Gestor de recursos sobre sistemas virtualizados

Creacion, diseño e implementación de una nube (cloud) basado en un clúster de servidores con sistema de ficheros distribuido en red y virtualización de sistemas operativos que mejora la utilización de los recursos disponibles. Esta nueva arquitectura ofrece una nube privada que simplifica la gestión de los servicios y aporta una disminución del coste de mantenimiento, ademas de añadir flexibilidad, dinamismo y escalabilidad al sistema. Las tecnologías con las que se trabaja son GNU/Linux, Xen Source, NFS, Java, Hibernate, Wicket, ShellScripting. El proyectista dispondrá de un clúster de 10 servidores para la implementación y las pruebas

Why consumers purchase organic products? The role of environment, health and age

El mercado de productos ecológicos está aumentando en todo el mundo, especialmente en la categoría de los alimentos, en particular de productos orgánicos. El objetivo de este estudio es entender mejor porque los consumidores compran productos orgánicos, profundizando en su preocupación ambiental, conciencia de salud y edad. La evidencia empírica se basa en una encuesta online, utilizando una muestra de 279 compradores habituales de productos orgánicos en España y Portugal. Los resultados muestran que existe una relación positiva entre preocupación ambiental, conciencia de salud y comportamiento de compra verde. La preocupación ambiental es más fuerte que la salud para explicar esta relación. También la edad es un predictor de la compra y los consumidores mayores de 35 años compran más productos orgánicos que los más jóvenes. Para los profesionales de marketing, el estudio permite desarrollar mejores estrategias de marketing para atraer y retener a estos consumidores.The market of green products is increasing all over the world, especially in food category that shows a great demand for biologic and organics. The aim of this study is to better understand the why consumers buy organic products, more specifically environmental concern, health consciousness and age The empirical evidence is based on an online survey, using a sample of 279, regular shoppers of organic products in Portugal and Spain. The results show there is a positive relation between environmental concern, health consciousness and green purchase behavior. Environmental concern is stronger than health to explain this relation. Also age is a predictor of green purchase behavior and older consumers with more than 35 years purchase more organics than younger consumers. For managers and marketers, the study enables to develop better marketing strategies to address these consumers and to enhance environmental concern, health and age to foster organics consumption

Why consumers purchase organic products? The role of environment, health and age

The market of green products is increasing all over the world, especially in food category that shows a great demand for biologic and organics. The aim of this study is to better understand the why consumers buy organic products, more specifically environmental concern, health consciousness and age The empirical evidence is based on an online survey, using a sample of 279, regular shoppers of organic products in Portugal and Spain. The results show there is a positive relation between environmental concern, health consciousness and green purchase behavior. Environmental concern is stronger than health to explain this relation. Also age is a predictor of green purchase behavior and older consumers with more than 35 years purchase more organics than younger consumers. For managers and marketers, the study enables to develop better marketing strategies to address these consumers and to enhance environmental concern, health and age to foster organics consumption.El mercado de productos ecológicos está aumentando en todo el mundo, especialmente en la categoría de los alimentos, en particular de productos orgánicos. El objetivo de este estudio es entender mejor porque los consumidores compran productos orgánicos, profundizando en su preocupación ambiental, conciencia de salud y edad. La evidencia empírica se basa en una encuesta online, utilizando una muestra de 279 compradores habituales de productos orgánicos en España y Portugal. Los resultados muestran que existe una relación positiva entre preocupación ambiental, conciencia de salud y comportamiento de compra verde. La preocupación ambiental es más fuerte que la salud para explicar esta relación. También la edad es un predictor de la compra y los consumidores mayores de 35 años compran más productos orgánicos que los más jóvenes. Para los profesionales de marketing, el estudio permite desarrollar mejores estrategias de marketing para atraer y retener a estos consumidores.info:eu-repo/semantics/publishedVersio

Circulating Metabolites Associated with Body Fat and Lean Mass in Adults with Overweight/Obesity

The interplay between fat mass and lean mass within human metabolism is not completely understood. We aimed to identify specific circulating metabolomic profiles associated with these body composition compartments. Cross-sectional analyses were conducted over 236 adults with overweight/obesity from the Satiety Innovation (SATIN) study. Body composition was assessed by dual-energy X-ray absorptiometry. A targeted multiplatform metabolite profiling approach was applied. Associations between 168 circulating metabolites and the body composition measures were assessed using elastic net regression analyses. The accuracy of the multimetabolite weighted models was evaluated using a 10-fold cross-validation approach and the Pearson's correlation coefficients between metabolomic profiles and body compartments were estimated. Two different profiles including 86 and 65 metabolites were selected for % body fat and lean mass. These metabolites mainly consisted of lipids (sphingomyelins, phosphatidylcholines, lysophosphatidylcholines), acylcarnitines, and amino acids. Several metabolites overlapped between these body composition measures but none of them towards the same direction. The Pearson correlation coefficients between the metabolomic profiles and % body fat or lean mass were 0.80 and 0.79, respectively. Our findings suggest alterations in lipid metabolism, fatty acid oxidation, and protein degradation with increased adiposity and decreased lean body mass. These findings could help us to better understand the interplay between body composition compartments with human metabolic processes

Farmacovigilancia en promoción y prevención de no automedicación de antibióticos para prevenir reacciones adversas en niños menores de seis años en la droguería la Rebaja del barrio Santa Rita en la ciudad de Ibagué, Tolima

El proyecto tiene como fin educar a familiares de niños menores de 6 años en pro a prevenir prácticas de automedicación de antibióticos con el fin de que conozcan como su uso desmedido puede presentar problemas de salud y la presencia de eventos adversos, se ha evidenciado que en la droguería la rebaja ubicada en el barrio santa Rita en la ciudad de Ibagué se realizan compras de antibióticos pediátricos sin formula medica por ello nace la necesidad de estudiar los factores que promueven dichas prácticas y sus implicaciones en la salud, para su realización se usó una metodología de tipo aplicada con enfoque cualitativo, se implementaron encuestas a 50 personas entre padres de familia, cuidadores y familiares que compraron antibióticos sin formula médica, determinando su impacto en la presencia de eventos adverso, sé evidencio que la gran mayoría efectivamente automedican a sus infantes, no tienen conocimiento de las posibles RAM y no conocen los pasos para notificarla, para mitigar los casos de automedicación se implementó estrategias de promoción y prevención promoviendo el uso adecuado de los antibióticos para prevenir factores de riesgos derivados por su uso y promover el interés de la comunidad en participar en la farmacovigilancia y prevenir y reportar los reacciones adversas.The purpose of the project is to educate relatives of children under 6 years of age to prevent self-medication practices of antibiotics so that they know how their excessive use can cause health problems and the presence of adverse events. It has been shown that in The La Rebate drugstore located in the Santa Rita neighborhood in the city of Ibagué purchases of pediatric antibiotics without medical formula is made, which is why the need arises to study the factors that promote these practices. For its implementation, an applied methodology with a focus was used. qualitative, surveys were implemented among Fifty people among parents, caregivers and relatives who bought antibiotics without a medical formula, determining their impact on the presence of adverse events, it is evident that the vast majority effectively self-medicate their infants, they do not have knowledge of the possible ADRs and do not know the steps to notify them, to mitigate cases of self-medication, promotion and prevention strategies were implemented, promoting the appropriate use of antibiotics to prevent risk factors derived from their use and promote the community's interest in participating in the pharmacovigilance and preventing and reporting adverse reactions

Predictors of successful weight loss with relative maintenance of fat-free mass in individuals with overweight and obesity on an 8-week low-energy diet

A low-energy diet (LED) is an effective approach to induce a rapid weight loss in individuals with overweight. However, reported disproportionally large losses of fat-free mass (FFM) after an LED trigger the question of adequate protein content. Additionally, not all individuals have the same degree of weight loss success. After an 8-week LED providing 5020 kJ/d for men and 4184 kJ/d for women (84/70 g protein/d) among overweight and obese adults, we aimed to investigate the relationship between protein intake relative to initial FFM and proportion of weight lost as FFM as well as the individual characteristics associated with weight loss success. We assessed all outcomes baseline and after the LED. A total of 286 participants (sixty-four men and 222 women) initiated the LED of which 82 % completed and 70 % achieved a substantial weight loss (defined as ≥8 %). Protein intake in the range 1·0–1·6 g protein/d per kg FFM at baseline for men and 1·1–2·2 g protein/d per kg FFM at baseline for women was not associated with loss of FFM (P = 0·632). Higher Three-Factor Eating Questionnaire (TFEQ) hunger at baseline and reductions in TFEQ disinhibition and hunger during the LED were associated with larger weight loss (all P ≤ 0·020); whereas lower sleep quality at baseline predicted less successful weight loss using intention to treat analysis (P = 0·021), possibly driven by those dropping out (n 81, P = 0·067 v. completers: n 198, P = 0·659). Thus, the protein intakes relative to initial FFM were sufficient for maintenance of FFM and specific eating behaviour characteristics were associated with weight loss succes

Inflammatory potential of diet and bone mineral density in a senior Mediterranean population : a cross-sectional analysis of PREDIMED-Plus study

Inflammation could play a key role in tissue damage and bone metabolism. The modified dietary inflammatory score (M-DIS) is a validated tool to estimate the inflammatory potential of the diet. In the present study, we evaluate the associations between the M-DIS and bone mineral density (BMD) in a senior Mediterranean population with overweight/obesity and metabolic syndrome. Baseline cross-sectional association between the M-DIS and bone mineral density was assessed in 1134 participants of the multicenter PREDIMED-Plus trial (aged 55-75 with overweight/obesity and metabolic syndrome). BMD was measured using Dual-energy X-ray Absorptiometry scans and participants answered a food frequency questionnaire to determine the M-DIS. BMD was categorized as low BMD when T score was equal or lower than -1 and normal BMD in another case. Associations between BMD and M-DIS were evaluated by using linear and logistic regressions adjusted by other co-variates. Participants in the top tertile of the M-DIS had a lower BMD at total femur [β (95% CI) − 0.02 (− 0.04, − 0.01)], trochanter areas [β (95% CI) − 0.03 (− 0.05, − 0.01)] and lumbar spine area [β (95% CI) − 0.03 (− 0.07, 0.01)] (but in the last case, measures were less precise and hence not statistically significant) compared to those in the lower M-DIS tertile. Multiple logistic regression analyses showed that the odds of the total femur and femoral trochanter osteopenia/osteoporosis were higher in participants in the top tertile compared to those in the lowest tertile of M-DIS [OR (95% CI) 1.71 (1.12, 2.64), P for trend 0.015; 2.02 (1.29, 3.21), P for trend 0.002, respectively]. A high pro-inflammatory diet, measured by the M-DIS, is associated with lower BMD in a senior Mediterranean population with metabolic syndrome. The online version contains supplementary material available at 10.1007/s00394-021-02751-5

Asociación entre fuerza de prensión manual y bienestar en mujeres con fibromialgia

La fibromialgia es una enfermedad caracterizada por una sintomatología compleja con presencia de dolor crónico generalizado junto con otros síntomas incapacitantes como fatiga y problemas de memoria. Como consecuencia, suelen verse deteriorados sus niveles de bienestar. Por lo tanto, es necesario encontrar factores modificables mediante terapia para mejorar el bienestar en la fibromialgia. En esta población, la fuerza de prensión manual es un conocido marcador relevante de salud física, pero se desconoce si también lo es de salud psicológica. Objetivo. Analizar la asociación entre los niveles de fuerza de prensión manual con el bienestar subjetivo en mujeres con fibromialgia. Métodos. Este estudio transversal incluyó a 465 mujeres pertenecientes a pertenecientes a la Comunidad de Andalucía (España). La fuerza se midió a través del test de prensión manual. Las dos dimensiones (i.e., afectiva y cognitiva) del bienestar subjetivo se midieron con cuestionarios, Positive and Negative Affect Scale (PANAS) para el afecto positivo y negativo y Satisfaction with Life Scale (SWLS) para la satisfacción con la vida. La asociación de la fuerza de prensión manual con estas dimensiones se analizó mediante regresiones lineales ajustadas por la edad y el consumo de medicamentos. Resultados. Mayores niveles de fuerza se asociaron con mayor afecto positivo (p<0,001), menor afecto negativo (p<0,001) y mayor satisfacción con la vida (p<0,05). Conclusión. En una muestra representativa de la población andaluza de mujeres con fibromialgia, este estudio ha identificado que los niveles de fuerza están positivamente asociados con puntuaciones más favorables de bienestar subjetivo (i.e., afecto positivo, afecto negativo y satisfacción con la vida). En general, la fuerza de estas asociaciones fue débil. Para esclarecer la causalidad de nuestros hallazgos se requieren futuros estudios longitudinales y experimentales

Olive oil consumption, plasma metabolites, and risk of type 2 diabetes and cardiovascular disease

BackgroundOlive oil consumption has been inversely associated with the risk of type 2 diabetes (T2D) and cardiovascular disease (CVD). However, the impact of olive oil consumption on plasma metabolites remains poorly understood. This study aims to identify plasma metabolites related to total and specific types of olive oil consumption, and to assess the prospective associations of the identified multi-metabolite profiles with the risk of T2D and CVD.MethodsThe discovery population included 1837 participants at high cardiovascular risk from the PREvención con DIeta MEDiterránea (PREDIMED) trial with available metabolomics data at baseline. Olive oil consumption was determined through food-frequency questionnaires (FFQ) and adjusted for total energy. A total of 1522 participants also had available metabolomics data at year 1 and were used as the internal validation sample. Plasma metabolomics analyses were performed using LC–MS. Cross-sectional associations between 385 known candidate metabolites and olive oil consumption were assessed using elastic net regression analysis. A 10-cross-validation (CV) procedure was used, and Pearson correlation coefficients were assessed between metabolite-weighted models and FFQ-derived olive oil consumption in each pair of training–validation data sets within the discovery sample. We further estimated the prospective associations of the identified plasma multi-metabolite profile with incident T2D and CVD using multivariable Cox regression models.ResultsWe identified a metabolomic signature for the consumption of total olive oil (with 74 metabolites), VOO (with 78 metabolites), and COO (with 17 metabolites), including several lipids, acylcarnitines, and amino acids. 10-CV Pearson correlation coefficients between total olive oil consumption derived from FFQs and the multi-metabolite profile were 0.40 (95% CI 0.37, 0.44) and 0.27 (95% CI 0.22, 0.31) for the discovery and validation sample, respectively. We identified several overlapping and distinct metabolites according to the type of olive oil consumed. The baseline metabolite profiles of total and extra virgin olive oil were inversely associated with CVD incidence (HR per 1SD: 0.79; 95% CI 0.67, 0.92 for total olive oil and 0.70; 0.59, 0.83 for extra virgin olive oil) after adjustment for confounders. However, no significant associations were observed between these metabolite profiles and T2D incidence.ConclusionsThis study reveals a panel of plasma metabolites linked to the consumption of total and specific types of olive oil. The metabolite profiles of total olive oil consumption and extra virgin olive oil were associated with a decreased risk of incident CVD in a high cardiovascular-risk Mediterranean population, though no associations were observed with T2D incidence.Trial registration: The PREDIMED trial was registered at ISRCTN (http://www.isrctn.com/, ISRCTN35739639).</p

Impact of COVID-19 pandemic on the PREDIMED-Plus randomized clinical trial: Effects on the interventions, participants follow-up, and adiposity

Background: The COVID-19 pandemic has affected the implementation of most ongoing clinical trials worldwide including the PREDIMED-Plus study. The PREDIMED-Plus is an ongoing, multicenter, controlled intervention trial, aimed at weight-loss and cardiovascular disease prevention, in which participants were randomized (1:1 ratio) to an intervention group (energy-reduced Mediterranean diet, promotion of physical activity, and behavioral support) or to a control group (Mediterranean diet with usual care advice). When the pandemic began, the trial was in the midst of the planned intervention. The objective of this report was to examine the effects of the pandemic on the delivery of the intervention and to describe the strategies established to mitigate the possible adverse effects of the pandemic lockdown on data collection and adiposity. Methods: We assessed the integrity of the PREDIMED-Plus trial during 5 identified periods of the COVID-19 pandemic determined according to restrictions dictated by the Spanish government authorities. A standardized questionnaire was delivered to each of the 23 PREDIMED-Plus recruiting centers to collected data regarding the trial integrity. The effect of the restrictions on intervention components (diet, physical activity) was evaluated with data obtained in the three identified lockdown phases: pre lockdown, lockdown proper, and post lockdown. Results: During the lockdown (March/2020-June/2021), 4,612 participants (48% women, mean age 65y) attended pre-specified yearly follow-up visits to receive lifestyle recommendations and obtain adiposity measures. The overall mean (SD) of the proportions reported by each center showed that 40.4% (25.4) participants had in-person visits, 39.8% (18.2) participants were contacted by telephone and 35% (26.3) by electronic means. Participants' follow-up and data collection rates increased across lockdown periods (from ≈10% at onset to ≈80% at the end). Compared to pre-lockdown, waist circumference increased during (0.75 cm [95% CI: 0.60-0.91]) and after (0.72 cm [95% CI: 0.56-0.89]) lockdown. Body weight did not change during lockdown (0.01 kg [95% CI: -0.10 to 0.13) and decreased after lockdown (-0.17 kg [95% CI: -0.30 to -0.04]). Conclusion: Mitigating strategies to enforce the intervention and patient's follow-up during lockdown have been successful in preserving the integrity of the trial and ensuring its continuation, with minor effects on adiposity. Clinical trial registration: https://doi.org/10.1186/ISRCTN89898870, identifier ISRCTN89898870. Keywords: COVID-19; Mediterraean diet; PREDIMED-Plus; clinical trial; lockdown; weight-loss. Copyright © 2023 Paz-Graniel, Fitó, Ros, Buil-Cosiales, Corella, Babio, Martínez, Alonso-Gómez, Wärnberg, Vioque, Romaguera, López-Miranda, Estruch, Tinahones, Lapetra, Serra-Majem, Bueno-Cavanillas, Tur, Martín-Sánchez, Pintó, Gaforio, Matía-Martín, Vidal, Vázquez, Daimiel, García-Gavilán, Toledo, Nishi, Sorlí, Castañer, García-Ríos, García de la Hera, Barón-López, Ruiz-Canela, Morey, Casas, Garrido-Garrido, Tojal-Sierra, Fernández-García, Vázquez-Ruiz, Fernández-Carrión, Goday, Peña-Orihuela, Compañ-Gabucio, Schröder, Martínez-Gonzalez and Salas-Salvadó. Conflict of interest statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest