181 research outputs found
Supersymmetric exact sequence, heat kernel and super KdV hierarchy
We introduce the free N=1 supersymmetric derivation ring and prove the
existence of an exact sequence of supersymmetric rings and linear
transformations. We apply necessary and sufficient conditions arising from this
exact supersymmetric sequence to obtain the essential relations between
conserved quantities, gradients and the N=1 super KdV hierarchy. We combine
this algebraic approach with an analytic analysis of the super heat operator.We
obtain the explicit expression for the Green's function of the super heat
operator in terms of a series expansion and discuss its properties. The
expansion is convergent under the assumption of bounded bosonic and fermionic
potentials. We show that the asymptotic expansion when of the Green's
function for the super heat operator evaluated over its diagonal generates all
the members of the N=1 super KdV hierarchy.Comment: 20 pages, to be published in JM
Moduli Stabilisation and de Sitter String Vacua from Magnetised D7 Branes
Anomalous U(1)'s are ubiquitous in 4D chiral string models. Their presence
crucially affects the process of moduli stabilisation and cannot be neglected
in realistic set-ups. Their net effect in the 4D effective action is to induce
a matter field dependence in the non-perturbative superpotential and a
Fayet-Iliopoulos D-term. We study flux compactifications of IIB string theory
in the presence of magnetised D7 branes. These give rise to anomalous U(1)'s
that modify the standard moduli stabilisation procedure. We consider simple
orientifold models to determine the matter field spectrum and the form of the
effective field theory. We apply our results to one-modulus KKLT and
multi-moduli large volume scenarios, in particular to the Calabi-Yau
P^4_{[1,1,1,6,9]}. After stabilising the matter fields, the effective action
for the Kahler moduli can acquire an extra positive term that can be used for
de Sitter lifting with non-vanishing F- and D-terms. This provides an explicit
realization of the D-term lifting proposal of hep-th/0309187.Comment: 35 pages, 1 figure. v2: Minor changes, references adde
The Supermembrane with Central Charges on a G2 Manifold
We construct the 11D supermembrane with topological central charges induced
through an irreducible winding on a G2 manifold realized from the T7/Z2xZ2xZ2
orbifold construction. The hamiltonian H of the theory on a T7 target has a
discrete spectrum. Within the discrete symmetries of H associated to large
diffeomorphisms, the Z2xZ2xZ2 group of automorphisms of the quaternionic
subspaces preserving the octonionic structure is relevant. By performing the
corresponding identification on the target space, the supermembrane may be
formulated on a G2 manifold, preserving the discretness of its supersymmetric
spectrum. The corresponding 4D low energy effective field theory has N=1
supersymmetry.Comment: Reviewed version. spectral propertis discussed, two more sections
added, 27 pages,Late
Astrophysical and Cosmological Implications of Large Volume String Compactifications
We study the spectrum, couplings and cosmological and astrophysical
implications of the moduli fields for the class of Calabi-Yau IIB string
compactifications for which moduli stabilisation leads to an exponentially
large volume V ~ 10^{15} l_s^6 and an intermediate string scale m_s ~
10^{11}GeV, with TeV-scale observable supersymmetry breaking. All K\"ahler
moduli except for the overall volume are heavier than the susy breaking scale,
with m ~ ln(M_P/m_{3/2}) m_{3/2} ~ (\ln(M_P/m_{3/2}))^2 m_{susy} ~ 500 TeV and,
contrary to standard expectations, have matter couplings suppressed only by the
string scale rather than the Planck scale. These decay to matter early in the
history of the universe, with a reheat temperature T ~ 10^7 GeV, and are free
from the cosmological moduli problem (CMP). The heavy moduli have a branching
ratio to gravitino pairs of 10^{-30} and do not suffer from the gravitino
overproduction problem. The overall volume modulus is a distinctive feature of
these models and is an M_{planck}-coupled scalar of mass m ~ 1 MeV and subject
to the CMP. A period of thermal inflation can help relax this problem. This
field has a lifetime ~ 10^{24}s and can contribute to dark matter. It may be
detected through its decays to 2\gamma or e^+e^-. If accessible the e^+e^-
decay mode dominates, with Br(\chi \to 2 \gamma) suppressed by a factor
(ln(M_P/m_{3/2}))^2. We consider the potential for detection of this field
through different astrophysical sources and find that the observed gamma-ray
background constrains \Omega_{\chi} <~ 10^{-4}. The decays of this field may
generate the 511 keV emission line from the galactic centre observed by
INTEGRAL/SPI.Comment: 31 pages, 2 figures; v2. refs adde
Correlational analysis and predictive validity of psychological constructs related with pain in fibromyalgia
<p>Abstract</p> <p>Background</p> <p>Fibromyalgia (FM) is a prevalent and disabling disorder characterized by a history of widespread pain for at least three months. Pain is considered a complex experience in which affective and cognitive aspects are crucial for prognosis. The aim of this study is to assess the importance of pain-related psychological constructs on function and pain in patients with FM.</p> <p>Methods</p> <p>Design</p> <p>Multicentric, naturalistic, one-year follow-up study.</p> <p><it>Setting and study sample</it>. Patients will be recruited from primary care health centres in the region of Aragon, Spain. Patients considered for inclusion are those aged 18-65 years, able to understand Spanish, who fulfil criteria for primary FM according to the American College of Rheumatology, with no previous psychological treatment.</p> <p>Measurements</p> <p>The variables measured will be the following: main variables (pain assessed with a visual analogue scale and with sphygmomanometer and general function assessed with Fibromyalgia Impact Questionnaire, and), psychological constructs (pain catastrophizing, pain acceptance, mental defeat, psychological inflexibility, perceived injustice, mindfulness, and positive and negative affect), and secondary variables (sociodemographic variables, anxiety and depression assessed with Hospital Anxiety and Depression Scale, and psychiatric interview assessed with MINI). Assessments will be carried at baseline and at one-year follow-up.</p> <p>Main outcome</p> <p>Pain Visual Analogue Scale.</p> <p>Analysis</p> <p>The existence of differences in socio-demographic, main outcome and other variables regarding pain-related psychological constructs will be analysed using Chi Square test for qualitative variables, or Student <it>t </it>test or variance analysis, respectively, for variables fulfilling the normality hypothesis. To assess the predictive value of pain-related psychological construct on main outcome variables at one-year follow-up, use will be made of a logistic regression analysis adjusted for socio-demographic and clinical variables. A Spearman Rho non-parametric correlation matrix will be developed to determine possible overlapping between pain-related psychological constructs.</p> <p>Discussion</p> <p>In recent years, the relevance of cognitive and affective aspects for the treatment of chronic pain, not only in FM but also in other chronic pain diseases, has been widely acknowledged. However, the relative importance of these psychological constructs, the relationship and possible overlapping between them, or the exact meaning of them in pain are not enough known.</p
Biology of moderately halophilic aerobic bacteria
The moderately halophilic heterotrophic aerobic bacteria form a diverse group of microorganisms. The property of halophilism is widespread within the bacterial domain. Bacterial halophiles are abundant in environments such as salt lakes, saline soils, and salted food products. Most species keep their intracellular ionic concentrations at low levels while synthesizing or accumulating organic solutes to provide osmotic equilibrium of the cytoplasm with the surrounding medium. Complex mechanisms of adjustment of the intracellular environments and the properties of the cytoplasmic membrane enable rapid adaptation to changes in the salt concentration of the environment. Approaches to the study of genetic processes have recently been developed for several moderate halophiles, opening the way toward an understanding of haloadaptation at the molecular level. The new information obtained is also expected to contribute to the development of novel biotechnological uses for these organisms
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Water Vapor Vertical Profiles on Mars in Dust Storms Observed by TGO/NOMAD
It has been suggested that dust storms efficiently transport water vapor from the near‐surface to the middle atmosphere on Mars. Knowledge of the water vapor vertical profile during dust storms is important to understand water escape. During Martian Year 34, two dust storms occurred on Mars: a global dust storm (June to mid‐September 2018) and a regional storm (January 2019). Here we present water vapor vertical profiles in the periods of the two dust storms (Ls = 162–260° and Ls = 298–345°) from the solar occultation measurements by Nadir and Occultation for Mars Discovery (NOMAD) onboard ExoMars Trace Gas Orbiter (TGO). We show a significant increase of water vapor abundance in the middle atmosphere (40–100 km) during the global dust storm. The water enhancement rapidly occurs following the onset of the storm (Ls~190°) and has a peak at the most active period (Ls~200°). Water vapor reaches very high altitudes (up to 100 km) with a volume mixing ratio of ~50 ppm. The water vapor abundance in the middle atmosphere shows high values consistently at 60°S‐60°N at the growth phase of the dust storm (Ls = 195°–220°), and peaks at latitudes greater than 60°S at the decay phase (Ls = 220°–260°). This is explained by the seasonal change of meridional circulation: from equinoctial Hadley circulation (two cells) to the solstitial one (a single pole‐to‐pole cell). We also find a conspicuous increase of water vapor density in the middle atmosphere at the period of the regional dust storm (Ls = 322–327°), in particular at latitudes greater than 60°S
Collider aspects of flavour physics at high Q
This review presents flavour related issues in the production and decays of
heavy states at LHC, both from the experimental side and from the theoretical
side. We review top quark physics and discuss flavour aspects of several
extensions of the Standard Model, such as supersymmetry, little Higgs model or
models with extra dimensions. This includes discovery aspects as well as
measurement of several properties of these heavy states. We also present public
available computational tools related to this topic.Comment: Report of Working Group 1 of the CERN Workshop ``Flavour in the era
of the LHC'', Geneva, Switzerland, November 2005 -- March 200
The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry
Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with >80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
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