Psicomotricidad y conducta agresiva en niños de 3,4 y 5 años Institución Educativa Shicun Pataz

El objetivo de este estudio fue determinar la relación entre psicomotricidad y conducta agresiva en niños y niñas de 3 a 5 años de la Institución Educativa Shicun- Pataz. El tipo de investigación fue descriptivo correlacional y de diseño no experimental - transversal, la muestra la conformaron un total de 15 estudiantes de inicial. Como técnica se usó la encuesta y como instrumentos el Tepsi Test de desarrollo Psicomotor para la variable psicomotricidad y una guía de observación para la variable Agresividad. Se concluyó que existe una correlación negativa alta (-0,751) siendo altamente significativa por tener el p-valor (0,001) menor que 0,01.Tesi

Factors Predicting the Response to a Vitamin D-Fortified Milk in Healthy Postmenopausal Women

Background: Milk products fortified with vitamin D may constitute an alternative to pharmacological supplements for reaching the optimal levels of serum 25-hydroxyvitamin D [25(OH)D]. Our aim was to analyze the response of serum 25(OH)D and its predictive factors in postmenopausal healthy women after a dietary intervention with a milk fortified with vitamin D and calcium. Methods: We designed a prospective study including 305 healthy postmenopausal women who consumed a fortified milk with calcium (900 mg/500 mL) and vitamin D3 (600 IU/500 mL) daily for 24 months. Results: The 25(OH)D concentrations at 24 months were correlated to weight, to body mass index, to the percentage of fat, triglycerides and to baseline 25(OH)D levels. We found significant differences in the levels of 25(OH)D at 24 months according to baseline 25(OH)D levels (p < 0.001) and body mass index (p = 0.019) expressed at quartiles. Multivariate analysis showed an association between levels of 25(OH)D after the intervention and at baseline 25(OH)D (Beta = 0.47, p < 0.001) and percentage of body fat (Beta = -0.227, p = 0.049), regardless of the body mass index. Conclusions: In healthy postmenopausal women, the improvement in 25(OH)D after an intervention with a fortified milk for 24 months depends mainly on the baseline levels of serum 25(OH)D and on the percentage of body fat

Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis

Studying axonal loss in the retina is a promising biomarker for multiple sclerosis (MS). Our aim was to compare optical coherence tomography (OCT) and Heidelberg retinal tomography (HRT) techniques to measure the thickness of the retinal nerve fiber layer (RNFL) in patients with MS, and to explore the relationship between changes in the RNFL thickness with physical and cognitive disability. We studied 52 patients with MS and 18 proportionally matched controls by performing neurological examination, neuropsychological evaluation using the Brief Repetitive Battery-Neuropsychology and RNFL thickness measurement using OCT and HRT. RESULTS: We found that both OCT and HRT could define a reduction in the thickness of the RNFL in patients with MS compared with controls, although both measurements were weakly correlated, suggesting that they might measure different aspects of the tissue changes in MS. The degree of RNFL atrophy was correlated with cognitive disability, mainly with the symbol digit modality test (r=0.754, P<0.001). Moreover, temporal quadrant RNFL atrophy measured with OCT was associated with physical disability. CONCLUSION: In summary, both OCT and HRT are able to detect thinning of the RNFL, but OCT seems to be the most sensitive technique to identify changes associated with MS evolution

Methylthioadenosine reverses brain autoimmune disease

OBJECTIVE: To assess the immunomodulatory activity of methylthioadenosine (MTA) in rodent experimental autoimmune encephalomyelitis (EAE) and in patients with multiple sclerosis. METHODS: We studied the effect of intraperitoneal MTA in the acute and chronic EAE model by quantifying clinical and histological scores and by performing immunohistochemistry stains of the brain. We studied the immunomodulatory effect of MTA in lymphocytes from EAE animals and in peripheral blood mononuclear cells from healthy control subjects and multiple sclerosis patients by assessing cell proliferation and cytokine gene expression, by real-time polymerase chain reaction, and by nuclear factor-kappaB modulation by Western blot. RESULTS: We found that MTA prevents acute EAE and, more importantly, reverses chronic-relapsing EAE. MTA treatment markedly inhibited brain inflammation and reduced brain damage. Administration of MTA suppressed T-cell activation in vivo and in vitro, likely through a blockade in T-cell signaling resulting in the prevention of inhibitor of kappa B (IkappaB-alpha) degradation and in the impaired activation transcription factor nuclear factor-kappaB. Indeed, MTA suppressed the production of proinflammatory genes and cytokines (interferon-gamma, tumor necrosis factor-alpha, and inducible nitric oxide synthase) and increased the production of antiinflammatory cytokines (interleukin-10). INTERPRETATION: MTA has a remarkable immunomodulatory activity and may be beneficial for multiple sclerosis and other autoimmune diseases

Grado de conocimiento acerca de la prevención de osteoporosis en cesantes y jubilados del sector educación de Lambayeque - junio del 2015

Objetivo: Determinar el grado de conocimiento acerca de la prevención de osteoporosis (OP) en cesantes y jubilados del sector educación de Lambayeque. Material y Métodos: Estudio transversal, descriptivo, observacional, sobre 311 personas perteneciente al Fondo de cesantes y jubilados del sector de educación en Lambayeque, para el grado de conocimiento acerca de la OP se utilizó un cuestionario previamente validado y estructurado a partir del modelo OKAT. El Análisis estadístico se realizó con Excel y SPSS, nivel de confianza del 95% y significancia de 0, 05. Resultados: El 56,59% tenía un conocimiento apropiado de osteoporosis, con una calificación promedio de 12 preguntas acertadas. El 62,7% mencionaron haber recibido información previa sobre OP. El 57,23% afirma haber escuchado información acerca de la osteoporosis en la televisión, seguido del consultorio médico 24,76% . Solo el 10,93% afirma tener el hábito de fumar y el 13,18% afirma tener el hábito de consumir alcohol. Conclusiones: El grado de conocimiento sobre la osteoporosis es bajo en los cesantes y jubilados del sector educación. La información recibida sobre la enfermedad previamente es pobre. La información que reciben las personas sobre OP no proviene de los médicos. Las actitudes hacia la osteoporosis demandan mayor compromiso por el personal de salud para difundir un mejor conocimiento y evitar las complicaciones propias de esta enfermedad

Molecularly Imprinted Polymers for Ochratoxin A Extraction and Analysis

Molecularly imprinted polymers (MIPs) are considered as polymeric materials that mimic the functionality of antibodies. MIPs have been utilized for a wide variety of applications in chromatography, solid phase extraction, immunoassays, and sensor recognition. In this article, recent advances of MIPs for the extraction and analysis of ochratoxins are discussed. Selection of functional monomers to bind ochratoxin A (OTA) with high affinities, optimization of extraction procedures, and limitations of MIPs are compared from different reports. The most relevant examples in the literature are described to clearly show how useful these materials are. Strategies on MIP preparation and schemes of analytical methods are also reviewed in order to suggest the next step that would make better use of MIPs in the field of ochratoxin research. The review ends by outlining the remaining issues and impediments

Reverse Translation for Assessment of Confidence in Animal Models of Multiple Sclerosis for Drug Discovery

The poor predictive quality of currently used animal models in preclinical research is an important cause of the high attrition of promising drug candidates for human autoimmune disease in clinical trials. Examples from own work in a primate multiple sclerosis (MS) model illustrate that important lessons can be learned from a critical reassessment of failed drugs in the animal model, which can help improve the animal model and better understand the targeted disease

Observació i estudis. Productes i usuaris

Facultat de Belles Arts, Universitat de Barcelona. Assignatura: Artefactes i usos: disseny inclusiu, Curs: 2022-2023, Coordinador: Miquel Mallol Esquef