1,950 research outputs found
Impact bias in student evaluations of higher education
In the context of higher education, this study examines the extent to which affective evaluations of the student experience are influenced by the point at which they are made (i.e. before the experience begins, whilst it is happening and after it has ended). It adopts a between-groups quantitative analysis of the affective evaluations made by 360 future, current and past postgraduate students of a UK business school. The study validates the proposition that affective forecasts and memories of the student experience are considerably inflated in prospect and retrospect; a finding that implies a significant impact bias. It is concluded that the impact bias may have important implications for influencing the effectiveness of student decision-making, the timing and comparability of student course evaluations, and understanding the nature and effects of word-of-mouth communication regarding the student experience
Development of a high capacity toroidal Ni/Cd cell
A nickel cadmium battery design which can offer better thermal management, higher energy density and much lower cost than the state-of-the-art is emphasized. A toroidal Ni/Cd cell concept is described. It was critically reviewed and used to develop two cell designs for practical implementation. One is a double swaged and the other a swaged welded configuration
All in the Family: Partisan Disagreement and Electoral Mobilization in Intimate Networks - a Spillover Experiment
We advance the debate about the impact of political disagreement in social networks on electoral participation by addressing issues of causal inference common in network studies, focusing on voters' most important context of interpersonal influence: the household. We leverage a randomly assigned spillover experiment conducted in the United Kingdom, combined with a detailed database of pretreatment party preferences and public turnout records, to identify social influence within heterogeneous and homogeneous partisan households. Our results show that intrahousehold mobilization effects are larger as a result of campaign contact in heterogeneous than in homogeneous partisan households, and larger still when the partisan intensity of the message is exogenously increased, suggesting discussion rather than behavioral contagion as a mechanism. Our results qualify findings from influential observational studies and suggest that within intimate social networks, negative correlations between political heterogeneity and electoral participation are unlikely to result from political disagreement
Loan Growth and Riskiness of Banks
We investigate whether loan growth affects the riskiness of banks in 14 major western countries under "regular conditions". Using Bankscope data from more than 10,000 individual banks during 1997-2005, we test three hypotheses on the relation between past loan growth and loan losses, bank profitability, and bank solvency. Our empirical evidence supports the view that loan growth leads to a peak in loan loss provisions three years later, to a decrease in relative interest income, and to lower capital ratios. Further analyses reveal that loan growth also has a negative impact on risk-adjusted interest income. These results suggest that loan growth represents an important driver of bank risk
Receptors for Insulin-Like Growth Factor-2 and Androgens as Therapeutic Targets in Triple-Negative Breast Cancer.
Triple-negative breast cancer (TNBC) occurs in 10-15% of all breast cancer patients, yet it accounts for about half of all breast cancer deaths. There is an urgent need to identify new antitumor targets to provide additional treatment options for patients afflicted with this aggressive disease. Preclinical evidence suggests a critical role for insulin-like growth factor-2 (IGF2) and androgen receptor (AR) in regulating TNBC progression. To advance this work, a panel of TNBC cell lines was investigated with all cell lines showing significant expression of IGF2. Treatment with IGF2 stimulated cell proliferation in vitro (p < 0.05). Importantly, combination treatments with IGF1R inhibitors BMS-754807 and NVP-AEW541 elicited significant inhibition of TNBC cell proliferation (p < 0.001). Based on Annexin-V binding assays, BMS-754807, NVP-AEW541 and enzalutamide induced TNBC cell death (p < 0.005). Additionally, combination of enzalutamide with BMS-754807 or NVP-AEW541 exerted significant reductions in TNBC proliferation even in cells with low AR expression (p < 0.001). Notably, NVP-AEW541 and BMS-754807 reduced AR levels in BT549 TNBC cells. These results provide evidence that IGF2 promotes TNBC cell viability and proliferation, while inhibition of IGF1R/IR and AR pathways contribute to blockade of TNBC proliferation and promotion of apoptosis in vitro
Recommended from our members
[Abstract] A re-examination of value co-creation in the age of interactive service robots: a service logic perspective
No description supplie
Pennsylvanian Sharon Formation, past and present: sedimentology, hydrogeology, and historical and environmental significance: a field guide to Gorge Metro Park, Virginia Kendall Ledges in the Cuyahoga Valley National Park, and other sites in Northeast Ohio
Prepared for the 2003 Annual Great Lakes Section-SEPM/Northern Ohio Geological Society Field Conference
Recommended from our members
Credit risk in European banks: The bright side of the internal ratings based approach
This paper investigates the accuracy of internal rating based (IRB) models in measuring credit risk. We contribute to the growing debate on the current prudential regulatory framework by investigating the use of validated IRB models in promoting efficient risk management practices. Our empirical analysis is based on a novel panel data set of 177 Western European banks observed from 2008 to 2015, in the aftermath of the financial and economic crisis. We find that IRB banks were able to curb the increase in credit risk driven by the macroeconomic slowdown better than banks under the standardized approach. This suggests that the introduction of the internal ratings based approach by Basel II has promoted the adoption of stronger risk management practices among banks, as meant by the regulators
- …
