1,950 research outputs found

    Impact bias in student evaluations of higher education

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    In the context of higher education, this study examines the extent to which affective evaluations of the student experience are influenced by the point at which they are made (i.e. before the experience begins, whilst it is happening and after it has ended). It adopts a between-groups quantitative analysis of the affective evaluations made by 360 future, current and past postgraduate students of a UK business school. The study validates the proposition that affective forecasts and memories of the student experience are considerably inflated in prospect and retrospect; a finding that implies a significant impact bias. It is concluded that the impact bias may have important implications for influencing the effectiveness of student decision-making, the timing and comparability of student course evaluations, and understanding the nature and effects of word-of-mouth communication regarding the student experience

    Development of a high capacity toroidal Ni/Cd cell

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    A nickel cadmium battery design which can offer better thermal management, higher energy density and much lower cost than the state-of-the-art is emphasized. A toroidal Ni/Cd cell concept is described. It was critically reviewed and used to develop two cell designs for practical implementation. One is a double swaged and the other a swaged welded configuration

    All in the Family: Partisan Disagreement and Electoral Mobilization in Intimate Networks - a Spillover Experiment

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    We advance the debate about the impact of political disagreement in social networks on electoral participation by addressing issues of causal inference common in network studies, focusing on voters' most important context of interpersonal influence: the household. We leverage a randomly assigned spillover experiment conducted in the United Kingdom, combined with a detailed database of pretreatment party preferences and public turnout records, to identify social influence within heterogeneous and homogeneous partisan households. Our results show that intrahousehold mobilization effects are larger as a result of campaign contact in heterogeneous than in homogeneous partisan households, and larger still when the partisan intensity of the message is exogenously increased, suggesting discussion rather than behavioral contagion as a mechanism. Our results qualify findings from influential observational studies and suggest that within intimate social networks, negative correlations between political heterogeneity and electoral participation are unlikely to result from political disagreement

    Loan Growth and Riskiness of Banks

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    We investigate whether loan growth affects the riskiness of banks in 14 major western countries under "regular conditions". Using Bankscope data from more than 10,000 individual banks during 1997-2005, we test three hypotheses on the relation between past loan growth and loan losses, bank profitability, and bank solvency. Our empirical evidence supports the view that loan growth leads to a peak in loan loss provisions three years later, to a decrease in relative interest income, and to lower capital ratios. Further analyses reveal that loan growth also has a negative impact on risk-adjusted interest income. These results suggest that loan growth represents an important driver of bank risk

    Receptors for Insulin-Like Growth Factor-2 and Androgens as Therapeutic Targets in Triple-Negative Breast Cancer.

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    Triple-negative breast cancer (TNBC) occurs in 10-15% of all breast cancer patients, yet it accounts for about half of all breast cancer deaths. There is an urgent need to identify new antitumor targets to provide additional treatment options for patients afflicted with this aggressive disease. Preclinical evidence suggests a critical role for insulin-like growth factor-2 (IGF2) and androgen receptor (AR) in regulating TNBC progression. To advance this work, a panel of TNBC cell lines was investigated with all cell lines showing significant expression of IGF2. Treatment with IGF2 stimulated cell proliferation in vitro (p < 0.05). Importantly, combination treatments with IGF1R inhibitors BMS-754807 and NVP-AEW541 elicited significant inhibition of TNBC cell proliferation (p < 0.001). Based on Annexin-V binding assays, BMS-754807, NVP-AEW541 and enzalutamide induced TNBC cell death (p < 0.005). Additionally, combination of enzalutamide with BMS-754807 or NVP-AEW541 exerted significant reductions in TNBC proliferation even in cells with low AR expression (p < 0.001). Notably, NVP-AEW541 and BMS-754807 reduced AR levels in BT549 TNBC cells. These results provide evidence that IGF2 promotes TNBC cell viability and proliferation, while inhibition of IGF1R/IR and AR pathways contribute to blockade of TNBC proliferation and promotion of apoptosis in vitro
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