Winter Feeding of Elk in the Greater Yellowstone Ecosystem and its Effects on Disease Dynamics

Providing food to wildlife during periods when natural food is limited results in aggregations that may facilitate disease transmission. This is exemplified in western Wyoming where institutional feeding over the past century has aimed to mitigate wildlife–livestock conflict and minimize winter mortality of elk (Cervus canadensis). Here we review research across 23 winter feedgrounds where the most studied disease is brucellosis, caused by the bacterium Brucella abortus. Traditional veterinary practices (vaccination, test-and-slaughter) have thus far been unable to control this disease in elk, which can spill over to cattle. Current disease-reduction efforts are being guided by ecological research on elk movement and density, reproduction, stress, co-infections and scavengers. Given the right tools, feedgrounds could provide opportunities for adaptive management of brucellosis through regular animal testing and population-level manipulations. Our analyses of several such manipulations highlight the value of a research–management partnership guided by hypothesis testing, despite the constraints of the sociopolitical environment. However, brucellosis is now spreading in unfed elk herds, while other diseases (e.g. chronic wasting disease) are of increasing concern at feedgrounds. Therefore experimental closures of feedgrounds, reduced feeding and lower elk populations merit consideration

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS.Peer reviewe

A park under pressure: The impacts of human disturbance in Murchison Falls Conservation Area, Uganda

The extent of human disturbance is increasing, even in protected areas. I evaluated human disturbance impacts in Murchison Falls Conservation Area (MFCA), Uganda, a park in the Albertine Rift biodiversity hotspot, using two approaches. First, I quantified vegetation patterns and edge effects using remote sensing data in the MFCA interior, a boundary zone, and exterior zone. I observed abrupt changes in productivity between the park and adjacent unprotected areas, indicating a "hard edge", and found evidence of edge effects that extended 4-6 km into MFCA. Second, I evaluated the impact of restored oil pads, roads, the park boundary, and anthropogenic noise on mammal distribution using camera traps and occupancy modeling. Few species avoided, and some were attracted to, more disturbed sites, where restoration may have provided food resources. As human populations continue growing around MFCA and oil production begins, evaluating human disturbance impacts on the landscape will be increasingly important

Drilling through Conservation Policy: Oil Exploration in Murchison Falls Protected Area, Uganda

Approximately 2.5 billion barrels of commercially-viable oil, worth $2 billion in annual revenue for 20 years, were discovered under the Ugandan portion of the Albertine Rift in 2006. The region also contains seven of Uganda's protected areas and a growing ecotourism industry. We conducted interviews and focus groups in and around Murchison Falls Protected Area, Uganda's largest, oldest, and most visited protected area, to assess the interaction of oil exploration with the three primary conservation policies employed by Uganda Wildlife Authority: protectionism, neoliberal capital accumulation, and community-based conservation. We find that oil extraction is legally permitted inside protected areas in Uganda, like many other African countries, and that the wildlife authority and oil companies are adapting to co-exist inside a protected area. Our primary argument is that neoliberal capital accumulation as a conservation policy actually makes protected areas more vulnerable to industrial exploitation because nature is commodified, allowing economic value and profitability of land uses to determine how nature is exploited. Our secondary argument is that the conditional nature of protected area access inherent within the protectionist policy permits oil extraction within Murchison Falls Protected Area. Finally, we argue that community-based conservation, as operationalized in Uganda, has no role in defending protected areas against oil industrialisation

Using animal movement behavior to categorize land cover and predict consequences for connectivity and patch residence times

Context Landscape-scale population dynamics are driven in part by movement within and dispersal among habitat patches. Predicting these processes requires information about how movement behavior varies among land cover types. Objectives We investigated how butterfly movement in a heterogeneous landscape varies within and between habitat and matrix land cover types, and the implications of these differences for within-patch residence times and among-patch connectivity. Methods We empirically measured movement behavior in the Baltimore checkerspot butterfly (Euphydryas phaeton) in three land cover classes that broadly constitute habitat and two classes that constitute matrix. We also measured habitat preference at boundaries. We predicted patch residence times and interpatch dispersal using movement parameters estimated separately for each habitat and matrix land cover subclass (5 categories), or for combined habitat and combined matrix land cover classes (2 categories). We evaluated the effects of including edge behavior on all metrics

R code for seroprevalence of unfed herds (fig 3) from Winter feeding of elk in the Greater Yellowstone Ecosystem and its effects on disease dynamics

Reads in serology data from 3 unfed elk populations and generates a plot illustrating brucellosis prevalence, sample sizes, and trends over time

R code. Function to create prevalence estimates by location and year. from Winter feeding of elk in the Greater Yellowstone Ecosystem and its effects on disease dynamics

This file is called in to other code files and is necessary for the generation of brucellosis prevalence estimates by site and year (and 95% confidence intervals)

R code. Function to create a smoother line using generalised additive models. from Winter feeding of elk in the Greater Yellowstone Ecosystem and its effects on disease dynamics

This file is called in to other code files and is necessary for the generation of smoothed brucellosis prevalence estimates, including in years for which there is no data

Test and slaughter serology data. from Winter feeding of elk in the Greater Yellowstone Ecosystem and its effects on disease dynamics

This is the serology data used to generate figure 4 in .csv format