Uma revisão narrativa da literatura sobre o uso de canabidiol no tratamento da ansiedade

The study highlights the growing global importance of mental health, particularly considering the prevalence of mental disorders such as depression and anxiety. In this context, cannabidiol (CBD) from the Cannabis sativa plant emerges as a potential treatment, given its wide molecular interaction and anxiolytic properties. The reviewed research consistently indicates the positive effects of CBD in reducing anxiety across a variety of conditions, including post-traumatic stress disorder (PTSD) and social anxiety disorder. However, the complex relationship between CBD plasma concentration and its therapeutic effects, along with the lack of detailed data on its pharmacokinetics, underscores the need for more clinical studies to validate its efficacy and safety in various psychiatric conditions. Additionally, CBD presents broad therapeutic potential in other areas such as schizophrenia and Parkinson's disease, as well as its role in modulating brain activity in areas related to anxiety and psychosis. However, the complexity of CBD effects and the need to explore individual differences in treatment response highlight the importance of a broader and more careful approach in investigating its therapeutic effects.O estudo destaca a crescente importância da saúde mental globalmente, especialmente considerando a prevalência de transtornos mentais como depressão e ansiedade. Nesse contexto, o canabidiol (CBD) da planta Cannabis sativa surge como um potencial tratamento, devido à sua ampla interação molecular e propriedades ansiolíticas. A pesquisa revisada indica consistentemente os efeitos positivos do CBD na redução da ansiedade em uma variedade de condições, incluindo transtorno de estresse pós-traumático (TEPT) e transtorno de ansiedade social. No entanto, a relação complexa entre a concentração plasmática do CBD e seus efeitos terapêuticos, juntamente com a falta de dados detalhados sobre sua farmacocinética, ressalta a necessidade de mais estudos clínicos para validar sua eficácia e segurança em diversas condições psiquiátricas. Além disso, o CBD apresenta amplo potencial terapêutico em outras áreas, como esquizofrenia e doença de Parkinson, além de seu papel na modulação da atividade cerebral em áreas relacionadas à ansiedade e à psicose. No entanto, a complexidade dos efeitos do CBD e a necessidade de explorar diferenças individuais na resposta ao tratamento evidenciam a importância de uma abordagem mais ampla e cuidadosa na investigação de seus efeitos terapêuticos

Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved