Différentes stratégies de prophylaxie de la bronchiolite à VRS par palivizumab chez le grand prématuré (analyse et comparaison)

MONTPELLIER-BU Pharmacie (341722105) / SudocSudocFranceF

Evolution of patients with Sézary syndrome after mogamulizumab discontinuation for any cause except progression: a multicenter retrospective study (Moga-stop study)

International audienceThe results of this study suggest that a progressive discontinuation of mogamulizumab should be considered once response is obtained in Sezary syndrome patients, even after a treatment of short-duration. This may possibly minimize the risk of adverse effects, costs, and resistance to mogamulizumab. Additionally, our study emphasizes that mogamulizumab rechallenge should be encouraged as first-choice for relapsing patients.No abstract availabl

Processus d'annotation dans les documents pour l'action : textualité et médiation de la coopération

International audienceThis chapter deals with digital documents used as a medium for collective practices. Documents of this kind are hyper- fragmented because they are authored at a different time (weblog) and even by different people (wiki). But these fragments are also massively linked to one another (“semantic web” in a broad sense). In the beginning of this chapter, a theoretical framework is given with the notions of document for action and annotation. Then, a state of the art is given in several domains: medical care, design in mechanics, design of open source software, scholarly documentation.Ce chapitre traite des documents numériques utilisés comme supports à une pratique collective. Ces documents se caractérisent à la fois par une hyper-fragmentation résultant d’une hétérogénéité temporelle (weblog) et auctoriale (wiki) mais aussi par une multiplication des relations explicites entre ces fragments (« web sémantique » au sens large). Le chapitre propose tout d’abord un cadre théorique autour des notions de document pour l’action et d’annotation pour ensuite analyser l’état des recherches dans différents domaines d’application : médecine, conception mécanique, conception de logiciels libres, documentation scientifique

Processus d'annotation dans les documents pour l'action : textualité et médiation de la coopération

International audienceThis chapter deals with digital documents used as a medium for collective practices. Documents of this kind are hyper- fragmented because they are authored at a different time (weblog) and even by different people (wiki). But these fragments are also massively linked to one another (“semantic web” in a broad sense). In the beginning of this chapter, a theoretical framework is given with the notions of document for action and annotation. Then, a state of the art is given in several domains: medical care, design in mechanics, design of open source software, scholarly documentation.Ce chapitre traite des documents numériques utilisés comme supports à une pratique collective. Ces documents se caractérisent à la fois par une hyper-fragmentation résultant d’une hétérogénéité temporelle (weblog) et auctoriale (wiki) mais aussi par une multiplication des relations explicites entre ces fragments (« web sémantique » au sens large). Le chapitre propose tout d’abord un cadre théorique autour des notions de document pour l’action et d’annotation pour ensuite analyser l’état des recherches dans différents domaines d’application : médecine, conception mécanique, conception de logiciels libres, documentation scientifique

Grams ME, Sang Y, Ballew SH, et al, for the Chronic Kidney Disease Prognosis Consortium. Predicting timing of clinical outcomes in patients with chronic kidney disease and severely decreased glomerular filtration rate. Kidney Int. 2018;93:1442–1451

International audienceFirst-line therapy of minimal change nephrotic syndrome (MCNS) in adults is extrapolated largely from pediatric studies and consists of high-dose oral corticosteroids. We assessed whether a low corticosteroid dose combined with mycophenolate sodium was superior to a standard oral corticosteroid regimen. We enrolled 116 adults with MCNS in an open-label randomized controlled trial involving 32 French centers. Participants randomly assigned to the test group (n=58) received low-dose prednisone (0.5 mg/kg/day, maximum 40 mg/day) plus enteric-coated mycophenolate sodium 720 mg twice daily for 24 weeks; those who did not achieve complete remission after week 8 were eligible for a second-line regimen (increase in the prednisone dose to 1 mg/kg/day with or without Cyclosporine). Participants randomly assigned to the control group (n=58) received conventional high-dose prednisone (1 mg/kg/day, maximum 80 mg/day) for 24 weeks. The primary endpoint of complete remission after four weeks of treatment was ascertained in 109 participants, with no significant difference between the test and control groups. Secondary outcomes, including remission after 8 and 24 weeks of treatment, did not differ between the two groups. During 52 weeks of follow-up, MCNS relapsed in 15 participants (23.1%) who had achieved the primary outcome. Median time to relapse was similar in the test and control groups (7.1 and 5.1 months, respectively), as was the incidence of serious adverse events. Five participants died from hemorrhage (n=2) or septic shock (n=3), including 2 participants in the test group and 3 in the control group. Thus, in adult patients, treatment with low-dose prednisone plus enteric-coated mycophenolate sodium was not superior to a standard high-dose prednisone regimen to induce complete remission of MCNS