39 research outputs found
Emergence of hyperons in failed supernovae: trigger of the black hole formation
We investigate the emergence of strange baryons in the dynamical collapse of
a non-rotating massive star to a black hole by the neutrino-radiation
hydrodynamical simulations in general relativity. By following the dynamical
formation and collapse of nascent proto-neutron star from the gravitational
collapse of a 40Msun star adopting a new hyperonic EOS table, we show that the
hyperons do not appear at the core bounce but populate quickly at ~0.5-0.7 s
after the bounce to trigger the re-collapse to a black hole. They start to show
up off center owing to high temperatures and later prevail at center when the
central density becomes high enough. The neutrino emission from the accreting
proto-neutron star with the hyperonic EOS stops much earlier than the
corresponding case with a nucleonic EOS while the average energies and
luminosities are quite similar between them. These features of neutrino signal
are a potential probe of the emergence of new degrees of freedom inside the
black hole forming collapse.Comment: 11 pages, 3 figures, accepted for publication in ApJ
Discontinuous transitions in double exchange materials
It is shown that the double exchange Hamiltonian, with weak antiferromagnetic
interactions, has a rich variety of first order transitions between phases with
different electronic densities and/or magnetizations. For band fillings in the
range , and at finite temperatures, a discontinuous
transition between phases with similar electronic densities but different
magnetizations takes place. This sharp transition, which is not suppressed by
electrostatic effects, and survives in the presence of an applied field, is
consistent with the phenomenology of the doped manganites near the transition
temperature.Comment: three more variational ansatzs considere
Variational Mean Field approach to the Double Exchange Model
It has been recently shown that the double exchange Hamiltonian, with weak
antiferromagnetic interactions, has a richer variety of first and second order
transitions than previously anticipated, and that such transitions are
consistent with the magnetic properties of manganites. Here we present a
thorough discussion of the variational Mean Field approach that leads to the
these results. We also show that the effect of the Berry phase turns out to be
crucial to produce first order Paramagnetic-Ferromagnetic transitions near half
filling with transition temperatures compatible with the experimental
situation. The computation relies on two crucial facts: the use of a Mean Field
ansatz that retains the complexity of a system of electrons with off-diagonal
disorder, not fully taken into account by the Mean Field techniques, and the
small but significant antiferromagnetic superexchange interaction between the
localized spins.Comment: 13 pages, 11 postscript figures, revte
Optimality regions and fluctuations for Bernoulli last passage models
We study the sequence alignment problem and its independent version,the discrete Hammersley process with an exploration penalty.
We obtain rigorous upper bounds for the number of optimality regions in both models near the soft edge.At zero penalty the independent model becomes an exactly solvable model and we identify cases for which the law of the last passage time converges to a Tracy-Widom law
Constructing majority-rule supertrees
<p>Abstract</p> <p>Background</p> <p>Supertree methods combine the phylogenetic information from multiple partially-overlapping trees into a larger phylogenetic tree called a supertree. Several supertree construction methods have been proposed to date, but most of these are not designed with any specific properties in mind. Recently, Cotton and Wilkinson proposed extensions of the majority-rule consensus tree method to the supertree setting that inherit many of the appealing properties of the former.</p> <p>Results</p> <p>We study a variant of one of Cotton and Wilkinson's methods, called majority-rule (+) supertrees. After proving that a key underlying problem for constructing majority-rule (+) supertrees is NP-hard, we develop a polynomial-size exact integer linear programming formulation of the problem. We then present a data reduction heuristic that identifies smaller subproblems that can be solved independently. While this technique is not guaranteed to produce optimal solutions, it can achieve substantial problem-size reduction. Finally, we report on a computational study of our approach on various real data sets, including the 121-taxon, 7-tree Seabirds data set of Kennedy and Page.</p> <p>Conclusions</p> <p>The results indicate that our exact method is computationally feasible for moderately large inputs. For larger inputs, our data reduction heuristic makes it feasible to tackle problems that are well beyond the range of the basic integer programming approach. Comparisons between the results obtained by our heuristic and exact solutions indicate that the heuristic produces good answers. Our results also suggest that the majority-rule (+) approach, in both its basic form and with data reduction, yields biologically meaningful phylogenies.</p
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic
The genetic architecture of the human cerebral cortex
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
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Dietary αâLinolenic Acid, Marine Ïâ3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvenciĂłn con DIeta MEDiterrĂĄnea (PREDIMED) Study
Background: Epidemiological evidence suggests a cardioprotective role of αâlinolenic acid (ALA), a plantâderived Ïâ3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine Ïâ3 fatty acids (longâchain nâ3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to allâcause and cardiovascular disease mortality. We also examined the effect of meeting the society's recommendation for longâchain nâ3 polyunsaturated fatty acids (â„500 mg/day). Methods and Results: We longitudinally evaluated 7202 participants in the PREvenciĂłn con DIeta MEDiterrĂĄnea (PREDIMED) trial. Multivariableâadjusted Cox regression models were fitted to estimate hazard ratios. ALA intake correlated to walnut consumption (r=0.94). During a 5.9ây followâup, 431 deaths occurred (104 cardiovascular disease, 55 coronary heart disease, 32 sudden cardiac death, 25 stroke). The hazard ratios for meeting ALA recommendation (n=1615, 22.4%) were 0.72 (95% CI 0.56â0.92) for allâcause mortality and 0.95 (95% CI 0.58â1.57) for fatal cardiovascular disease. The hazard ratios for meeting the recommendation for longâchain nâ3 polyunsaturated fatty acids (n=5452, 75.7%) were 0.84 (95% CI 0.67â1.05) for allâcause mortality, 0.61 (95% CI 0.39â0.96) for fatal cardiovascular disease, 0.54 (95% CI 0.29â0.99) for fatal coronary heart disease, and 0.49 (95% CI 0.22â1.01) for sudden cardiac death. The highest reduction in allâcause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [95% CI 0.45â0.87]). Conclusions: In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to allâcause mortality, whereas protection from cardiac mortality is limited to fishâderived longâchain nâ3 polyunsaturated fatty acids. Clinical Trial Registration URL: http://www.Controlled-trials.com/. Unique identifier: ISRCTN35739639
Queratoplastia penetrante en el Hospital Universitario de Canarias. Nuestra experiencia
Penetrating keratoplasty is nowadays the most frequent organ transplant and the most successful one in the world. The establishment of common criteria for donation and conservation procedures as well as for surgical indications has contributed to an improvement of the process and its results. We present a retrospective study about 142 penetrating keratoplasties made between 1998 and 2002 at the Hospital Universitario de Canarias (Canary Islands University Hospital), analysing a series of variables such as patientÂżs age, ethiology, systemic and ophthalmic pathology, process risk; previous best corrected visual acuity, refraction, and keratometry and after surgery; size of the donor grafts and corneal trephination both in the recipient and donorÂżs cornea, associated techniques, suture modality, complications, treatment before and after surgery; and graftÂżs survival. We have compared our results with the published literature and we find no significant statistic differences. We insist on the need for specific staff to carry out the surgical procedure as well as the handling and follow up of patients, taking into account the peculiarities of this pathology.El transplante de cĂłrnea es actualmente la tĂ©cnica de trasplante de Ăłrganos mĂĄs frecuentemente realizada y de mayor Ă©xito en todo el mundo. El establecimiento de unos criterios comunes en nuestra especialidad tanto referente a la donaciĂłn como a los procedimientos de conservaciĂłn e indicaciĂłn quirĂșrgica ha contribuido a una mejora del proceso y sus resultados. Hemos realizado un estudio retrospectivo de 142 queratoplastias realizadas entre los años 1998 y 2002 en el Hospital Universitario de Canarias con un seguimiento mĂnimo de un año, analizando una serie de variables como edad, etiologĂa, patologĂa sistĂ©mica y oftalmolĂłgica acompañante, grupo asignado de riesgo (pronĂłstico estimado prequirĂșrgico); agudeza visual, refracciĂłn y queratometrĂa previa y posquirĂșrgica, diĂĄmetro de la trepanaciĂłn en cĂłrnea donante y receptora, tĂ©cnicas asociadas, modalidad de sutura, complicaciones registradas, tratamientos previos y tras la cirugĂa asĂ como supervivencia del injerto. No hallamos en nuestro estudio diferencias estadĂsticamente significativas con los resultados encontrados en las publicaciones realizadas al respecto. Creemos que para ello ha sido importante contar con personal especĂfico que lleve a cabo tanto el procedimiento quirĂșrgico como el manejo y seguimiento de los pacientes intervenidos debido a las particularidades de esta patologĂ