870 micron continuum observations of the bubble-shaped nebula Gum 31

We are presenting here a study of the cold dust in the infrared ring nebula Gum 31. We aim at deriving the physical properties of the molecular gas and dust associated with the nebula, and investigating its correlation with the star formation in the region, that was probably triggered by the expansion of the ionization front. We use 870 micron data obtained with LABOCA to map the dust emission. The obtained LABOCA image was compared to archival IR,radio continuum, and optical images. The 870 micron emission follows the 8 micron (Spitzer), 250 micron, and 500 micron (Herschel) emission distributions showing the classical morphology of a spherical shell. We use the 870 micron and 250 micron images to identify 60 dust clumps in the collected layers of molecular gas using the Gaussclumps algorithm. The clumps have effective deconvolved radii between 0.16 pc and 1.35 pc, masses between 70 Mo and 2800 Mo, and volume densities between 1.1x10^3 cm^-3 and 2.04x10^5 cm^-3. The total mass of the clumps is 37600 Mo. The dust temperature of the clumps is in the range from 21 K to 32 K, while inside the HII region reaches ~ 40 K. The clump mass distribution is well-fitted by a power law dN/dlog(M/Mo) proportional to M^(-alpha), with alpha=0.93+/-0.28. The slope differs from those obtained for the stellar IMF in the solar neighborhood, suggesting that the clumps are not direct progenitors of single stars/protostars. The mass-radius relationship for the 41 clumps detected in the 870 microns emission shows that only 37% of them lie in or above the high-mass star formation threshold, most of them having candidate YSOs projected inside. A comparison of the dynamical age of the HII region with the fragmentation time, allowed us to conclude that the collect and collapse mechanism may be important for the star formation at the edge of Gum 31, although other processes may also be acting.Comment: 15 pages, 10 figures. Accepted for publication in A&

Pentamethylcyclopentadienyl halo- and alkyl-alkoxo tantalum(V) complexes. Crystal structure of TaCp*(CH2SiMe3) 2{η2-O(2-CH2-6-MeC6H3)}

Reaction of TaCp" C! 4 with MOR (M - Li, Na) in different molar ratios gives halo alkoxides TaCp" CI,(OR)4_,, (n - 3: R -tBu 1; $iPh 3 2; 2,6-Me2C6H 3 3; n -- 2: R -~Bu 4; SiPh 3 5; 2,6-Me2C6H3 6; a - !: R - SiMe 3 7) in good yields. The alkylidene complex TaCp'(CH2SiMe,02(CHSiMe ~) is hydrolyzed in the presence of traces of water to give the oxo dialkyl derivative [TaCp'(CH2SiM¢3)~O],, 8, and reacts with I equivalent of 2,6-MezC6H~NC affording a new 'q2-iminoacyi compound TaCp" (CH 2$iMe3XCHSiMe3){~ 2"C(CH 2SiMe3 ) = N(2,6"MeaC6 H 3)} 9. Reactions of TaCp "(CH 2SiMe3)a(CHSiMe3 ) with I equivalent of C6HsOH and 4-MeC6H3(OH) 2 result in the formation of the alkyl phenoxo TaCp'(CH2SiMe3)3(OC6Hs) 10 and 4-methyl pyrocatecholate TaCp'(CH2SiMe~)2(O2C6H3Me) 11, whereas the related re,",,:don with 2,6-Me2C6H 3OH leads to the cyclic alkyi-aikoxo compound TaCp (CH2SiMej)2(~2-O(2-CH2-6-MeC6H3)) 12. All the complexes were characterized by IR and NMR (tH and 13C) spectroscopy. The crystal and molecular structure of 12 has been determine~i. C~ystals of 12 are triclinic, space group P'[ with Z - 2 in a unit cell of dimensions a- 9.151(5) ~, b- 11.835(5) ~,, c- 14.045(4) A, a- 89.35(3) °, /3- 72.34(3) 0 and 'y-88.51(4) °, V- 1449(I) ~s. Final values of R -0.025 and Rw -0.0655 were obtained from 554'7 reflections measured (50'70, > 2o'(i))

ZnO-mesoporous glass scaffolds loaded with osteostatin and mesenchymal cells improve bone healing in a rabbit bone defect.

The use of 3D scaffolds based on mesoporous bioactive glasses (MBG) enhanced with therapeutic ions, biomolecules and cells is emerging as a strategy to improve bone healing. In this paper, the osteogenic capability of ZnO-enriched MBG scaffolds loaded or not with osteostatin (OST) and human mesenchymal stem cells (MSC) was evaluated after implantation in New Zealand rabbits. Cylindrical meso-macroporous scaffolds with composition (mol %) 82.2SiO2–10.3CaO–3.3P2O5–4.2ZnO (4ZN) were obtained by rapid prototyping and then, coated with gelatin for easy handling and potentiating the release of inorganic ions and OST. Bone defects (7.5 mm diameter, 12 mm depth) were drilled in the distal femoral epiphysis and filled with 4ZN, 4ZN+MSC, 4ZN+OST or 4ZN+MSC+OST materials to evaluate and compare their osteogenic features. Rabbits were sacrificed at 3 months extracting the distal third of bone specimens for necropsy, histological and microtomography (µCT) evaluations. Systems investigated exhibited bone regeneration capability. Thus, trabecular bone volume density (BV/TV) values obtained from µCT showed that the good bone healing capability of 4ZN was significantly improved by the scaffolds coated with OST and MSC. Our findings in vivo suggest the interest of these MBG complete systems to improve bone repair in the clinical practice

Unveiling the stellar origin of the Wolf-Rayet nebula NGC6888 through infrared observations

We present a comprehensive infrared (IR) study of the iconic Wolf-Rayet (WR) wind-blown bubble NGC6888 around WR136. We use Wide-field Infrared Survey Explorer (WISE), Spitzer IRAC and MIPS and Herschel PACS IR images to produce a sharp view of the distribution of dust around WR136. We complement these IR photometric observations with Spitzer IRS spectra in the 5-38 $\mu$m wavelength range. The unprecedented high-resolution IR images allowed us to produce a clean spectral energy distribution, free of contamination from material along the line of sight, to model the properties of the dust in NGC6888. We use the spectral synthesis code Cloudy to produce a model for NGC6888 that consistently reproduces its optical and IR properties. Our best model requires a double distribution with the inner shell composed only of gas, whilst the outer shell requires a mix of gas and dust. The dust consists of two populations of grain sizes, one with small sized grains $a_\mathrm{small}$=[0.002-0.008] $\mu$m and another one with large sized grains $a_\mathrm{big}$=[0.05-0.5] $\mu$m. The population of big grains is similar to that reported for other red supergiants stars and dominates the total dust mass, which leads us to suggest that the current mass of NGC6888 is purely due to material ejected from WR136, with a negligible contribution of swept up interstellar medium. The total mass of this model is 25.5$^{+4.7}_{-2.8}$ M$_{\odot}$, a dust mass of $M_\mathrm{dust}=$0.14$^{+0.03}_{-0.01}$ M$_{\odot}$, for a dust-to-gas ratio of $5.6\times10^{-3}$. Accordingly, we suggest that the initial stellar mass of WR136 was $\lesssim$50 M$_{\odot}$, consistent with current single stellar evolution models.Comment: 13 pages, 11 figures, 6 tables; Accepted to MNRA

Hackathon in teaching: Machine Learning applied to Life Sciences

La programación ha sido tradicionalmente una competencia perteneciente a las ingenierías, que recientemente está adquiriendo una importancia significativa en áreas como Ciencias de la Vida, donde resulta fundamental para la resolución de problemas de análisis de datos. Este trabajo es un caso de estudio enmarcado en la necesidad de mejorar las habilidades, sobre análisis de datos en el alumnado de Ciencias de la Vida y de la base temática en los estudiantes de ingeniería. Mediante la herramienta del hackathon y el trabajo en equipo, se combinó al alumnado de ambas disciplinas y se le enfrentó a una serie de problemas de análisis de datos. Se establecieron equipos de trabajo que recibieron una formación previa al comienzo de la competición. De cada equipo, se valoró la metodología empleada para la obtención de los datos, su análisis, interpretación de resultados, y exposición de las diversas tareas. Se hizo un análisis descriptivo de los resultados del Proyecto mediante encuestas al alumnado, así como su percepción sobre las actividades realizadas. El Proyecto ha conseguido que el alumnado resuelva los problemas planteados, difícilmente abordables con equipos unidisciplinares, generando un aprendizaje común y una experiencia multidisciplinar altamente satisfactoria tanto para el alumnado como para el profesorado.Programming has traditionally been an engineering competence, but recently it is acquiring significant importance in several areas, such as Life Sciences, which is considered essential for problem-solving based on data analysis. This work is a case study framed within the need to improve not only the data analysis skills of life science students, but also the biological background concerning the given issue of engineering students. Using hackathon and teamwork-based tools, students from both disciplines have been made and challenged with a series of problems in the area of Life Sciences. To solve these problems, we established work teams trained before the competition's beginning. Their results were assessed concerning the approach to obtain the data, perform the analysis, and finally interpret and present the results to solve the challenges. The project outcomes were assessed using structured surveys for students and their overall perception. The project succeeded, meaning students solved the proposed problems and achieved the activity's goals. These goals would have been difficult to address with teams composed of students from the same field of study. The hackathon succeeded in generating a shared learning and a multidisciplinary experience for their professional training, being highly rewarding for both students and faculty members

Reciprocal responses in the interaction between Arabidopsis and the cell-content feeding chelicerate herbivore spider mite

Most molecular-genetic studies of plant defense responses to arthropod herbivores have focused on insects. However, plant-feeding mites are also pests of diverse plants, and mites induce different patterns of damage to plant tissues than do well-studied insects (e.g. lepidopteran larvae or aphids). The two-spotted spidermite (Tetranychus urticae) is among the most significant mite pests in agriculture, feeding on a staggering number of plant hosts. To understand the interactions between spider mite and a plant at the molecular level, we examined reciprocal genome-wide responses of mites and its host Arabidopsis (Arabidopsis thaliana). Despite differences in feeding guilds, we found that transcriptional responses of Arabidopsis to mite herbivory resembled those observed for lepidopteran herbivores. Mutant analysis of induced plant defense pathways showed functionally that only a subset of induced programs, including jasmonic acid signaling and biosynthesis of indole glucosinolates, are central to Arabidopsis's defense to mite herbivory. On the herbivore side, indole glucosinolates dramatically increased mite mortality and development times. We identified an indole glucosinolate dose-dependent increase in the number of differentially expressedmite genes belonging to pathways associated with detoxification of xenobiotics. This demonstrates that spider mite is sensitive to Arabidopsis defenses that have also been associated with the deterrence of insect herbivores that are very distantly related to chelicerates. Our findings provide molecular insights into the nature of, and response to, herbivory for a representative of a major class of arthropod herbivores

Surfactantless Emulsions Containing Eugenol for Imidacloprid Solubilization: Physicochemical Characterization and Toxicity against Insecticide-Resistant Cimex lectularius

Synthetic insecticides have been used for a long time as one of the most effective tools for insect pest control. However, the re-emergence of insect pests and their fast development of resistance, as has occurred for pyrethroid-resistant bed bugs Cimex lectularius L., make it necessary to develop new and safe strategies for effective pest control. This has fostered the research on new eco-sustainable formulations based on essential oils, which allows reducing the impact associated with the intensive use of synthetic insecticides on the environment and their effects on human health. This research explores the stability of water/eugenol/ethanol surfactantless emulsions loaded with imidacloprid (0.003 wt%), and their toxicity against a resistant bed bug strain. The results have shown that these emulsions enable the solubilization of a poorly water-soluble drug, such as the imidacloprid, without any significant modification of their stability. Furthermore, the application of the obtained formulations against the pyrethroid-resistant bed bug results in mortality in the 50–85% range upon topical and spray applications, with the increase of the eugenol content enhancing the effectiveness of the formulations. It may be expected that the ternary water/eugenol/ethanol mixtures could be further developed in the preparation of ready to use formulations, enabling the dispersion of insecticides for pest control

Mechanical properties of freely suspended atomically thin dielectric layers of mica

We have studied the elastic deformation of freely suspended atomically thin sheets of muscovite mica, a widely used electrical insulator in its bulk form. Using an atomic force microscope, we carried out bending test experiments to determine the Young's modulus and the initial pre-tension of mica nanosheets with thicknesses ranging from 14 layers down to just one bilayer. We found that their Young's modulus is high (190 GPa), in agreement with the bulk value, which indicates that the exfoliation procedure employed to fabricate these nanolayers does not introduce a noticeable amount of defects. Additionally, ultrathin mica shows low pre-strain and can withstand reversible deformations up to tens of nanometers without breaking. The low pre-tension and high Young's modulus and breaking force found in these ultrathin mica layers demonstrates their prospective use as a complement for graphene in applications requiring flexible insulating materials or as reinforcement in nanocomposites.Comment: 9 pages, 5 figures, selected as cover of Nano Research, Volume 5, Number 8 (2012

Total absorption gamma-ray spectroscopy study of the β-decay of 186Hg

7 pags., 9 figs., 1 tab.The Gamow-Teller strength distribution of the decay of Hg into Au has been determined for the first time using the total absorption gamma spectroscopy technique and has been compared with theoretical QRPA calculations using the SLy4 Skyrme force. The measured Gamow-Teller strength distribution and the half-life are described by mixing oblate and prolate configurations independently in the parent and daughter nuclei. In this theoretical framework the best description of the experimental beta strength is obtained with dominantly prolate components for both parent Hg and daughter Au. The approach also allowed us to determine an upper limit of the oblate component in the parent state. The complexity of the analysis required the development of a new approach in the analysis of the X-ray gated total absorption spectrum.This work was supported by Spanish Ministerio de Economía y Competitividad under grants FPA2011-24553, FPA2014-52823-C2-1-P, FPA2017-83946-C2-1-P, FPA2017-87568-P, Ministerio de Ciencia e Innovación grants PID2019-104714GB-C21 and RTI2018-098868-B-100, program Severo Ochoa (SEV-2014-0398), ENSAR (grant 262010) and by the European Union Horizon 2020 research and innovation programme under Grant Agreement No. 654002. S.E.A.O. thanks the support of CPAN Consolider-Ingenio 2010 Programme CSD2007-00042 grant. E.G. acknowledges support from TÜBITAK 2219 Abroad Research Fellowship Programme. R.B.C. acknowledges support by the Max-Planck-Partner group. Support from the technical staff and engineers of ISOLDE-CERN is acknowl- edged. W.G. acknowledges the support of STFC (UK) council grant ST/P005314/1. V.G. acknowledges the support of the National Science Center, Poland, under Contract No. 2019/35/D/ST2/02081. This work was also supported by the National Research, Development and Innovation Fund of Hungary, financed under the K18 funding scheme with Projects No. K 128729 and NN128072. P.S. acknowledges support from MCI/AEI/FEDER, UE (Spain) under grant PGC2018-093636-B-I0

Un análisis exploratorio de la relación entre pobreza multidimensional y conflicto armado : el caso de Antioquia en Colombia

RESUMEN: Este artículo analiza la relación entre pobreza y conflicto armado en Antioquia, Colombia. El análisis de la pobreza está enmarcado en el enfoque de las capacidades de Sen, el cual conforma la base conceptual del índice de pobreza multidimensional (IPM) desarrollado por Alkire y Foster. El IPM es calculado con información derivada de la base de datos Sisbén, la cual se utiliza para seleccionar la población atendida por los programas de asistencia social del Gobierno colombiano. Este artículo consideró tres dimensiones de pobreza: estándares de vida, salud, y educación. El conflicto armado fue medido por medio de datos de conteo acerca de la ocurrencia de eventos de violencia registrados entre 1996 y 2010 en cada municipalidad de Antioquia. Luego, la relación entre la pobreza y el conflicto armado se analizó mediante métodos exploratorios y no paramétricos como las distribuciones kernel. Los resultados sugieren que el IPM es robusto con respecto a la elección del umbral de pobreza multidimensional. Los mapas de caja y bigotes sugieren que los pobres están localizados en las regiones periféricas de Antioquia. Las distribuciones kernel muestran que las áreas más afectadas por el conflicto, usualmente, tienen altos niveles de pobreza multidimensional.ABSTRACT: This paper analyses the relationship between poverty and armed conflict in Antioquia, Colombia. The poverty analysis it uses is framed according to Sen’s capability approach, which constitutes the conceptual basis for the Multidimensional Poverty Index (MPI) subsequently developed by Alkire and Foster. The MPI is measured employing data from the government database SISBEN, which is used by the Colombian authorities to identify beneficiaries of social assistance programmes. The paper considers three poverty dimensions: living standards, health, and education. Armed conflict is measured using count data on violent events recorded for every municipality in the Department of Antioquia between 1996 and 2010. The relationship between poverty and armed conflict is then analysed using exploratory and non-parametric methods such as kernel distributions. Results suggest that the MPI is robust when compared multidimensional cutoffs. The MPI box-plot maps suggest that poor people are located in Antioquia’s peripheral areas. Kernel distributions show that areas most affected by conflict tend to show higher levels of multidimensional poverty