41 research outputs found
65 YEARS OF THE DOUBLE HELIX Genetics informs precision practice in the diagnosis and management of pheochromocytoma
- Author
- Bausch Birke
- Bayley Jean-Pierre
- Beltsevich Dmitry
- Boedeker Carsten C.
- Castinetti Frederic
- Eng Charis
- Gimm Oliver
- Groeben Harald-Thomas
- Krauss Tobias
- Leijon Helena
- Links Thera P.
- Lourenco Delmar M.
- Makay Ozer
- Neumann Hartmut P.
- Ngeow Joanne
- Opocher Giuseppe
- Patocs Attila
- Peczkowska Mariola
- Pennelli Gianmaria
- Pfeifer Marija
- Ruf Juri
- Schiavi Francesca
- Shah Nalini S.
- Tirosh Amit
- Tischler Arthur
- Villar Gomez de las Heras Karina
- von Dobschuetz Ernst
- Walz Martin
- Wohllk Nelson
- Young William F.
- Publication venue
- Publication date
- 01/01/2018
- Field of study
Although the authors of the present review have contributed to genetic discoveries in the field of pheochromocytoma research, we can legitimately ask whether these advances have led to improvements in the diagnosis and management of patients with pheochromocytoma. The answer to this question is an emphatic Yes! In the field of molecular genetics, the well-established axiom that familial (genetic) pheochromocytoma represents 10% of all cases has been overturned, with >35% of cases now attributable to germline disease-causing mutations. Furthermore, genetic pheochromocytoma can now be grouped into five different clinical presentation types in the context of the ten known susceptibility genes for pheochromocytoma-associated syndromes. We now have the tools to diagnose patients with genetic pheochromocytoma, identify germline mutation carriers and to offer gene-informed medical management including enhanced surveillance and prevention. Clinically, we now treat an entire family of tumors of the paraganglia, with the exact phenotype varying by specific gene. In terms of detection and classification, simultaneous advances in biochemical detection and imaging localization have taken place, and the histopathology of the paraganglioma tumor family has been revised by immunohistochemical-genetic classification by gene-specific antibody immunohistochemistry. Treatment options have also been substantially enriched by the application of minimally invasive and adrenal-sparing surgery. Finally and most importantly, it is now widely recognized that patients with genetic pheochromocytoma/paraganglioma syndromes should be treated in specialized centers dedicated to the diagnosis, treatment and surveillance of this rare neoplasm.Peer reviewe
Long-term prognosis of patients with pediatric pheochromocytoma
- Author
- Angelica Malinoc
- Asari
- Attila Patocs
- BARONTINI
- Bausch
- Bayley
- Beltsevich
- Birke Bausch
- Charis Eng
- Ciftci
- Comino-Mendez
- David Taieb
- DE KRIJGER
- Detlef Bockenhauer
- Dirk Bausch
- Dmitry Zabolotnyi
- Ein
- Ernst von Dobschuetz
- Francesca Schiavi
- Frederic Castinetti
- Gabriela Sanso
- Georges Weryha
- Gianni Bisogno
- Giovanni Cecchetto
- Giuseppe Opocher
- Hartmut P H Neumann
- Iveta Dzivite-Krisane
- Jochen Roessler
- Karoly Rácz
- Kaufman
- KHORRAM-MANESH
- Kurt W Schmid
- Lars C Moeller
- Mariola Peczkowska
- Marta Barontini
- Martin K Walz
- Neumann
- Neumann
- Newcombe
- Patrizia Dall'Igna
- Pham
- Qin
- Ross
- Stackpole
- Svetlana Yaremchuk
- Ulrich Wellner
- Publication venue
- 'Bioscientifica'
- Publication date
- 01/01/2013
- Field of study
A third of patients with paraganglial tumors, pheochromocytoma, and paraganglioma, carry germline mutations in one of the susceptibility genes, RET, VHL, NF1, SDHAF2, SDHA, SDHB, SDHC, SDHD, TMEM127, and MAX. Despite increasing importance, data for long-term prognosis are scarce in pediatric presentations. The European-American-Pheochromocytoma-Paraganglioma-Registry, with a total of 2001 patients with confirmed paraganglial tumors, was the platform for this study. Molecular genetic and phenotypic classification and assessment of gene-specific long-term outcome with second and/or malignant paraganglial tumors and life expectancy were performed in patients diagnosed at <18 years. Of 177 eligible registrants, 80% had mutations, 49% VHL, 15% SDHB, 10% SDHD, 4%NF1, and one patient each in RET, SDHA, and SDHC. A second primary paraganglial tumor developed in 38% with increasing frequency over time, reaching 50% at 30 years after initial diagnosis. Their prevalence was associated with hereditary disease (P=0.001), particularly in VHL and SDHD mutation carriers (VHL vs others, P=0.001 and SDHD vs others, P=0.042). A total of 16 (9%) patients with hereditary disease had malignant tumors, ten at initial diagnosis and another six during follow-up. The highest prevalence was associated with SDHB (SDHB vs others, P<0.001). Eight patients died (5%), all of whom had germline mutations. Mean life expectancy was 62 years with hereditary disease. Hereditary disease and the underlying germline mutation define the long-term prognosis of pediatric patients in terms of prevalence and time of second primaries, malignant transformation, and survival. Based on these data, gene-adjusted, specific surveillance guidelines can help effective preventive medicine.publishersversionPeer reviewe
International initiative for a curated SDHB variant database improving the diagnosis of hereditary paraganglioma and pheochromocytoma
- Author
- Publication venue
- Journal of Medical Genetics
- Publication date
- 26/08/2021
- Field of study
Funder: Cancer Research UK Cambridge Cancer CentreBackground: SDHB is one of the major genes predisposing to paraganglioma/pheochromocytoma (PPGL). Identifying pathogenic SDHB variants in patients with PPGL is essential to the management of patients and relatives due to the increased risk of recurrences, metastases and the emergence of non-PPGL tumours. In this context, the ‘NGS and PPGL (NGSnPPGL) Study Group’ initiated an international effort to collect, annotate and classify SDHB variants and to provide an accurate, expert-curated and freely available SDHB variant database. Methods: A total of 223 distinct SDHB variants from 737 patients were collected worldwide. Using multiple criteria, each variant was first classified according to a 5-tier grouping based on American College of Medical Genetics and NGSnPPGL standardised recommendations and was then manually reviewed by a panel of experts in the field. Results: This multistep process resulted in 23 benign/likely benign, 149 pathogenic/likely pathogenic variants and 51 variants of unknown significance (VUS). Expert curation reduced by half the number of variants initially classified as VUS. Variant classifications are publicly accessible via the Leiden Open Variation Database system (https://databases.lovd.nl/shared/genes/SDHB). Conclusion: This international initiative by a panel of experts allowed us to establish a consensus classification for 223 SDHB variants that should be used as a routine tool by geneticists in charge of PPGL laboratory diagnosis. This accurate classification of SDHB genetic variants will help to clarify the diagnosis of hereditary PPGL and to improve the clinical care of patients and relatives with PPGL
Basic science232. Certolizumab pegol prevents pro-inflammatory alterations in endothelial cell function
- Author
- Abdulkader Rita
- Abozaid Hanan S.
- Adab Peymané
- Adizie Tochukwu
- Adshead Rebecca
- Ahmad Yasmeen
- Ahmed Azeem A.
- Akil Mohammed
- Alavi Azita
- Alcorn Desmond
- Alexander Yvonne
- Alexander Yvonne
- Alexander Yvonne
- Allen Maggie
- Amarasena Roshan
- Amarasena Roshan I.
- Ambler Nick
- Amft Nicole
- Amft Nicole
- Amissah-Arthur Maame
- Amos Nicholson
- Anderson David
- Andres Mariano
- Andrews Jacqueline
- Arthur Catherine
- Ashton Simon
- Axford John
- Ayalew Yezenash
- Baburaj Krishnan
- Bacon Paul A.
- Baguley Elaine
- Ball Elisabeth
- Banik Snehashish
- Bari Syed F.
- Barone Francesca
- Barone Francesca
- Barton Anne
- Barton Anne
- Basu Neil
- Bateman James
- Bavakunji Riaz
- Bayley Rachel
- Beasley Marcus
- Bell Aubrey
- Bell Aubrey L.
- Birnbaum Julius
- Bombardieri M.
- Bombardieri Michele
- Bombardieri Michele
- Bombardieri Michele
- Bond Christine
- Bond Ursula
- Borg Frances
- Borg Frances A.
- Bosworth Ailsa
- Boulton John
- Bowman Simon
- Bowness Paul
- Bowness Paul
- Bowness Paul
- Braude Simon
- Brooksby Alan
- Brophy Sinead
- Brown Deborah
- Brown Nina
- Brown Sue J.
- Bruce Ian
- Bruce Ian
- Bruce Ian
- Bruce Ian
- Bruce Ian
- Buckley Chris
- Buckley Chris
- Buckley Chris
- Buckley Chris D.
- Bukhari Marwan
- Bukhari Marwan
- Bukhari Marwan
- Bullock Craig
- Bunn Diane
- Bunn Diane
- Bunning Rowena
- Bunning Rowena A. D.
- Bunning Rowena D.
- Calnan Michael
- Cardy Caroline M.
- Casey Matthew
- Caswell Richard
- Ceeraz Sabrina
- Chan Antoni
- Chana Jasroop K.
- Chapman Victoria
- Chen Liye
- Cheng K. K.
- Chitale Sarang
- Chitale Sarang
- Chiverton Neil
- Chiverton Neil
- Choy Ernest
- Choy Ernest H.
- Christidis Dimitrios
- Cloake Tom
- Cloake Tom
- Clunie Gavin
- Coady David
- Coady David
- Coady David
- Colaco Bernard
- Cole Zoe A.
- Coles Mark
- Collins Fraser
- Cooksey Roxanne
- Cooper Annie
- Cooper Cyrus
- Cooper Cyrus
- Cooper Nicola
- Cope Andrew
- Cordingley Lis
- Corrigall Valerie
- Coward Lucy
- Crawford Aileen
- Crilly Anne
- Cross Alison
- Cross Alison K.
- Crouch Carina
- Crozier Sarah R.
- Cumming Jo
- Curtis Elizabeth M.
- D'Cruz David
- Danda Debashish
- Daniel Priya
- Daniels Jodie
- Darroch James
- Dasgupta Bhaskar
- Dasgupta Bhaskar
- Dasgupta Bhaskar
- Davies Charlotte
- Davies David
- Davies Rebecca
- Davies Ursula M.
- Dent Caroline
- Devanny Ian
- Dey Ida D.
- Dhanjal Mandish
- Dhillon Veena
- DiCicco Maria
- Dixey Josh
- Dixey Josh
- Doherty Teresa
- Donnelly Simon P.
- Driscoll Paul C.
- Duncan G.
- Duncan Rosie
- Dunn Sara
- Dures Emma
- Edgar Suzanne
- Edmonds Sally
- Edwards Christopher J.
- Edwards Christopher J.
- Edwards Steven W.
- Ellis Benjamin
- Ellis Corrinne
- Else Sara
- Emery Paul
- Ennis H.
- Estrach Cristina
- Estrach Cristina
- Evans Bronwen
- Evans Hayley G.
- Evans Laura
- Eyre Tracey
- Fang Hong
- Farrow Luke
- Fattah Zozik
- Ferrell William R.
- Field Max
- Finlay Ron
- Fisher Roman
- Fleming S.
- Fletcher Debbie
- Fluess Elisa
- Foggo Heather
- Fortune F.
- Fu Bo
- Gainsborough Nicola
- Galloway James
- Galloway James
- Garner Rozeena
- Garza-Garcia Acely
- Gathany Tim
- Gayed Mary
- Gayed Mary
- Georgia Ntani
- Giles Ian
- Giles Ian
- Giles Ian
- Giles Joanna L.
- Godfrey Keith M.
- Goff Iain
- Golor G.
- Goodson Nicola J.
- Goodson Nicola J.
- Goodson Nicola J.
- Gordon Caroline
- Gordon Caroline
- Gordon Caroline
- Gorman Claire L.
- Greenbank Cathi
- Griffiths Bridget
- Griffiths Bridget
- Gullick Nicola J.
- Gullick Nicola J.
- Gupta Monica
- Haddock Gail
- Haddock Gail
- Hakim Alan J.
- Halsey John
- Han Chenglong
- Hands Rebecca
- Harper Lorraine
- Harris Claire L.
- Harta N.
- Harvey Nicholas C.
- Hashmi Tahir M.
- Hassan Ahmed I.
- Hassell Andrew
- Hayes Fiona
- Hayes Fiona
- Heaney Jonathan
- Heathfield Sarah
- Heron Louise
- Herrick Ariane
- Hewlett Sarah
- Hewlett Sarah
- Hickling M.
- Horan Michael
- Hsia Elizabeth
- Hughes Michael
- Hui Michelle
- Hull Richard
- Hull Richard G.
- Humby Frances
- Humphreys Jennifer
- Hunter John
- Hunter John
- Husain Muhammad J.
- Hutchinson David
- Hyrich Kimme
- Hyrich Kimme
- Ibrahim Ibrahim
- Inskip Hazel M.
- Ioannou John
- Ioannou Yiannis
- Iqbal Itrat
- Irvine Elizabeth
- Isaacs John
- Isenberg David
- Isenberg David
- Isenberg David
- Isenberg David
- Isenberg David
- Ismajli Mediola
- Jani Meghna
- Jani Meghna
- Jayaraj David M.
- Jayne David
- Jenkins Jessica
- Jennens Hannah
- Jiang C. Q.
- John Elizabeth
- Johnson Phil
- Jones Gareth T.
- Jones Gareth T.
- Jones Simon A.
- Jullion A.
- Kallankara Sathish
- Kate I.
- Kay Lesley
- Keeley Philip
- Keidel Sarah
- Kelly Sara
- Kelly Stephen
- Kendall David
- Kenu Ernest
- Kessler Benedikt M.
- Khamashta Munther
- Khattak Fazlihakim
- Kiely Patrick D.
- Kindness Kathy
- Kollnberger Simon
- Kollnberger Simon
- Kollnberger Simon
- Kretsos K.
- Kumar Kanta
- Kumar Namita
- Kuvikova Inna
- Lam T. H.
- Lane Peter
- Lanyon Peter
- Lanyon Peter
- Lanyon Peter
- Lawton Sally
- Le Maitre Christine
- Le Maitre Christine L.
- Le Maitre Christine L.
- Ledingham Jo
- Lendrem Dennis
- Leung Jansen
- Lewis Cathryn M.
- Lim Ken
- Ling Stephanie
- Lip Stefanie
- Little Jayne
- Littlewood Alison
- Lockhart John
- Loke Yoon
- Lovell Karina
- Low Audrey
- Lunt Mark
- Lunt Mark
- Lutalo Pamela M.
- Macfarlane Gary J.
- Macfarlane Gary J.
- Macfarlane Gary J.
- Macfarlane Matthew V.
- MacGregor Alex
- MacGregor Alex
- MacGregor Alex
- Mackie Sarah L.
- Macphie Elizabeth
- Mahadik Younis
- Mahendranath K. M.
- Main Wong Way
- Malaviya Anshuman P.
- Marks Jonathan
- Marroquin Osiris
- Mason Justin
- Mc Laughlin Maeve
- McBeth John
- McBeth John
- McBurney H.
- McHugh Kirsty
- McHugh Kirsty
- McHugh Neil
- McHugh Neil
- McHugh Neil
- McInnes Iain
- McInnes Ian
- McKenna Frank
- McKeogh John
- Mckew Jennifer R.
- McLaren John
- McLoughlin Yokemei
- Mehta Puja
- Mehta Puja
- Meldrum Gillian
- Mercer Louise
- Middleton Jim
- Millar Auleen M.
- Misra Ramnath
- Mitchell Adam
- Mitchell Sheryl
- Mobasheri Ali
- Moots Robert J.
- Moots Robert J.
- Moots Robert J.
- Morgan Anne
- Morgan Matthew
- Morris Marianne
- Mugford Miranda
- Mulvey Matthew
- Mulvey Matthew R.
- Murfitt Lucy
- Murphy Helen
- Murray-Brown William
- Mérida Angeles Acosta
- Nayar Saba
- Nayar Saba
- Nazeer Moideen Abdul
- Nelson-Piercy Catherine
- Newman W.
- Ng Nora
- Ng Wan-Fai
- Nicholl Karl
- Nikiphorou Elena
- Nikiphorou Elena
- Nowell Mari A.
- O'Connor Mortimer B.
- O'Neill Terence
- Ogunbambi Olabambo
- Oldroyd Alexander G.
- Oomatia Amin
- Oreffo Richard O.
- Osei-Bordom Daniel-Clement
- Osgood Louise
- Ostor Andrew J.
- Owens Martina
- Palmer Helen
- Parker Ben
- Parker Ben
- Parker Ben
- Patel Dipti
- Patel Yusuf
- Patil Pravin
- Paudyal Priya
- Paul Morgan B.
- Pauling John D.
- Payeli Sravan
- Pearce Fiona
- Pease Colin T.
- Pease Colin T.
- Pendleton Neil
- Pericleous Charis
- Pericleous Charis
- Perry Liz
- Petri Michelle
- Phelan Mark J.
- Phillips Ceri J.
- Phillips E.
- Phillips Kate L. E.
- Picarelli G.
- Pierangeli Silvia
- Pierangeli Silvia S.
- Pilling Claire
- Pitzalis C.
- Pitzalis Costantino
- Pitzalis Costantino
- Pitzalis Costantino
- Plant Darren
- Plant Darren
- Platt Philip N.
- Plevin Robin
- Pope Denise
- Popham Maria
- Price Elizabeth
- Price Elizabeth
- Price-Forbes Alec
- Priori R.
- Pushpakom S.
- Rahman Anisur
- Rahman Anisur
- Rahman Anisur
- Rankin Elizabeth
- Rao Chandini
- Ray David W.
- Raza Karim
- Rees Frances
- Regan Marian
- Regan Marian
- Reid David M.
- Renner Christoph
- Reynolds John A.
- Reynolds Piero
- Rhys-Dillon Brian
- Ridley Anna
- Robertson Calum
- Robinson Frances
- Robinson Sandra
- Robinson Siân M.
- Rooke Royston
- Rooney Madeleine
- Roskell S.
- Roussou Thalia
- Roussou Thalia
- Rump-Goodrich Lisa
- Russell M.
- Rutherford Michelle
- Ryan Sarah
- Rysnik Oliwia J.
- Sanderson Tessa
- Sayer Avan A.
- Scott David L.
- Scott Ian C.
- Segeda Iuliia
- Selvan Shilpa
- Semenova Olga
- Sensky T.
- Seoudi N.
- Severn Andrew
- Shah Preeti
- Sharp Charlotte A.
- Shastri Nilabh
- Shaw Jackie
- Shaw Jacqueline
- Shaw S.
- Sheldon Jo
- Shevchuk Sergii
- Siebert Stefan
- Siebert Stefan
- Simpson John
- Sivakumar Rajappa
- Skeoch Sarah
- Sofat Nidhi
- Solymossy Csilla
- Spandley A.
- Spector Tim
- Spencer Jo
- Srikanth Asha
- Steer Sophia
- Stewart Kirsty
- Stockton Marie
- Stone Michael
- Strand V.
- Sutcliffe Nurhan
- Sutton Emily J.
- Swan Joan
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Taams Leonie S.
- Tahir Hasan
- Tan Shaun
- Tandon Neeta
- Tappuni T.
- Tarelli Edward
- Taylor P.
- Taylor Peter
- Taylor Peter
- Teh Lee-Suan
- Thapper Muryum
- Thapper Muryum
- Thomas Huw B.
- Thompson Helen
- Timoshanko J.
- Tugnet Nicola
- Tysoe Carolyn
- Vadivelu Saravanan
- Valesini G.
- Vartoukian S.
- Varughese Sneha
- Venning Michael
- Verstappen Suzanne M.
- Viatte Sebastien
- Vincent Tonia
- Walker David
- Walker-Bone Karen
- Walker-Bone Karen
- Walsh David A.
- Wang Edward
- Watson Kath
- Watson Kath D.
- Watts Richard
- Weaver Dan
- West Louise
- West Lucy
- Wilkinson Mark
- Williams Anwen S.
- Williams Anwen S.
- Williams Emma L.
- Williams Frances M.
- Williams Mark
- Williams Mark R.
- Wilson Anthony
- Wilson Gillian
- Wilson Jo
- Win Maw Win
- Woby Steve
- Wong-Baeza Isabel
- Wood Elizabeth F.
- Worthington J.
- Worthington Jane
- Wright Helen L.
- Wright Stephen A.
- Yates Max
- Yee Chee-Seng
- Young Adam
- Young Adam
- Young Stephen
- Young Stephen P.
- Zaki Awal
- Zeef Leo
- Zoma Asad
- Publication venue
- Publication date
- 02/08/2017
- Field of study
Background: Cardiovascular disease is a major comorbidity of rheumatoid arthritis (RA) and a leading cause of death. Chronic systemic inflammation involving tumour necrosis factor alpha (TNF) could contribute to endothelial activation and atherogenesis. A number of anti-TNF therapies are in current use for the treatment of RA, including certolizumab pegol (CZP), (Cimzia ®; UCB, Belgium). Anti-TNF therapy has been associated with reduced clinical cardiovascular disease risk and ameliorated vascular function in RA patients. However, the specific effects of TNF inhibitors on endothelial cell function are largely unknown. Our aim was to investigate the mechanisms underpinning CZP effects on TNF-activated human endothelial cells. Methods: Human aortic endothelial cells (HAoECs) were cultured in vitro and exposed to a) TNF alone, b) TNF plus CZP, or c) neither agent. Microarray analysis was used to examine the transcriptional profile of cells treated for 6 hrs and quantitative polymerase chain reaction (qPCR) analysed gene expression at 1, 3, 6 and 24 hrs. NF-κB localization and IκB degradation were investigated using immunocytochemistry, high content analysis and western blotting. Flow cytometry was conducted to detect microparticle release from HAoECs. Results: Transcriptional profiling revealed that while TNF alone had strong effects on endothelial gene expression, TNF and CZP in combination produced a global gene expression pattern similar to untreated control. The two most highly up-regulated genes in response to TNF treatment were adhesion molecules E-selectin and VCAM-1 (q 0.2 compared to control; p > 0.05 compared to TNF alone). The NF-κB pathway was confirmed as a downstream target of TNF-induced HAoEC activation, via nuclear translocation of NF-κB and degradation of IκB, effects which were abolished by treatment with CZP. In addition, flow cytometry detected an increased production of endothelial microparticles in TNF-activated HAoECs, which was prevented by treatment with CZP. Conclusions: We have found at a cellular level that a clinically available TNF inhibitor, CZP reduces the expression of adhesion molecule expression, and prevents TNF-induced activation of the NF-κB pathway. Furthermore, CZP prevents the production of microparticles by activated endothelial cells. This could be central to the prevention of inflammatory environments underlying these conditions and measurement of microparticles has potential as a novel prognostic marker for future cardiovascular events in this patient group. Disclosure statement: Y.A. received a research grant from UCB. I.B. received a research grant from UCB. S.H. received a research grant from UCB. All other authors have declared no conflicts of interes
Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial
- Author
- Abbott Tom
- Abdul Nazar
- Abercrombie John
- Abraham Ajit
- Ackland Gareth
- Adams Ferdinand
- Adegoke Kenneth
- Agarwal Banwari
- Agostini Helen
- Akhtar Mansoor
- Al Shama Majed
- Alegria Ana
- Alexander Peter
- Ali Dhiraj
- Allen Katherine
- Anderson Iain
- Andrews Sam
- Ankers Alastair
- Aravind Biju
- Arnold Glenn
- Aryal Kamal
- Asaria Miqdad
- Baig Faisal
- Bailey Flora
- Bailey Lindsay
- Bailey Simon
- Baillie Kirsty
- Baker Susie
- Baldwin Lee
- Banerjea Ayan
- Banks Victoria
- Barker Jonathon
- Bartlett Rachel
- Baxter Linden
- Baxter Stephen
- Beavis Sarah
- Belagodu Zakaulla
- Bell Louise
- Bell Stephanie
- Bengeri Sheshagiri
- Benlloch Raoul
- Bews-hair Maria
- Bhardwaj Sian
- Bhowmick Arnab
- Bion Julian
- Bion Julian
- Black Helen
- Blazeby Jane
- Blenk Karl
- Blunt Mark
- Bodger Phoebe
- Borgeaud Nathan
- Bothma Pieter
- Bothma Pieter
- Bottomley David
- Bowery Sarah
- Boyd Christine
- Bradburn Mike
- Bradburn Mike
- Brady Will
- Brennan Andrew
- Brennan Emma
- Brescia Giovanni
- Brett Stephen
- Broad Dan
- Brodbeck Andreas
- Bromilow James
- Bronder Christine
- Browell David
- Brown James
- Brown Stephanie
- Bryce Gavin
- Buckley Sarah
- Bunker Nick
- Burns Karen
- Burrow James
- Burrow James
- Burrows Lorna
- Burtenshaw Andrew
- Cabreros Leilani
- Cain Kathryn
- Cain Martyn
- Calder Verity
- Campbell Marta
- Campbell-smith Tim
- Carey Kate
- Carmichael Jack
- Cartmell Mark
- Cartwright Charles
- Cecconi Maurizio
- Chadwick Michael
- Chambers Rob
- Chan Peter
- Chana Avninder
- Chatzimichail Stelios
- Chitre Vivek
- Christie Iain
- Cirstea Emanuel
- Claxton Andrew
- Clement Ian
- Coldwell Chris
- Coleman Mark
- Colley Julie
- Collins Paddy
- Conway Daniel
- Cook Esther
- Cook Fabian
- Cook Nicola
- Cooke Katie
- Cope Sean
- Cornforth Belinda
- Correia Carmen
- Corson John
- Crabtree Michael
- Craven Rachael
- Cromwell David
- Cruickshank Neil
- Cuming Tamzin
- Cunha Pedro
- Cupitt Jason
- Curtis Edward
- D'souza Rovan
- Davies Peter
- Davis Emma
- Davis Huw
- Dawson Chris
- Debrunner Robert
- Desikan Somi
- Dhingsa Rajpal
- Dickinson Natalie
- Divekar Nandita
- Dodd Phil
- Dorman Frankie
- Doughan Samer
- Dowling Susan
- Downey Sarah
- Doyle Donna
- Drake Sharon
- Dreyer Fanus
- Dumpala Rajesh
- Durant Emma
- Edwards Jennifer
- Edwards Mark
- El-damatty Essam
- El-masry Nabil
- Engel Arnth
- Escofet Xavier
- Evans Thomas
- Everingham Kirsty
- Evley Rachel
- Faiz Omar
- Farhat Sami
- Farrow Catherine
- Fawcet Adrian
- Felipe Rowena
- Fernandes Roy
- Finch Guy
- Fitton Laura
- Fitzgerald Peter
- Fletcher Simon
- Fletcher Steve
- Flint Neil
- Forbes Gordon
- Freshwater-turner Dan
- Full Jens
- Furneval Julie
- Ganepola Ranjit
- Gardner Matt
- Garg Sudha
- Gaughan Matthew
- Gay Mike
- Geary Tim
- Gerrard David
- Gerstina Nabua
- Gibbs Richard
- Gibson Bruce
- Gibson Simon
- Gill Kathryn
- Gillies Michael
- Girgis Amira
- Girling Alan
- Gokhale Jay
- Gordon Anthony
- Graham Laura
- Graham Linda
- Greenwood Jamie
- Griffin Ruth
- Griffith John
- Griffiths Ewen
- Griffiths Megan
- Grocott Mike
- Gursevak Singh
- Gurung Sarada
- Guruswamy Raman
- Hadi Nada
- Haigh Fran
- Hale Beth
- Hales Dawn
- Hall Elizabeth
- Hall Elizabeth
- Hanousek Jan
- Harper Nick
- Harris James
- Harris Simon
- Harrison Ewen
- Harrison Paul
- Hartopp Richard
- Harvard Tim
- Harwood Elizabeth
- Haslop Richard
- Hayden Paul
- Henderson Steven
- Henwood Mark
- Hermandes Anil
- Hester Simon
- Hill Oliver
- Hilton Valerie
- Hodges Stacy
- Hollister Nigel
- Holt Peter
- Holtham Anitha
- Hool Alison
- Hopkins Phil
- Hopper John
- Horner Chris
- Howard-griffin Richard
- Howell Simon
- Howes Helen
- Hu Ying
- Hudson Liam
- Humes David
- Hurford Dom
- Husain Tariq
- Hutchinson Steve
- Iftikhar Syed
- Ijaz Sami
- Inglis David
- Iqbal Qamar
- Ishaan Maitra
- Jah Asif
- Jain Susan
- Janokowski Stas
- Januszewska Marta
- Jardine Catherine
- Jemmet Kim
- Jennings Adrian
- Jhamatt Anita
- Jovaisa Tomas
- Jovestani Keiarash
- Kahan Brennan
- Kahan Brennan
- Karat Isabella
- Karlikowsk Michael
- Karvonen Jyrki
- Kerry Sally
- Kerry Sally
- Khalaf Wael
- Khater Magdy
- Kightly Lynsey
- Kirby-bott James
- Kirk-bayley Justin
- Knight Georgia
- Knowles Charles
- Kocman David
- Kuduvalli Preeti
- Kukreja Neil
- Kuldip Rai
- Kumar Peeyush
- Kunst Gudrun
- Kushakovsky Vlad
- Laba Damian
- Lake Stephen
- Lal Roshan
- Lamb Peter
- Lams Edward
- Langton Helen
- Lawson Maria
- Lawton Greg
- Leno Emma
- Leuwer Martin
- Leuwer Martin
- Lewis Chris
- Lewis Ricky
- Liasis Lampros
- Lilford Richard
- Limb James
- Lindner Andrew
- Linnett Vanessa
- Lobo Dileep
- Lourtie Jose
- Lyness Craig
- Lynne Kaighan
- Lythell Nicola
- Machesney Michael
- Mackinnon John
- Macklin Christopher
- Mahajan Ravi
- Mahroof Razeen
- Maiya Bala
- Makris Nikolaos
- Marangoni Gabriele
- Martin Graham
- Martin Graham
- Martin Graham
- Martin Michael
- Marwick Jeremy
- Mason Nick
- Mateo Dolores
- May Denzil
- Mcafee Sean
- Mcarthur Carol
- Mccairn Amanda
- Mccullough Jonathan
- Mcilveen Erin
- Mclachan Jenny
- Mclaren Paul
- Mcmenemie Fiona
- Mcmullan Sean
- Mcnelis Una
- Medici Thomas
- Melville David
- Menezes Flavia
- Mercer Stuart
- Miller Andrew
- Millican Dean
- Milne Gordon
- Minto Gary
- Minto Gary
- Mirza Nazzia
- Misane Inga
- Modha Jigna
- Mohanty Manab
- Mohr Otto
- Mohsen Yasser
- Mole Jonathon
- Moncaster Gareth
- Monk David
- Monkhouse Diane
- Moonesinghe Ramani
- Morgan Richard
- Morgan-jones Tom
- Morris Craig
- Morrison Alan
- Mosley Frances
- Moug Susan
- Mukherjee Dipankar
- Mull Ajaya
- Mullenheim Jost
- Munro Mark
- Murray Dave
- Murray David
- Murray Diane
- Murray Therese
- Muthuswamy Babu
- Myers Alister
- Mythen Monty
- Nadarajavan Senthil
- Naik Veena
- Narula Harjeet
- Nash Guy
- Natarajan Nat
- Niebrzegowska Edyta
- Noble Hamish
- Noble Paul
- Noblett Sophie
- Northey Martin
- Nutt Chris
- O'carroll-kuehn Britta
- O'connell Gillian
- O'dwyer Grainne
- O'loughlin Paul
- Obichere Marion
- Obideyi Ayodele
- Odejinmi Oluremi
- Omer Abdel
- Outram Matt
- Owen Tom
- Owen Tom
- Paddle Jonathan
- Panikkar Kumar
- Papagrigoriadis Savvas
- Parker Thomas
- Parrington Simon
- Parry Jones Jack
- Parsons Anthony
- Patel Hitesh
- Patel Panna
- Patel Rajan
- Patel Sanjiv
- Patil Vishal
- Patrick Abigail
- Pearse Rupert
- Pearse Rupert M
- Peden Carol
- Peden Carol J
- Pemberton Phillippa
- Perrin-brown Laura
- Phull Mandeep
- Pick Sara
- Pickford Alison
- Pitman Catherine
- Pogson David
- Porter Helen
- Pow Colin
- Prabhudesai Ash
- Pratt Heather
- Prematie Andreou
- Prestwich Stewart
- Protopapas Michael
- Pulletz Mark
- Pulsa Stefan
- Pushpa Nathan
- Radford Nicola
- Rafi Amir
- Raj Ashok
- Rajagopal Ramesh
- Raju Pasupathy
- Raulusaite Ilona
- Razouk Khaled
- Reed Helen
- Rehman Almas
- Richardson Gerry
- Richardson Gerry
- Richardson Peter
- Riddington David
- Riddington Sid
- Rimmer Catherine
- Ritzema Jenny
- Rivett Kate
- Rivett Kate
- Robert Glenn
- Robin Nicole
- Rochester Chloe
- Rooney Kevin
- Rooney Laura
- Rope Tamsin
- Rose Alastair
- Ross-anderson Davina
- Roth Sally
- Rousseau Guy
- Roy Alistair
- Rubulotta Francesca
- Sagadai Saravanna
- Sanders Grant
- Sange Mansoor
- Saran Taj
- Sarfi Shameem
- Satisha Mallikarjunappa
- Saunders David
- Saunders David
- Scase Anne
- Schwarz Magen
- Scott Alexandra
- Sebastian Dominic
- Shah Tanuja
- Shankar Kirosh
- Sharma Abhiram
- Sharma Meghna
- Shaw Debbie
- Shawcross Robert
- Shenoy Shrisha
- Shukla Amit
- Silsby Joseph
- Sim Kevin
- Sim Malcolm
- Simeson Karen
- Singh Jagdeep
- Singh Satish
- Singh Surjait
- Sivasankaranand Ajit
- Sleight Simon
- Smart Simon
- Smith Hannah
- Smith Neil
- Snazelle Mark
- Somasekar Krishnamurthy
- Sonia Makvana
- Sonksen Julian
- Spimpolo Jennifer
- Stacey Brenda
- Stafford Helena
- Stanley David
- Stapleton Clare
- Stapleton Clare
- Stark Gail
- Steel Alistair
- Stephens Tim
- Stephens Tim
- Stergios Tezas
- Stevens Amanda
- Stevenson Richard
- Stewart Lynn
- Stone Julian
- Stotz Martin
- Stranix Nicola
- Stuart Hazel
- Subar Daren
- Sugavanam Anita
- Suggett Nigel
- Sunthareswaran Rame
- Surendran Karthik
- Susarla Jay
- Sutcliffe Robert
- Szakmany Tamas
- Szakmany Tamas
- Talwar Anjay
- Tan Kerwei
- Tan Melanie
- Tanqueray Tabitha
- Tansley John
- Tarrant Carolyn
- Taylor Lynn
- Thacker Andy
- Thomas Ruth
- Thomson Ann
- Thomson Ann
- Thorn Chris
- Thorniley Andrew
- Thrush Jessica
- Tierney Gill
- Tighe Sean
- Tofte Barclay
- Toth-tarsoly Piroska
- Townsend Roger
- Tucker Olga
- Tucker Vanessa
- Tutton Matthew
- Tyson Susan
- Ukoumunne Obioha
- Vaganov Sergei
- Van De Velde Niko
- Varcada Massimo
- Varma Sandeep
- Vashisht Shubha
- Velchuru Vamsi
- Verma Karan
- Vig Stella
- Vimalchandran Dale
- Visavadia Rakhee
- Vivek Chitre
- Waddy Sam
- Wakeford Julie
- Waldmann Carl
- Walker Simon
- Waring Justin
- Waring Justin
- Warusavitarne Janindra
- Watfah Josef
- Watson Geoff
- Watson Mark
- Watson Nicholas
- Watson Nick
- Watters Malcolm
- Way Carolyn
- Wells Duncan
- Wells Duncan
- Wells John
- Welsh Fenella
- Welters Ingeborg
- Wharton Richard
- White Andrew
- White Tim
- Wijeykoon Sanjay
- Wilkinson Jonny
- Wilkinson Mark
- Williams Alexandra
- Williams Dewi
- Williams Gail
- Williams Gethin
- Wilson Chris
- Wilson Graham
- Wilson Lawrence
- Wollaston Julie
- Wolverson Adam
- Wong Kate
- Wood Marcus
- Woods Justin
- Wrathall Wayne
- Wright Jenny
- Yang Fan
- Ziprin Paul
- Ziprin Paul
- Zuzan Oliver
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/06/2019
- Field of study
Background: Emergency abdominal surgery is associated with poor patient outcomes. We studied the effectiveness of a national quality improvement (QI) programme to implement a care pathway to improve survival for these patients. Methods: We did a stepped-wedge cluster-randomised trial of patients aged 40 years or older undergoing emergency open major abdominal surgery. Eligible UK National Health Service (NHS) hospitals (those that had an emergency general surgical service, a substantial volume of emergency abdominal surgery cases, and contributed data to the National Emergency Laparotomy Audit) were organised into 15 geographical clusters and commenced the QI programme in a random order, based on a computer-generated random sequence, over an 85-week period with one geographical cluster commencing the intervention every 5 weeks from the second to the 16th time period. Patients were masked to the study group, but it was not possible to mask hospital staff or investigators. The primary outcome measure was mortality within 90 days of surgery. Analyses were done on an intention-to-treat basis. This study is registered with the ISRCTN registry, number ISRCTN80682973. Findings: Treatment took place between March 3, 2014, and Oct 19, 2015. 22 754 patients were assessed for elegibility. Of 15 873 eligible patients from 93 NHS hospitals, primary outcome data were analysed for 8482 patients in the usual care group and 7374 in the QI group. Eight patients in the usual care group and nine patients in the QI group were not included in the analysis because of missing primary outcome data. The primary outcome of 90-day mortality occurred in 1210 (16%) patients in the QI group compared with 1393 (16%) patients in the usual care group (HR 1·11, 0·96–1·28). Interpretation: No survival benefit was observed from this QI programme to implement a care pathway for patients undergoing emergency abdominal surgery. Future QI programmes should ensure that teams have both the time and resources needed to improve patient care. Funding: National Institute for Health Research Health Services and Delivery Research Programme
Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial
- Author
- Abbott
- Abdel Omer
- Abhiram Sharma
- Abigail Patrick
- Adam Wolverson
- Adrian Fawcet
- Adrian Jennings
- Aggarwal
- Ahmed
- Ajaya Mull
- Ajit Abraham
- Ajit Sivasankaranand
- Alan Girling
- Alan Morrison
- Alastair Ankers
- Alastair Rose
- Alexandra Scott
- Alexandra Williams
- Alison Hool
- Alison Pickford
- Alistair Roy
- Alistair Steel
- Alister Myers
- Almas Rehman
- Amanda McCairn
- Amanda Stevens
- Amir Rafi
- Amira Girgis
- Amit Shukla
- Ana Alegria
- Anderson
- Andreas Brodbeck
- Andreou Prematie
- Andrew Brennan
- Andrew Burtenshaw
- Andrew Claxton
- Andrew Lindner
- Andrew Miller
- Andrew Thorniley
- Andrew White
- Andy Thacker
- Anil Hermandes
- Anita Jhamatt
- Anita Sugavanam
- Anitha Holtham
- Anjay Talwar
- Ann Thomson
- Ann Thomson
- Anne Scase
- Anthony Gordon
- Anthony Parsons
- Arnab Bhowmick
- Arnth Engel
- Ash Prabhudesai
- Ashok Raj
- Asif Jah
- Auerbach
- Avninder Chana
- Ayan Banerjea
- Ayodele Obideyi
- Babu Muthuswamy
- Bala Maiya
- Banwari Agarwal
- Barclay Tofte
- Batalden
- Belinda Cornforth
- Benning
- Beth Hale
- Biju Aravind
- Bion
- Brenda Stacey
- Brennan C Kahan
- Brennan Kahan
- Britta O'Carroll-Kuehn
- Bruce Gibson
- Carl Waldmann
- Carmen Correia
- Carol J Peden
- Carol Mcarthur
- Carol Peden
- Carolyn Tarrant
- Carolyn Way
- Catherine Farrow
- Catherine Jardine
- Catherine Pitman
- Catherine Rimmer
- Charles Cartwright
- Charles Knowles
- Chitre Vivek
- Chloe Rochester
- Chris Coldwell
- Chris Dawson
- Chris Horner
- Chris Lewis
- Chris Nutt
- Chris Thorn
- Chris Wilson
- Christine Boyd
- Christine Bronder
- Christopher Macklin
- Clare Stapleton
- Clare Stapleton
- Colin Pow
- Craig Lyness
- Craig Morris
- Dale Vimalchandran
- Damian Laba
- Damschroder
- Dan Broad
- Dan Freshwater-Turner
- Daniel Conway
- Daren Subar
- Dave Murray
- David Bottomley
- David Browell
- David Cromwell
- David Gerrard
- David Humes
- David Inglis
- David Kocman
- David Melville
- David Monk
- David Murray
- David Pogson
- David Riddington
- David Saunders
- David Saunders
- David Stanley
- Davina Ross-Anderson
- Dawn Hales
- Dean Millican
- Debbie Shaw
- Denzil May
- Dewi Williams
- Dhiraj Ali
- Diane Monkhouse
- Diane Murray
- Dileep Lobo
- Dipankar Mukherjee
- Dixon-Woods
- Dolores Mateo
- Dom Hurford
- Dominic Sebastian
- Donna Doyle
- Duncan Wells
- Duncan Wells
- Edward Curtis
- Edward Lams
- Edyta Niebrzegowska
- Elizabeth Hall
- Elizabeth Hall
- Elizabeth Harwood
- Emanuel Cirstea
- Emma Brennan
- Emma Davis
- Emma Durant
- Emma Leno
- Erin Mcilveen
- Essam El-Damatty
- Esther Cook
- Everingham
- Ewen Griffiths
- Ewen Harrison
- Fabian Cook
- Faisal Baig
- Fan Yang
- Fanus Dreyer
- Fenella Welsh
- Ferdinand Adams
- Fiona McMenemie
- Flavia Menezes
- Flora Bailey
- Fran Haigh
- Frances Mosley
- Francesca Rubulotta
- Frankie Dorman
- Gabriele Marangoni
- Gail Stark
- Gail Williams
- Gareth Ackland
- Gareth Moncaster
- Gary Minto
- Gary Minto
- Gavin Bryce
- Geoff Watson
- Georgia Knight
- Gerry Richardson
- Gerry Richardson
- Gethin Williams
- Gill Tierney
- Gillian O'Connell
- Giovanni Brescia
- Glenn Arnold
- Glenn Robert
- Gordon Forbes
- Gordon Milne
- Graham Martin
- Graham Martin
- Graham Martin
- Graham Wilson
- Grainne O'Dwyer
- Grant Sanders
- Greg Lawton
- Gudrun Kunst
- Guy Finch
- Guy Nash
- Guy Rousseau
- Hamish Noble
- Hannah Smith
- Harjeet Narula
- Haynes
- Hazel Stuart
- Heather Pratt
- Helen Agostini
- Helen Black
- Helen Howes
- Helen Langton
- Helen Porter
- Helen Reed
- Helena Stafford
- Hitesh Patel
- Huddart
- Hussey
- Huw Davis
- Iain Anderson
- Iain Christie
- Ian Clement
- Ilona Raulusaite
- Inga Misane
- Ingeborg Welters
- Isabella Karat
- Jack Carmichael
- Jack Parry Jones
- Jagdeep Singh
- James Bromilow
- James Brown
- James Burrow
- James Burrow
- James Harris
- James Kirby-Bott
- James Limb
- Jamie Greenwood
- Jan Hanousek
- Jane Blazeby
- Janindra Warusavitarne
- Jason Cupitt
- Jay Gokhale
- Jay Susarla
- Jennifer Edwards
- Jennifer Spimpolo
- Jenny McLachan
- Jenny Ritzema
- Jenny Wright
- Jens Full
- Jeremy Marwick
- Jessica Thrush
- Jigna Modha
- John Abercrombie
- John Corson
- John Griffith
- John Hopper
- John Mackinnon
- John Tansley
- John Wells
- Jonathan Mccullough
- Jonathan Paddle
- Jonathon Barker
- Jonathon Mole
- Jonny Wilkinson
- Jose Lourtie
- Josef Watfah
- Joseph Silsby
- Jost Mullenheim
- Julian Bion
- Julian Bion
- Julian Sonksen
- Julian Stone
- Julie Colley
- Julie Furneval
- Julie Wakeford
- Julie Wollaston
- Justin Kirk-Bayley
- Justin Waring
- Justin Waring
- Justin Woods
- Jyrki Karvonen
- Kahan
- Kahan
- Kaighan Lynne
- Kamal Aryal
- Karan Verma
- Karen Burns
- Karen Simeson
- Karl Blenk
- Karthik Surendran
- Kate Carey
- Kate Rivett
- Kate Rivett
- Kate Wong
- Katherine Allen
- Kathryn Cain
- Kathryn Gill
- Katie Cooke
- Keiarash Jovestani
- Kenneth Adegoke
- Kerwei Tan
- Kevin Rooney
- Kevin Sim
- Khaled Razouk
- Kim Jemmet
- Kirosh Shankar
- Kirsty Baillie
- Kirsty Everingham
- Krishnamurthy Somasekar
- Kumar Panikkar
- Kuper
- Lampros Liasis
- Langley
- Laura Fitton
- Laura Graham
- Laura Perrin-Brown
- Laura Rooney
- Lawrence Wilson
- Leatherman
- Lee Baldwin
- Leilani Cabreros
- Liam Hudson
- Linda Graham
- Linden Baxter
- Lindsay Bailey
- Lorna Burrows
- Louise Bell
- Lynn Stewart
- Lynn Taylor
- Lynsey Kightly
- Magdy Khater
- Magen Schwarz
- Maitra Ishaan
- Majed Al Shama
- Makvana Sonia
- Malcolm Sim
- Malcolm Watters
- Mallikarjunappa Satisha
- Manab Mohanty
- Mandeep Phull
- Mansoor Akhtar
- Mansoor Sange
- Marcus Wood
- Maria Bews-Hair
- Maria Lawson
- Marion Obichere
- Mark Blunt
- Mark Cartmell
- Mark Coleman
- Mark Edwards
- Mark Henwood
- Mark Munro
- Mark Pulletz
- Mark Snazelle
- Mark Watson
- Mark Wilkinson
- Marta Campbell
- Marta Januszewska
- Martin
- Martin Leuwer
- Martin Leuwer
- Martin Northey
- Martin Stotz
- Martyn Cain
- Massimo Varcada
- Matt Gardner
- Matt Outram
- Matthew Gaughan
- Matthew Tutton
- Maurizio Cecconi
- Megan Griffiths
- Meghna Sharma
- Melanie Tan
- Michael Chadwick
- Michael Crabtree
- Michael Gillies
- Michael Karlikowsk
- Michael Machesney
- Michael Martin
- Michael Protopapas
- Michie
- Mike Bradburn
- Mike Bradburn
- Mike Gay
- Mike Grocott
- Miqdad Asaria
- Moller
- Monty Mythen
- Moraros
- Morgan
- Nabil El-Masry
- Nabua Gerstina
- Nada Hadi
- Nandita Divekar
- Nat Natarajan
- Natalie Dickinson
- Nathan Borgeaud
- Nathan Pushpa
- Nazar Abdul
- Nazzia Mirza
- Neil Cruickshank
- Neil Flint
- Neil Kukreja
- Neil Smith
- Nicholas Watson
- Nick Bunker
- Nick Harper
- Nick Mason
- Nick Watson
- Nicola Cook
- Nicola Lythell
- Nicola Radford
- Nicola Stranix
- Nicole Robin
- Nigel Hollister
- Nigel Suggett
- Niko Van De Velde
- Nikolaos Makris
- Obioha Ukoumunne
- Olga Tucker
- Oliver Hill
- Oliver Zuzan
- Oluremi Odejinmi
- Omar Faiz
- Otto Mohr
- Paddy Collins
- Panna Patel
- Pannick
- Pasupathy Raju
- Paul Harrison
- Paul Hayden
- Paul Mclaren
- Paul Noble
- Paul O'Loughlin
- Paul Ziprin
- Paul Ziprin
- Pedro Cunha
- Peeyush Kumar
- Peter Alexander
- Peter Chan
- Peter Davies
- Peter Fitzgerald
- Peter Holt
- Peter Lamb
- Peter Richardson
- Phil Dodd
- Phil Hopkins
- Phillippa Pemberton
- Phoebe Bodger
- Pieter Bothma
- Pieter Bothma
- Piroska Toth-Tarsoly
- Preeti Kuduvalli
- Presseau
- Qamar Iqbal
- Rachael Craven
- Rachel Bartlett
- Rachel Evley
- Rai Kuldip
- Rajan Patel
- Rajesh Dumpala
- Rajpal Dhingsa
- Rakhee Visavadia
- Raman Guruswamy
- Ramani Moonesinghe
- Rame Sunthareswaran
- Ramesh Rajagopal
- Ranjit Ganepola
- Raoul Benlloch
- Ravi Mahajan
- Razeen Mahroof
- Richard Gibbs
- Richard Hartopp
- Richard Haslop
- Richard Howard-Griffin
- Richard Lilford
- Richard Morgan
- Richard Stevenson
- Richard Wharton
- Ricky Lewis
- Rob Chambers
- Robert DeBrunner
- Robert Shawcross
- Robert Sutcliffe
- Roger Townsend
- Roshan Lal
- Rovan D'souza
- Rowena Felipe
- Roy Fernandes
- Rupert M Pearse
- Rupert Pearse
- Ruth Griffin
- Ruth Thomas
- Sally Kerry
- Sally Kerry
- Sally Roth
- Sam Andrews
- Sam Waddy
- Samer Doughan
- Sami Farhat
- Sami Ijaz
- Sandeep Varma
- Sanjay Wijeykoon
- Sanjiv Patel
- Sara Pick
- Sarada Gurung
- Sarah Beavis
- Sarah Bowery
- Sarah Buckley
- Sarah Downey
- Saravanna Sagadai
- Satish Singh
- Saunders
- Savvas Papagrigoriadis
- Schouten
- Sean Cope
- Sean McAfee
- Sean Mcmullan
- Sean Tighe
- Sedgwick
- Senthil Nadarajavan
- Sergei Vaganov
- Shameem Sarfi
- Sharon Drake
- Sheshagiri Bengeri
- Shrisha Shenoy
- Shubha Vashisht
- Sian Bhardwaj
- Sid Riddington
- Simon Bailey
- Simon Fletcher
- Simon Gibson
- Simon Harris
- Simon Hester
- Simon Howell
- Simon Parrington
- Simon Sleight
- Simon Smart
- Simon Walker
- Singh Gursevak
- Somi Desikan
- Sophie Noblett
- Stacy Hodges
- Stas Janokowski
- Stefan Pulsa
- Stelios Chatzimichail
- Stella Vig
- Stephanie Bell
- Stephanie Brown
- Stephen Baxter
- Stephen Brett
- Stephen Lake
- Stephens
- Steve Fletcher
- Steve Hutchinson
- Steven Henderson
- Stewart Prestwich
- Stuart Mercer
- Sudha Garg
- Surjait Singh
- Susan Dowling
- Susan Jain
- Susan Moug
- Susan Tyson
- Susie Baker
- Syed Iftikhar
- Tabitha Tanqueray
- Taj Saran
- Tamas Szakmany
- Tamas Szakmany
- Tamsin Rope
- Tamzin Cuming
- Tanuja Shah
- Tariq Husain
- Tengberg
- Tezas Stergios
- Therese Murray
- Thomas Evans
- Thomas Medici
- Thomas Parker
- Tim Campbell-Smith
- Tim Geary
- Tim Harvard
- Tim Stephens
- Tim Stephens
- Tim White
- Tom Abbott
- Tom Morgan-Jones
- Tom Owen
- Tom Owen
- Tomas Jovaisa
- Una McNelis
- Valerie Hilton
- Vamsi Velchuru
- Vanessa Linnett
- Vanessa Tucker
- Veena Naik
- Verity Calder
- Vester-Andersen
- Victoria Banks
- Vishal Patil
- Vivek Chitre
- Vlad Kushakovsky
- Wael Khalaf
- Wayne Wrathall
- White
- White
- Will Brady
- Williams
- Xavier Escofet
- Yasser Mohsen
- Ying Hu
- Zakaulla Belagodu
- Publication venue
- 'Elsevier BV'
- Publication date
- 05/10/2018
- Field of study
BACKGROUND: Emergency abdominal surgery is associated with poor patient outcomes. We studied the effectiveness of a national quality improvement (QI) programme to implement a care pathway to improve survival for these patients. METHODS: We did a stepped-wedge cluster-randomised trial of patients aged 40 years or older undergoing emergency open major abdominal surgery. Eligible UK National Health Service (NHS) hospitals (those that had an emergency general surgical service, a substantial volume of emergency abdominal surgery cases, and contributed data to the National Emergency Laparotomy Audit) were organised into 15 geographical clusters and commenced the QI programme in a random order, based on a computer-generated random sequence, over an 85-week period with one geographical cluster commencing the intervention every 5 weeks from the second to the 16th time period. Patients were masked to the study group, but it was not possible to mask hospital staff or investigators. The primary outcome measure was mortality within 90 days of surgery. Analyses were done on an intention-to-treat basis. This study is registered with the ISRCTN registry, number ISRCTN80682973. FINDINGS: Treatment took place between March 3, 2014, and Oct 19, 2015. 22 754 patients were assessed for elegibility. Of 15 873 eligible patients from 93 NHS hospitals, primary outcome data were analysed for 8482 patients in the usual care group and 7374 in the QI group. Eight patients in the usual care group and nine patients in the QI group were not included in the analysis because of missing primary outcome data. The primary outcome of 90-day mortality occurred in 1210 (16%) patients in the QI group compared with 1393 (16%) patients in the usual care group (HR 1·11, 0·96-1·28). INTERPRETATION: No survival benefit was observed from this QI programme to implement a care pathway for patients undergoing emergency abdominal surgery. Future QI programmes should ensure that teams have both the time and resources needed to improve patient care. FUNDING: National Institute for Health Research Health Services and Delivery Research Programme
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L.
- Arif Shaikh Md
- Aritomi N.
- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Attadio Francesca
- Aubin Florian
- AVALLONE Guerino
- Azrad D.
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Baier Jeremy
- Baiotti Luca
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
- Barayoga J. C.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Dániel
- Bartoletti A. M.
- Barton Mark Andrew
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- Xu Victoria
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- Yadav Nikesh
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- Yamamura S.
- Yamazaki Ryo
- Yan S.
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- Yang Fengwei
- Yang Kate Z.
- Yang Yi
- Yarbrough Zach
- Yasui H.
- Yeh S. -W.
- Yelikar A. B.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuan S.
- Yuzurihara Hirotaka
- Zadrożny A.
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- Zeeshan M.
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- Zerrad M.
- Zevin Michael
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badalyan A.
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Baltus Grégory
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
- Barayoga J. C.
- Barber J.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Dániel
- Barthelmy S. D.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
- Basti Andrea
- Bawaj Mateusz
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- Bayley Joseph
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- Bedakihale V. M.
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- Bejger Michał
- Bell Angus
- Benedetto V.
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- Bergamin Fabio
- Berger Beverly
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- Bertolini A.
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- Beveridge Damon
- Bevins Nathaniel
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- Bhandari A. V.
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- Bhattacharjee Dripta
- Bhaumik Shubhagata
- Bianchi A.
- Bilenko I. A.
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- Bossilkov V.
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- Bécsy Bence
- C. Utina Andrei
- Cabourn Davies Gareth
- Cabras Giuseppe
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- Cadonati Laura
- Cagnoli Gianpietro
- Cahillane Craig
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- Camp J. B.
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- Caneva Santoro Giada
- Cannavacciuolo M.
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- Cao H.
- Capistran L. A.
- Capocasa Eleonora
- Capote E.
- Carapella G.
- Carbognani F.
- Carlassara M.
- Carlin Julian
- Carolina Silva Oliveira Ana
- Carpinelli Massimo
- Carter Jonathan
- Carullo Gregorio
- Casentini C.
- Castaldi G.
- Castro-Lucas S. Y.
- Caudill S.
- Cavaglia Marco
- Cavalieri Roberto
- Cella Giancarlo
- Cerdá-Durán Pablo
- Cesarini Elisabetta
- Chaibi W.
- Chalathadka Subrahmanya Shreevathsa
- Chan C.
- Chan M.
- Chan W. L.
- Chandra K.
- Chang I. P.
- Chang R. -J.
- Chang W.
- Chanial Pierre
- Chao Shiuh
- Chapman-Bird Christian
- Charlton E. L.
- Charlton Philip
- CHASSANDE-MOTTIN Eric
- Chastain L.
- Chatterjee Chayan
- Chatterjee Debarati
- Chatterjee Deep
- Chaturvedi M.
- Chaty Sylvain
- Chatziioannou Katerina
- Chen A.
- Chen A. H. -Y.
- Chen Dan
- Chen H.
- Chen Hsin-Yu
- Chen Junxin
- Chen K. H.
- Chen X.
- Chen Y.
- Chen Y. -R.
- Cheng H.
- Chessa Piero
- Chia H. Y.
- Chiadini Francesco
- Chiang C.
- Chiarini G.
- Chiba A.
- Chiba R.
- Chierici R.
- Chincarini Andrea
- Chiofalo M. L.
- Chiummo Antonino
- Chou C.
- Choudhary Sunil
- Christensen Nelson
- Chua Sheon S. Y.
- Chun Lung Chan Juno
- Chung K. W.
- Ciani Giacomo
- Ciecieląg Paweł
- Cieślar Marek
- Cifaldi M.
- Ciobanu A. A.
- Ciolfi Riccardo
- Clara F.
- Clark James
- Clarke Teagan
- Clasey Essick Reed
- Claudio Diaz Mario
- Clearwater P.
- Clesse S.
- Cleva F.
- Coccia E.
- Codazzo Elena
- Cohadon Pierre-François
- Colleoni Marta
- Collette C. G.
- Collins J.
- Colombo Alberto
- Colpi M.
- Compton C. M.
- Concetta Tringali Maria
- Conti Livia
- Cooper Sam
- Corbitt Thomas
- Cordero-Carrión Isabel
- Corezzi S.
- Cornish Neil
- Corsi Alessandra
- Cortese Stefano
- Costa C. A.
- Cottingham R.
- Coughlin Michael
- Couineaux A.
- Coulon J. -P.
- Countryman S. T.
- Coupechoux J. -F.
- Cousins Bryce
- Couvares Peter
- Coward D. M.
- Cowart M. J.
- Cowburn B. D.
- Coyne Dennis
- Coyne Robert
- Craig K.
- Creighton Jolien
- Creighton T. D.
- Criswell Alexander
- Crockett-Gray J. C. G.
- Croquette Michaël
- Crouch R.
- Crowder S. G.
- Cudell Jean-René
- Cullen T. J.
- Cumming Alan
- Cuoco E.
- Curyło M.
- Cusinato Marco
- D'Angelo Beatrice
- D'Antonio S.
- d'Emilio V.
- D'Onofrio Luca
- D'Urso D.
- Dabadie P.
- Dal Canton Tito
- DALL'OSSO Simone
- Danilishin Stefan
- Danzmann K.
- Darroch K. E.
- Darsow-Fromm Christian
- Dartez L. P.
- Dasgupta A.
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- Yeung T. Y.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
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- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhang Jue
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- Zhang T.
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
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- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
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- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
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- Antier Sarah
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- Antonio Font Roda Jose
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- Armato F.
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- Arogeti Megan
- Aronson Scott
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- de rossi camilla
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- Yeung S. M. C.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zeoli M.
- Zerrad M.
- Zevin Michael
- Zhang A. C.
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network
- Author
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aiello Lorenzo
- Ain A.
- Ajith Parameswaran
- Akutsu Tomotada
- Albanesi S.
- Alfaidi R. A.
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Amato Alex
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Arnaud Nicolas
- Arogeti M.
- Aronson S. M.
- Arène M.
- Asada Hideki
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badaracco Francesca
- Badger C.
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- Zhao Yuhang
- Zheng Yanyan
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- Zhu Zong-Hong
- Zimmerman Aaron
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- Árpád Gergely László
- 劉 國欽
- 曹周键
- 王谨
- 都丸 隆行
- Publication venue
- Publication date
- 01/04/2023
- Field of study
Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects