Unveiling the nature of the "Green Pea" galaxies

We review recent results on the oxygen and nitrogen chemical abundances in extremely compact, low-mass starburst galaxies at redshifts between 0.1-0.3 recently named to as "Green Pea" galaxies. These galaxies are genuine metal-poor galaxies ($\sim$ one fifth solar) with N/O ratios unusually high for galaxies of the same metallicity. In combination with their known general properties, i.e., size, stellar mass and star-formation rate, these findings suggest that these objects could be experiencing a short and extreme phase in their evolution. The possible action of both recent and massive inflow of gas, as well as stellar feedback mechanisms are discussed here as main drivers of the starburst activity and their oxygen and nitrogen abundances.Comment: To appear in JENAM Symposium "Dwarf Galaxies: Keys to Galaxy Formation and Evolution", P. Papaderos, G. Hensler, S. Recchi (eds.). Lisbon, September 2010, Springer Verlag, in pres

Giant HII Regions in NGC 7479 & NGC 6070

We present new results from our search for Giant H\,{\sc ii} Regions in galaxies visible from the southern hemisphere. In this work we study two galaxies: NGC\,7479 and NGC\,6070. Using high-resolution spectra, obtained with different instruments at Las Campanas Observatory, we are able to resolve the emission-line profile widths and determine the intrinsic velocity dispersion of the ionised gas. We detect profile widths corresponding to supersonic velocity dispersions in the six observed H\,{\sc ii} regions. We find that all of them show at least two distinct kinematical components: a relatively narrow feature (between ~11 and ~22\kms) and a broader (between ~31 and ~77\kms) component. Two of the regions show a complex narrow profile in all ion lines, which can be further split into two components with different radial velocities. Whereas the wing broadening of the overall profile can be fitted with a low-intensity broad component for almost all profiles, in one region it was better reproduced by two separate shell-like wings. We have analysed the impact that the presence of multiple components has on the location of the H{\sc ii} regions in the $\log(L) - \log(\sigma)$ plane. Although the overall distribution confirms the presence of a regression, the precise location of the regions in the plane is strongly dependent on the components derived from the profile fitting.Comment: This manuscript has been accepted for publication in Monthly Notices of the Royal Astronomical Society Main Journal. 16 pages, 11 figure

Revealing the last 13,500 years of environmental history from the multiproxy record of a mountain lake (Lago Enol, northern Iberian Peninsula)

This is the author's accepted manuscript. The final publication is available at Springer via http://dx.doi.org/10.1007/s10933-009-9387-7.We present the Holocene sequence from Lago Enol (43°16′N, 4°59′W, 1,070 m a.s.l.), Cantabrian Mountains, northern Spain. A multiproxy analysis provided comprehensive information about regional humidity and temperature changes. The analysis included sedimentological descriptions, physical properties, organic carbon and carbonate content, mineralogy and geochemical composition together with biological proxies including diatom and ostracod assemblages. A detailed pollen study enabled reconstruction of variations in vegetation cover, which were interpreted in the context of climate changes and human impact. Four distinct stages were recognized for the last 13,500 years: (1) a cold and dry episode that includes the Younger Dryas event (13,500–11,600 cal. year BP); (2) a humid and warmer period characterizing the onset of the Holocene (11,600–8,700 cal. year BP); (3) a tendency toward a drier climate during the middle Holocene (8,700–4,650 cal. year BP); and (4) a return to humid conditions following landscape modification by human activity (pastoral activities, deforestation) in the late Holocene (4,650–2,200 cal. year BP). Superimposed on relatively stable landscape conditions (e.g. maintenance of well established forests), the typical environmental variability of the southern European region is observed at this site.The Spanish Inter-Ministry Commission of Science and Technology (CICYT), the Spanish National Parks agency, the European Commission, the Spanish Ministry of Science, and the European Social Fund

Revealing the last 13,500 years of environmental history from the multiproxy record of a mountain lake (Lago Enol, northern Iberian Peninsula)

This is the author's accepted manuscript. The final publication is available at Springer via http://dx.doi.org/10.1007/s10933-009-9387-7.We present the Holocene sequence from Lago Enol (43°16′N, 4°59′W, 1,070 m a.s.l.), Cantabrian Mountains, northern Spain. A multiproxy analysis provided comprehensive information about regional humidity and temperature changes. The analysis included sedimentological descriptions, physical properties, organic carbon and carbonate content, mineralogy and geochemical composition together with biological proxies including diatom and ostracod assemblages. A detailed pollen study enabled reconstruction of variations in vegetation cover, which were interpreted in the context of climate changes and human impact. Four distinct stages were recognized for the last 13,500 years: (1) a cold and dry episode that includes the Younger Dryas event (13,500–11,600 cal. year BP); (2) a humid and warmer period characterizing the onset of the Holocene (11,600–8,700 cal. year BP); (3) a tendency toward a drier climate during the middle Holocene (8,700–4,650 cal. year BP); and (4) a return to humid conditions following landscape modification by human activity (pastoral activities, deforestation) in the late Holocene (4,650–2,200 cal. year BP). Superimposed on relatively stable landscape conditions (e.g. maintenance of well established forests), the typical environmental variability of the southern European region is observed at this site.The Spanish Inter-Ministry Commission of Science and Technology (CICYT), the Spanish National Parks agency, the European Commission, the Spanish Ministry of Science, and the European Social Fund

GRB 021004: Tomography of a gamma-ray burst progenitor and its host galaxy

We analyse the distribution of matter around the progenitor star of gamma-ray burst GRB 021004 as well as the properties of its host galaxy with high-resolution echelle as well as near-infrared spectroscopy. Observations were taken by the 8.2m Very Large Telescope with the Ultraviolet and Visual Echelle spectrograph (UVES) and the Infrared Spectrometer And Array Camera (ISAAC) between 10 and 14 hours after the onset of the event. We report the first detection of emission lines from a GRB host galaxy in the near-infrared, detecting H-alpha and the [O III] doublet. These allow an independent measurement of the systemic redshift (z = 2.3304 +/- 0.0005) which is not contaminated by absorption as the Ly-alpha line is, and the deduction of properties of the host galaxy. From the visual echelle spectroscopy, we find several absorption line groups spanning a range of about 3,000 km/s in velocity relative to the redshift of the host galaxy. The absorption profiles are very complex with both velocity-broadened components extending over several 100 km/s and narrow lines with velocity widths of only 20 km/s. By analogy with QSO absorption line studies, the relative velocities,widths, and degrees of ionization of the lines ("line-locking", "ionization--velocity correlation") show that the progenitor had both an extremely strong radiation field and several distinct mass loss phases (winds). These results are consistent with GRB progenitors being massive stars, such as Luminous Blue Variables (LBVs) or Wolf--Rayet stars, providing a detailed picture of the spatial and velocity structure of the GRB progenitor star at the time of explosion. The host galaxy is a prolific star-forming galaxy with a SFR of about 40 solar masses per year.Comment: 11 pages, 5 figures. Accepted for publication in Astronomy and Astrophysics

On the importance of the few most massive stars: the ionizing cluster of NGC 588

We present the results of a double analysis of the ionizing cluster in NGC 588, a giant HII region (GHR) in the outskirts of the nearby galaxy M33. For this purpose, we obtained ground based long-slit spectroscopy and combined it with archival ground based and space borne imaging and spectroscopy, in the wavelength range 1100-9800 A. A first modeling of the cluster was performed using integrated properties, such as the spectral energy distribution (SED), broad band colors, nebular emission Hbeta equivalent width, the main ultraviolet resonance lines, and the presence of Wolf-Rayet star features. By applying standard assumptions about the initial mass function (IMF), we were unable to fit satisfactorily these observational data. This contradictory result led us to carry out a second modeling, based on a resolved photometric analysis of individual stars in Hubble Space Telescope (HST) images, by means of finding the best fit isochrone in color-magnitude diagrams (CMD), and assigning a theoretical SED to each individual star. The overall SED of the cluster, obtained by integrating the individual stellar SEDs, is found to fit better the observed SED than the best solution found through the integrated first analysis, but at a significantly later stage of evolution of the cluster of 4.2 Myr, as obtained from the best fit to the CMD. A comparative analysis of both methods traces the different results to the effects of statistical fluctuations in the upper end of the IMF, which are significant in NGC 588, with a computed cluster mass of 5600 Msun, as predicted by Cervino et al (2002). We discuss the results in terms of the strong influence of the few most massive stars, six in the case of NGC 588, that dominate the overall SED and, in particular, the ionizing far ultraviolet range beyond the Lyman limit

Unraveling the effect of silent, intronic and missense mutations on VWF splicing: contribution of next generation sequencing in the study of mRNA

Large studies in von Willebrand disease patients, including Spanish and Portuguese registries, led to identification of >250 different mutations. It is a challenge to determine the pathogenic effect of potential splice site mutations on VWF mRNA. This study aimed to elucidate the true effects of 18 mutations on VWF mRNA processing, investigate the contribution of next-generation sequencing to in vivo mRNA study in von Willebrand disease, and compare the findings with in silico prediction. RNA extracted from patient platelets and leukocytes was amplified by RT-PCR and sequenced using Sanger and next generation sequencing techniques. Eight mutations affected VWF splicing: c.1533+1G>A, c.5664+2T>C and c.546G>A (p.=) prompted exon skipping; c.3223-7_3236dup and c.7082-2A>G resulted in activation of cryptic sites; c.3379+1G>A and c.7473G>A (p.=) demonstrated both molecular pathogenic mechanisms simultaneously; and the p.Cys370Tyr missense mutation generated two aberrant transcripts. Of note, the complete effect of 3 mutations was provided by next generation sequencing alone because of low expression of the aberrant transcripts. In the remaining 10 mutations, no effect was elucidated in the experiments. However, the differential findings obtained in platelets and leukocytes provided substantial evidence that 4 of these would have an effect on VWF levels. In this first report using next generation sequencing technology to unravel the effects of VWF mutations on splicing, the technique yielded valuable information. Our data bring to light the importance of studying the effect of synonymous and missense mutations on VWF splicing to improve the current knowledge of the molecular mechanisms behind von Willebrand disease.info:eu-repo/semantics/publishedVersio

Prognostic factors in left-sided endocarditis: results from the andalusian multicenter cohort

<p>Abstract</p> <p>Background</p> <p>Despite medical advances, mortality in infective endocarditis (IE) is still very high. Previous studies on prognosis in IE have observed conflicting results. The aim of this study was to identify predictors of in-hospital mortality in a large multicenter cohort of left-sided IE.</p> <p>Methods</p> <p>An observational multicenter study was conducted from January 1984 to December 2006 in seven hospitals in Andalusia, Spain. Seven hundred and five left-side IE patients were included. The main outcome measure was in-hospital mortality. Several prognostic factors were analysed by univariate tests and then by multilogistic regression model.</p> <p>Results</p> <p>The overall mortality was 29.5% (25.5% from 1984 to 1995 and 31.9% from 1996 to 2006; Odds Ratio 1.25; 95% Confidence Interval: 0.97-1.60; p = 0.07). In univariate analysis, age, comorbidity, especially chronic liver disease, prosthetic valve, virulent microorganism such as <it>Staphylococcus aureus</it>, <it>Streptococcus agalactiae </it>and fungi, and complications (septic shock, severe heart failure, renal insufficiency, neurologic manifestations and perivalvular extension) were related with higher mortality. Independent factors for mortality in multivariate analysis were: Charlson comorbidity score (OR: 1.2; 95% CI: 1.1-1.3), prosthetic endocarditis (OR: 1.9; CI: 1.2-3.1), <it>Staphylococcus aureus </it>aetiology (OR: 2.1; CI: 1.3-3.5), severe heart failure (OR: 5.4; CI: 3.3-8.8), neurologic manifestations (OR: 1.9; CI: 1.2-2.9), septic shock (OR: 4.2; CI: 2.3-7.7), perivalvular extension (OR: 2.4; CI: 1.3-4.5) and acute renal failure (OR: 1.69; CI: 1.0-2.6). Conversely, <it>Streptococcus viridans </it>group etiology (OR: 0.4; CI: 0.2-0.7) and surgical treatment (OR: 0.5; CI: 0.3-0.8) were protective factors.</p> <p>Conclusions</p> <p>Several characteristics of left-sided endocarditis enable selection of a patient group at higher risk of mortality. This group may benefit from more specialised attention in referral centers and should help to identify those patients who might benefit from more aggressive diagnostic and/or therapeutic procedures.</p