Using network analysis for the prediction of treatment dropout in patients with mood and anxiety disorders: a methodological proof-of-concept study

There are large health, societal, and economic costs associated with attrition from psychological services. The recently emerged, innovative statistical tool of complex network analysis was used in the present proof-of-concept study to improve the prediction of attrition. Fifty-eight patients undergoing psychological treatment for mood or anxiety disorders were assessed using Ecological Momentary Assessments four times a day for two weeks before treatment (3,248 measurements). Multilevel vector autoregressive models were employed to compute dynamic symptom networks. Intake variables and network parameters (centrality measures) were used as predictors for dropout using machine-learning algorithms. Networks for patients differed significantly between completers and dropouts. Among intake variables, initial impairment and sex predicted dropout explaining 6% of the variance. The network analysis identified four additional predictors: Expected force of being excited, outstrength of experiencing social support, betweenness of feeling nervous, and instrength of being active. The final model with the two intake and four network variables explained 32% of variance in dropout and identified 47 out of 58 patients correctly. The findings indicate that patients’ dynamic network structures may improve the prediction of dropout. When implemented in routine care, such prediction models could identify patients at risk for attrition and inform personalized treatment recommendations.This work was supported by the German Research Foundation National Institute (DFG, Grant nos. LU 660/8-1 and LU 660/10-1 to W. Lutz). The funder of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the manuscript. The corresponding author had access to all data in the study and had final responsibility for the decision to submit for publication. Dr. Hofmann receives financial support from the Alexander von Humboldt Foundation (as part of the Humboldt Prize), NIH/NCCIH (R01AT007257), NIH/NIMH (R01MH099021, U01MH108168), and the James S. McDonnell Foundation 21st Century Science Initiative in Understanding Human Cognition - Special Initiative. (LU 660/8-1 - German Research Foundation National Institute (DFG); LU 660/10-1 - German Research Foundation National Institute (DFG); Alexander von Humboldt Foundation; R01AT007257 - NIH/NCCIH; R01MH099021 - NIH/NIMH; U01MH108168 - NIH/NIMH; James S. McDonnell Foundation 21st Century Science Initiative in Understanding Human Cognition - Special Initiative)Accepted manuscrip

Supported accommodation evaluation framework (SAEF) guide

High hopes for the NDIS are that people with disability will be able to live as independently as they choose, with the housing of their choice, and with the paid support that suits their preferences and life goals. Research conducted by the Social Policy Research Centre for the NSW government about disability housing support that is like the NDIS found that most people did achieve some positive outcomes. Least change was evident in people’s interpersonal relationships and employment, and some people did not live in housing that met their needs.&nbsp

A simple mathematical model for anomalous diffusion via Fisher's information theory

Starting with the relative entropy based on a previously proposed entropy function $S_q[p]=\int dx p(x)(-\ln p(x))^q$, we find the corresponding Fisher's information measure. After function redefinition we then maximize the Fisher information measure with respect to the new function and obtain a differential operator that reduces to a space coordinate second derivative in the $q\to 1$ limit. We then propose a simple differential equation for anomalous diffusion and show that its solutions are a generalization of the functions in the Barenblatt-Pattle solution. We find that the mean squared displacement, up to a $q$-dependent constant, has a time dependence according to $\sim K^{1/q}t^{1/q}$, where the parameter $q$ takes values $q=\frac{2n-1}{2n+1}$ (superdiffusion) and $q=\frac{2n+1}{2n-1}$ (subdiffusion), $\forall n\geq 1$.Comment: 13 pages,3 figure

Follow-Up Near-infrared Spectroscopy of Ultraluminous Infrared Galaxies observed by ISO

We present low resolution near-infrared spectroscopy of an unbiased sample of 24 ultraluminous infrared galaxies (ULIRGs), selected from samples previously observed spectroscopically in the mid-infrared with the Infrared Space Observatory (ISO). Qualitatively, the near-infrared spectra resemble those of starbursts. Only in one ULIRG, IRAS 04114-5117E, do we find spectroscopic evidence for AGN activity. The spectroscopic classification in the near-infrared is in very good agreement with the mid-infrared one. For a subset of our sample for which extinction corrections can be derived from Pa-alpha and Br-gamma, we find rather high Pa-alpha luminosities, in accordance with the powering source of these galaxies being star formation.[Fe] emission is strong in ULIRGs and may be linked to starburst and superwind activity. Additionally, our sample includes two unusual objects. The first, IRAS F00183-7111, exhibits extreme [Fe] emission and the second, IRAS F23578-5307, is according to our knowledge one of the most luminous infrared galaxies in H2 rotation-vibration emission.Comment: Accepted for publication in A&A (12 pages, 4 figures). See http://www.mpia-hd.mpg.de/homes/dannerb/ for a version with higher quality figure

Exploring the active galactic nucleus and starburst content of local ultraluminous infrared galaxies through 5-8 micron spectroscopy

We present a 5-8 micron analysis of the Spitzer-IRS spectra of 71 ultraluminous infrared galaxies (ULIRGs) with redshift z < 0.15, devoted to the study of the role of active galactic nuclei (AGN) and starbursts (SB) as the power source of the extreme infrared emission. Around 5 micron an AGN is much brighter (by a factor 30) than a starburst of equal bolometric luminosity. This allows us to detect the presence of even faint accretion-driven cores inside ULIRGs: signatures of AGN activity are found in 70 per cent of our sample (50/71 sources). Through a simple analytical model we are also able to obtain a quantitative estimate of the AGN/SB contribution to the overall energy output of each source. Although the main fraction of ULIRG luminosity is confirmed to arise from star formation events, the AGN contribution is non-negligible (23 per cent) and is shown to increase with luminosity. The existence of a rather heterogeneous pattern in the composition and geometrical structure of the dust among ULIRGs is newly supported by the comparison between individual absorption features and continuum extinction.Comment: 56 pages, 13 figures, 4 tables. Accepted for publication in MNRA

Chemistry, temperature, and faunal distributions at diffuse-flow hydrothermal vents : comparison of two geologically distinct ridge systems

Author Posting. © The Oceanography Society, 2012. This article is posted here by permission of The Oceanography Society for personal use, not for redistribution. The definitive version was published in Oceanography 25, no. 1 (2012): 234–245, doi:10.5670/oceanog.2012.22.Diffuse-flow, low-temperature areas near hydrothermal vents support life via chemosynthesis: hydrogen sulfide (and other reduced chemical compounds) emanating from the subsurface is oxidized with bottom-water oxygen through bacterial mediation to fix carbon dioxide and produce biomass. This article reviews the in situ diffuse-flow chemistry (mainly H2S and O2) and temperature data collected in 2006 and 2009 along the Eastern Lau Spreading Center (ELSC), and from 2004 to 2008 at 9°N along the East Pacific Rise (9 N EPR), predominantly around macrofauna that contain endosymbionts at these two hydrothermal vent regions. More than 48,000 and 20,000 distinct chemical and temperature data points were collected with a multi-analyte electrochemical analyzer in the diffuse-flow waters at 9 N EPR and the ELSC, respectively. Despite their different geological settings and different macrofauna (two different species of snails and mussels at the ELSC versus two different species of tubeworms and mussels at 9 N EPR), there are similarities in the temperature and chemistry data, as well as in the distributions of organisms. The pattern of water chemistry preferred by the provannid snails (Alviniconcha spp., Ifremeria nautilei) and Bathymodiolus brevior at the ELSC is similar to the water chemistry pattern found for the siboglinid tubeworms (Tevnia jerichonana, Riftia pachyptila) and the Bathymodiolus thermophilus mussels at 9 N EPR. The eruptions at 9 N EPR in 2005 and 2006 resulted in increased H2S concentrations, increased H2S/T ratios, and an initial change in the dominant tubeworm species from Riftia pachyptila to Tevnia jerichonana after the eruption created new vent habitats. In 2005, two sites at 9 N EPR showed major increases in the H2S/T ratio from 2004, which suggested a probable eruption in this basalt-dominated system. At the ELSC, there was a decrease in the H2S/T ratio from northern to southern sites, which reflects the change in geological setting from basalt to andesite and the shallower water depths at the southern sites.This work was supported by NSF grants OCE-0240896, OCE-073243 (ELSC), OCE-0308398 (OTIC), OCE-0326434, and OCE-0937324 (EPR) to GWL; ESI-0087679, OCE-9529819, and OCE-0327353 to RAL; OCE-0327261, OCE-0328117, OCE-0451983 to TMS; and OCE 0240985 and OCE 0732333 to CRF

The aza-Morita-Baylis-Hillman reaction of electronically and sterically deactivated substrates.

The aza-Morita–Baylis–Hillman (azaMBH) reaction has been studied for electronically and sterically deactivated Michael acceptors. It is found that electronically deactivated systems can be converted with electron-rich phosphanes and pyridines as catalysts equally well. For sterically deactivated systems clearly better catalytic turnover can be achieved with pyridine catalysts. This is in accordance with the calculated affinities of the catalysts towards different Michael-acceptors

The complications of ‘hiring a hubby’: gender relations and the commoditisation of home maintenance in New Zealand

This paper examines the commoditization of traditionally male domestic tasks through interviews with handymen who own franchises in the company ‘Hire a Hubby’ in New Zealand and homeowners who have paid for home repair tasks to be done. Discussions of the commoditization of traditionally female tasks in the home have revealed the emotional conflicts of paying others to care as well as the exploitative and degrading conditions that often arise when work takes place behind closed doors. By examining the working conditions and relationships involved when traditionally male tasks are paid for, this paper raises important questions about the valuing of reproductive labour and the production of gendered identities. The paper argues that while working conditions and rates of pay for ‘hubbies’ are better than those for people undertaking commoditized forms of traditionally female domestic labour, the negotiation of this work is still complex and implicated in gendered relations and identities. Working on the home was described by interviewees as an expression of care for family and a performance of the ‘right’ way to be a ‘Kiwi bloke’ and a father. Paying others to do this labour can imply a failure in a duty of care and in the performance of masculinity