The Central Engines of Fermi Blazars

We present a catalog of central engine properties, i.e., black hole mass (mbh) and accretion luminosity (ld), for a sample of 1077 blazars detected with the Fermi~Large Area Telescope. This includes broad emission line systems and blazars whose optical spectra lack emission lines but dominated by the absorption features arising from the host galaxy. The average mbh for the sample is $\langle \log~M_{{\rm BH,all}~msun} \rangle=8.60$ and there are evidences suggesting the association of more massive black holes with absorption line systems. Our results indicate a bi-modality of ld~in Eddington units (ld/ledd) with broad line objects tend to have a higher accretion rate (ld/ledd$>$0.01). We have found that ld/ledd and Compton dominance (CD, the ratio of the inverse Compton to synchrotron peak luminosities) are positively correlated at $>$5$\sigma$ confidence level, suggesting that the latter can be used to reveal the state of accretion in blazars. Based on this result, we propose a CD based classification scheme. Sources with CD$>$1 can be classified as High-Compton Dominated or HCD blazars, whereas, that with CD$\lesssim$1 are Low-Compton Dominated (LCD) objects. This scheme is analogous to that based on the mass accretion rate proposed in the literature, however, it overcomes the limitation imposed by the difficulty in measuring ld and mbh for objects with quasi-featureless spectra. We conclude that the overall physical properties of Fermi blazars are likely to be controlled by the accretion rate in Eddington units. The catalog is made public at http://www.ucm.es/blazars/engines and Zenodo.Comment: to appear in the ApJ Supplement serie

Adipose-Derived Stem Cells in Crohn's Rectovaginal Fistula

Therapeutic options for recto-vaginal fistula in the setting of Crohn's disease are limited and many data are available in the literature. The manuscript describes the history of a patient who has been the pioneer of our Clinical Trials in treating this disease in fistulizing Crohn's disease environment. We believe it is the first time that a patient with this disease has been treated by adipose-derived stem cells in allogeneic form. The conclusion of our study with Mary is that the use of mesenchymal stem cells derived from adipose tissue is secure, either in autologous or allogeneic form. Furthermore, we have proved that if we use multi-dose and multiple applications on a patient, it does not produce any adverse effect, which confirms us the safety of using these cells in patients at least in the fistulizing Crohn's disease environment

Armonización del análisis NIRS de grasa de cerdo ibérico: transferencia de calibraciones de ácidos grasos

El objetivo del presente trabajo es mostrar la posibilidad de transferir ecuaciones de calibración para la determinación de ácidos grasos en grasa de cerdo Ibérico en diferentes instrumentos NIRS, empleando para ello cápsulas no selladas

Pathways to global-change effects on biodiversity: new opportunities for dynamically forecasting demography and species interactions

In structured populations, persistence under environmental change may be particularly threatened when abiotic factors simultaneously negatively affect survival and reproduction of several life cycle stages, as opposed to a single stage. Such effects can then be exacerbated when species interactions generate reciprocal feedbacks between the demographic rates of the different species. Despite the importance of such demographic feedbacks, forecasts that account for them are limited as individual-based data on interacting species are perceived to be essential for such mechanistic forecasting-but are rarely available. Here, we first review the current shortcomings in assessing demographic feedbacks in population and community dynamics. We then present an overview of advances in statistical tools that provide an opportunity to leverage population-level data on abundances of multiple species to infer stage-specific demography. Lastly, we showcase a state-of-the-art Bayesian method to infer and project stage-specific survival and reproduction for several interacting species in a Mediterranean shrub community. This case study shows that climate change threatens populations most strongly by changing the interaction effects of conspecific and heterospecific neighbours on both juvenile and adult survival. Thus, the repurposing of multi-species abundance data for mechanistic forecasting can substantially improve our understanding of emerging threats on biodiversity.12 página

Follow-up study to evaluate the long-term safety and efficacy of darvadstrocel (mesenchymal stem cell treatment) in patients with perianal fistulizing crohn’s disease: ADMIRE-CD phase 3 randomized controlled trial

BACKGROUND: Darvadstrocel is an expanded allogeneic adipose-derived mesenchymal stem cell therapy for the treatment of complex perianal fistulas in patients with Crohn’s disease. Safety and efficacy outcomes from the clinical trial known as “Adipose derived mesenchymal stem cells for induction of remission in perianal fistulizing Crohn’s disease,” or ADMIRE-CD (NCT01541579), from up to 52 weeks posttreatment were previously reported. Here, the outcomes from an extended 104-week follow-up are reported. OBJECTIVE: The goal of this study was to assess the long-term safety and efficacy of darvadstrocel at 2 years post-treatment in patients with Crohn’s disease and complex perianal fistulas. DESIGN: This was a phase 3 double-blind randomized controlled study (ADMIRE-CD) in patients with perianal fistulizing Crohn’s disease. SETTINGS: This study extension was conducted in multiple hospitals across 7 European countries and Israel. PATIENTS: Forty patients entered the extended follow-up period: 25 patients in the darvadstrocel treatment group and 15 in the control group. INTERVENTIONS: Darvadstrocel or saline solution (control group) was administered once, locally, after fistula tract curettage and internal opening closure (with previous seton placement). All patients were permitted to continue ongoing medical treatments for fistulas. MAIN OUTCOME MEASURES: Treatment-emergent serious adverse events were recorded through week 104. Clinical remission, defined as closure of all treated external openings that were draining at baseline despite gentle finger compression, was assessed at week 104. RESULTS: Of 40 patients, 37 completed the extended follow-up. Through week 104, 7 treatment-emergent serious adverse events were reported, of which 4 occurred between weeks 52 and 104. At week 104, clinical remission was reported in 14/25 (56%) patients in the darvadstrocel group and 6/15 (40%) patients in the control group. LIMITATIONS: Limitations include the small number of patients who entered the extended follow-up period, and no imaging examinations were performed at the 104-week time point. CONCLUSIONS: Darvadstrocel was well tolerated and clinical remission after treatment with darvadstrocel may be sustained for up to 104 weeks in patients with perianal fistulizing Crohn’s diseaseThis study was sponsored by Takeda Pharmaceuticals International Co. Medical writing support was provided by Sally McTaggart, PhD, of Oxford PharmaGenesis, Oxford, UK, and was funded by Takeda Pharmaceuticals International C

Tracing kinematic (mis)alignments in CALIFA merging galaxies: Stellar and ionized gas kinematic orientations at every merger stage

We present spatially resolved stellar and/or ionized gas kinematic properties for a sample of 103 interacting galaxies, tracing all merger stages: close companions, pairs with morphological signatures of interaction, and coalesced merger remnants. We compare our sample with 80 non-interacting galaxies. We measure for the stellar and the ionized gas components the major (projected) kinematic position angles (PA$_{\mathrm{kin}}$, approaching and receding) directly from the velocity fields with no assumptions on the internal motions. This method allow us to derive the deviations of the kinematic PAs from a straight line ($\delta$PA$_{\mathrm{kin}}$). Around half of the interacting objects show morpho-kinematic PA misalignments that cannot be found in the control sample. Those misalignments are present mostly in galaxies with morphological signatures of interaction. Alignment between the kinematic sides for both samples is similar, with most of the galaxies displaying small misalignments. Radial deviations of the kinematic PA from a straight line in the stellar component measured by $\delta$PA$_{\mathrm{kin}}$ are large for both samples. However, for a large fraction of interacting galaxies the ionized gas $\delta$PA$_{\mathrm{kin}}$ is larger than typical values derived from isolated galaxies (48%), making this parameter a good indicator to trace the impact of interaction and mergers in the internal motions of galaxies. By comparing the stellar and ionized gas kinematic PA, we find that 42% (28/66) of the interacting galaxies have misalignments larger than 16 degrees, compared to 10% from the control sample. Our results show the impact of interactions in the internal structure of galaxies as well as the wide variety of their velocity distributions. This study also provides a local Universe benchmark for kinematic studies in merging galaxies at high redshift.Comment: 24 pages,11 Figures, Accepted for publication in Astronomy & Astrophysics. The entire set of stellar and ionized gas velocity fields of the interacting/merging sample will be available in the electronic version of the journa

Ionized gas kinematics of galaxies in the CALIFA survey : I. Velocity fields, kinematic parameters of the dominant component, and presence of kinematically distinct gaseous systems

J.M.A. acknowledges support from the European Research Council Starting Grant (SEDmorph; P.I. V. Wild). Date of Acceptance: 01/08/2014Context. Ionized gas kinematics provide important clues to the dynamical structure of galaxies and hold constraints to the processes driving their evolution. Aims. The motivation of this work is to provide an overall characterization of the kinematic behavior of the ionized gas of the galaxies included in the Calar Alto Legacy Integral field Area (CALIFA), offering kinematic clues to potential users of the CALIFA survey for including kinematical criteria in their selection of targets for specific studies. From the first 200 galaxies observed by CALIFA survey in its two configurations, we present the two-dimensional kinematic view of the 177 galaxies satisfaying a gas content/detection threshold. Methods. After removing the stellar contribution, we used the cross-correlation technique to obtain the radial velocity of the dominant gaseous component for each spectrum in the CALIFA data cubes for different emission lines (namely, [O ii] λλ3726,3729, [O iii] λλ4959,5007, Hα+[N ii] λλ6548,6584, and [SII]λλ6716,6730). The main kinematic parameters measured on the plane of the sky were directly derived from the radial velocities with no assumptions on the internal prevailing motions. Evidence of the presence of several gaseous components with different kinematics were detected by using [O iii] λλ4959,5007 emission line profiles. Results. At the velocity resolution of CALIFA, most objects in the sample show regular velocity fields, although the ionized-gas kinematics are rarely consistent with simple coplanar circular motions. Thirty-five percent of the objects present evidence of a displacement between the photometric and kinematic centers larger than the original spaxel radii. Only 17% of the objects in the sample exhibit kinematic lopsidedness when comparing receding and approaching sides of the velocity fields, but most of them are interacting galaxies exhibiting nuclear activity (AGN or LINER). Early-type (E+S0) galaxies in the sample present clear photometric-kinematic misaligments. There is evidence of asymmetries in the emission line profiles in 117 out of the 177 analyzed galaxies, suggesting the presence of kinematically distinct gaseous components located at different distances from the optical nucleus. The kinematic decoupling between the dominant and secondary component/s suggested by the observed asymmetries in the profiles can be characterized by a limited set of parameters. Conclusions. This work constitutes the first determination of the ionized gas kinematics of the galaxies observed in the CALIFA survey. The derived velocity fields, the reported kinematic distortions/peculiarities and the identification of the presence of several gaseous components in different regions of the objects might be used as additional criteria for selecting galaxies for specific studies.Publisher PDFPeer reviewe

Spiral-like star-forming patterns in CALIFA early-type galaxies

Based on a combined analysis of SDSS imaging and CALIFA integral field spectroscopy data, we report on the detection of faint (24 < {\mu}$_r$ mag/arcsec$^2$ < 26) star-forming spiral-arm-like features in the periphery of three nearby early-type galaxies (ETGs). These features are of considerable interest because they document the still ongoing inside-out growth of some local ETGs and may add valuable observational insight into the origin and evolution of spiral structure in triaxial stellar systems. A characteristic property of the nebular component in the studied ETGs, classified i+, is a two-radial-zone structure, with the inner zone that displays faint (EW(H\alpha)$\simeq$1{\AA}) low-ionization nuclear emission-line region (LINER) properties, and the outer one (3{\AA}<EW(H\alpha)<~20{\AA}) HII-region characteristics. This spatial segregation of nebular emission in two physically distinct concentric zones calls for an examination of aperture effects in studies of type i+ ETGs with single-fiber spectroscopic data.Comment: Accepted to A&A, 5 pages, 1 figur

Spectroscopic aperture biases in inside-out evolving early-type galaxies from CALIFA

Integral field spectroscopy studies based on CALIFA data have recently revealed the presence of ongoing low-level star formation (SF) in the periphery of ~10% of local early-type galaxies (ETGs), witnessing a still ongoing inside-out galaxy growth process. A distinctive property of the nebular component in these ETGs, classified i+, is a two-radial-zone structure, with the inner zone displaying LINER emission with a H\alpha equivalent width EW~1{\AA}, and the outer one (3{\AA}<EW<~20{\AA}) showing HII-region characteristics. Using CALIFA IFS data, we empirically demonstrate that the confinement of nebular emission to the galaxy periphery leads to a strong aperture (or, redshift) bias in spectroscopic single-fiber studies of type i+ ETGs: At low redshift (<~0.45), SDSS spectroscopy is restricted to the inner (SF-devoid LINER) zone, thereby leading to their erroneous classification as "retired" galaxies (systems lacking SF and whose faint emission is powered by pAGB stars). Only at higher z's the SDSS aperture can encompass the outer SF zone, permitting their unbiased classification as "composite SF/LINER". We also demonstrate that the principal effect of a decreasing aperture on the classification of i+ ETGs via standard BPT emission-line ratios consists in a monotonic up-right shift precisely along the upper-right wing of the "seagull" distribution. Motivated by these insights, we also investigate theoretically these biases in aperture-limited studies of inside-out growing galaxies as a function of z. To this end, we devise a simple model, which involves an outwardly propagating SF process, that reproduces the radial extent and two-zone EW distribution of i+ ETGs. By simulating on this model the spectroscopic SDSS aperture, we find that SDSS studies at z<~1 are progressively restricted to the inner LINER-zone, and miss an increasingly large portion of the H\alpha-emitting periphery.Comment: Accepted to A&A, 6 pages, 4 figure

Bar pattern speeds in CALIFA galaxies: I. Fast bars across the Hubble sequence

The bar pattern speed ($\Omega_{\rm b}$) is defined as the rotational frequency of the bar, and it determines the bar dynamics. Several methods have been proposed for measuring $\Omega_{\rm b}$. The non-parametric method proposed by Tremaine \& Weinberg (1984; TW) and based on stellar kinematics is the most accurate. This method has been applied so far to 17 galaxies, most of them SB0 and SBa types. We have applied the TW method to a new sample of 15 strong and bright barred galaxies, spanning a wide range of morphological types from SB0 to SBbc. Combining our analysis with previous studies, we investigate 32 barred galaxies with their pattern speed measured by the TW method. The resulting total sample of barred galaxies allows us to study the dependence of $\Omega_{\rm b}$ on galaxy properties, such as the Hubble type. We measured $\Omega_{\rm b}$ using the TW method on the stellar velocity maps provided by the integral-field spectroscopy data from the CALIFA survey. Integral-field data solve the problems that long-slit data present when applying the TW method, resulting in the determination of more accurate $\Omega_{\rm b}$. In addition, we have also derived the ratio $\cal{R}$ of the corotation radius to the bar length of the galaxies. According to this parameter, bars can be classified as fast ($\cal{R}$ $1.4). For all the galaxies,$\cal{R}$is compatible within the errors with fast bars. We cannot rule out (at 95$\%$level) the fast bar solution for any galaxy. We have not observed any significant trend between$\cal{R}$ and the galaxy morphological type. Our results indicate that independent of the Hubble type, bars have been formed and then evolve as fast rotators. This observational result will constrain the scenarios of formation and evolution of bars proposed by numerical simulations.Comment: 17 pages, 10 figures, accepted for publication in A&