Ignition of thermally sensitive explosives between a contact surface and a shock

The dynamics of ignition between a contact surface and a shock wave is investigated using a one-step reaction model with Arrhenius kinetics. Both large activation energy asymptotics and high-resolution finite activation energy numerical simulations are employed. Emphasis is on comparing and contrasting the solutions with those of the ignition process between a piston and a shock, considered previously. The large activation energy asymptotic solutions are found to be qualitatively different from the piston driven shock case, in that thermal runaway first occurs ahead of the contact surface, and both forward and backward moving reaction waves emerge. These waves take the form of quasi-steady weak detonations that may later transition into strong detonation waves. For the finite activation energies considered in the numerical simulations, the results are qualitatively different to the asymptotic predictions in that no backward weak detonation wave forms, and there is only a weak dependence of the evolutionary events on the acoustic impedance of the contact surface. The above conclusions are relevant to gas phase equation of state models. However, when a large polytropic index more representative of condensed phase explosives is used, the large activation energy asymptotic and finite activation energy numerical results are found to be in quantitative agreement

Eculizumab-C5 complexes express a C5a neoepitope in vivo: Consequences for interpretation of patient complement analyses

Contains fulltext : 177337.pdf (Publisher’s version ) (Open Access)The complement system has obtained renewed clinical focus due to increasing number of patients treated with eculizumab, a monoclonal antibody inhibiting cleavage of C5 into C5a and C5b. The FDA approved indications are paroxysmal nocturnal haemoglobinuria and atypical haemolytic uremic syndrome, but many other diseases are candidates for complement inhibition. It has been postulated that eculizumab does not inhibit C5a formation in vivo, in contrast to what would be expected since it blocks C5 cleavage. We recently revealed that this finding was due to a false positive reaction in a C5a assay. In the present study, we identified expression of a neoepitope which was exposed on C5 after binding to eculizumab in vivo. By size exclusion chromatography of patient serum obtained before and after infusion of eculizumab, we document that the neoepitope was exposed in the fractions containing the eculizumab-C5 complexes, being positive in this actual C5a assay and negative in others. Furthermore, we confirmed that it was the eculizumab-C5 complexes that were detected in the C5a assay by adding an anti-IgG4 antibody as detection antibody. Competitive inhibition by anti-C5 antibodies localized the epitope to the C5a moiety of C5. Finally, acidification of C5, known to alter C5 conformation, induced a neoepitope reacting identical to the one we explored, in the C5a assays. These data are important for interpretation of complement analyses in patients treated with eculizumab

Electromagnetic gauge measurements of shock initiating PBX9501 and PBX9502 explosives

The authors have used an embedded electromagnetic particle velocity gauge technique to measure the shock initiation behavior in PBX9501 and PBX9502 explosives. Experiments have been conducted in which up to twelve separate measurements have been made in a single experiment which detail the growth from an input shock to a detonation. In addition, another gauge element called a shock tracker has been used to monitor the progress of the shock front as a function of time, thus providing a position-time trajectory of the wave front as it moves through the explosive sample. This provides similar data to that obtained in a traditional wedge test and is used to determine the position and time that the wave attains detonation. Data on both explosives show evidence of heterogeneous initiation (growth in the front) and homogeneous initiation (growth behind the front) with the PBX9502 showing more Heterogeneous behavior and the PBX 9501 showing more homogeneous behavior

Towards Activity Context using Software Sensors

Service-Oriented Computing delivers the promise of configuring and reconfiguring software systems to address user's needs in a dynamic way. Context-aware computing promises to capture the user's needs and hence the requirements they have on systems. The marriage of both can deliver ad-hoc software solutions relevant to the user in the most current fashion. However, here it is a key to gather information on the users' activity (that is what they are doing). Traditionally any context sensing was conducted with hardware sensors. However, software can also play the same role and in some situations will be more useful to sense the activity of the user. Furthermore they can make use of the fact that Service-oriented systems exchange information through standard protocols. In this paper we discuss our proposed approach to sense the activity of the user making use of software

Inhibition of Y1 receptor signaling improves islet transplant outcome

Failure to secrete sufficient quantities of insulin is a pathological feature of type-1 and type-2 diabetes, and also reduces the success of islet cell transplantation. Here we demonstrate that Y1 receptor signaling inhibits insulin release in β-cells, and show that this can be pharmacologically exploited to boost insulin secretion. Transplanting islets with Y1 receptor deficiency accelerates the normalization of hyperglycemia in chemically induced diabetic recipient mice, which can also be achieved by short-term pharmacological blockade of Y1 receptors in transplanted mouse and human islets. Furthermore, treatment of non-obese diabetic mice with a Y1 receptor antagonist delays the onset of diabetes. Mechanistically, Y1 receptor signaling inhibits the production of cAMP in islets, which via CREB mediated pathways results in the down-regulation of several key enzymes in glycolysis and ATP production. Thus, manipulating Y1 receptor signaling in β-cells offers a unique therapeutic opportunity for correcting insulin deficiency as it occurs in the pathological state of type-1 diabetes as well as during islet transplantation.Islet transplantation is considered one of the potential treatments for T1DM but limited islet survival and their impaired function pose limitations to this approach. Here Loh et al. show that the Y1 receptor is expressed in β- cells and inhibition of its signalling, both genetic and pharmacological, improves mouse and human islet function.info:eu-repo/semantics/publishe

Rewetting offers rapid climate benefits for tropical and agricultural peatlands but not for forestry‐drained peatlands

Peat soils drained for agriculture and forestry are important sources of carbon dioxide and nitrous oxide. Rewetting effectively reduces these emissions. However, rewetting also increases methane emissions from the soil and, on forestry-drained peatlands, decreases the carbon storage of trees. To analyze the effect of peatland rewetting on the climate, we built radiative forcing scenarios for tropical peat soils, temperate and boreal agricultural peat soils, and temperate and boreal forestry-drained peat soils. The effect of tree and wood product carbon storage in boreal forestry-drained peatlands was also estimated as a case study for Finland. Rewetting of tropical peat soils resulted in immediate cooling. In temperate and boreal agricultural peat soils, the warming effect of methane emissions offsets a major part of the cooling for the first decades after rewetting. In temperate and boreal forestry-drained peat soils, the effect of rewetting was mostly warming for the first decades. In addition, the decrease in tree and wood product carbon storage further delayed the onset of the cooling effect for decades. Global rewetting resulted in increasing climate cooling, reaching -70 mW (m(2)Earth)(-1)in 100 years. Tropical peat soils (9.6 million ha) accounted for approximately two thirds and temperate and boreal agricultural peat soils (13.0 million ha) for one third of the cooling. Forestry-drained peat soils (10.6 million ha) had a negligible effect. We conclude that peatland rewetting is beneficial and important for mitigating climate change, but abandoning tree stands may instead be the best option concerning forestry-drained peatlands.Peer reviewe

Development of UHPLC-MS/MS methods to quantify 25 antihypertensive drugs in serum in a cohort of patients treated for hypertension

We developed three ultra-high pressure liquid chromatography coupled to mass spectrometry detection (UHPLC-MS/MS) methods to quantify 25 antihypertensive drugs in serum samples. Patient-reported drug lists were collected, and drug concentrations were analysed in samples from 547 patients, half with uncontrolled hypertension, and all treated with ≥ 2 antihypertensive drugs. For sample preparation, serum was mixed with deuterated internal standards and acetonitrile and precipitated. Aliquots of the supernatant were injected on UHPLC-MSMS with a C18 reversed phase column. The mobile phase was 0.1 % HCOOH (formic acid) in water and 0.1 % HCOOH in acetonitrile (except in methanol for spironolactone/canrenone) at a flow rate of 0.4 mL/min. The calibrators and internal controls were prepared in Autonorm™. The calibration ranges were wide, and the models were linear or quadratic with squared correlation coefficients ≥ 0.97. The limits of detection and quantification, specificity, carry-over, and matrix effects were acceptable. The accuracy of the internal controls was in the range 85–121 %, and the intermediate precision for all drugs was 4–28 %. The patient-reported antihypertensive drug use and the detected serum drug concentrations were in accordance with that most frequently prescribed nationally. The percent non-detectable level was 5–10 % for bendroflumethiazide, doxazosin, nifedipine, and ramipril. Often the drug dose chosen was lower than the recommended maximum daily dose. We report the maximum (Cmax) and minimum (Cmin) drug concentrations after drug intake. The inter-individual pharmacokinetic variability at Cmin was 18-fold for hydrochlorothiazide, 22-fold for losartan carboxyl acid, 26-fold for amlodipine, 44-fold for candesartan, and 50-fold for valsartan. Our methods are suitable for measuring antihypertensive drugs in patient serum for therapy control.publishedVersio

Insights into the shock initiation/detonation of homogeneous and heterogeneous HE

It has long been known that there are fundamental differences between homogeneous and heterogeneous high explosives. The shock initiation behavior of these materials was first described in the literature by Campbell et al, in 1961. Chaiken was also involved in describing this process for liquid nitromethane. Since then, there have been a number of studies which have added considerable incite into the shock initiation/detonation behavior of these materials. We only give a few references here (Refs. 4 - 11) and these should be considered representative; e.g. they do not represent an exhaustive list of references available. Many of these studies were done on homogeneous explosives, most often nitromethane (NM) and include particle velocity gauge measurements, optical temperature measurements, VISAR measurements, as well as streak camera measurements of interfaces. In some cases NM was heterogenized by gelling and adding silica particles. Homogeneous materials are typically liquids or single crystals in which there are a minimal number of physical imperfections (e.g. bubbles or voids) that can cause perturbations in the input shock and the flow behind it. Homogeneous materials viewed with macroscopic probes characteristic of detonation physics experiments appear uniform. Heterogeneous explosives are generally all other types; these are usually pressed, cast, machined, or extruded into the shapes or parts desired. These materials contain imperfections of a variety of types that cause fluid-mechanical irregularities (called hot spots) when a shock or detonation wave passes over them. Such hot spots cause associated space/time fluctuations in the thermodynamic fields (e.g., the pressure or temperature fields) in the material. These thermodynamic variations affect the local chemical-heat-release rate - they produce an average heat-release rate that is a combination of chemistry and mechanics. Hot spots could be the result of voids, shock interactions, jetting, shock impedance mismatches, etc. Shock initiation of homogeneous explosives is due to a thermal explosion that occurs in the material shocked the longest. This reaction produces a reactive wave that grows behind the front and eventually overtakes the front. The reactive wave may grow into what is called a superdetonation before it overtakes the initial shock and settles down to a steady detonation. The shock initiation process in heterogeneous explosives differs a great deal because the hot spots cause early chemical reaction as soon as the shock passing over a region creates them. This causes reactive growth both in and behind the shock front. This leads to a relatively smooth growth of the initiating shock to a detonation, in contrast to the abrupt changes that occur in the homogeneous case. These differences are apparent in both the in-situ reaction wave profiles and the acceleration of the shock front

International outbreak of Salmonella Oranienburg due to German chocolate

BACKGROUND: This report describes a large international chocolate-associated Salmonella outbreak originating from Germany. METHODS: We conducted epidemiologic investigations including a case-control study, and food safety investigations. Salmonella (S.) Oranienburg isolates were subtyped by the use of pulsed-field gel electrophoresis (PFGE). RESULTS: From 1 October 2001 through 24 March 2002, an estimated excess of 439 S. Oranienburg notifications was registered in Germany. Simultaneously, an increase in S. Oranienburg infections was noted in other European countries in the Enter-net surveillance network. In a multistate matched case-control study in Germany, daily consumption of chocolate (matched odds ratio [MOR]: 4.8; 95% confidence interval [CI]: 1.3–26.5), having shopped at a large chain of discount grocery stores (MOR: 4.2; CI: 1.2–23.0), and consumption of chocolate purchased there (MOR: 5.0; CI: 1.1–47.0) were associated with illness. Subsequently, two brands from the same company, one exclusively produced for that chain, tested positive for S. Oranienburg. In two other European countries and in Canada chocolate from company A was ascertained that also contained S. Oranienburg. Isolates from humans and from chocolates had indistinguishable PFGE profiles. No source or point of contamination was identified. Epidemiological identification of chocolate as a vehicle of infections required two months, and was facilitated by proxy measures. CONCLUSIONS: Despite the use of improved production technologies, the chocolate industry continues to carry a small risk of manufacturing Salmonella-containing products. Particularly in diffuse outbreak-settings, clear associations with surrogates of exposure should suffice to trigger public health action. Networks such as Enter-net have become invaluable for facilitating rapid and appropriate management of international outbreaks