Methodology to improve the model of series inductance in CMOS integrated inductors

This paper presents a systematic optimization methodology to achieve an accurate estimation of series inductance of inductors implemented in standard CMOS technologies. Proposed method is based on an optimization procedure which aims to obtain adjustment factors associated to main physical inductor characteristics, allowing to estimate more accurate series inductance values that can be used in design stage. Experimental measurements of diverse square inductor geometries are shown and compared with previous approaches in order to demonstrate and validate presented approach.National Council of Science and Technology of México (CONACYT) TEC2013-45638-C3-3-RSpanish Ministry of Economy and Competitiveness TEC2013-45638-C3-3-REuropean Regional Development Fund TEC2013-45638-C3-3-RConsejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía P12-TIC-148

One-pot preparation of surface modified boehmite nanoparticles with rare-earth cyclen complexes

We report on the one-pot synthetic procedure of cyclen derivatives bearing three acetate groups attached on boehmite nanoparticles, the complexing capabilities of these inorganic–organic hybrid materials with rare earth cations, and the behaviour as contrast agents or fluorescence probes.Delgado Pinar, Estefania, [email protected] ; Frias Martinez, Juan Carlos, [email protected] ; Albelda Gimeno, Maria Teresa, [email protected] ; Alarcon Navarro, Javier, [email protected] ; Garcia-España Monsonis, Enrique, [email protected]

Impact of power ultrasound on chemical and physicochemical quality indicators of strawberries dried by convection

[EN] A study on the quality parameters of strawberries dehydrated by convection assisted by power ultrasound (US) at 40 70 C and 30 and 60W has been carried out for the first time. In general, the quality of US-treated samples was higher than that of commercial samples. Even under the most severe conditions used (US at 70 C and 60 W), high values of vitamin C retention (>65%) and scarce advance of Maillard reaction (2-furoylmethyl derivatives of Lys and Arg < 90 mg 100 g 1 protein) were observed. Rehydration ratio was not affected by the power applied and the obtained values were similar to those of convectively-treated samples. According to the results here presented, US is a suitable example of an emerging and environmentally friendly technology that accelerates convective drying, allowing the obtainment of dried strawberries with premium quality.This work has been funded by Ministry of Economy and Competitiveness of Spain and ERDF (FEDER) (Project DPI2012-37466-C03-03), Fun-c-Food (CSD2007-00063 Consolider-INGENIO 2010), CYTED IBEROFUN (P109AC0302) and Comunidad de Valencia, Project PROMETEO/2010/062. J.G.S. also thanks CSIC and the EU for a predoctoral JAE grant. A.C.S. thanks the Spanish Ministry of Economy and Competitiveness for a Ramon y Cajal contract.Gamboa-Santos, J.; Montilla, A.; Cortijo Soria, A.; Cárcel Carrión, JA.; García Pérez, JV.; Villamiel, M. (2014). Impact of power ultrasound on chemical and physicochemical quality indicators of strawberries dried by convection. Food Chemistry. 161:40-46. https://doi.org/10.1016/j.foodchem.2014.03.106S404616

Tratamiento quirúrgico e intervencionista de la coartación aórtica nativa en neonatos y lactantes

Introduction: Surgical relief of Coarctation of the aorta (CoA) and catheter interventional techniques are available alternatives even though no consensus has been reached in regard to the method of intervention (surgery vs. balloon angioplasty) in neonates and infants with native CoA. Many cardiologists prefer surgical intervention, whereas a few may choose for balloon angioplasty.Objective: To analyze surgical and interventional techniques outcomes in neonates and infants with native CoA. To identify the complications and the intensive care unit (ICU) stays. To determine the risk factors related to recoarctation (ReCoA).Method: An observational, analytical, longitudinal and prospective study was made aiming to analyze the surgical and balloon angioplasty outcomes in newborns and infants with native CoA at the William Soler Pediatric Cardiology Hospital from 2006 - 2011. Patients were distributed in two groups: Group I: patients treated with surgery (n=50); Group II: patients treated with angioplasty (n=14).Results: 75.0 % of patients in Group I and 57.1 % of the Group II were less than the six months old. ICU stays of patients treated surgically were the largest (median of 36 hours). The percentage of ReCoA was higher in patients treated with angioplasty (28.5 %). Paradoxical arterial hypertension was the most common complication found (60.0 %). A residual gradient higher than 15 mm Hg following surgical correction or balloon angioplasty was identified as a risk factor for ReCoA (interventional catheterization RR: 7.5; surgery RR: 11.4).Conclusions: ICU stays were longer in the patients underwent surgery. Patients treated with balloon angioplasty showed higher incidence of ReCoA. Complications were not so frequent. A gradient higher than 15 mm Hg was identified as a risk factor for ReCoA irrespective of the procedure performed.Introduction: le soulagement chirurgicale de coarctation de l'aorte (CoA) et le cathéter d'intervention techniques sont des alternatives disponibles, même si aucun consensus n'a été atteint en ce qui concerne la méthode d'intervention (chirurgie vs angioplastie par ballonnet) dans les nouveau-nés et les nourrissons avec natif CoA. Beaucoup de cardiologues préfèrent une intervention chirurgicale, tandis que quelques-uns peuvent choisir pour l'angioplastie par ballonnet. Objectif: analyser les techniques chirurgicales et interventionnelles résultats dans les nouveau-nés et les nourrissons avec natif CoA. Pour identifier les complications et les unités de soins intensifs (USI). Pour déterminer les facteurs de risque liés à recoarctation (ReCoA). Méthode: Une étude observationnelle analytique, longitudinale et prospective a été faite visant à analyser la chirurgie et l'angioplastie par ballonnet résultats des nouveau-nés et les nourrissons avec natif CoA à l'hôpital William Soler cardiologie pédiatrique de 2006 - 2011. patients ont été répartis en deux groupes: Groupe I : patients traités par chirurgie (n = 50); Groupe II: patients traités par angioplastie (n = 14). Résultats: 75,0% des patients du groupe I et 57,1% du groupe II étaient inférieures à la l'âge de six mois. Séjours aux soins intensifs des patients traités chirurgicalement ont le plus grand (médiane de 36 heures). Le pourcentage de ReCoA était plus élevée dans les patients traités à l'angioplastie (28,5%). L'hypertension artérielle paradoxale a été la complication la plus commune (60,0%). Un gradient résiduel supérieur à 15 mm Hg suivante chirurgicale correction ou l'angioplastie par ballonnet a été identifié comme un facteur de risque pour ReCoA (interventionnelle cathétérisme RR: 7,5; chirurgie RR: 11,4). Conclusions: séjours en soins intensifs étaient plus dans les patients ont été opérés. Les patients traités par angioplastie par ballonnet ont montré une incidence plus élevée de ReCoA. Les complications sont pas si fréquentes. Un gradient supérieur à 15 mm Hg a été identifiée comme un facteur de risque pour ReCoA quelle que soit l'intervention effectuée.Introdução: alívio cirúrgico da coarctação da aorta (CoA) e cateter intervencionista técnicas são alternativas disponíveis, embora nenhum consenso foi alcançado em relação ao método de intervenção (cirurgia vs angioplastia por balão) em recém-nascidos e lactentes com CoA nativa. Muitos cardiologistas preferem intervenção cirúrgica, enquanto que alguns podem optar por angioplastia com balão. Objetivo: Analisar a técnica cirúrgica e intervencionista resultados em recém-nascidos e lactentes com CoA nativa. Para identificar as complicações e Unidade de Terapia Intensiva (UTI) estadias. Para determinar os fatores de risco relacionados à recoartaram (RECOA). Método: um estudo observacional, analítico e prospectivo foi feito com o objetivo de analisar a cirurgia e balão de angioplastia resultados em recém-nascidos e lactentes com CoA nativa no William Soler Cardiologia Pediátrica do Hospital de 2006 - 2011. Os pacientes foram distribuídos em dois grupos: Grupo I : os doentes tratados com a cirurgia (n = 50); Grupo II: os doentes tratados com angioplastia (n = 14). Resultados: 75,0% dos pacientes do Grupo I e 57,1% do grupo II foram menores do que os seis meses de idade. Permanência na UTI de pacientes tratados cirurgicamente foram o maior (média de 36 horas). O percentual de RECOA foi maior nos pacientes tratados com angioplastia (28,5%). Hipertensão arterial paradoxal foi a complicação mais comum encontrada (60,0%). Um gradiente residual maior que 15 mm Hg após correção cirúrgica ou balão de angioplastia foi identificado como um fator de risco para RECOA (intervencionista RR cateterismo: 7,5; cirurgia RR: 11,4). Conclusões: permanência na UTI foram maiores quando os pacientes foram submetidos a cirurgia. Os pacientes tratados com angioplastia com balão mostrou maior incidência de RECOA. As complicações não foram tão freqüentes. Um gradiente maior que 15 mm Hg foi identificado como um fator de risco para RECOA independentemente do procedimento realizado.Introducción: La Coartación aórtica se puede resolver con cirugíao a través del intervencionismo. Aunque existe controversia, la mayor parte de los autores recomiendan laprimera para el tratamiento de la coartación aórtica nativa en menores de un año.Objetivos: Analizar losresultados de lacirugía y elcateterismo intervencionista en neonatos y lactantes con coartación de la aorta nativa. Identificar las complicaciones posprocedimiento y la estadía en la terapia intensiva .Determinar los factores de riesgo en la aparición de recoartación.Método: Se realizó un estudio observacional, analítico, prospectivo y longitudinal con el objetivo de analizar los resultados de la cirugía y el cateterismo intervencionista en recién nacidos y lactantes con Coartación de la Aorta nativa en el Cardiocentro Pediátrico“William Soler”, durante el período 2006 a 2011. Los pacientes se dividieron en dos grupos: Grupo I: pacientes operados (n=50); Grupo II: intervenidos por cateterismo intervencionista(n=14). Resultados: Los menores de 6 meses constituyeron 76,5% del grupo I y 57,1 % del grupo II. La estadía en laterapia intensiva fue mayor en los pacientes operados (mediana de 36 horas). El porciento de recoartación fue mayor en los pacientes llevados a hemodinámica (28,5 %). La complicación posprocedimiento más frecuente fue la hipertensión arterial paradójica (60 %). Elgradiente mayor de 15 mm Hg posproceder fue un factor de riesgo para la recidiva (hemodinamia RR: 7,5, cirugía RR: 11,4).Conclusiones: La estadía en la unidad de cuidados intensivos es mayor en los intervenidos quirúrgicamente. En la coartación aortica la recoartación es más frecuente en los tratados con angioplastia percutánea de balón. Las complicaciones son infrecuentes, y los pacientes con gradiente mayor de 15 mm Hg posprocedertienen un riesgo aumentado de recoartación en ambos grupos

Small Bowel Enteroscopy - A Joint Clinical Guideline by the Spanish and Portuguese Small-Bowel Study Groups

The present evidence-based guidelines are focused on the use of device-assisted enteroscopy in the management of small-bowel diseases. A panel of experts selected by the Spanish and Portuguese small-bowel study groups reviewed the available evidence focusing on the main indications of this technique, its role in the management algorithm of each indication, and its diagnostic and therapeutic yield. A set of recommendations was issued accordingly.info:eu-repo/semantics/publishedVersio

Small bowel enteroscopy - A joint clinical guideline from the spanish and portuguese small bowel study groups

The present evidence-based guidelines are focused on the use of device-assisted enteroscopy in the management of small-bowel diseases. A panel of experts selected by the Spanish and Portuguese small bowel study groups reviewed the available evidence focusing on the main indications of this technique, its role in the management algorithm of each indication and on its diagnostic and therapeutic yields. A set of recommendations were issued accordingly.Estas recomendações baseadas na evidência detalham o uso da enteroscopia assistida por dispositivo no manejo clínico das doenças do intestino delgado. Um conjunto de Gastrenterologistas diferenciados em patologia do intestino delgado foi selecionado pelos grupos de estudos Espanhol e Português de intestino delgado para rever a evidência disponível sobre as principais indicações desta técnica, o seu papel nos algoritmos de manejo de cada indicação e sobre o seu rendimento diagnóstico e terapêutico. Foi gerado um conjunto de recomendações pelos autores

Revista de Vertebrados de la Estación Biológica de Doñana

Clave preliminar de las escamas de los peces de agua dulce de España, a nivel de familiaExito reproductor del Buitre leonado (Gyps fulvus) en NavarraAlimentación del Gavilán (Accipiter nisus) en la Isla de TenerifeEl Verdecillo (Serinus serinus): Tendencias en la estación de nidificación, en el tamaño del huevo y en la supervivencia.las batidas como método de censo en especiesde caza mayor: aplicación al caso del Jabalí (Sus scrofa L.) en la provincia de Burgos (Norte de España)La adquisición de madurez sexual en el camaleón común (Chamaeleo chamaeleon)Nuevas citas de Hemidactylus turcicus en la provincia de CáceresLa focha común (Fulica atra) en la isla de Gran Canaria: nueva especie nidificante en el archipiélago CanarioTraslado de huevos en incubación por la urraca (Pica pica)Predación de Falco peregrinus sobre Oryctolagus cuniculusCuatro nuevas especies de aves para Bolivia.Sobre la utilización de nidos de golondrina común abandonados.Parasitismo múltiple del críalo (Clamator glandarius)Predación del topo de rio (Galemys pyrenaicus, Geoffroy 1811) por parte de la lechuza común (Tyto alba, Scopoli 1769)Predación del zorro (Vulpes vulpes) sobre un pollo de buitre leonado (Gyps fulvus).Vulpes vulpes L. criando en una colonia de marmota (Marmota marmota L.) en el pirineo de LéridaObservaciones sobre la incidencia de Rattus (Fischer, 1803) en los cultivos ibéricos de caña de azúcaSituación actual de la jutiita de la tierra Capromys sanfelipensis (Rodentia, Mammalia)Notas sobre la intraducción y expansión de la ardilla común en Sierra Nevada, sureste de EspañaPeer reviewe

Progressive Telomere Dysfunction Causes Cytokinesis Failure and Leads to the Accumulation of Polyploid Cells

Most cancer cells accumulate genomic abnormalities at a remarkably rapid rate, as they are unable to maintain their chromosome structure and number. Excessively short telomeres, a known source of chromosome instability, are observed in early human-cancer lesions. Besides telomere dysfunction, it has been suggested that a transient phase of polyploidization, in most cases tetraploidization, has a causative role in cancer. Proliferation of tetraploids can gradually generate subtetraploid lineages of unstable cells that might fire the carcinogenic process by promoting further aneuploidy and genomic instability. Given the significance of telomere dysfunction and tetraploidy in the early stages of carcinogenesis, we investigated whether there is a connection between these two important promoters of chromosomal instability. We report that human mammary epithelial cells exhibiting progressive telomere dysfunction, in a pRb deficient and wild-type p53 background, fail to complete the cytoplasmatic cell division due to the persistence of chromatin bridges in the midzone. Flow cytometry together with fluorescence in situ hybridization demonstrated an accumulation of binucleated polyploid cells upon serial passaging cells. Restoration of telomere function through hTERT transduction, which lessens the formation of anaphase bridges by recapping the chromosome ends, rescued the polyploid phenotype. Live-cell imaging revealed that these polyploid cells emerged after abortive cytokinesis due to the persistence of anaphase bridges with large intervening chromatin in the cleavage plane. In agreement with a primary role of anaphase bridge intermediates in the polyploidization process, treatment of HMEC-hTERT cells with bleomycin, which produces chromatin bridges through illegimitate repair, resulted in tetraploid binucleated cells. Taken together, we demonstrate that human epithelial cells exhibiting physiological telomere dysfunction engender tetraploid cells through interference of anaphase bridges with the completion of cytokinesis. These observations shed light on the mechanisms operating during the initial stages of human carcinogenesis, as they provide a link between progressive telomere dysfunction and tetraploidy

A vaccine based on a modified vaccinia virus Ankara vector expressing Zika virus structural proteins controls Zika virus replication in mice

Zika virus (ZIKV) is a re-emerging mosquito-borne flavivirus that affects humans and can cause severe neurological complications, including Guillain-Barré syndrome and microcephaly. Since 2007 there have been three large outbreaks; the last and larger spread in the Americas in 2015. Actually, ZIKV is circulating in the Americas, Southeast Asia, and the Pacific Islands, and represents a potential pandemic threat. Given the rapid ZIKV dissemination and the severe neurological and teratogenic sequelae associated with ZIKV infection, the development of a safe and efficacious vaccine is critical. In this study, we have developed and characterized the immunogenicity and efficacy of a novel ZIKV vaccine based on the highly attenuated poxvirus vector modified vaccinia virus Ankara (MVA) expressing the ZIKV prM and E structural genes (termed MVA-ZIKV). MVA-ZIKV expressed efficiently the ZIKV structural proteins, assembled in virus-like particles (VLPs) and was genetically stable upon nine passages in cell culture. Immunization of mice with MVA-ZIKV elicited antibodies that were able to neutralize ZIKV and induced potent and polyfunctional ZIKV-specific CD8+ T cell responses that were mainly of an effector memory phenotype. Moreover, a single dose of MVA-ZIKV reduced significantly the viremia in susceptible immunocompromised mice challenged with live ZIKV. These findings support the use of MVA-ZIKV as a potential vaccine against ZIKVassembled in virus-like particles (VLPs) and was genetically stable upon nine passages in cell culture. Immunization of mice with MVA-ZIKV elicited antibodies that were able to neutralize ZIKV and induced potent and polyfunctional ZIKV-specific CD8+ T cell responses that were mainly of an effector memory phenotype. Moreover, a single dose of MVA-ZIKV reduced significantly the viremia in susceptible immunocompromised mice challenged with live ZIKV. These findings support the use of MVA-ZIKV as a potential vaccine against ZIK