195 research outputs found
Normal mode analysis for scalar fields in BTZ black hole background
We analyze the possibility of inequivalent boundary conditions for a scalar
field propagating in the BTZ black hole space-time. We find that for certain
ranges of the black hole parameters, the Klein-Gordon operator admits a
one-parameter family of self-adjoint extensions. For this range, the BTZ
space-time is not quantum mechanically complete. We suggest a physically
motivated method for determining the spectra of the Klein-Gordon operator.Comment: 6 pages, no figure, late
Chromosomal aberrations in mouse lymphocytes exposed in vivo and in vitro to aliphatic epoxides
Mouse lymphocytes in vivo or in vitro were exposed for 24 h to 4 aliphatic epoxides, glycidyl 1-naphthyl ether, glycidyl 4-nitrophenyl ether, 1-naphthylpropylene oxide and trichloropropylene oxide (TCPO), and tested for the induction of chromosomal aberrations (CA). These epoxides were among the most genotoxic aliphatic epoxides in our previous studies. With the exception of TCPO, the test epoxides caused significant increases in CA in vivo compared to a negative control. There were concentration related increases in CA for all 4 epoxides in vitro and TCPO produced the greatest cellular toxicity and genotoxic effects towards cultured lymphocytes. The difference in the order of genotoxicity for the two test systems can be explained on the basis of a much shorter half-life for TCPO than for the other epoxides.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/30912/1/0000581.pd
Using untagged B^0 -> D K_S to determine gamma
It is shown that the weak phase gamma=arg(-V_{ud}V^*_{ub}V_{cb}V_{cd}^*) can
be determined using only untagged decays B/Bbar--> D K_S. In order to reduce
the uncertainty in gamma, we suggest combining information from B^{+-}-->
DK^{+-} and from untagged B^0 decays, where the D meson is observed in common
decay modes. Theoretical assumptions, which may further reduce the statistical
error, are also discussed.Comment: 18 pages, same as published versio
Degree-scale galactic radio emission at 122 MHz around the North Celestial Pole with LOFAR-AARTFAAC
Large scale structure and cosmolog
Analysis of \Lambda_b \rar \Lambda \ell^+ \ell^- transition in SM4 using form factors from Full QCD
Using the responsible form factors calculated via full QCD, we analyze the
transition in the standard
model containing fourth generation quarks (SM4). We discuss effects of the
presence of fourth family quark on related observables like branching
ratio, forward-backward asymmetry, baryon polarization as well as double lepton
polarization asymmetries. We also compare our results with those obtained in
the SM as well as with predictions of the SM4 but using form factors calculated
within heavy quark effective theory. The obtained results on branching ratio
indicate that the transition
is more probable in full QCD comparing to the heavy quark effective theory. It
is also shown that the results on all considered observables in SM4 deviate
considerably from the SM predictions when .Comment: 22 Pages and 21 Figure
Substituent effects on the genotoxicity of 4-nitrostilbene derivatives
4-Nitrostilbene and twelve of its derivatives (eleven E-stilbenes and two Z-stilbenes) were examined for possible quantitative structure-activity relationships of their in vitro and in vivo genotoxicity. Relative mutagenicity was studied with and without S9 activation in Salmonella strains TA98 and TA100, as well as in the nitroreductase deficient strains TA98/NR and TA100/NR. Chromosomal aberrations in the bone-marrow cells of mice following intraperitoneal administration of the nitrostilbenes were observed as an indicator of in vivo genotoxicity. All of the compounds were active in TA98 and TA100 without S9 activation, with the exception of 4-amino-4'-nitrostilbene in TA100. Mutagenic activity was greatly reduced or eliminated in the NR strains, which is consistent with metabolic activation of the compounds by bacterial reductase. The presence of S9 lowered the activity of most of the nitrostilbenes presumedly by enzymatic detoxication. Hammet values of substituents, partition coefficients and frontier orbital energies (ELUMO and EHOMO) were studied for correlations with mutagenicity of the eleven E-stilbenes. Correlations could be established between mutagenicity in TA98 without S9 activation and the Hammet values. The same mutagenicity could also be correlated to ELUMO. Rationales for these correlations include the concept that electron-withdrawing groups which lower ELUMO should facilitate the reduction of the nitro group, leading to the proximate mutagen hydroxylamine. The correlations are also explained by the concept that electron-withdrawing groups should help stabilize the hydroxylamine intermediate and make the ultimate mutagenic species, the nitrenium ions, more reactive toward DNA. The relationship between mutagenicity and electronic effects of substituent groups found in vitro could not be extended to the in vivo results. However, except for the dinitrostilbenes, where insolubility prevented their testing, all the nitrostilbenes produced a statistically significant increase in chromosomal aberrations compared to the negative solvent control.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31200/1/0000102.pd
Substituent effects on the in vitro and in vivo genotoxicity of 4-aminobiphenyl and 4-aminostilbene derivatives
4-Amino-4'-substituted biphenyls and 4-aminostilbenes substituted in the 3' or 4' position were studied for their in vitro and in vivo genotoxicity. The in vitro mutagenicity of the biphenyls with and without S9 activation was established with Salmonella strains TA98 and TA100 and that of the stilbenes with the same strains plus TA98/1,8-DNP6. The in vivo genotoxicity assay with both series of compounds was for chromosomal aberrations in the bone-marrow cells of mice following intraperitoneal administration of the chemicals. Hammett values of substituents, partition coefficients and frontier orbital energies (ELUMO and EHOMO) of the compounds were used for correlations with mutagenicity. The Salmonella mutagenicity in TA98 and TA98/1,8-DNP6 with S9 was correlated to Hammett [sigma]+ values for the 4-aminostilbene substituents, showing a strong trend of increasing mutagenicity with an increase in the electron-withdrawing capability of the substituent. Hydrophobicity of the stilbenes, however, had little effect on their relative mutagenicity. The 4-aminobiphenyls showed a correlation between their mutagenicity and Hammett [sigma]+ values of their 4'-substituents in stain TA98 with S9, although the trend was not as strong as for the stilbenes. But unlike the stilbenes, TA98 mutagenicity of the biphenyls could also be correlated to hydrophobicity, and structure-activity correlations for the biphenyls was substantially improved when both [sigma]+ and hydrophobicity data were included. For strain TA100 with S9, little correlation was found between mutagenicity of the stilbenes and any of, the parameters. However, a limited correlation did exist between the mutagenicity of the biphenyls and their hydrophobicity. There was also limited correlations of the mutagenicity for the stilbenes in TA98 and TA98/1,8-DNP6 with S9 to ELUMO or EHOMO. The in vivo genotoxicity results for the biphenyls and stilbenes could not be correlated to electronic effects as for the in vitro results, nor could they be explained by hydrophobicity. However, it is interesting to note that 3'-substituted 4-aminostilbenes were all substantially more genotoxic in vivo than their corresponding 4'-substituted counterparts. The most genotoxic compound in vivo in either series was 4-aminostilbene which would not have been predicted from the in vitro results.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31865/1/0000815.pd
First observation of the decay and a measurement of the ratio of branching fractions
The first observation of the decay using
data collected by the LHCb detector at a centre-of-mass energy of 7 TeV,
corresponding to an integrated luminosity of 36 pb, is reported. A
signal of events is obtained and the absence of signal is
rejected with a statistical significance of more than nine standard deviations.
The branching fraction is measured relative to
that of : , where the first uncertainty is statistical, the second systematic and
the third is due to the uncertainty on the ratio of the and
hadronisation fractions.Comment: 10 pages, 3 figures, submitted to Phys. Lett. B; ISSN 0370-269
Constraining the intergalactic medium at z ≈ 9.1 using LOFAR Epoch of Reionization observations
We derive constraints on the thermal and ionization states of the intergalactic medium (IGM) at redshift ≈ 9.1 using new upper
limits on the 21-cm power spectrum measured by the LOFAR radio telescope and a prior on the ionized fraction at that redshift
estimated from recent cosmic microwave background (CMB) observations. We have used results from the reionization simulation
code GRIZZLY and a Bayesian inference framework to constrain the parameters which describe the physical state of the IGM.
We find that, if the gas heating remains negligible, an IGM with ionized fraction 0.13 and a distribution of the ionized regions
with a characteristic size 8 h−1 comoving megaparsec (Mpc) and a full width at half-maximum (FWHM) 16 h−1 Mpc is
ruled out. For an IGM with a uniform spin temperature TS 3 K, no constraints on the ionized component can be computed. If
the large-scale fluctuations of the signal are driven by spin temperature fluctuations, an IGM with a volume fraction 0.34 of
heated regions with a temperature larger than CMB, average gas temperature 7–160 K, and a distribution of the heated regions
with characteristic size 3.5–70 h−1 Mpc and FWHM of 110 h−1 Mpc is ruled out. These constraints are within the 95 per cent
credible intervals. With more stringent future upper limits from LOFAR at multiple redshifts, the constraints will become tighter
and will exclude an increasingly large region of the parameter space
ortho-Substituent effects on the in vitro and in vivo genotoxicity of benzidine derivatives
Benzidine and its 3,3'-diamino, 3,3'-dimethyl, 3,3'-dimethoxy, 3,3'-difluoro, 3,3'-dichloro, 3,3'-dibromo, 3,3'-dicarbomethoxy and 3,3'-dinitro derivatives together with 2-nitrobenzidine and 3-nitrobenzidine were compared for their in vitro and in vivo genotoxicity. Relative mutagenicity was established with Salmonella strains TA98, TA98/1,8-DNP6 and TA100 with and without S9 activation. All the derivatives in the presence of S9 were more mutagenic than benzidine with 3,3'-dinitro- and 3-nitro-benzidine having the greatest mutagenicity. Mutagenicity in all 3 strains with S9 activation could be correlated to electron-withdrawing ability of substituent groups, as measured by the basicity of the amines. This correlation was explained on the basis that electron-withdrawing groups could favor the stability of the mutagenic intermediate N-hydroxylamine and also enhance the reactivity of the ultimate mutagenic species, the nitrenium ion. Mutagenicity was also correlated to the energy of the lowest unoccupied molecular orbitals (ELUMO). Hydrophobicity was found to have very limited effect on the relative mutagenicity of our benzidine derivatives. The in vivo endpoint was chromosomal aberrations in the bone-marrow cells of mice following intraperitoneal administration of benzidine and its derivatives. In contrast to the in vitro results, while all the amines were genotoxic in vivo, only the 3-nitro derivative had a significant increase in toxicity over benzidine.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/30582/1/0000219.pd
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