Improving multi-objective reservoir operation optimization with sensitivity-informed dimension reduction

There is another ORE record for this article: http://hdl.handle.net/10871/21284This study investigates the effectiveness of a sensitivity-informed method for multi-objective operation of reservoir systems, which uses global sensitivity analysis as a screening tool to reduce computational demands. Sobol's method is used to screen insensitive decision variables and guide the formulation of the optimization problems with a significantly reduced number of decision variables. This sensitivity-informed method dramatically reduces the computational demands required for attaining high-quality approximations of optimal trade-off relationships between conflicting design objectives. The search results obtained from the reduced complexity multi-objective reservoir operation problems are then used to pre-condition the full search of the original optimization problem. In two case studies, the Dahuofang reservoir and the inter-basin multi-reservoir system in Liaoning province, China, sensitivity analysis results show that reservoir performance is strongly controlled by a small proportion of decision variables. Sensitivity-informed dimension reduction and pre-conditioning are evaluated in their ability to improve the efficiency and effectiveness of multi-objective evolutionary optimization. Overall, this study illustrates the efficiency and effectiveness of the sensitivity-informed method and the use of global sensitivity analysis to inform dimension reduction of optimization problems when solving complex multi-objective reservoir operation problems.China Postdoctoral Science FoundationNatural Science Foundation of Chin

Imprecise probabilistic estimation of design floods with epistemic uncertainties

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.An imprecise probabilistic framework for design flood estimation is proposed on the basis of the Dempster-Shafer theory to handle different epistemic uncertainties from data, probability distribution functions and probability distribution parameters. These uncertainties are incorporated in cost-benefit analysis to generate the lower and upper bounds of the total cost for flood control, thus presenting improved information for decision making on design floods. Within the total cost bounds, a new robustness criterion is proposed to select a design flood that can tolerate higher levels of uncertainty. A variance decomposition approach is used to quantify individual and interactive impacts of the uncertainty sources on total cost. Results from three case studies, with 127-, 104- and 54-year flood data sets respectively, show that the imprecise probabilistic approach effectively combines aleatory and epistemic uncertainties from the various sources and provides upper and lower bounds of the total cost. Between the total cost and the robustness of design floods, a clear trade-off which is beyond the information that can be provided by the conventional minimum cost criterion is identified. The interactions among data, distributions and parameters have a much higher contribution than parameters to the estimate of the total cost. It is found that the contributions of the various uncertainty sources and their interactions vary with different flood magnitude, but remain roughly the same with different return periods. This study demonstrates that the proposed methodology can effectively incorporate epistemic uncertainties in cost-benefit analysis of design floods.This study was supported by the National Natural Science Foundation of China (Grant No. 51320105010 and 51279021). The first author gratefully acknowledges the financial support provided by the China Scholarship Council. The authors are deeply indebted to editors, Dr Francesco Serinaldi and another anonymous reviewer for their valuable time and constructive suggestions that greatly improved the quality of this paper. The data of Three Gorges were obtained from the China Three Gorges Corporation. The data of Biliu were obtained from the Biliu reservoir administration. The data of Harbin were obtained from the Harbin hydrology bureau. These data are available as in Supporting Information Data Set which includes Data Set S1, Data Set S2 and Data Set S3. Data Set S1 corresponds to Three Gorges; Data Set S2 corresponds to Biliu; Data Set S3 corresponds to Harbin

A two stage Bayesian stochastic optimization model for cascaded hydropower systems considering varying uncertainty of flow forecasts

Copyright © 2014 American Geophysical UnionThis paper presents a new Two Stage Bayesian Stochastic Dynamic Programming (TS-BSDP) model for real time operation of cascaded hydropower systems to handle varying uncertainty of inflow forecasts from Quantitative Precipitation Forecasts. In this model, the inflow forecasts are considered as having increasing uncertainty with extending lead time, thus the forecast horizon is divided into two periods: the inflows in the first period are assumed to be accurate, and the inflows in the second period assumed to be of high uncertainty. Two operation strategies are developed to derive hydropower operation policies for the first and the entire forecast horizon using TS-BSDP. In this paper, the newly developed model is tested on China's Hun River cascade hydropower system and is compared with three popular stochastic dynamic programming models. Comparative results show that the TS-BSDP model exhibits significantly improved system performance in terms of power generation and system reliability due to its explicit and effective utilization of varying degrees of inflow forecast uncertainty. The results also show that the decision strategies should be determined considering the magnitude of uncertainty in inflow forecasts. Further, this study confirms the previous finding that the benefit in hydropower generation gained from the use of a longer horizon of inflow forecasts is diminished due to higher uncertainty and further reveals that the benefit reduction can be substantially mitigated through explicit consideration of varying magnitudes of forecast uncertainties in the decision-making process.National Natural Science Foundation of ChinaHun River cascade hydropower reservoirs development company, Ltd.UK Royal Academy of Engineerin

J2EE-based authentication system of expansive training for the university student

Conference Name:2013 3rd International Conference on Consumer Electronics, Communications and Networks, CECNet 2013. Conference Address: Xianning, China. Time:November 20, 2013 - November 22, 2013.The paper presents an authentication system that allows the user to query expansive training certification records for the university student. Firstly, we analyze the requirements of authentication system and come up with feasible solutions on the basis of learning the plan on expansive training to the cultivation of student quality. Before carrying out the system, the paper introduces the design thought of developing the system and the network technology it needs, and decides the design idea of oriented object, technique standard of J2EE and Web Service as technical solutions. In the end of the paper, it mainly discusses how to apply the J2EE technology to design the whole framework of authentication system. ? 2013 IEEE

CEP290 is essential for the initiation of ciliary transition zone assembly.

Cilia play critical roles during embryonic development and adult homeostasis. Dysfunction of cilia leads to various human genetic diseases, including many caused by defects in transition zones (TZs), the "gates" of cilia. The evolutionarily conserved TZ component centrosomal protein 290 (CEP290) is the most frequently mutated human ciliopathy gene, but its roles in ciliogenesis are not completely understood. Here, we report that CEP290 plays an essential role in the initiation of TZ assembly in Drosophila. Mechanistically, the N-terminus of CEP290 directly recruits DAZ interacting zinc finger protein 1 (DZIP1), which then recruits Chibby (CBY) and Rab8 to promote early ciliary membrane formation. Complete deletion of CEP290 blocks ciliogenesis at the initiation stage of TZ assembly, which can be mimicked by DZIP1 deletion mutants. Remarkably, expression of the N-terminus of CEP290 alone restores the TZ localization of DZIP1 and subsequently ameliorates the defects in TZ assembly initiation in cep290 mutants. Our results link CEP290 to DZIP1-CBY/Rab8 module and uncover a previously uncharacterized important function of CEP290 in the coordination of early ciliary membrane formation and TZ assembly

Seawater carbonate chemistry and sperm motility and fertilisation success in blood clam, Tegillarca granosa

Although it has been shown that ocean acidification generally has a negative impact on fertilisation success of broadcast spawning marine organisms, whether induced fertilisation success reduction is a consequence of elevated pCO2 or decreased pH remains unclear. Therefore, the impacts of HCl- and CO2-induced acidified seawater on sperm motility and gametes fertilisation capability of a broadcast spawning bivalve species, Tegillarca granosa were investigated in the present study. The results showed that the fertilisation capability of both gametes was significantly reduced in either HCl- or CO2-acidified seawater. In addition, significant impacts on sperm motility were observed in the group exposed to CO2-acidified seawater, suggesting that this parameter is sensitive to pCO2 instead of solely pH value. The differences between the two seawater acidification manipulating methods may be due to the intrinsic difference in diffusion capability of CO2 and protons

Synthetic defects in Cep290 localization in <i>cep162; fam92</i> or <i>fam92; cep290</i>^<i>ΔC</i> mutants.

Cep290 are absent from the TZ in the spermatocyte of cep162; fam92 or fam92; cep290ΔC mutants. The BB was labeled with γ-Tubulin (red). The error bars represent the mean ± SD, n = 30. Scale bars, 2 μm. The data underlying this figure can be found in S1 Data. (TIF)</p

Identification and phenotype analysis of <i>cep131</i> mutants.

(A) Diagram showing of the generation of cep131 mutants. Schematics show the genomic (upper panel) and protein (lower panel) structures of Cep131, along with the predict protein product of Cep1311 mutant (Cep1311_p.(His480_Leu708delfsTer61)). Two arrows represent gRNA target sites. cep1311, a frameshift line, has a deletion in cDNA from nt 1439 to 2123, resulting in a reading frame shift and C-terminus loss. (B) Genotyping of cep131 mutants using PCR. The PCR amplification products were 1471 bp long for w1118 and 603 bp long for cep131 flies. (C) Sequence confirmation of the deletion in cep131 mutant. Primers used for sequence are marked with orange frames. The locations of 2 gRNAs used for mutant generation are underlined with black. Red and blue frames label the boundary of deletion cep131 in mutant. (D) Immunostaining of CG6652 in spermatocyte cilia of WT or cep1311 testis. CG6652 (green) marks the ciliary axoneme. In cep1311, a few centrioles have over elongated CG6652 signals (arrows). Centriole/basal body is marked with γ-Tubulin (red). Scale bars, 5 μm. (E) Quantification of the radial distance of Cep290 or Cep290-N. In cep131 mutants, the radial distance of Cep290 or Cep290-N were significantly reduced compared to WT. The error bars represent the mean ± SD, n = 60. The data underlying this figure can be found in S1 Data. (TIF)</p

Protein sequence alignment of the C-terminus of human Cep162, mice Cep162, and <i>Drosophila</i> CG42699.

CG42699 is the only one significant alignment sequence when searching for homology of human or mice Cep162 protein in Drosophila melanogaster. (TIF)</p

Models for ciliogenesis initiation and the mechanism of CEP290 localization in <i>Drosophila</i>.

(A) Model for ciliogenesis initiation in Drosophila. ① In spermatogonia, Cep131 localizes to the distal end of centriole and recruits Cep162. ② When the centriole starts to grow cilia in spermatocytes, Cep162 recruits Cep290 and promotes the binding of Cep290-C to the axoneme. ③ Subsequently, the conformation of Cep290 changes from a closed to an open state, and the N-terminus of Cep290 recruits Dzip1-Cby-Fam92 module; ④ and then start early ciliary membrane formation and ciliary bud formation. (B) The cooperative model for Cep290 localization. Cep131-Cep162 module together with Cby-Fam92 module regulates the localization of Cep290 at the TZ. Mechanistically, Cep131 recruits Cep162 which mediates the association of C-terminus of Cep290 to microtubule. The N-terminus of Cep290 recruits Dzip1-Cby-Fam92 module to start early ciliary membrane formation and ciliary bud formation, whereas Cby-Fam92-mediated ciliary membrane formation has a positive feedback effect on promoting the association of Cep290 N-terminus with the ciliary membrane. TZ, transition zone.</p