Detection of Spectral Resources in Cognitive Radios Using Reinforcement Learning

On-Off-Keying with energy detection is a promising candidate when aiming at simple receiver concepts, due to the fact that simple energy detection reduces receiver complexity. On the other hand, data rates are low and interference mitigation by correlation is no longer possible. This paper proposes and analyzes a method for mitigating asynchronous interferers in energy detection receivers by adapting the maximum likelihood decision rule. It is shown that detection in the presence of interferers is improved and detection in absence of interferers is not declined

Single-stranded heteroduplex intermediates in λ Red homologous recombination

<p>Abstract</p> <p>Background</p> <p>The Red proteins of lambda phage mediate probably the simplest and most efficient homologous recombination reactions yet described. However the mechanism of dsDNA recombination remains undefined.</p> <p>Results</p> <p>Here we show that the Red proteins can act via full length single stranded intermediates to establish single stranded heteroduplexes at the replication fork. We created asymmetrically digestible dsDNA substrates by exploiting the fact that Redα exonuclease activity requires a 5' phosphorylated end, or is blocked by phosphothioates. Using these substrates, we found that the most efficient configuration for dsDNA recombination occurred when the strand that can prime Okazaki-like synthesis contained both homology regions on the same ssDNA molecule. Furthermore, we show that Red recombination requires replication of the target molecule.</p> <p>Conclusions</p> <p>Hence we propose a new model for dsDNA recombination, termed 'beta' recombination, based on the formation of ssDNA heteroduplexes at the replication fork. Implications of the model were tested using (i) an <it>in situ </it>assay for recombination, which showed that recombination generated mixed wild type and recombinant colonies; and (ii) the predicted asymmetries of the homology arms, which showed that recombination is more sensitive to non-homologies attached to 5' than 3' ends. Whereas beta recombination can generate deletions in target BACs of at least 50 kb at about the same efficiency as small deletions, the converse event of insertion is very sensitive to increasing size. Insertions up to 3 kb are most efficiently achieved using beta recombination, however at greater sizes, an alternative Red-mediated mechanism(s) appears to be equally efficient. These findings define a new intermediate in homologous recombination, which also has practical implications for recombineering with the Red proteins.</p

Superconductivity in three-dimensional spin-orbit coupled semimetals

Motivated by the experimental detection of superconductivity in the low-carrier density half-Heusler compound YPtBi, we study the pairing instabilities of three-dimensional strongly spin-orbit coupled semimetals with a quadratic band touching point. In these semimetals the electronic structure at the Fermi energy is described by spin j=3/2 quasiparticles, which are fundamentally different from those in ordinary metals with spin j=1/2. For both local and nonlocal pairing channels in j=3/2 materials we develop a general approach to analyzing pairing instabilities, thereby providing the computational tools needed to investigate the physics of these systems beyond phenomenological considerations. Furthermore, applying our method to a generic density-density interaction, we establish that: (i) The pairing strengths in the different symmetry channels uniquely encode the j=3/2 nature of the Fermi surface band structure—a manifestation of the fundamental difference with ordinary metals. (ii) The leading odd-parity pairing instabilities are different for electron doping and hole doping. Finally, we argue that polar phonons, i.e., Coulomb interactions mediated by the long-ranged electric polarization of the optical phonon modes, provide a coupling strength large enough to account for a Kelvin-range transition temperature in the s-wave channel, and are likely to play an important role in the overall attraction in non-s-wave channels. Moreover, the explicit calculation of the coupling strengths allows us to conclude that the two largest non-s-wave contributions occur in nonlocal channels, in contrast with what has been commonly assumed.Gordon and Betty Moore Foundation. EPiQS Initiative (Grant GBMF4303)National Science Foundation (U.S.) (Grant PHY-1125915)United States. Department of Energy (Grant FG02-03ER46076)United States. Department of Energy. Division of Materials Sciences and Engineering (Award DE-SC0010526

Identification of nematic superconductivity from the upper critical field

Recent nuclear magnetic resonance and specific heat measurements have provided concurring evidence of spontaneously broken rotational symmetry in the superconducting state of the doped topological insulator Cu[subscript x]Bi[subscript 2]Se[subscript 3]. This suggests that the pairing symmetry corresponds to a two-dimensional representation of the D[subscript 3d] crystal point group, and that Cu[subscript x]Bi[subscript 2]Se[subscript 3] is a nematic superconductor. In this paper, we present a comprehensive study of the upper critical field H[subscript c2] of nematic superconductors within Ginzburg-Landau (GL) theory. Contrary to typical GL theories which have an emergent U(1) rotational symmetry obscuring the discrete symmetry of the crystal, the theory of two-component superconductors in trigonal D[subscript 3d] crystals reflects the true crystal rotation symmetry. This has direct implications for the upper critical field. First, H[subscript c2] of trigonal superconductors with D[subscript 3d] symmetry exhibits a sixfold anisotropy in the basal plane. Second, when the degeneracy of the two components is lifted by, e.g., uniaxial strain, H[subscript c2] exhibits a twofold anisotropy with characteristic angle and temperature dependence. Our thorough study shows that measurement of the upper critical field is a direct method of detecting nematic superconductivity, which is directly applicable to recently-discovered trigonal superconductors Cu[subscript xBi[subscript 2Se[subscript 3], Sr[subscript x]Bi[subscript 2]Se[subscript 3], Nb[subscript x]Bi[subscript 2]Se[subscript 3], and Tl[subscript x]Bi[subscript 2]Te[subscript 3].David & Lucile Packard FoundationUnited States. Department of Energy. Office of Basic Energy Science. Division of Materials Sciences and Engineering. (Award No. DESC0010526)Netherlands Organization for Scientific Research (Rubicon grant

Atomistic modelling of large-scale metal film growth fronts

We present simulations of metallization morphologies under ionized sputter deposition conditions, obtained by a new theoretical approach. By means of molecular dynamics simulations using a carefully designed interaction potential, we analyze the surface adsorption, reflection, and etching reactions taking place during Al physical vapor deposition, and calculate their relative probability. These probabilities are then employed in a feature-scale cellular-automaton simulator, which produces calculated film morphologies in excellent agreement with scanning-electron-microscopy data on ionized sputter deposition.Comment: RevTeX 4 pages, 2 figure

Special Hermitian metrics on compact solvmanifolds

We review some constructions and properties of complex manifolds admitting pluriclosed and balanced metrics. We prove that for a 6-dimensional solvmanifold endowed with an invariant complex structure J having holomorphically trivial canonical bundle the pluriclosed flow has a long time solution for every invariant initial datum. Moreover, we state a new conjecture about the existence of balanced and SKT metrics on compact complex manifolds. We show that the conjecture is true for nilmanifolds of dimension 6 and 8 and for 6-dimensional solvmanifolds with holomorphically trivial canonical bundle.Comment: 16 pages. To appear in a special issue of the Journal of Geometry and Physic

Gauge-Gravity Dualities, Dipoles and New Non-Kahler Manifolds

In this work we explore many directions in the framework of gauge-gravity dualities. In type IIB theory we give an explicit derivation of the local metric for five branes wrapped on rigid two-cycles. Our derivation involves various interplays between warp factors, dualities and fluxes and the final result confirms our earlier predictions. We also find a novel dipole-like deformation of the background due to an inherent orientifold projection in the full global geometry. The supergravity solution for this deformation takes into account various things like the presence of a non-trivial background topology and fluxes as well as branes. Considering these, we manage to calculate the precise local solution using equations of motion. We also show that this dipole-like deformation has the desired property of decoupling the Kaluza-Klein modes from the IR gauge theory. Finally, for the heterotic theory we find new non-Kahler complex manifolds that partake in the full gauge-gravity dualities and study the mathematical structures of these manifolds including the torsion classes, Betti numbers and other topological data.Comment: Harvmac, 80 pages, 4 .eps figures; v2: Some typos corrected and new references added; v3: More typos corrected and references updated. Final version to appear in Nucl. Phys.

Dynamics of a deformable self-propelled particle under external forcing

We investigate dynamics of a self-propelled deformable particle under external field in two dimensions based on the model equations for the center of mass and a tensor variable characterizing deformations. We consider two kinds of external force. One is a gravitational-like force which enters additively in the time-evolution equation for the center of mass. The other is an electric-like force supposing that a dipole moment is induced in the particle. This force is added to the equation for the deformation tensor. It is shown that a rich variety of dynamics appears by changing the strength of the forces and the migration velocity of self-propelled particle

Dipole-Deformed Bound States and Heterotic Kodaira Surfaces

We study a particular N = 1 confining gauge theory with fundamental flavors realised as seven branes in the background of wrapped five branes on a rigid two-cycle of a non-trivial global geometry. In parts of the moduli space, the five branes form bound states with the seven branes. We show that in this regime the local supergravity solution is surprisingly tractable, even though the background topology is non-trivial. New effects such as dipole deformations may be studied in detail, including the full backreactions. Performing the dipole deformations in other ways leads to different warped local geometries. In the dual heterotic picture, which is locally given by a C* fibration over a Kodaira surface, we study details of the geometry and the construction of bundles. We also point out the existence of certain exotic bundles in our framework.Comment: 40 pages, 3 .eps figures, Harvma

Validation of serum IGF-I as a biomarker to monitor the bioactivity of exogenous growth hormone agonists and antagonists in rabbits

The development of new growth hormone (GH) agonists and growth hormone antagonists (GHAs) requires animal models for pre-clinical testing. Ideally, the effects of treatment are monitored using the same pharmacodynamic marker that is later used in clinical practice. However, intact rodents are of limited value for this purpose because serum IGF-I, the most sensitive pharmacodynamic marker for the action of GH in humans, shows no response to treatment with recombinant human GH and there is little evidence for the effects of GHAs, except when administered at very high doses or when overexpressed. As an alternative, more suitable model, we explored pharmacodynamic markers of GH action in intact rabbits. We performed the first validation of an IGF-I assay for the analysis of rabbit serum and tested precision, sensitivity, linearity and recovery using an automated human IGF-I assay (IDS-iSYS). Furthermore, IGF-I was measured in rabbits of different strains, age groups and sexes, and we monitored IGF-I response to treatment with recombinant human GH or the GHA Pegvisomant. For a subset of samples, we used LC-MS/MS to measure IGF-I, and quantitative western ligand blot to analyze IGF-binding proteins (IGFBPs). Although recovery of recombinant rabbit IGF-I was only 50% in the human IGF-I assay, our results show that the sensitivity, precision (1.7–3.3% coefficient of variation) and linearity (90.4–105.6%) were excellent in rabbit samples. As expected, sex, age and genetic background were major determinants of IGF-I concentration in rabbits. IGF-I and IGFBP-2 levels increased after single and multiple injections of recombinant human GH (IGF-I: 286±22 versus 434±26 ng/ml; P<0.01) and were highly correlated (P<0.0001). Treatment with the GHA lowered IGF-I levels from the fourth injection onwards (P<0.01). In summary, we demonstrated that the IDS-iSYS IGF-I immunoassay can be used in rabbits. Similar to rodents, rabbits display variations in IGF-I depending on sex, age and genetic background. Unlike in rodents, the IGF-I response to treatment with recombinant human GH or a GHA closely mimics the pharmacodynamics seen in humans, suggesting that rabbits are a suitable new model to test human GH agonists and antagonists