the influence of baseline-BMI, sex, source/form of administration, medication and country of investigation on some of the outcome measures and suggest that flavanols may be more effective in specific subgroups such as those with a BMI ≥ 25.0 kg/m2, non-medicated individuals or by specifically using tea products. This meta-analysis provides the first robust evidence of the effects induced by the consumption of flavanol-containing tea, cocoa and apple products on weight and lipid biomarkers and shows the influence of various factors that can affect their bioefficacy in humans. Of note, some of these effects are quantitatively comparable to those produced by drugs, life-style changes or other natural products. Further, RCTs in well-characterized populations are required to fully comprehend the factors affecting inter-individual responses to flavanol and thereby improve flavanols efficacy in the prevention of cardiometabolic disorders
Partial Transmutation of Singularities in Optical Instruments
Some interesting optical instruments such as the Eaton lens and the Invisible
Sphere require singularities of the refractive index for their implementation.
We show how to transmute those singularities into harmless topological defects
in anisotropic media without the need for anomalous material properties
Consenso de expertos sobre el uso de alemtuzumab en la práctica clínica diaria en España
Alemtuzumab; Eficacia; Práctica clínica habitualAlemtuzumab; Effectiveness; Daily clinical practiceAlemtuzumab; Eficàcia; Pràctica clínica habitualIntroduction
Alemtuzumab is a highly effective drug approved by the European Medicines Agency as a disease-modifying drug for the treatment of relapsing-remitting multiple sclerosis.
Objective
A consensus document was drafted on the management of alemtuzumab in routine clinical practice in Spain.
Development
A group of multiple sclerosis specialists reviewed articles addressing treatment with alemtuzumab in patients with multiple sclerosis and published before December 2017. The included studies assessed the drug's efficacy, effectiveness, and safety; screening for infections and vaccination; and administration and monitoring aspects. The initial proposed recommendations were developed by a coordinating group and based on the available evidence and their clinical experience. The consensus process was carried out in 2 stages, with the initial threshold percentage for group agreement established at 80%. The final document with all the recommendations agreed by the working group was submitted for external review and the comments received were considered by the coordinating group.
Conclusion
The present document is intended to be used as a tool for optimising the management of alemtuzumab in routine clinical practice.Introducción Alemtuzumab es un fármaco de alta eficacia aprobado por la Agencia Europea de Medicamentos como tratamiento modificador de la enfermedad en pacientes con esclerosis múltiple remitente recurrente. Objetivo Elaborar un documento de consenso sobre el manejo de alemtuzumab en la práctica clínica habitual, que sea de aplicación en el ámbito español. Desarrollo Un grupo de expertos en esclerosis múltiple revisó las publicaciones disponibles hasta diciembre de 2017, de tratamiento con alemtuzumab y esclerosis múltiple. Se incluyeron trabajos sobre eficacia, efectividad y seguridad, despistaje de infecciones y vacunación, administración y monitorización. La propuesta inicial de recomendaciones fue desarrollada por un grupo coordinador con base en la evidencia disponible y en su experiencia clínica. El proceso de consenso se llevó a cabo en 2 etapas; se estableció como porcentaje inicial de acuerdo grupal el 80%. El documento final con todas las recomendaciones acordadas por el grupo de trabajo se sometió a revisión externa y los comentarios recibidos fueron considerados por el grupo coordinador. Conclusiones El documento aportado pretende ser una herramienta útil para facilitar el manejo del fármaco en condiciones de práctica clínica habitual.Sanofi-Genzyme provided financial support to this project
Conformal mechanics inspired by extremal black holes in d=4
A canonical transformation which relates the model of a massive relativistic
particle moving near the horizon of an extremal black hole in four dimensions
and the conventional conformal mechanics is constructed in two different ways.
The first approach makes use of the action-angle variables in the angular
sector. The second scheme relies upon integrability of the system in the sense
of Liouville.Comment: V2: presentation improved, new material and references added; the
version to appear in JHE
- …