Abordagens Multidisciplinares para o Tratamento da Dor Crônica: Uma revisão das terapias integrativas e estratégias de manejo da dor crônica, incluindo medicamentos, fisioterapia e terapias alternativas.

Chronic pain is a debilitating condition that affects millions of people worldwide, significantly impacting their quality of life. This review article explores multidisciplinary approaches to chronic pain treatment, encompassing integrative therapies and management strategies that include medications, physiotherapy, and alternative therapies. Medicine plays a crucial role in alleviating chronic pain but should not be the sole consideration. Medications can provide immediate relief but may come with side effects and risks. Therefore, personalized treatment is essential, taking into account the cause of the pain and patient preferences. Physiotherapy stands out as an effective approach, improving physical function and quality of life. Therapeutic exercises, stretching, and joint mobilization have a positive impact on a variety of conditions, with active patient participation playing a crucial role in treatment success. Alternative therapies such as acupuncture, chiropractic care, and meditation offer significant benefits to many patients. While their effectiveness may vary, it is important for patients to have the opportunity to explore therapies that align with their preferences. Future research should address methodological issues and focus on personalized approaches. With a deeper understanding of pain mechanisms and more targeted therapies, it is possible to enhance the management of this challenging condition, promoting the well-being and functionality of patients.A dor crônica é uma condição debilitante que afeta milhões de pessoas em todo o mundo, tendo um impacto significativo na qualidade de vida. Este artigo de revisão explora abordagens multidisciplinares para o tratamento da dor crônica, abrangendo terapias integrativas e estratégias de manejo que incluem medicamentos, fisioterapia e terapias alternativas. A medicina desempenha um papel importante no alívio da dor crônica, mas não deve ser a única consideração. Medicamentos podem trazer alívio imediato, mas podem vir acompanhados de efeitos colaterais e riscos. Portanto, a personalização do tratamento é essencial, levando em consideração a causa da dor e as preferências do paciente. A fisioterapia destaca-se como uma abordagem eficaz, melhorando a função física e a qualidade de vida. Exercícios terapêuticos, alongamento e mobilização articular têm um impacto positivo em uma variedade de condições, com a participação ativa do paciente desempenhando um papel crucial no sucesso do tratamento. Terapias alternativas, como acupuntura, quiropraxia e meditação, oferecem benefícios significativos para muitos pacientes. Embora sua eficácia varie, é importante que os pacientes tenham a oportunidade de explorar terapias que se alinhem às suas preferências. A pesquisa futura deve abordar questões metodológicas e se concentrar em abordagens personalizadas. Com uma compreensão mais profunda dos mecanismos da dor e terapias mais direcionadas, é possível melhorar o manejo dessa condição desafiadora, promovendo o bem-estar e a funcionalidade dos pacientes

Impactos do tratamento com liraglutida na progressão da doença renal crônica em pacientes com diabetes mellitus tipo 2 / Impacts of treatment with liraglutide on the progression of chronic kidney disease in patients with type 2 diabetes mellitus

INTRODUÇÃO: A doença renal diabética é uma importante complicação decorrente da diabetes mellitus tipo 2. O estudo visa analisar o impacto da utilização da liraglutida, um fármaco agonista de GLP-1, no controle desse agravo. METODOLOGIA: Foi realizada uma revisão narrativa baseada em artigos encontrados entre os anos 2016 e 2020, nas bases de dados LILACS e PubMed, por meio de consulta ao DeCs, através dos descritores: GLP-1, liraglutide, diabetes mellitus e kidney chronic disease. RESULTADOS: Foram selecionadas 9 publicações para serem utilizadas como referencial para este artigo. DISCUSSÃO: Estudos estão sendo realizados a fim de identificar medicamentos que controlam a glicemia e sejam eficazes na preservação da função renal, assim evidenciou-se a Liraglutida. O fármaco apresentou bons resultados sobre o controle glicêmico, mostrando-se mais eficaz em relação a outros medicamentos. Além disso, foram evidenciados resultados positivos sobre o controle da obesidade e da pressão arterial, sendo esses fatores contribuintes para diminuir a progressão da doença renal diabética. Importante ressaltar também a atuação da liraglutida no sistema renal, reduzindo o declínio da taxa de filtração glomerular e os valores de albuminúria. CONCLUSÃO: A liraglutida se mostrou eficiente na redução da progressão da doença renal crônica em pacientes diabéticos tipo 2

Os principais tipos e manifestações da Cirrose Hepática: uma atualização clínica

Introdução: A cirrose hepática é um processo patológica crônico, considerado a hepatopatia mais comum, definido como a conversão difusa morfoestrutural por nódulos de arquitetura anômalo envoltos por fibrose. Objetivou-se descrever os tipos mais relevantes de cirrose e suas devidas manifestações. Metodologia: Trata-se de uma revisão bibliográfica, fundamentada nas plataformas do SciELO, PubMed, Scopus, utilizando os termos “hepatical cirrhosis”, “liver disease” e “hepatocellular insufficiency” a qual através da revisão narrativa, abordou amplamente a respeito da contextualização da cirrose e as principais etiologias. Resultados e Discussão: Foi analisado que tal condição afeta qualquer faixa etária, sexo, etnia e independe da classe socioeconômica, mas as diversas etiologias impõem um perfil epidemiológico específico conforme a aparição. As principais origens abordam o tipo alcoólico, hepatite, aplicação crônica de alguns fármacos e esteatose gordurosa ou não. Ademais, estima-se que estas afetam a anatomofuncionalidade do órgão responsável por grande parte da homeostase, culminando em diversas manifestações clínicas.  Conclusão: A cirrose é uma consequência grave de fatores de base em estágio avançado, a qual devido ao seu curso geralmente silencioso culmina no desenvolvimento e progressão clínica. Neste contexto, a atenção aos fatores predisponentes como alimentação rica em lipídios, estilismo, negligência a exames de rotina, sedentarismo e obesidade contribuem constituem medidas eficazes de prevenção primária.&nbsp

ATLANTIC EPIPHYTES: a data set of vascular and non-vascular epiphyte plants and lichens from the Atlantic Forest

Epiphytes are hyper-diverse and one of the frequently undervalued life forms in plant surveys and biodiversity inventories. Epiphytes of the Atlantic Forest, one of the most endangered ecosystems in the world, have high endemism and radiated recently in the Pliocene. We aimed to (1) compile an extensive Atlantic Forest data set on vascular, non-vascular plants (including hemiepiphytes), and lichen epiphyte species occurrence and abundance; (2) describe the epiphyte distribution in the Atlantic Forest, in order to indicate future sampling efforts. Our work presents the first epiphyte data set with information on abundance and occurrence of epiphyte phorophyte species. All data compiled here come from three main sources provided by the authors: published sources (comprising peer-reviewed articles, books, and theses), unpublished data, and herbarium data. We compiled a data set composed of 2,095 species, from 89,270 holo/hemiepiphyte records, in the Atlantic Forest of Brazil, Argentina, Paraguay, and Uruguay, recorded from 1824 to early 2018. Most of the records were from qualitative data (occurrence only, 88%), well distributed throughout the Atlantic Forest. For quantitative records, the most common sampling method was individual trees (71%), followed by plot sampling (19%), and transect sampling (10%). Angiosperms (81%) were the most frequently registered group, and Bromeliaceae and Orchidaceae were the families with the greatest number of records (27,272 and 21,945, respectively). Ferns and Lycophytes presented fewer records than Angiosperms, and Polypodiaceae were the most recorded family, and more concentrated in the Southern and Southeastern regions. Data on non-vascular plants and lichens were scarce, with a few disjunct records concentrated in the Northeastern region of the Atlantic Forest. For all non-vascular plant records, Lejeuneaceae, a family of liverworts, was the most recorded family. We hope that our effort to organize scattered epiphyte data help advance the knowledge of epiphyte ecology, as well as our understanding of macroecological and biogeographical patterns in the Atlantic Forest. No copyright restrictions are associated with the data set. Please cite this Ecology Data Paper if the data are used in publication and teaching events. © 2019 The Authors. Ecology © 2019 The Ecological Society of Americ

Catálogo Taxonômico da Fauna do Brasil: setting the baseline knowledge on the animal diversity in Brazil

The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others

Brazilian Flora 2020: Leveraging the power of a collaborative scientific network

International audienceThe shortage of reliable primary taxonomic data limits the description of biological taxa and the understanding of biodiversity patterns and processes, complicating biogeographical, ecological, and evolutionary studies. This deficit creates a significant taxonomic impediment to biodiversity research and conservation planning. The taxonomic impediment and the biodiversity crisis are widely recognized, highlighting the urgent need for reliable taxonomic data. Over the past decade, numerous countries worldwide have devoted considerable effort to Target 1 of the Global Strategy for Plant Conservation (GSPC), which called for the preparation of a working list of all known plant species by 2010 and an online world Flora by 2020. Brazil is a megadiverse country, home to more of the world's known plant species than any other country. Despite that, Flora Brasiliensis, concluded in 1906, was the last comprehensive treatment of the Brazilian flora. The lack of accurate estimates of the number of species of algae, fungi, and plants occurring in Brazil contributes to the prevailing taxonomic impediment and delays progress towards the GSPC targets. Over the past 12 years, a legion of taxonomists motivated to meet Target 1 of the GSPC, worked together to gather and integrate knowledge on the algal, plant, and fungal diversity of Brazil. Overall, a team of about 980 taxonomists joined efforts in a highly collaborative project that used cybertaxonomy to prepare an updated Flora of Brazil, showing the power of scientific collaboration to reach ambitious goals. This paper presents an overview of the Brazilian Flora 2020 and provides taxonomic and spatial updates on the algae, fungi, and plants found in one of the world's most biodiverse countries. We further identify collection gaps and summarize future goals that extend beyond 2020. Our results show that Brazil is home to 46,975 native species of algae, fungi, and plants, of which 19,669 are endemic to the country. The data compiled to date suggests that the Atlantic Rainforest might be the most diverse Brazilian domain for all plant groups except gymnosperms, which are most diverse in the Amazon. However, scientific knowledge of Brazilian diversity is still unequally distributed, with the Atlantic Rainforest and the Cerrado being the most intensively sampled and studied biomes in the country. In times of “scientific reductionism”, with botanical and mycological sciences suffering pervasive depreciation in recent decades, the first online Flora of Brazil 2020 significantly enhanced the quality and quantity of taxonomic data available for algae, fungi, and plants from Brazil. This project also made all the information freely available online, providing a firm foundation for future research and for the management, conservation, and sustainable use of the Brazilian funga and flora